TWI262921B - Selective antagonists of A2B adenosine receptors - Google Patents

Selective antagonists of A2B adenosine receptors

Info

Publication number: TWI262921B
Authority: TW; Taiwan
Prior art keywords: adenosine receptors; selective antagonists; pharmaceutically acceptable; acceptable salt; formula
Prior art date: 1999-08-31

Application number

TW089117772A

Other languages

English (en)

Inventor

Italo O Biaggioni

Igor A Feoktistov

Jack N Wells

Original Assignee

Univ Vanderbilt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-31

Filing date

2000-09-21

Publication date

2006-10-01

2000-09-21 Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt

2006-10-01 Application granted granted Critical

2006-10-01 Publication of TWI262921B publication Critical patent/TWI262921B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Virology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Toxicology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)

TW089117772A 1999-08-31 2000-09-21 Selective antagonists of A2B adenosine receptors TWI262921B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15164999P	1999-08-31	1999-08-31

Publications (1)

Publication Number	Publication Date
TWI262921B true TWI262921B (en)	2006-10-01

Family

ID=22539669

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW089117772A TWI262921B (en)	1999-08-31	2000-09-21	Selective antagonists of A2B adenosine receptors

Country Status (22)

Country	Link
EP (1)	EP1208100B1 (zh)
JP (1)	JP3914434B2 (zh)
KR (1)	KR100502757B1 (zh)
CN (1)	CN1178940C (zh)
AR (1)	AR029178A1 (zh)
AT (1)	ATE236160T1 (zh)
AU (1)	AU760071B2 (zh)
BR (1)	BR0013673A (zh)
CA (1)	CA2383351C (zh)
DE (1)	DE60001969T2 (zh)
DK (1)	DK1208100T3 (zh)
ES (1)	ES2190422T3 (zh)
HK (1)	HK1049835B (zh)
IL (2)	IL148366A0 (zh)
MX (1)	MXPA02002262A (zh)
NO (1)	NO328489B1 (zh)
NZ (1)	NZ517546A (zh)
PT (1)	PT1208100E (zh)
TR (1)	TR200201132T2 (zh)
TW (1)	TWI262921B (zh)
WO (1)	WO2001016134A1 (zh)
ZA (1)	ZA200201650B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6403567B1 (en)	1999-06-22	2002-06-11	Cv Therapeutics, Inc.	N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en)	1999-06-22	2019-04-16	Gilead Sciences, Inc.	2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
AU2001238665A1 (en)	2000-02-23	2001-09-03	Cv Therapeutics, Inc.	Method of identifying partial agonists of the a2a receptor
WO2003002566A1 (en) *	2001-06-29	2003-01-09	Cv Therapeutics, Inc.	Purine derivatives as a2b adenosine receptor antagonists
US8470801B2 (en)	2002-07-29	2013-06-25	Gilead Sciences, Inc.	Myocardial perfusion imaging methods and compositions
ATE410168T1 (de) *	2003-07-22	2008-10-15	Cv Therapeutics Inc	A1 adenosin-rezeptor-antagonisten
JPWO2005053695A1 (ja) *	2003-12-04	2007-12-06	エーザイ・アール・アンド・ディー・マネジメント株式会社	多発性硬化症予防剤または治療剤
WO2005077950A2 (en) *	2004-02-14	2005-08-25	Smithkline Beecham Corporation	Medicaments with hm74a receptor activity
NZ554485A (en) *	2004-10-15	2010-12-24	Gilead Palo Alto Inc	Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists
AU2005295437B2 (en)	2004-10-20	2011-05-19	Gilead Palo Alto, Inc.	Use of A2A adenosine receptor agonists
ES2270715B1 (es)	2005-07-29	2008-04-01	Laboratorios Almirall S.A.	Nuevos derivados de pirazina.
ES2274712B1 (es)	2005-10-06	2008-03-01	Laboratorios Almirall S.A.	Nuevos derivados imidazopiridina.
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
KR101494125B1 (ko)	2006-02-03	2015-02-16	길리애드 사이언시즈, 인코포레이티드	Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법
US7795427B2 (en) *	2006-02-14	2010-09-14	New York University	Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
DE102011005232A1 (de)	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
WO2017106352A1 (en)	2015-12-14	2017-06-22	Raze Therapeutics, Inc.	Caffeine inhibitors of mthfd2 and uses thereof
JOP20210164A1 (ar)	2019-01-11	2023-01-30	Omeros Corp	طرق وتركيبات علاج السرطان

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7810946L (sv) *	1978-10-20	1980-04-21	Draco Ab	Metod att behandla kronisk obstruktiv luftvegssjukdom
DE4019892A1 (de) *	1990-06-22	1992-01-02	Boehringer Ingelheim Kg	Neue xanthinderivate
AU649091B2 (en) *	1990-12-21	1994-05-12	Beecham Group Plc	Xanthine derivatives
GB9210839D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Plc	Novel compounds

2000
- 2000-08-28 ES ES00971055T patent/ES2190422T3/es not_active Expired - Lifetime
- 2000-08-28 DK DK00971055T patent/DK1208100T3/da active
- 2000-08-28 EP EP00971055A patent/EP1208100B1/en not_active Expired - Lifetime
- 2000-08-28 AT AT00971055T patent/ATE236160T1/de not_active IP Right Cessation
- 2000-08-28 IL IL14836600A patent/IL148366A0/xx active IP Right Grant
- 2000-08-28 AU AU80348/00A patent/AU760071B2/en not_active Ceased
- 2000-08-28 CN CNB00813717XA patent/CN1178940C/zh not_active Expired - Fee Related
- 2000-08-28 NZ NZ517546A patent/NZ517546A/en unknown
- 2000-08-28 JP JP2001519700A patent/JP3914434B2/ja not_active Expired - Fee Related
- 2000-08-28 HK HK03101920.0A patent/HK1049835B/zh not_active IP Right Cessation
- 2000-08-28 DE DE60001969T patent/DE60001969T2/de not_active Expired - Lifetime
- 2000-08-28 WO PCT/US2000/040751 patent/WO2001016134A1/en not_active Ceased
- 2000-08-28 BR BR0013673-5A patent/BR0013673A/pt not_active Application Discontinuation
- 2000-08-28 CA CA002383351A patent/CA2383351C/en not_active Expired - Fee Related
- 2000-08-28 KR KR10-2002-7002718A patent/KR100502757B1/ko not_active Expired - Fee Related
- 2000-08-28 PT PT00971055T patent/PT1208100E/pt unknown
- 2000-08-28 MX MXPA02002262A patent/MXPA02002262A/es active IP Right Grant
- 2000-08-28 TR TR2002/01132T patent/TR200201132T2/xx unknown
- 2000-08-30 AR ARP000104523A patent/AR029178A1/es active IP Right Grant
- 2000-09-21 TW TW089117772A patent/TWI262921B/zh not_active IP Right Cessation
2002
- 2002-02-25 IL IL148366A patent/IL148366A/en not_active IP Right Cessation
- 2002-02-27 ZA ZA200201650A patent/ZA200201650B/en unknown
- 2002-02-27 NO NO20020979A patent/NO328489B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100502757B1 (ko)	2005-07-22
NO20020979D0 (no)	2002-02-27
CA2383351A1 (en)	2001-03-08
AU8034800A (en)	2001-03-26
DK1208100T3 (da)	2003-06-30
JP3914434B2 (ja)	2007-05-16
HK1049835A1 (zh)	2003-05-30
KR20020041419A (ko)	2002-06-01
JP2003508398A (ja)	2003-03-04
ZA200201650B (en)	2003-05-28
PT1208100E (pt)	2003-07-31
AU760071B2 (en)	2003-05-08
ATE236160T1 (de)	2003-04-15
IL148366A (en)	2006-12-10
EP1208100B1 (en)	2003-04-02
MXPA02002262A (es)	2002-09-30
NZ517546A (en)	2003-10-31
WO2001016134A1 (en)	2001-03-08
IL148366A0 (en)	2002-09-12
CN1377352A (zh)	2002-10-30
CN1178940C (zh)	2004-12-08
NO328489B1 (no)	2010-03-01
CA2383351C (en)	2005-11-01
DE60001969D1 (de)	2003-05-08
BR0013673A (pt)	2002-05-28
EP1208100A1 (en)	2002-05-29
DE60001969T2 (de)	2004-02-05
HK1049835B (zh)	2005-04-08
TR200201132T2 (tr)	2002-08-21
AR029178A1 (es)	2003-06-18
NO20020979L (no)	2002-04-26
ES2190422T3 (es)	2003-08-01

Publication	Publication Date	Title
TWI262921B (en)	2006-10-01	Selective antagonists of A2B adenosine receptors
YU5399A (sh)	2002-03-18	Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove
IL142768A0 (en)	2002-03-10	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
YU69902A (sh)	2005-07-19	Novi derivati piperazina
MXPA02003977A (es)	2003-09-25	Inhibidores de adhesion de celula mediada por al°2.
MXPA02012712A (es)	2003-04-25	N-ureidoheterocicloalquil-piperidinas como moduladores de la actividad del receptor de quimiocinas.
IL102951A0 (en)	1993-01-31	1-substituted 1h-imidazo(4,5-c)quinolin-4-amines and pharmaceutical compositions containing them
ES2161373T3 (es)	2001-12-01	Derivados de meta-guanidina, urea, tiourea o acido azaciclico-aminobenzoico como antagonistas de integrinas.
MX9800411A (es)	1998-04-30	Compuestos quimicos.
CA2263913A1 (en)	1998-03-05	Substituted 6,6-hetero-bicyclic derivatives
CA2195677A1 (en)	1996-02-29	Endothelin antagonists
PL350651A1 (en)	2003-01-27	4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents
AU4064597A (en)	1998-03-06	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
FR2677982B1 (fr)	1993-09-24	Composes polyfluoroalkylthiopoly(ethylimidazolium), procede de preparation et leur utilisation comme agents biocides.
AU2267495A (en)	1995-11-16	Benzamide derivatives as vasopressin antagonists
WO1999006397A3 (en)	1999-12-09	Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
HRP970040A2 (en)	1998-06-30	Piperidones
CA2289787A1 (en)	1998-11-26	Fungicidal mixtures
UA37311C2 (uk)	2001-05-15	Засіб для лікування статевої дисфункції і фармацевтичний препарат
MXPA02012470A (es)	2004-01-26	Inhibidores de fosfodiesterasa especificos para gmp ciclico.
UA41880C2 (uk)	2001-10-15	Серотонінергічні похідні ерголіну і фармацевтична композиція
EP1134219A4 (en)	2002-11-06	AMINOMETHYLPYRROLIDINE DERIVATIVES SUBSTITUTED BY CYCLOALKYLES
ES8700242A1 (es)	1986-09-16	Un procedimiento para preparar un derivado de dihidropirida-zinona
MY133169A (en)	2007-10-31	Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect

Legal Events

Date	Code	Title	Description
2011-07-11	MM4A	Annulment or lapse of patent due to non-payment of fees