TWI224005B - Pharmaceutical composition for nasal spray in treatment of cold and fever and method for producing the same - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for a nasal spray in treatment of cold and fever and a method for producing the same. The pharmaceutical composition includes Bupleurum Scorzonerifolium Wilid, Radix Isatidis Indigotica, Folium Isatidis, and vitamin C. The pharmaceutical composition receives distillation and filtration operations to form a medical agent. A patient can directly spray (drip) the medical agent to the nasal cavity for the agent to be absorbed by the nasal mucus membrane for relieving cold and fever related symptoms, e.g. headache, nasal congestion, coughing, sore throat, sneezing, running nose, body discomfort, etc. The invented pharmaceutical composition is also suitable for fever caused by various infections, particularly upper respiratory tract inflammation.

Description

1224005 IX. Description of the invention: [Technical field to which the invention belongs] The present invention relates to a pharmaceutical composition for fever and cold spray (drop) nasal solution and its method, the Bupleurum Scorzonerifolium Willd, Banlangen ( Radix Isatidis Indigotica) and Folium Isatidis are used to extract and filter out the ingredients after they are boiled and extracted and filtered out, and then this medicine is mixed with vitamin C to make a medicament. The prepared medicine can be sprayed (dropped) directly into the inside of the nasal cavity by the patient. After absorption by the nasal mucosa, it has antipyretic, antipyretic, analgesic, and relief of cold symptoms such as headache, nasal congestion, cough, sore throat, spit throat, fluent and The effects of cold symptoms such as general discomfort are also applicable to fever caused by various infectious diseases, especially the upper respiratory tract inflammation is more suitable. [Previous technology] Colds are generally considered to be insignificant. In fact, colds are a highly contagious viral infectious disease. It is characterized by a common set of recognizable symptoms-burnout, fever, tearing, stuffy nose, headache, dry throat or pain. Many viruses can cause a cold. The cold virus is very small and can easily slip into the body through a filter in the nasal passage. This filter usually only catches large bacteria. The virus multiplies quickly, invades the nose and throat, and causes common cold symptoms. Sometimes it can cause complications such as pneumonia or bronchitis. If not handled properly, it can even cause death. In fact, colds are a common disease that cannot be ignored. Treating colds In terms of Western medicine treatment, it is nothing more than taking antibiotics to reduce fever, steroids to relieve nasal, antihistamines, etc. to alleviate cold symptoms, plus drink plenty of water and rest. 1224005-In general, the effects of cisicide are relatively rapid and accurate, but the resistance caused by antibiotics, the toxicity of steroids to humans, and the damage to human organs caused by chemicals are all adverse effects known to modern people. In addition, the above-mentioned chemical drugs are not ideal for the relief and prevention of fever and cold. In terms of dosage forms, the drugs that rely on the stomach and the stomach are commonly used in capsules, creams, suppositories, oral liquids, and nasal sprays. For the prevention and cure of colds, in the field of towel medicine, it is generally composed mainly of antihypertensive drugs, and mainly sweating to achieve evacuation. The prescriptions used to relieve the card are collectively referred to as anti-table drugs. There are three main effects of the formula for relieving the epidemic. Sweating can be achieved through sweating. The sweat can also prevent the spread of disease and evil; dissolving the muscles and demystifying means that the evil has gone deeper. Although the sweat is out, the evidence is not resolved. It is necessary to use to clear the muscle surface to relieve the evil of the muscle surface; ⑶ In the treatment, some of the prescriptions for relieving the skin relied on the table to promote the bribery, because of the cold and heat of external evils, the body has the difference between deficiency and actual disease. Therefore, the interpretation is divided into Xin Wen solution table (for exogenous wind and cold table certificate) 'Xin Liang solution table (for exogenous wind and heat table certificate) and Fuzheng solution table (for physique deficiency and external evil caused table Card) three categories. Chinese herbal medicines are commonly used in traditional Chinese medicines. It is safe to use and has low side effects; however, it has the disadvantages of slow efficacy and inconvenient use. In terms of antipyretic and antipyretic, in addition to the effects of chemical drugs and Chinese herbal medicines, there are also physical cooling methods such as ice compresses, alcohol rubbing baths, and ice water enema. As far as possible, the above-mentioned method also has a certain effect in clinical practice, but there are also cases where the button is not used. After using the method, the body temperature will not decrease, but will increase. Among them, ice compress and alcohol are used to cool down, because the patient's high-temperature wire is difficult to accept, and it is inconvenient to work. 1224005 Looking at the above towels, Xiqiao for fever, stomach sensation, and ecstasy treatment, no matter there is western medicine, cap, or material, each kind of green has the disadvantages of perfect materials. [Summary of the Invention] If there is a kind of preparation that can quickly reduce fever, alleviate the symptoms of gastric sensation, have no paragamma and is convenient to use, and can be used for men, women, and children, it can be used to reduce fever and stomach. The main feature of the present invention is that it can effectively dissolve all the advantages of Chinese and Western medicines and physical antipyretics in one body and remove all seams, which means that human beings should be inventions of financial significance. The present invention is a nasal spray made of pure secret medicine granules and effective components of tissues, which is a medicine solution capable of rapidly reducing fever and alleviating colds. Reusing the characteristics of the human physiology and organs, administering from the nasal mucosa, avoiding the damage of the drug by the gastrointestinal pH value or enzymes, and directly absorbing it from the nasal mucosa, avoiding the effect of the medicine being damaged by the first pass of the liver when taken orally. Toxicity and side effects of the drug on the liver. In order to achieve a rapid fever, alleviate the symptoms of colds, female all-ping has no side effects, easy to use, suitable for men, women and children, and carry convenient natural plant medicines to make fever and relieve cold nose spray. In addition, in the form of a dosage form, the mouth (drop) is particularly convenient for patients or children who cannot or cannot swallow. The pharmaceutical composition of the fever and cold nasal spray (drops) of the present invention includes: Bupleurum Scorzonerifolium Willd, Radix Isatidis Indigotica, Folium Isatidis, and Vitamin C. The aforementioned medicine is composed of After the extract is made into a medicament, it is sprayed (dropped) into the nasal cavity and absorbed by the nasal drill film to achieve fever, antipyretics, analgesia, and relief of cold symptoms, such as headache, nasal congestion, cough, sore throat, sneezing, runny nose, and general discomfort. The efficacy of cold symptoms, 7 1224005 is also suitable for hair training caused by various causes, especially the respiratory tract inflammation.

Irregular menstruation 'prolapse of qi deficiency, prolapse of the uterus, drooping of the stomach. Radix Isatidis lndigotica, a medicinal composition of the present invention, has plaques, high fever, headache, varicella, anesthesia, hepatitis, and has antipyretic, detoxifying, cooling blood, and pharyngeal. Indications Wendu hair spot, scar disease, throat Dan #, erysipelas, itchy legs, itchy throat, sores, water pain influenza. The medicine and composition of the present invention (Isatidis)

The vitamin C of the medicinal composition of the present invention has the functions of preventing colds, enhancing resistance, and alleviating cold symptoms. Indications for colds caused by filtered pathogens. It is related to the detailed description and technical content of the present invention, and is illustrated with the following chart: [Embodiment] Please refer to "shown in Fig. 1", which is a schematic diagram of the manufacturing process of the fever and cold nasal spray (drop) of the present invention. As shown in the figure: the pharmaceutical composition of the fever and cold nasal spray (drops) of the present invention and the preparation method thereof, and the pharmaceutical composition includes: 25 ～ 3〇§Bupleurum Scorzonerifolium Willd, 120 ~ 144g Radix Isatidis Indigotica, 12G ~ 144g Folium isatidis & 8 1 ^ 24005 10 12g Vitamin C 'After extracting the other pharmaceutical composition into a medicament, spray or use it to the nose Endometrium is absorbed from the nose and foot tank, which can achieve antipyretic, antipyretic, analgesic, and alleviate cold symptoms, such as ..., nasal congestion, sputum, sore throat, dysentery, flowing ocean, and general discomfort. It also has symptoms and effects. Symptoms of fever, especially the upper respiratory tract inflammation are better. The chemical components, pharmacological aspects, functions, and indications contained in each of the above medicinal compositions have medical effects. Each of the medical surplus products in Benfa County are described as follows: 1. Bupleurum Scorzonerifolium Willd [ Chemical composition] The root of Bupleurum chinense contains volatile oil, which contains terpinene, limonene, camphene, camphene, cold-fenchene, menthol, allosaurus Brain (is〇b〇rne〇i), terpineol (cold-terpineol), linalool, α-copaene (α-copaene), humulene, a-farnesene Aromadendrene, cis and trans syringene, yS-elemene, r-muurolene, patchoulane, nut Teka flower cypress, ledol. It also contains Chaihu total formula 0.5%, of which Chaihu soap type a0.05%, Chaihu urgent formula d trace amount, Chaihu soap Wu c0. Jump. The above-ground part contains flavonoids: mountain cable type, mountain tree 7-rhamnoside, quercetirO, isoquercetin, isorhamnetin, rutin, 9! 224〇05 narcissin. [Pharmacological aspect] It has analgesic effect. Both mouse tail pressing method and acetic acid writhing method have proved the oral analgesic side of the glutinous soap. The experiment showed that Chaihu Xi formula 478mg / kg (l / 4LD50) can significantly increase the pain threshold. Chaihu crude Wuyuan a and sugar residue intraperitoneal injection of 50mg / kg or 10Gmg / kg can inhibit mice Intraperitoneal injection = reduced reaction caused by sugar residues and sclerosing method of scales and cranes analgesic ^. Some people think that _ soap can also relax and smoothen the analgesic effect by relaxing and smoothing. It has an antitussive effect, Chaihu total soap type and Chai Hu rough soap type joints __ with 'mechanical ship fired Niu Ming, guinea pig abdominal examination total soap touch _ is 9 · ling / kg', the effect is similar to Wei codeine 7.6 mg / kg. Chai The antitussive effect of Hu fufuyuan a is related to the dose. 'Guina pig intraperitoneal injection of ⑽ ~ 2 () () mg / kg has the most obvious antitussive effect. [Function and indications] — with solution Relieve fever and relieve stagnation of the liver, lift yang qi. Qi is responsible for exogenous fever, cold and heat, miscellaneous, liver, bloating and headache, irregular menstruation, prolapse of qi due to qi deficiency, prolapse of the uterus, stomach prolapse. 2. Radix isatidis Indig〇tica) [Chemical composition] Roots of Banjian Roots contain regrets Gnchgotin, indig〇), Yuhong (Mianxiao Xiao / 5 Gutian alcohol (million-speaking 丨), r glutanol (b 5 丨 t〇 ster〇 丨) and various amino 1224005 acids: arginine, glutamic acid, tyrosine, proline, valine, τ-aminobutyric acid Acid (r-aminobutyric ack〇, also contains black mustard (sinigrin), indoxy (/ 5-glucoside), tryptanthrine, l-thiocyanate 2-light-butan-3-ene (1-thiocyano-2-hydroxy-3-butene), report to Yichun

CepigoitrirO, glandular Udenosine}, palmitic acid, sucrose, sucrose, and proteoglycan containing 12% amino acids.

[Pharmacological aspects] I has antibacterial and viral effects. In vitro tests, 100% isatis root water decoction has antibacterial effects on Staphylococcus aureus and Staphylococcus epidermidis. A single layer of Shenyangye cells was adsorbed with hemorrhagic fever virus with a 50/0 histocytosis amount (TCID50). Banlangen injection was used for antiviral experiments. Results: 1: 100 Banlangen has a nephrotic syndrome hemorrhagic fever virus. Obvious killing effect. Isatis root extract can inhibit virus infection and inhibit proliferation. Effect on immune dysfunction, intraperitoneal injection of Isatis indigotica polysaccharides at 25 mg / kg, 50 mg / kg, and 100 mg / kg can significantly enhance p-dinitrochlorobenzene (1 ^ (: phantom delayed allergy reaction) in mice. Induces lymphocyte transformation in vivo and enhances natural killer cell (Nκ) live vomiting of spleen cells. Intraperitoneal injection of Isatis indigotica ^ 50 mg / kg can significantly promote the immune function of mice, which shows that it significantly increases the spleen weight of normal mice. , The total number of white blood cells and the number of lymphocytes, has a significant counteracting effect on the spleen index of hydrocortisone immunosuppressive mice, and has a significant effect on the reduction of the total number of cells and the number of lymphocytes. Causes immunosuppression of Tonzaki Weimin response; correction, can also enhance the formation of antibody 11 1224005 cell function, increase the rate of carbon injection in mice. [Functions and Indications] clearing heat, detoxification, cooling blood, pharyngeal. Spots, high fever, pain, big head plague, throat stasis, erysipelas, cheeks, itching, sore throat, chicken pox, numbness, liver $ influenza. 3. Folium Isatidis [Chemical composition] Leaf contains indigo (Indigo, indigo tin), 菘 蓝 式 (isat

Ldn β), indirubin. It also contains inorganic elements such as iron, titanium, manganese, zinc, copper, and cobalt, furnace, code, complex, and arsenic. Indigo-hydrolysis can be changed to indigo and xylofuranose (D-xylo-5-hexulofuranosonic acid). y, 酉 夂 [Pharmacological aspects] Anti-pathogenic microorganism effect, in vitro test of Daqingye decoction on Staphylococcus aureus, Streptococcus aureus, Meningococcus pneumoniae, Streptococcus pneumoniae, typhoid bacteria, E. coli, Epidemic, diphtheria, and dysentery all have some inhibitory effects. Daqingye has inhibitory effect on Japanese encephalitis virus, Yuesi adenovirus, influenza virus, etc. In addition, Daqingye still has the effect of killing Leptospira. [Functions and Indications] Clearing away heat and detoxifying, Liang A eliminates spots. Indications of fever, fever, thirst, fainting, spot rash, soil jk blood ’Θ itch], erysipelas, itchy throat, aphthous ulcer, treatment of moonlight. 4. Vitamin C (Vitamin C) ί2 1224005 [Chemical composition] It is composed of carbon, hydrogen and oxygen. ‘[Pharmacological aspects] Prevent colds, cold symptoms include fever, chills, general weakness, intense coughing, thinness, stuffy nose, headache, joint pain, and so on. Colds are mostly caused by filter pathogens, so your body will be weak. If you get bacterial infection again, it will easily cause serious diseases such as lung inflammation, bronchitis, tonsillitis, and myelitis. [Functions and Indications] Prevent colds, increase resistance, and reduce cold symptoms. Treats colds caused by filtered pathogens. The above medical music composition is extracted, filtered, and extracted separately, and the ingredients contained in each medical composition are extracted and filtered, and then mixed and combined to make it available for spraying (dropping) into the patient. The nasal mucosa absorbs the fever and cold nasal spray (drops), and the preparation process is as follows: The first step is to extract the volatile oil, and 250 ~ 300g Bupleurum chinense is first doubled with the amount of sweet water / and / pack 2 small At the same time, add 4 times more water to decoction, and use the steam steaming method to extract 2ml ~ 2.4W of volatile oil, and then filter out 1000ml ~ 1200ml of liquid medicine, and then use the volatile oil, filtrate and drug residue separately. The container is temporarily stored. In the second step, 120 to 144 g of isatis root and 120 to 144 g of big green leaves are respectively added to seven times the amount of water for 1 hour and then filtered, and the filtered liquid is temporarily stored in a container. The third step is to store the first Step 12 and the second step after extracting or filtering the remaining 13 1224005 medicine residues, and then add _ Wenqian five times the amount of water He Hour, work out the liquid ^ and then add four times the amount of water to cook for 40 minutes, Then the filtrates are combined; ^ The fourth step is to combine the three filtrates and the filtrate, and Ω reduced to the equivalent of liquid to raw music. Then add 95% ethanol to 70% alcohol content; the fifth step, the county's above-mentioned static body office, wealth, current medicine lg; f six steps, then the chest ~ 2.4ml volatile oil and 1 () ~ 12§ Vitamin C is added to the medicinal solution after dissolution, mixed and filtered, and then obtained by dispensing. The above-mentioned medicinal composition is extracted into a spray (drop) nasal preparation, and the fine nasal preparation is not directly damaged by the intestinal Ph value or enzyme, and is absorbed directly from the nasal cavity. Not only avoid the destruction of the first pass of the viscera when oral, but also reduce the toxicity or side effects of the agent on the liver. Lexan is less absorbed in the nasal membrane than π, and Gamma is generally quicker in mouth and mouth. 'For patients with mixed or swallowing drugs _ Qian Tong, _ nasal administration and in the above pharmaceutical composition After having a fever and cold mouth and nose liquid liniment preparation, it has a prostitute effect and safety in the experiments of antipyretic effect and toxicological research, so that it can be used safely when it is used. The antipyretic effect and toxicological research mentioned above are described as follows: 1. The antipyretic effect of nasal spray (drops): [Experimental materials] 1. Each nasal spray (drops) contains 2g of crude drug. The clinical medication 4 is 14 drops per ten kilograms of body weight (about 0.1 ml), which is completed within ten minutes and used 10 times in a row. The cumulative dose per kilogram of body weight is equivalent to about 0.2 g of crude medicine. Before the experiment, a nasal spray will be used. (Drops) diluted to the required drug concentration. 2. Analgin injection, produced by Wuhan Pharmaceutical Factory, batch number 9511104, specification 0.5 g / ml, clinical infants and young children use 20% solution for nasal drops, 2 drops on each side of the nostril, that is, each time When the maximum dosage is about 40 mg, the average weight of infants and young children is calculated as 10 kg. When 44 mg per kg of body weight is administered, Shilin will inject and release Analgin into the required drug concentration. 3. Tylenol antipyretic π liquid drop (mEN〇L children S Ps LIQUID), produced by Johnson & Johnson in the United States, batch number SGM199, each bottle I5πα, each Q.8ml contains 80mg of petaminophen (Acetaminophen) The clinical administration is based on age or body weight, about 0.12 mi per a kilogram of body weight-human administration, that is, about 121,111 amino acids are given. 4 physiological saline, produced by Pingdingshan Pharmaceutical Factory in Henan Province, batch number read. 5 ^ l〇W ^ > S ## t ^ (Themingling ferment liquid for fresh beer), take the fresh beer yeast suspension, evacuate it, take the dregs and centrifuge with physiological saline repeatedly, and discard the supernatant. Then · 5 test methylcellulose is formulated into a cis concentration. 6 Wistar big breasts, weight m ~ · g, provided by Experimental Animal Center of Henan Medical University. [Methods and results] The experiment was performed at room temperature 20 ~ 25 t: Chromium A 卞 / (see Table 1), and 1224005 hearts were added to the rat's mysterious body error G ~ 21Gg. The anus is turned slightly to measure the temperature of the basal basal body twice, and the rats with fluctuating temperature and money were subcutaneously injected with Natto Yeast. Liquid Li / kg, 4 hours after the injection, the body temperature was measured again, and the body temperature was increased by lt or more-and Fifty rats with similar heating temperature were used for experiments. The rats were randomly divided into 5 groups, that is, spraying with liquid-rich stalks, stealing high, stealing, and lowering, and then, she, ^, agent group and air self-examination (as shown in the table below) The effect of nasal fluid (_) on the mother's miscellaneous temperature α, Qing)), green ·, riding test _ Ridge test substance nasal drops to China, each time 0.14ml / kg, finished within 10 minutes, Gamma minutes administration -Times, continuously _ the total dose volume of each time is 4ml / kg, the two oral and nasal fluid (_) groups are given nasal spray (drops) of the two concentrations after dilution, the total dose, high dose The group is equivalent to crude drug Ug / kg 'low dose is equivalent to crude drug 12 _, the Analgin group was given diluted Analgin injection', the cumulative dose of Analgin was 0.08 g / kg, Tylenol fever oral drops Agent group Give Tylenol Antipyretic Oral Drops 'Total dose of hunger 14_ for ethaminophen, * the white control group was given an equal volume of normal saline, and the temperature was measured again at the last q5,' the experimental results are shown in the table . (Note: The dose of nasal spray is based on the amount of raw phi given, and the amount of Tylenol Antipyretic Oral Drops is _ the amount is compared with the control group B and the blank control group. * P < 〇. () 5 ** — p & G (n.. The experimental results show that: nasal spray (drops), Tylenol antipyretic oral drops, An Naijin. Injectable nasal injections give _ a lot of antipyretic, compared with the blank control group, it has significant Significant difference between sex and non-f, in three kinds of test towels, An Najin's antipyretic effect was weaker. 'The antipyretic effect was only two hours after administration. (5)), 16 1224005 Nasal spray high pressure group Compared with its clinical multiples of copper and the blank control group, 0.5, 2, 4, and 4 were given at first use: Stronger at first use. ^ T spoon has a significant non-book antipyretic effect. At first glance, see the short-term effects of Tylenol after antipyretic use. Better, (drops) last longer. Second, the toxicological research of nasal spray (drops): [Experimental materials] 1. Nasal spray (drops), per milliliter of nasal spray (drops) confluence Drugs are also administered clinically in a nasal spray (drops) of 2g crude drug per milliliter, 2 drops per 1G kg of weight in children (ie about 0.1ml), and the drops are completed within ten minutes, one every ten minutes Continuously administer about 0.2g of crude drug per kilogram of body weight. 2. Wistar rats, both male and female, weigh 180-220. § provided by the Experimental Animal Center of Henan Medical University. [Methods and Results] 1. Acute toxicity test for health Rats ~ 22 g were randomly divided into 3 groups according to body weight and gender, that is, high-dose group, low-dose group and blank control group, 10 rats in each group, half male and half female. 20 25 C to warm temperature, nasal spray (drops) in the high-dose group was given nasal spray of 3 4g crude drug per hair liter, and the low-dose group was sprayed with bismuth-containing nasal spray per milliliter of blank control. In the group, physiological saline was administered by nasal drip, each time G · lml / kg, and the mother was given 10 knives once in 1G minutes, 10 times in a row, with an interval of 8 hours, and then repeated the above-mentioned administration process. Total daily dose, high-dose group is equivalent to crude drug 17 1224005 8g / kg 'low-dose group is equivalent to crude drug 4g / kg reared at room temperature after administration, and observed continuously for seven days. Rats drink water, eat, and move after administration. , Weight, hair color, etc. are all normal, see the table below for details. Rats were dissected and examined for heart, liver, spleen, lung, kidney, stomach, intestine, brain, nose, throat, trachea, bronchus and other tissues and organs. No abnormal changes were observed. Therefore, nasal spray was administered to rats by nasal administration of 8g / kg. (Equivalent to crude drugs) Does not cause acute toxicity, this dose is equivalent to 40 times the clinical dose. Results of acute toxicity test of nasal spray (drops) Organ system ------- Performance of central nervous system after administration System and body movement freely, no abnormal response to various stimuli, autonomic nervous system, normal pupil size, normal breathing, stable breathing, normal frequency and rhythm, no cough and asthma, cardiovascular system beating, no abnormal gastrointestinal system stool formation, no other abnormalities Change the fur color and luster, the skin elasticity is good, not ~ ^^ __ 一 _ see abnormality ----------- irritation test of nasal spray (drops) k healthy rats 20 weight, 18 ~ 220g 'Randomly divided into a nasal spray (drops) group and a blank control, 10 in each group, male and female, the experiment was performed at 22 ± 2 ° C in a greenhouse. Drip into rat nasal cavity every 10 Once every 12 to 18,24,005 t) kilograms of continuous administration of 1 qi, the appearance of each male ㈣ can contain nt large nt, both breathing is stable, the breathing frequency is normal, and there is no snoring or wheezing, and the respiratory adverse reactions are special, The rats were dissected 24 hours after the administration, and the light-absorbing membranes of Otani, larynx, trachea, and bronchial department were examined, and no congestion was seen. The above-mentioned nasal spray (_) of the present invention has a good antipyretic effect, and its strength is sustained. The effect is sustained. _Jiepu Anaijin is similar to the imported drug Tylenol: oral drops, and no irritation. According to the clinical dosage _ times (8_ Shengle), no acute toxicity was observed in the rat's nose, which provided a pharmacological experimental basis for its clinical use, indicating that the nasal spray (drops) is a safe medicine Composition: Please refer to "shown in Table 2 to Table 5" again, which is a therapeutic effect observation table of the fever and cold nasal spray (drop) of the present invention. It can be seen in these efficacy observation tables that when used at different ages, different drug doses are given according to different sensations of f, and it can be clearly seen that the fever sensation of the present invention is sprayed directly on patients. (Dripping) inside the nasal cavity. After being sucked by the dead film inside the nasal cavity, the condition can be controlled for a short period of time, so it has significant medical effects in terms of medical effects. In summary, the present invention uses the medical composition of Bupleurum chinense, Isatis indigotica, Daqingye, and vitamin c to extract and filter out the medicinal solution, and then it can be sprayed (dropped) directly into the patient's nasal cavity, and from the inside of the nasal cavity. After the mucous membrane is absorbed, it can treat fever and cold diseases, and at the same time, it can provide a very convenient medical effect for patients who cannot swallow medicine or liquid. [Simplified illustration of the figure] 19 1224005 Schematic diagram of the nasal spray (drop) preparation process. [Brief description of Tables 1 to 5] Table 1 is a schematic diagram of the effect of the fever and cold nasal spray (drop) of the present invention on the body temperature (° C, soil SD) of beer yeast-heated rats. Tables 2 to 5 are observation tables for the efficacy of the fever and cold nasal spray (drops) of the present invention.

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Claims (1)

1224005 blue, indigo red, sitosterol, r-sitosterol and various amino acids. 7. The pharmaceutical composition according to item 6 of the scope of the patent application, wherein the plurality of amino acids are arginine, glutamic acid, glutamic acid, proline, linear acid, aminobutyric acid. 8. The pharmaceutical composition according to item 1 of the scope of the patent application, wherein the isatis root further contains black mustard, indigo, tryptophan, 1-thiocyanate-2-hydroxybutan-3-ene, epidemic Spring, glandular, palmitic acid, sucrose and proteoglycan with 12% amino acids. 9. The pharmaceutical composition as described in the item # 1 of the patent application park, wherein the big green leaf contains indigo, is blue, and is jade red. 10. The pharmaceutical composition according to item 1 or 9 of the scope of the patent application, wherein the large green leaf further contains inorganic elements such as iron, titanium, manganese, zinc, copper, and diamond, nickel, selenium, road, and stone. U. The medicinal composition according to item 9 of the scope of the patent application, wherein the indigo-blue solution can be changed into loose blue and arachidonic acid. 12. Shanru applies for patent scope! The pharmaceutical composition according to the item, wherein the living carbon, hydrogen and oxygen are composed of about 6 ·· 8 ·· 6. 13 ·-A method for preparing a nasal solution for fever (drops). The steps of the method include: Θ: Extract T volatile oil, soak the Bupleurum spp. With water, then add: decoction, and extract the volatile oil by water hunger reading method. , And then spit out the medicine solution, and then the discharge solution and the medicine residue are temporarily stored in a container;, x / b), the board record and the big ingredients are used to temporarily store the decoction money liquid in a container; Long Guoyu 'will pass 3 C). After the extraction and step __ of the medicine residues in step __ are mixed with 27 1224005, then add the medicine residues mixed with double the amount of water to cook, and then filter the solution; then add the medicine residues times the quantity Decoction with water, and then combine the filtrates; d) combine the three filtrates a, b, and ^ above, and condense the liquid medicine, and then add the aforementioned cold to ethanol; e), and then the above liquid medicine is still Set it for several hours, filter, and recover ethanol; f), dissolve the above volatile oil and vitamin C, add it to the above medicinal solution, mix and filter, and then separate. 14. The preparation of the fever and cold spray (drop) nasal solution as described in item 13 of the patent application group. When extracting the volatile oil from the Bupleurum angustifolia, first soak it in double water for 2 hours, and then add four times. Fry. 15. The method for preparing a fever and cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein the volatile oil extracted from the Bupleurum chinense is about 2na to 2.4ml. 16. The method for preparing a fever and cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein after extracting the volatile oil from the Bupleurum angustifolia, about 1000ml ~ 1200ml of liquid medicine is filtered out. 17. The method for preparing a fever and cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein ‘the islet root and Daqing leaf are added with seven times water for 1 hour. 18. The method for preparing a fever, cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein after the a and b steps are extracted and filtered, the drug residues remaining are mixed, and then the drug residues are added and mixed The next five times the amount of water to cook for 丨 hours. 19. Method 28 for preparing a nasal fluid (drip) nasal solution as described in the article of the application of the scope of application, in which the remaining drug residues after extraction and filtration in step a and step b are mixed and cooked, and filtered After dispensing, add four times more water for 1 hour. 20. The method for preparing a fever and cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein the three filtrates of the a, b, and c steps of the concentrated liquid concentrate are about imi equivalent to lg raw medicine. 21 · The method for preparing a fever and cold spray (drop) nasal solution as described in item 13 of the scope of the patent application, wherein the three filtrates of steps a, b, and c are concentrated, cooled, and then 95% ethanol is added to the mixture. The alcohol content is 70%. 22. The method for preparing a fever and cold spray (drop) nasal solution according to item 13 of the scope of the patent application, wherein about 1 ml of ethanol is recovered containing the crude drug lg.