TW274546B - - Google Patents
Info
- Publication number
- TW274546B TW274546B TW082107213A TW82107213A TW274546B TW 274546 B TW274546 B TW 274546B TW 082107213 A TW082107213 A TW 082107213A TW 82107213 A TW82107213 A TW 82107213A TW 274546 B TW274546 B TW 274546B
- Authority
- TW
- Taiwan
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
- B65H2511/00—Dimensions; Position; Numbers; Identification; Occurrences
- B65H2511/50—Occurence
- B65H2511/51—Presence
- B65H2511/512—Marks, e.g. invisible to the human eye; Patterns
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94335392A | 1992-09-10 | 1992-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW274546B true TW274546B (zh) | 1996-04-21 |
Family
ID=25479507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW082107213A TW274546B (zh) | 1992-09-10 | 1993-09-03 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US5523314A (zh) |
| EP (2) | EP0587377A3 (zh) |
| JP (1) | JPH06192091A (zh) |
| KR (1) | KR940006590A (zh) |
| CN (1) | CN1091006A (zh) |
| AU (1) | AU676843B2 (zh) |
| CA (1) | CA2105598A1 (zh) |
| CZ (1) | CZ181493A3 (zh) |
| FI (1) | FI933946A7 (zh) |
| HU (1) | HUT70184A (zh) |
| IL (1) | IL106877A (zh) |
| MX (1) | MX9305444A (zh) |
| MY (1) | MY131443A (zh) |
| NO (2) | NO933198L (zh) |
| NZ (1) | NZ248573A (zh) |
| PL (1) | PL300335A1 (zh) |
| RU (1) | RU2131251C1 (zh) |
| TW (1) | TW274546B (zh) |
| YU (1) | YU59593A (zh) |
| ZA (1) | ZA936492B (zh) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005119252A2 (en) * | 2004-05-26 | 2005-12-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr35 for the treatment of metabolic-related disorders |
| EP0587377A3 (en) * | 1992-09-10 | 1994-09-21 | Lilly Co Eli | Thiazolidinone derivatives as hypoglycemic agents and for treating alzheimer's disease |
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| DE69530501D1 (de) * | 1994-10-20 | 2003-05-28 | Nippon Chemiphar Co | Chinolinderivat |
| US5563277A (en) * | 1994-12-21 | 1996-10-08 | Eli Lilly And Company | Process for preparing benzyl-substituted rhodanine derivatives |
| IL117208A0 (en) * | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
| US5849711A (en) * | 1995-06-06 | 1998-12-15 | Athena Neurosciences, Inc. | Cathepsin and methods and compositions for inhibition thereof |
| WO1996039194A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
| US5783434A (en) * | 1995-06-06 | 1998-07-21 | Tung; Jay S. | Cathepsin and methods and compositions for inhibition thereof |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| CA2255073A1 (en) * | 1996-07-11 | 1998-01-22 | Brenda Derae Shivers | Method for treating and preventing neurodegenerative disorders by administering a thiazolidinone |
| US6005142A (en) * | 1996-09-03 | 1999-12-21 | Eli Lilly And Company | Process for preparing benzyl-substituted rhodanine derivatives |
| US6063799A (en) * | 1996-09-03 | 2000-05-16 | Eli Lilly And Company | Alternate crystal form of Tazofelone |
| DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
| EP1006794B1 (en) * | 1997-03-12 | 2007-11-28 | Robert W. Esmond | A method for treating or preventing alzheimer's disease |
| US6297262B1 (en) | 1997-05-29 | 2001-10-02 | H. Lundbeck A/S | Treatment of schizophrenia and psychosis |
| US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
| WO1999055894A1 (en) | 1998-04-29 | 1999-11-04 | Oklahoma Medical Research Foundation | Construction of retroviral producer cells from adenoviral and retroviral vectors |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| JP2002525362A (ja) * | 1998-09-30 | 2002-08-13 | エスヴァイン、アンゲリカ | 代謝性骨障害の治療および予防のためのロダニンカルボン酸誘導体 |
| AU6330999A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Rhodanine derivatives for the treatment and prevention of metabolic bone disorders |
| WO2000024392A1 (en) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
| US6191154B1 (en) * | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| US6127394A (en) * | 1999-03-08 | 2000-10-03 | The University Of Mississippi | 1,2-Dithiolane derivatives |
| US6204288B1 (en) | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| MXPA01010490A (es) * | 1999-06-10 | 2005-05-27 | Warner Lambert Co | Derivados rodanina para usarse en un metodo de inhibicion de la agregacion de proteinas amiloides y la formacion de imagenes de los depositos amiloides. |
| CA2370316A1 (en) * | 1999-06-10 | 2000-12-21 | Warner-Lambert Company | Rhodanine derivatives and their use in inhibiting and imaging amyloids |
| US6372742B1 (en) | 1999-07-01 | 2002-04-16 | Geron Corporation | Substituted indole compounds and methods of their use |
| EP1593677A3 (en) * | 1999-08-31 | 2006-01-04 | Incyte San Diego Incorporated | Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes |
| JP2003508391A (ja) * | 1999-08-31 | 2003-03-04 | マキシア・ファーマシューティカルズ・インコーポレイテッド | ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用 |
| US20070060606A1 (en) * | 1999-10-07 | 2007-03-15 | Robertson Harold A | Compounds and methods for modulating phosphodiesterase 10A |
| US6706766B2 (en) * | 1999-12-13 | 2004-03-16 | President And Fellows Of Harvard College | Small molecules used to increase cell death |
| ES2248242T3 (es) * | 2000-04-21 | 2006-03-16 | Pfizer Products Inc. | Ligandos de receptores tiroideos. |
| US6620830B2 (en) | 2000-04-21 | 2003-09-16 | Pfizer, Inc. | Thyroid receptor ligands |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| AU2001255646A1 (en) * | 2000-05-04 | 2001-11-12 | Warner Lambert Company | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives |
| GB0021421D0 (en) * | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| IL157740A0 (en) | 2001-03-07 | 2004-03-28 | Incyte San Diego Inc | Heterocyclic derivatives and pharmaceutical compositions containing the same |
| EP1377559A4 (en) * | 2001-03-08 | 2005-09-28 | Incyte San Diego Inc | MOLECULES ACTIVATING AN RXR RECEPTOR |
| CA2340824A1 (en) * | 2001-03-14 | 2002-09-14 | Ibm Canada Limited-Ibm Canada Limitee | Method and system for application behavior analysis |
| JP2005500379A (ja) * | 2001-08-17 | 2005-01-06 | インサイト サンディエゴ インコーポレーテッド | 異脂肪血症および高コレステロール血症を治療するオキシム誘導体 |
| US7071218B2 (en) * | 2001-11-15 | 2006-07-04 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases |
| US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| CA2493843C (en) * | 2002-07-10 | 2012-04-17 | Applied Research Systems Ars Holding N.V. | Azolidinone-vinyl fused-benzene derivatives |
| US7005523B2 (en) * | 2002-08-30 | 2006-02-28 | Pfizer Inc. | Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines |
| US20060276520A1 (en) * | 2002-11-13 | 2006-12-07 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| NZ539873A (en) | 2002-11-22 | 2008-09-26 | Smithkline Beecham Corp | Novel chemical compounds, thiazolidin-4-one, thiazol-4-one |
| WO2004066952A2 (en) * | 2003-01-29 | 2004-08-12 | Incyte Corporation | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases |
| US20040242566A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| MXPA05011242A (es) * | 2003-04-18 | 2006-07-06 | Incyte San Diego Inc | Compuestos isocromanos sustituidos para el tratamiento de trastornos metabolicos, cancer y otras enfermedades. |
| US20060106077A1 (en) * | 2003-07-18 | 2006-05-18 | Pintex Pharmaceuticals, Inc. | Pin1-Modulating compounds and methods of use thereof |
| CA2535619A1 (en) | 2003-08-13 | 2005-02-24 | Takeda Pharmaceutical Company Limited | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| JP2007505121A (ja) | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| GEP20094679B (en) | 2004-03-15 | 2009-05-10 | Takeda Pharmaceuticals Co | Dipeptidyl peptidase inhibitors |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| US7872124B2 (en) | 2004-12-21 | 2011-01-18 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| DE102005022182A1 (de) * | 2005-05-09 | 2006-11-16 | Combinature Biopharm Ag | Modulatoren der PDZ-Domäne |
| TW200716580A (en) * | 2005-06-08 | 2007-05-01 | Smithkline Beecham Corp | (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one |
| ME02005B (me) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
| CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
| KR100814109B1 (ko) * | 2006-01-09 | 2008-03-14 | 한국생명공학연구원 | 로다닌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 약학적 조성물 |
| CA2640678C (en) | 2006-02-03 | 2015-03-31 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| WO2007126111A1 (ja) | 2006-04-28 | 2007-11-08 | Kagoshima University | アミロイドβ線維化阻害ペプチド |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
| EP2650379B1 (en) | 2007-07-31 | 2015-09-16 | Accera, Inc. | Use of genomic testing and ketogenic compounds for treatment of reduced cognitive function |
| EP2217573A4 (en) * | 2007-11-01 | 2011-08-31 | Uab Research Foundation | TREATMENT AND PREVENTION OF VIRUS INFECTIONS |
| KR20160127181A (ko) * | 2008-08-12 | 2016-11-02 | 진판델 파마슈티컬스 인코포레이티드 | 질환 위험 인자의 식별 방법 |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| AU2010232923A1 (en) * | 2009-04-03 | 2011-11-03 | Medisyn Technologies, Inc. | Compositions for treatment of Alzheimer's disease |
| RU2636589C2 (ru) * | 2009-12-23 | 2017-11-24 | ДЖАСКО ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Аминопиримидиновые ингибиторы киназ |
| EP2399612B1 (en) * | 2009-12-25 | 2018-02-21 | Canon Kabushiki Kaisha | Composition for labeling tissues of central nervous system, method for labeling tissues of central nervous system, and screening method using the composition for labeling tissues of central nervous system |
| CN102558088A (zh) * | 2010-12-31 | 2012-07-11 | 中国科学院上海药物研究所 | 联苯亚甲基-2-硫代-4-噻唑酮类化合物及其制备方法和用途 |
| UA114704C2 (uk) | 2011-01-10 | 2017-07-25 | Зінфандел Фармасьютікалз, Інк. | Способи та лікарські засоби для лікування хвороби альцгеймера |
| JP6014816B2 (ja) | 2011-05-10 | 2016-10-26 | 国立大学法人神戸大学 | Ｒａｓ機能阻害作用を有するチオキソチアゾリジン誘導体 |
| JPWO2013183718A1 (ja) * | 2012-06-06 | 2016-02-01 | 国立大学法人京都大学 | スクリーニング方法、タンパク質の不安定性及び／又は安定性を誘導する物質、及び、タンパク質の活性評価 |
| AU2013340478B2 (en) | 2012-11-05 | 2018-08-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a STAT5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
| WO2016077793A1 (en) * | 2014-11-14 | 2016-05-19 | Children's Hospital Medical Center | Sos1 inhibitors for cancer treatment |
| CN104557767B (zh) * | 2015-01-14 | 2016-06-29 | 成都中医药大学 | 罗丹宁手性环己烷螺环化合物及其制备方法与用途 |
| CN106008494B (zh) * | 2016-05-31 | 2019-08-27 | 广东工业大学 | 一种含4-氧代-2-硫代噻唑烷基衍生物及其制备方法与应用 |
| EP4083037A4 (en) * | 2019-12-26 | 2024-01-24 | Yonsei University, University-Industry Foundation(UIF). | Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU173773A (zh) * | ||||
| DE1038050B (de) * | 1955-11-17 | 1958-09-04 | Farmaceutici Italia S A Soc | Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen |
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS5697277A (en) * | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| AU6610081A (en) * | 1980-01-24 | 1981-07-30 | Senju Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
| JPS5728074A (en) * | 1980-07-28 | 1982-02-15 | Ono Pharmaceut Co Ltd | Rhodanine derivative, its preparation, and inhibitor for aldose reducing enzyme consisting essentially of it |
| JPS5740478A (en) * | 1980-08-22 | 1982-03-06 | Ono Pharmaceut Co Ltd | Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative |
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
| JPS58118577A (ja) * | 1982-01-07 | 1983-07-14 | Takeda Chem Ind Ltd | チアゾリジン誘導体 |
| US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
| US4552891A (en) * | 1983-09-13 | 1985-11-12 | Eli Lilly And Company | Benzothiophene derivatives |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| HU210339B (en) * | 1985-05-21 | 1995-03-28 | Pfizer | Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect |
| JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
| JPS6212776A (ja) * | 1985-07-10 | 1987-01-21 | Taiho Yakuhin Kogyo Kk | ロ−ダニン誘導体 |
| US5356917A (en) * | 1985-08-09 | 1994-10-18 | Eli Lilly And Company | Aryl-substituted rhodanine derivatives |
| IL79648A (en) * | 1985-08-09 | 1991-12-12 | Lilly Co Eli | Pharmaceutical anti-inflammatory and ischemia preventing compositions containing di-t-butylphenol derivatives,some such novel compounds and process for their preparation |
| CA1325222C (en) * | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
| KR870006897A (ko) * | 1986-01-07 | 1987-08-13 | 모리오까 시게오 | 헤테로시클릭 화합물, 그의 제조 방법 및 이를 함유하는 제약 조성물 |
| DE3874257T2 (de) * | 1987-03-11 | 1993-02-11 | Kanegafuchi Chemical Ind | Hydroxystyren-derivate. |
| FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
| US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| EP0316723B1 (en) * | 1987-11-20 | 1992-09-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments |
| US5223522A (en) * | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5330998A (en) * | 1988-03-08 | 1994-07-19 | Pfizer Inc. | Thiazolidinedione derivatives as hypoglycemic agents |
| IE940525L (en) * | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
| US5208250A (en) * | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
| US4863923A (en) * | 1988-07-01 | 1989-09-05 | Eli Lilly And Company | Method of inhibiting superoxide release |
| ATE139531T1 (de) * | 1989-04-07 | 1996-07-15 | Lilly Co Eli | Arylsubstituierte rhodaninderivate |
| JPH02300119A (ja) * | 1989-05-11 | 1990-12-12 | Kanegafuchi Chem Ind Co Ltd | 過酸化脂質生成抑制剤 |
| EP0398179B1 (en) * | 1989-05-19 | 1996-01-17 | Nisshin Flour Milling Co., Ltd. | Rhodanine derivatives and pharmaceutical compositions |
| GB8919434D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| US4997948A (en) * | 1989-10-27 | 1991-03-05 | American Home Products | 5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof |
| ZA9010041B (en) * | 1989-12-21 | 1992-08-26 | Lilly Co Eli | Compounds for treating inflammatory bowel disease |
| US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| DE4027038A1 (de) * | 1990-08-27 | 1992-03-05 | Wella Ag | 3-amino-5-benzyliden-2-thioxo-thiazolidin-4- one, verfahren zu deren herstellung und diese enthaltendes kosmetisches mittel |
| DE69223823T2 (de) * | 1991-02-15 | 1998-05-20 | Mitsui Toatsu Chemicals | Durchsichtige schlagzähe Formkörper |
| US5158966A (en) * | 1991-02-22 | 1992-10-27 | The University Of Colorado Foundation, Inc. | Method of treating type i diabetes |
| US5143929A (en) * | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| US5320770A (en) * | 1992-04-27 | 1994-06-14 | Dow Corning Corporation | Electrorheological (ER) fluid based on amino acid containing metal polyoxo-salts |
| AU679675B2 (en) * | 1992-05-11 | 1997-07-10 | Bayer Corporation | Methods for detecting beta amyloid precursor protein processing enzymes |
| US5236941A (en) * | 1992-06-30 | 1993-08-17 | American Home Products Corporation | 5-(2-hydroxy-1-arylethylidene)- and 5-(2-oxo-1-arylethylidene)-2,4-thiazolidinediones and derivatives thereof |
| EP0587377A3 (en) * | 1992-09-10 | 1994-09-21 | Lilly Co Eli | Thiazolidinone derivatives as hypoglycemic agents and for treating alzheimer's disease |
| US5506745A (en) * | 1994-08-05 | 1996-04-09 | Xerox Corporation | Hollow conformable charge roll |
-
1993
- 1993-09-02 EP EP19930306959 patent/EP0587377A3/en not_active Withdrawn
- 1993-09-02 CZ CZ931814A patent/CZ181493A3/cs unknown
- 1993-09-02 EP EP98201389A patent/EP0915090A1/en not_active Withdrawn
- 1993-09-02 IL IL106877A patent/IL106877A/en not_active IP Right Cessation
- 1993-09-02 ZA ZA936492A patent/ZA936492B/xx unknown
- 1993-09-02 NZ NZ248573A patent/NZ248573A/en unknown
- 1993-09-03 TW TW082107213A patent/TW274546B/zh active
- 1993-09-06 MX MX9305444A patent/MX9305444A/es unknown
- 1993-09-07 CA CA002105598A patent/CA2105598A1/en not_active Abandoned
- 1993-09-07 MY MYPI93001815A patent/MY131443A/en unknown
- 1993-09-08 NO NO933198A patent/NO933198L/no unknown
- 1993-09-08 HU HU9302551A patent/HUT70184A/hu unknown
- 1993-09-08 RU RU93051176A patent/RU2131251C1/ru active
- 1993-09-08 AU AU46218/93A patent/AU676843B2/en not_active Ceased
- 1993-09-09 CN CN93119081A patent/CN1091006A/zh active Pending
- 1993-09-09 FI FI933946A patent/FI933946A7/fi unknown
- 1993-09-09 PL PL93300335A patent/PL300335A1/xx unknown
- 1993-09-09 KR KR1019930018138A patent/KR940006590A/ko not_active Ceased
- 1993-09-09 JP JP5224434A patent/JPH06192091A/ja not_active Withdrawn
- 1993-09-15 YU YU59593A patent/YU59593A/sh unknown
-
1994
- 1994-03-16 US US08/213,651 patent/US5523314A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/470,822 patent/US5716975A/en not_active Expired - Fee Related
-
1996
- 1996-07-10 US US08/678,015 patent/US5661168A/en not_active Expired - Fee Related
-
1998
- 1998-04-28 NO NO981911A patent/NO981911D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9302551D0 (en) | 1993-11-29 |
| KR940006590A (ko) | 1994-04-25 |
| ZA936492B (en) | 1995-03-02 |
| FI933946L (fi) | 1994-03-11 |
| CZ181493A3 (en) | 1994-03-16 |
| AU4621893A (en) | 1994-03-17 |
| HUT70184A (en) | 1995-09-28 |
| IL106877A0 (en) | 1993-12-28 |
| CA2105598A1 (en) | 1994-03-11 |
| FI933946A0 (fi) | 1993-09-09 |
| NO933198L (no) | 1994-03-11 |
| NZ248573A (en) | 1996-02-27 |
| NO981911L (no) | 1994-03-11 |
| YU59593A (sh) | 1997-01-08 |
| PL300335A1 (en) | 1994-03-21 |
| CN1091006A (zh) | 1994-08-24 |
| NO981911D0 (no) | 1998-04-28 |
| NO933198D0 (no) | 1993-09-08 |
| MY131443A (en) | 2007-08-30 |
| US5716975A (en) | 1998-02-10 |
| EP0915090A1 (en) | 1999-05-12 |
| JPH06192091A (ja) | 1994-07-12 |
| US5661168A (en) | 1997-08-26 |
| EP0587377A3 (en) | 1994-09-21 |
| AU676843B2 (en) | 1997-03-27 |
| RU2131251C1 (ru) | 1999-06-10 |
| MX9305444A (es) | 1994-05-31 |
| EP0587377A2 (en) | 1994-03-16 |
| FI933946A7 (fi) | 1994-03-11 |
| IL106877A (en) | 1998-03-10 |
| US5523314A (en) | 1996-06-04 |