CN107029058A - A kind of Chinese medicine composition for treating chronic pharyngitis - Google Patents
A kind of Chinese medicine composition for treating chronic pharyngitis Download PDFInfo
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- CN107029058A CN107029058A CN201710174758.0A CN201710174758A CN107029058A CN 107029058 A CN107029058 A CN 107029058A CN 201710174758 A CN201710174758 A CN 201710174758A CN 107029058 A CN107029058 A CN 107029058A
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- 238000009602 toxicology test Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The present invention provides a kind of Chinese medicine composition for treating chronic pharyngitis, belongs to technical field of traditional Chinese medicines, the Chinese medicine composition is prepared from by the Chinese medicine of following parts by weight：15~80 parts of vine tea, 10~25 parts of chrysanthemum, 5~40 parts of fig, 5~20 parts of emblic.Chinese medicine composition of the present invention has effects that clearing heat and detoxicating, swelling and pain relieving, relieving sore-throat promote the production of body fluid, and itches for dry throat caused by chronic pharyngitis, pharynx, the symptom such as irritable cough, and instant effect is evident in efficacy, does not recur.The present invention is using medicine-food two-purpose Chinese herbal medicine as raw material, and medicine source is wide, and cost is low, and decoction is in good taste, has no toxic side effect, and is adapted to be used for a long time.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, espespecially a kind of Chinese medicine composition for treating chronic pharyngitis.
Background technology
Chronic pharyngitis is under pharyngeal mucous membrane, mucous membrane and the chronic inflammation of lymphoid tissue, often for upper respiratory tract chronic inflammation
A part.The disease is more common in adult, and the course of disease is long, and symptom is obstinate, is difficult to cure.Its inducement includes the factor of many aspects：1、
Irrational diet.Most of patients with chronic pharyngitis lack water soluble vitamin, have a liking for greasy, pungent, overheat, food really up to the mark
Or the poor eating habits such as there is long-term smoking to drink, this is the most common inducement of chronic pharyngitis；2nd, surrounding adjacent organs infects.Face
Chronic pharyngitis caused by bed mesopharynx adjacent organs disease is not rare, such as acute and chronic rhinitis nasosinusitis, nasal polyp, deviated nasal septum
Song, allergic rhinitis, adenoids, acute and chronic tonsillitis etc. can cause chronic pharyngitis；3rd, allergy.Chronic pharyngitis
The detection of patient's allergen has positive rate to be up to 50%~60% report, points out allergy factor to have in chronic pharyngitis morbidity
Play an important role；4th, whole body chronic disease factor.Chronic pharyngitis is learned both at home and abroad with snore disease or coexisting for GERD
The extensive concern of person；5th, other spirit, environment and occupational factors.With the deterioration of air quality in recent years, the sick incidence of disease
Have and constantly increase trend, be clinically mainly shown as that pharynx foreign body sensation, burning heat sensation, dry sensation or hypodynia sense, irritable cough etc. are planted
Pharyngeal uncomfortable symptom is planted, visible pharyngeal mucosa chronic congestion is checked, rear wall lymph foilicie hyperplasia, or lateral pharyngeal band plumpness, pharynx is swallowed
Portion's mucous membrane dries atrophy, causes the consequences such as not good patient sleeps, insomnia, poor appetite, has seriously endangered the physical and mental health of people.
Modern medicine believes that, its pathogenesis is mainly three kinds, first is viral infection, is Coxsackie virus, adenovirus, sidestream first
Influenza Virus, is secondly rhinovirus, influenza virus；Second is bacterium infection, including the double balls of alpha streptococcus, staphylococcus and pneumonia
Bacterium, haemophilus influenzae etc., most serious is infected with A groups beta streptococcus；3rd is physical chemical factor, such as high temperature, dust, cigarette
Mist, irritative gas etc..
Theory of traditional Chinese medical science thinks that chronic pharyngitis category " larynx numbness " category refers to, pharyngeal portion flare uncomfortable with pharyngalgia or foreign body sensation, or
There is the disease of pharynx that graininess projection is principal character at larynx bottom.The sick position of larynx numbness is being swallowed, very close with lung, spleen, the dirty relation of kidney three
Cut.Throat is the communications centre of twelve regular channels circulation and convergence, and therefore, visceral dysfunction is then followed through above disturbing throat.This sick cause of disease
The interpretation of the cause, onset and process of an illness, mostly daily life accidentally, diseases caused by external factors when evil, labor be intended to excessively, the pungent tobacco and wine of addiction it is greasy, the smoked bright or protracted inflammation of inside and outside heat evil,
Cause lung-kidney deficiency, flaring up of deficient fire, qi-blood-body fluid imbalance, cause the turbid stasis of qi and blood phlegm, hold phlegm under the arm and be condensed in pharyngeal, or cold-evil is solidifying
Close, throat, which loses, supports, or empty sun is floating more, above disturbs throat；Sick is then qi and blood stagnation throat long.This sick onset urgency person, many category lung stomaches it
Heat, fire burns bright throat, then pharyngeal pain is more acute, dysphagia.If recurrent exerbation, obstinate disease then has gas because constitution is different
The tired difference disease type of void, the deficiency of yang, the deficiency of Yin, phlegm.
At present, the treatment clinically for chronic pharyngitis is concentrated mainly on vitamin supplementation, antianaphylactic treatment, proton
The local treatments such as pump inhibitor treatment, physical treatment and Neulized inhalation.Though above-mentioned treatment method has certain curative effect, there is also
Effect is limited, cure the symptoms, not the disease, more after the easy weak point such as recurrent exerbation, cause chronic pharyngitis to turn into the persistent ailment for being difficult to effect a radical cure.
For many years, relatively satisfactory effect is achieved with the method treatment chronic pharyngitis controlled outside oral medicinal herb, in the treatment of chronic pharyngitis
Occupy critical role, but there is also some problems：1st, [CN201510935757.4 one kind treats chronic to most prescription prescriptions complexity
The medicine of pharyngitis], or contain a kind of valuable medicinals such as Moschus, agalloch eaglewood, cow-bezoar [Chinese medicines for treating pharyngitis of CN201410811506.0
And preparation method thereof] so that treatment cost is high, is unfavorable for promoting.2nd, containing the smell weight such as radix scrophulariae, myrobalan, balloonflower root, poor taste
Medicine [CN201410305488.9 is a kind of to treat pharmaceutical composition of chronic pharyngitis and its production and use], adds and takes
Inconvenience, most of patients is difficult to adhere to taking medicine on time for a long time, therefore treatment is often given up halfway.3rd, the dried venom of toads is contained
[CN201610235020.6 is a kind of for [a kind of medicines and preparation method for treating chronic pharyngitis of CN201410075037.0], the tuber of pinellia
Treat the traditional Chinese herbal decoction of chronic pharyngitis] etc. strong, the poisonous medicine of excitant, toxic side effect is obvious.4th, in clinical practice, many doctors
Family sticks to the interpretation of the cause, onset and process of an illness of inflammation in abnormal heat, and the relation for ignoring " dysfunction of the spleen in transport, pharynx becomes homeless foster " [rectifys the ruling by law of fine jade fine jade strengthening the spleen and stomaches and treats spleen
The clinical observation of qi-asthenia type chnonic pharyngtis and Exploration of Mechanism [D] Beijing University of Chinese Medicine, 2012.], disorderly throw simply in the treatment
Nourishing Yin and falling fire, clearing heat and detoxicating cold and cool medicine, are damaged spleen and stomach function, and essence of water and grain, which can not be transferred to pharynx, makes it lose in moistening
Support, finally make the state of an illness more touching refractory, notably also cause it is sick it.
The content of the invention
The present invention in view of the shortcomings of the prior art, according to theory of traditional Chinese medical science, clinic by the drug screening of several years and repeatedly
There is provided a kind of prescription is simple, compatibility is reasonable, the Chinese medicine of in good taste, evident in efficacy, safety non-toxic treatment chronic pharyngitis for checking
Composition.
A kind of Chinese medicine composition for treating chronic pharyngitis that the present invention is provided, is prepared from by following Chinese medicine：Vine tea 15
~80 parts, 10~25 parts of chrysanthemum, 5~40 parts of fig, 5~20 parts of emblic.The unit of parts by weight of the invention alleged for kg or
g。
Further, the Chinese medicine composition is prepared from by the Chinese medicine of following parts by weight：31~76 parts of vine tea, chrysanthemum
10~20 parts, 8~31 parts of fig, 6~18 parts of emblic.
Further, the Chinese medicine composition is prepared from by the Chinese medicine of following parts by weight：45 parts of vine tea, chrysanthemum 18
Part, 27 parts of fig, 10 parts of emblic.
The Chinese medicine composition adds customary adjuvant, and clinically acceptable preparation is made according to common process.Described
Preparation includes tablet, capsule, granule, decoction, powder, tea bag, oral liquid and syrup etc..
Chinese medicine composition of the present invention can be applied in the medicine for treating or preventing acute/chronic pharyngitis is prepared.
Chinese medicine details employed in the present invention is as follows：
Vine tea is vitaceae ampelopsis grossdentata (Ampelopsis grossedentata (Hand.Mazz.)
W.T.Wang cauline leaf or root), medicine-food two-purpose have many reports in herbal books and Modern Literature in ancient times.Its is sweet, light,
It is cool in nature, Return liver, lung, kidney channel.Have clearing heat and detoxicating, inducing diuresis and reducing edema work(.Cure mainly cold, fever, abscess of throat, icteric hepatitis, mesh
It is red to swell and ache, the disease such as carbuncle swells boil, in the treatment among the people for being widely used in chronic pharyngitis.Modern chemical composition and pharmacology activity research table
Bright, vine tea contains abundant flavonoids, polysaccharide and polyphenol components, wherein main active component is dihydromyricetin, contains
Amount up to 40%, with the multiple pharmacological effect such as antibacterial, anti-inflammatory, antitumor, anti-oxidant, reducing blood lipid, hypoglycemic, liver protection, vine tea
Significant treating pharyngitis effect may be relevant with its antibacterial and anti-inflammatory activity.
Chrysanthemum is the dry capitulum of feverfew chrysanthemum (Chrysanthemum morifolium Ramat.).Its taste
Sweet, hardship, is slightly cold.Return lung, Liver Channel.The effect of having wind and heat dispersing, flat liver improving eyesight.For anemopyretic cold, dizziness of having a headache, hot eyes swells
Bitterly, eyes is dim-sighted.It contains a variety of chemical compositions such as flavonoids, terpene, volatile oil, organic acid and polysaccharide, with protection painstaking effort
The pharmacological action such as pipe, antibacterial, antiviral, antitumor, Adjust-blood lipid, liver protection, analgesia, for the metabolism of immune system and cholesterol
Have a certain impact.Clinically it is mainly used in treating anemopyretic cold, the fever and headache at warm disease initial stage, abscess of throat, illness in eye, ulcer
Property colitis and antimigraine etc., be one of the medicinal herbs most in use for treating chronic pharyngitis.
Fig is the fruit of Moraceae machaka or dungarunga fig (Ficuscarica L.).Its is sweet, acid,
It is flat.Return lung, stomach, large intestine channel.According to《Chinese book on Chinese herbal medicine》Record, fig " clearing heat and promoting fluid；Spleen benefiting and stimulating the appetite；Removing toxicity for detumescence.Main throat
Swell and ache；Cough caused by dryness trachyphonia；Milk is rare；The hot constipation of intestines；Poor appetite；Indigestion, dysentery；Carbuncle swells；Tinea ".Modern times grind
Study carefully and also indicate that, it contains abundant carbohydrate, protein, amino acid, organic acid, enzyme and trace element, with reinforcing spleen to promote digestion,
Relax bowel, reducing blood lipid, hypotensive, reducing pharyngeal swelling, extra-nutrition, effect of a variety of medicine-food two-purposes such as cancer-resisting, chronic
Played an important role in the treatment of pharyngitis.
Emblic is the dry mature fruit of euphorbiaceae phyllanthus emblica platymiscium emblic (Phyllanthusemblica L.).
Its is sweet, sour, puckery, cool in nature.Attach to the lung and stomach meridians.Main clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid.For blood-head blood stasis, digestion is not
Good, abdominal distension , hai cough, laryngalgia, dry.In recent years, reported emblic have liver protection, relieving sore-throat, antibacterial, antiviral, immunological regulation,
The various active such as antitumor and anti-oxidant.The applicating history that it is used to treat pharyngitis is long, determined curative effect, is that the Ministry of Public Health announces
One of " integration of drinking and medicinal herbs " kind, is also that the United Nations's health organization is appointed as one of 3 kinds of health plants of world's popularizing planting.
Fang Zhong, vine tea is clearing heat and detoxicating, inducing diuresis and reducing edema, and specially the disease of the upper harmony throat of main heat, is monarch drug in a prescription；Chrysanthemum light weight is pungent to be dissipated, and is had
Dissipate the effect of wind-heat, with bitter cold can heat-clearing, it is sweet it is cold without impairment of yin the characteristics of, be ministerial drug；Papillary, can dispersing superficial exopathogens
Wind-heat, and can removing summer-heat lung stomach excess fire, the inducement of chronic pharyngitis can be inherently eliminated.Can be moistened the lung and relieve the cough on fig,
Detumescence relieving sore-throat, it is lower with stomach invigorating the spleen, ease constipation heat-clearing while principal drug assistance relieving sore-throat is helped, the protection to taste to be taken into account, contribute to medicine
The absorption of thing and the radical cure of chronic pharyngitis.Emblic is sweet, acid, puckery, can clearing heat and cooling blood, significantly secretion replenishing and throat moistening, alleviation dry throat mouthful
Thirsty symptom, the property of its sweet acid, is more conducive to the stabilization of monarch drug in a prescription active ingredient.Above all medicines share, plays wind and heat dispersing altogether, removing toxic substances
Detumescence, the work(that promotes the production of body fluid of relieving sore-throat.
Modern pharmacology research shows that vine tea general flavone can reduce bacterium surface hydrophobicity, increases bacterium permeability, makes
Ne ar changes, and by suppressing bacterial dehydrogenase activation plays antibacterial action；Some scholars think, vine tea water extract
The effect of clearing anti-inflammatory is played by adjusting row parathyrine E2 generation；Chrysanthemum to Escherichia coli, shigella dysenteriae, typhoid bacillus,
The bacterium such as paratyphosum Bacterium, mycetozoan and Pseudomonas aeruginosa and comma bacillus has direct inhibitory action, and can pass through
Suppress the permeability of capillary and reach the effect of anti-inflammatory.Another to have document report, there is chrysanthemum total flavone obvious analgesia to make
With the release that its mechanism may be with NO in promotion serum and brain tissue, the generation for reducing PGE2 is relevant；Fig can promote huge
Phagocyte is produced and secretion interleukin I L-1 α, and splenocyte is produced and secretion IL-2, promotes canavaline (ConA) and lipopolysaccharides
(LPS) Spleen cell proliferation stimulated, reduces serum SIL-2 R level (sIL-2R) level, so as to strengthen pharyngeal
Immunity.On the one hand emblic can promote the growth of pars oralis pharyngis dominant bacteria alpha streptococcus, recover local flora balance；It is another
Aspect is played to chronic pharyngitis by stimulating the secretion of Healthy People SIgA content in saliva, the local mucosa-immune of enhancing human body pars oralis pharyngis
Preventive and therapeutic action.
Compared with prior art, beneficial effects of the present invention are：
1st, the present invention is directed to the pathogenesis of chronic pharyngitis, and selected vine tea, chrysanthemum, fig, emblic are used as medicine, and formula is new
It is clever reasonable, meet traditional Chinese medical science prescription principle of medication.Theory of traditional Chinese medical science thinks that the prosperity and decline of taste metaplasia water paddy directly influences Oropharynx mucosa
Rong Run dry up, and many patent prescriptions are simply using cold and cool medicine that [CN201410035543.7 is a kind of to treat chronic pharyngitis
Chinese medicine composition], cause spleen and stomach function to be damaged, the discomfort of patient has been aggravated on the contrary.Fig is added in prescription of the present invention,
While treating pharyngitis, the protection to spleen and stomach function is taken into account, a kind of new choosing is provided for the clinical weakness of the spleen and the stomach patient medication
Select.
2nd, selected therapeutic action of the medicinal material to chronic pharyngitis has document support in the present invention, has pharmaceutical research foundation.
Modern medicine believes that, the generation of chronic pharyngitis mainly due to bacterium repeatedly, virus infect or be chronically at high temperature, dust,
In the environment such as smog, irritative gas, throat is caused to be constantly in congestive state, and then produce inflammatory edema and local organization increasing
Raw, the inflammatory mediator of release stimulates nerve endings, causes pain.Ingredients is respectively acting on pharyngitis and developed in the present invention
Each stage, by antibacterial, anti-inflammatory, analgesia, strengthen the different action target spots such as pharyngeal immunity and play and chronic pharyngitis is controlled
Treatment is acted on, various mechanism cooperative compensatings, and compared with the mode of action single chemical drugs relatively or single medicinal material treatment, curative effect is more
Plus it is notable, reliable and stable.
3rd, compared with disclosed treating pharyngitis drug patent before, Chinese medicine composition of the present invention is free of Chinese blister beetle
[a kind of Chinese medicine compositions for treating pharyngitis of CN201310382711.5], processing scorpio, [CN201410579679.4 one kind is treated slowly
The Chinese medicine composition of property pharyngitis], the dried venom of toads [a kind of medicines and preparation method for treating chronic pharyngitis of CN201410075037.0] etc.
Toxic herb, selected medicinal material is the Chinese medicine of medicine-food two-purpose, effect safety, no toxicity.
4th, Chinese medicine composition of the present invention does not contain the smells such as radix scrophulariae, balloonflower root, dried immature fruit of citron orange weight, the medicine of poor taste, aftertaste
Sweetness, can not only be used for tea bag drink, also can be developed into clinically-acceptable preparation, be widely used, can improve pharyngitis patient medication
Long-term use compliance.
5th, with disclosed treating pharyngitis drug patent before [a kind of Chinese medicines for treating pharyngitis of CN201410811506.0 and its
Preparation method] to compare, Chinese medicine composition of the present invention is without precious Chinese medicines such as Moschus, agalloch eaglewood, and raw material is cheap and easy to get, medicine source
Extensively, cost is low.And disappear with conventional nebulae inhalation or micro-wave therapeutic, laser therapy, Fluid nitrogen cryopreservation treatment, low-temperature plasma
Melt the physical therapies such as treatment to compare, it is not necessary to which any instrument and equipment, use more facilitates, and medical expense is low.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the embodiment should not be construed as to the present invention
Limitation.,
Embodiment 1
In the present embodiment treat chronic pharyngitis Chinese medicine composition, weigh 45 parts of vine tea, 18 parts of chrysanthemum, 27 parts of fig,
10 parts of emblic, co-grinding is packed with heat-sealing type tea filter paper, every bag of 2.0g, and bagged instant preparation is made.
Embodiment 2
The Chinese medicine composition of chronic pharyngitis is treated in the present embodiment, 68 parts of vine tea is weighed, 16 parts of chrysanthemum, 8 parts of fig, remaining
Sweet sub 8 parts, co-grinding is packed with heat-sealing type tea filter paper, every bag of 2.0g, and bagged instant preparation is made.
Embodiment 3
The Chinese medicine composition of chronic pharyngitis is treated in the present embodiment, 76 parts of vine tea is weighed, 10 parts of chrysanthemum, 8 parts of fig is remaining
Sweet sub 6 parts.Plus 10 times of amount water, decoct 2 hours, filtration；Filter residue adds 8 times of amount water, decocts 1 hour, filtration；Filtrate merges, concentration,
Dry, add supplementary product starch, ethanol, talcum powder, tablet is made.
Embodiment 4
The Chinese medicine composition of chronic pharyngitis is treated in the present embodiment, 31 parts of vine tea is weighed, 20 parts of chrysanthemum, 31 parts of fig,
18 parts of emblic.Plus 10 times of amount water, decoct 2 hours, filtration；Filter residue adds 8 times of amount water, decocts 1 hour, filtration；Filtrate merges, dense
Contracting, is dried, and adds supplementary product starch, ethanol, dextrin, magnesium stearate, loads capsule shells, capsule is made.
Embodiment 5
The Chinese medicine composition of chronic pharyngitis is treated in the present embodiment, 50 parts of vine tea is weighed, 20 parts of chrysanthemum, 20 parts of fig,
10 parts of emblic.Plus 10 times of amount water, decoct 2 hours, filtration；Filter residue adds 8 times of amount water, decocts 1 hour, filtration；Filtrate merges, dense
Contracting, is dried, and adds auxiliary material Icing Sugar, starch, dextrin, ethanol, and granule is made.
Toxicology test：
First, test material：
Animal：Kunming mice, 18~22g of body weight, male and female half and half are purchased from Hubei Province Animal Experimental Study center.
Reagent：The bagged instant preparation that Example 1 and Example 2 of the present invention is provided soaks 4 times respectively, each 15min, respectively will
Leachate merges, concentration, 60 DEG C of drying, obtains the dry extract of embodiment 1 and the Chinese medicine composition of embodiment 2.
2nd, method：
1st, LD50 is calculated：Using improvement karber's method, mouse is randomly divided into 10 groups, every group 10, male and female half and half respectively will
The dry extract dissolving of bagged instant preparation given by embodiment 1 and embodiment 2, is made into Cmax, is administered by the maximum allowable capacity of mouse,
Institute is followed successively by 15.00,12.00,9.60,7.68,6.14 (g.kg-1) to dosage by crude drug amount, and it is small to can't help water 18 in animal fasting
Shi Hou, is administered (interval half an hour) in two times in one day, and each 0.5ml observes animal dead situation.
2nd, maximum tolerated dose determines (MTD values)：Take mouse 40, each 20 of male and female.Respectively by embodiment 1 and embodiment
The dry extract of bagged instant preparation given by 2 adds distilled water to dissolve, and is made into maximum concentration, by the maximal tolerance dose of animal, is fed with injecting
Device can be twitched and is defined.After animal fasting can't help water 18 hours, (interval half an hour), each 0.5ml is administered in one day in two times
(containing crude drug 0.3g per ml), total dose is 15g crude drugs/kgd, successive administration 7 days.
3rd, result of the test：
LD50 calculating in when giving mouse with maximum acceptable concentration and maximum allowable capacity (15g/kgd), each group
Dead mouse is showed no, i.e., does not measure LD50, only seeks maximum tolerated dose, in 7 days treatment phases, each group animal its appetite,
Activity, hair color, state of mind etc. are all normal, and development is normal, there are no death.Show that bag given by embodiment 1 and embodiment 2 steeps
Agent acute toxicity is minimum, MTD ＞ 15g/kgd.
Pharmacology test：
First, test material：
Animal：3 monthly age Japan large ear rabbits, male and female half and half, 2.02 ± 0.17kg of body weight is purchased from Hubei Province experimental animal and ground
Study carefully center.Instrument and reagent：Daphne Larynol sprayer, laryngeal spray, Hitachi's H-600 transmission electron microscopes, CC-180 type electronics blood
Ball count instrument, multi-purpose light microscope, Medical frontal mirror, electronic anus temperature table, pedometer, tonsil needle, make by oneself rabbit opener,
Spatula etc..Ammoniacal liquor (concentration 25%~27%), turpentine oil, water melon frost pulvis.Reagent：By Example 1 and Example 2 of the present invention
The bagged instant preparation provided soaks 4 times respectively, and each 15min respectively merges leachate, is concentrated into by crude drug amount 50mg/ml.
2nd, animal administration and processing
Japan large ear rabbit 50 is taken, 5 groups, respectively every group 10, model group, blank control group, the positive are randomly divided into
Control group, Example 1 and Example 2 of the present invention concentrate group.In addition to blank control group, the upper and lower noon is each daily for other 4 groups of rabbit
Sprayed its pharyngeal 1 time with 2.5% ammoniacal liquor, pressed, sprayed 15 altogether with laryngeal spray spray 3 every time.At the 8th day, tonsil needle is used
0.5mL turpentine oil is injected under rabbit pharyngeal mucosa.Blank control group sprays isometric physiological saline, does not inject turpentine oil, its
His same model group.Observation animal appearance state, and its mobility is recorded with animal activity analyzer daily；Observed 1 time every 1 day
The pharyngeal situation of animal, including Mucosa Morphology, color and luster and secretion etc..
Model group takes rabbit auricular vein blood film and determines ammonia concentration on the 16th, is stood after femoral artery sacrificed by exsanguination animal
Remove pharyngeal mucosa and its undertissue makees routine pathology section and transmission electron microscope sample, in observation under light microscopic and transmission electron microscope.
Example 1 and Example 2 of the present invention medicinal extract group gave rabbit pharyngeal spray Chinese medicine composition concentrate on 16th~25,
2 times a day, and spray 3 every time is pressed, positive controls spray water melon frost, blank control spray physiological saline；Take within 26th each group animal ear edge
Vein blood film simultaneously determines ammonia concentration, removes pharyngeal mucosa immediately after femoral artery sacrificed by exsanguination and its undertissue makees routine pathology
Section and transmission electron microscope sample, in observation under light microscopic and transmission electron microscope.
3rd, result：
1st, general state：Since modeling the 3rd day, most of rabbit engendered oral area of scratching, frequency drinking-water and measured seldom,
Oral secretion increases, metal fatigue, and food of receiving is reduced, and Body weight loss, spontaneous activity is reduced, and congestion of throat is in kermesinus, micro- swollen
It is swollen；Modeling symptom on the 15th is most obvious.Blank control group does not occur above-mentioned situation then.Water melon frost control group and Chinese medicine group of the present invention
Compound administration group above-mentioned sign after treating 10 days is returned to normal.
2nd, routine blood indexes change：After modeling, lymph, monocyte increased in model group animal blood, but with sky
White control group compares, no difference of science of statistics (P ＞ 0.05)；Water melon frost control group and Chinese medicine composition administration group of the present invention are in treatment
After 10 days, each group blood routine compares no difference of science of statistics (P ＞ 0.05).
3rd, pharyngeal pathological observation：Pharyngeal model group rabbit is in chronic congestion state, and kermesinus, glossiness is not good enough,
Mucus sexual secretion increases.Mucous epithelium is in follow closely prominent shape hyperplasia, the different degrees of swelling of tunica propria, and blood vessel hyperplasia, increasing number can
See obvious cell infiltration, based on lymphocyte and monocyte, submucosa lymphocyte, histocyte and fiber are female thin
Born of the same parents' hyperplasia, serous gland mucous modification etc. changes, and being compared with blank control group has significant difference (P ＜ 0.05).
4th, pharyngeal Ultrastructural observation：What model group animal pharyngeal mucosa had thickens, and what is had is thinning, regional area table
The denaturation that layer epithelial cell has, the cell membrane fracture of some cellss of superficial layer is even disappeared, and desmosome is reduced, dilatation of rough endoplasmic reticula,
Visible capillary endothelial cell swelling in interstitial, tube chamber narrows, the fibroblast and lymphocyte of denaturation.And administration group is swallowed
Portion's mucomembranous cell structure tends to be normal.
The present invention is done clinical efficacy and summarized such as with a kind of Chinese medicine composition for treating chronic pharyngitis given by embodiment 2
Under：
First, general data：Chinese medicine composition of the present invention is applied to clinical observation case 60, wherein man 32, female 28
Example, 19~56 years old age.The course of disease most short person 2 months, most elder is average 1.5 years up to 5 years.
2nd, diagnostic criteria：
1st, patient has acpuei pharyngitis history of repeated attack, or because the long-term mouth breathing of rhinopathy and excessive drinking and smoking, surrounding air are dry
Dry, dust and irritative gas pollution etc..
2nd, pharyngeal discomfort, or pain or itch or dry sensation, burning heat sensation, sootiness sense, foreign body sensation etc.；Irritable cough, from morning
Firmly expectoration secretion, even feel sick.The course of disease more than 2 months, Chang Yin suffers from cold, caught a cold, fatigue, the reason such as speech more cause symptom to add
Weight.
3rd, pharyngeal chronic congestion, is aggravated.In kermesinus, or dendroid congested；Swallow rear wall lymph foilicie hyperplasia, or lateral pharyngeal band
Enlargement；Swallow mucosal hyperplasia plump, or it is drying, atrophy, thinning, there is secretion attachment.
3rd, usage and dosage：
The bagged instant preparation prepared using the embodiment of the present invention 2, takes 1~2 bag every time, plus 200~250ml boiling water brews 15~
30min, on behalf of the tea, 2 times a day, each 1 time sooner or later.It is within 7 days 1 course for the treatment of.
4th, criterion of therapeutical effect：
1st, cure：Pharyngeal symptom disappears, and checks normal；
2nd, take a turn for the better：Pharyngeal sings and symptoms substantially mitigates；
3rd, it is not cured：Sings and symptoms is without significant change.
5th, therapeutic effect：In the clinical observation case, the 2-8 course for the treatment of of taking medicine is cured 33, taken a turn for the better 24, not more 3.
During reaching 95%, and treatment toxic side effect does not occur for total effective rate.
6th, model case：
Case 1：Chen, female, 28 years old.There is allergic rhinitis history of repeated attack, readme is pharyngeal recently to be done, itches, and is added when swallowing
Weight, night pain substantially, retch by influence sleep, nausea of being brushed teeth from morning.Commonly use water melon frost and build the buccal treatment of people's throat piece, effect
It is not good enough.After 1 course for the treatment of of Chinese medicine composition for taking the present invention, feel that pharyngeal pain mitigates, retch frequency is reduced from morning；Continue to use
3 courses for the treatment of of medicine, each symptom disappears, and cures.
Case 2：Certain is thanked, man, 45 years old.Pharyngeal uncomfortable 2 years of readme, dry throat, shouting pain or is eaten after maror more very at smoking.
Foreign body in pharynx sense substantially, hawk again and again, expectoration does not go out, pharynx not under.After 2 courses for the treatment of of Chinese medicine composition for taking the present invention, from
Feel that pharyngeal tingling sensation is alleviated, foreign body sensation mitigates；Continue to take 3 courses for the treatment of, each symptom disappears, and cures.
Obviously, those skilled in the art can carry out the essence of various changes and modification without departing from the present invention to the present invention
God and scope.So, if these modifications and variations of the present invention belong to the scope of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to comprising including these changes and modification.
The content not being described in detail in this specification belongs to prior art known to professional and technical personnel in the field.
Claims (3)
1. a kind of Chinese medicine composition for treating chronic pharyngitis, it is characterised in that：The Chinese medicine composition is in following parts by weight
Medicinal material is prepared from：15~80 parts of vine tea, 10~25 parts of chrysanthemum, 5~40 parts of fig, 5~20 parts of emblic.
2. a kind of Chinese medicine composition for treating chronic pharyngitis according to claim 1, it is characterised in that：The Chinese traditional medicine composition
Thing is prepared from by the Chinese medicine of following parts by weight：31~76 parts of vine tea, 10~20 parts of chrysanthemum, 8~31 parts of fig, emblic
6~18 parts.
3. a kind of Chinese medicine composition for treating chronic pharyngitis according to claim 2, it is characterised in that：The Chinese traditional medicine composition
Thing is prepared from by the Chinese medicine of following parts by weight：45 parts of vine tea, 18 parts of chrysanthemum, 27 parts of fig, 10 parts of emblic.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686178A (en) * | 2020-07-02 | 2020-09-22 | 恩施市鸿汲康润生物医药科技有限责任公司 | Selenium-containing plant composition with throat clearing function and preparation method and application thereof |
-
2017
- 2017-03-22 CN CN201710174758.0A patent/CN107029058A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686178A (en) * | 2020-07-02 | 2020-09-22 | 恩施市鸿汲康润生物医药科技有限责任公司 | Selenium-containing plant composition with throat clearing function and preparation method and application thereof |
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