TW221996B - - Google Patents
Info
- Publication number
- TW221996B TW221996B TW081108989A TW81108989A TW221996B TW 221996 B TW221996 B TW 221996B TW 081108989 A TW081108989 A TW 081108989A TW 81108989 A TW81108989 A TW 81108989A TW 221996 B TW221996 B TW 221996B
- Authority
- TW
- Taiwan
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919124221A GB9124221D0 (en) | 1991-11-14 | 1991-11-14 | Chemical compounds |
| GB929201052A GB9201052D0 (en) | 1992-01-16 | 1992-01-16 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW221996B true TW221996B (zh) | 1994-04-01 |
Family
ID=26299862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW081108989A TW221996B (zh) | 1991-11-14 | 1992-11-10 |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0612313A1 (zh) |
| JP (1) | JPH07501063A (zh) |
| CN (1) | CN1073169A (zh) |
| AP (1) | AP330A (zh) |
| AU (1) | AU2915892A (zh) |
| IL (1) | IL103746A0 (zh) |
| IS (1) | IS3945A (zh) |
| MX (1) | MX9206541A (zh) |
| TW (1) | TW221996B (zh) |
| WO (1) | WO1993010091A2 (zh) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4127404A1 (de) | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| TW257757B (zh) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
| SK120895A3 (en) * | 1993-03-29 | 1996-06-05 | Zeneca Ltd | Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| WO1994022835A2 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| JPH06340619A (ja) * | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
| GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
| USRE39263E1 (en) * | 1994-05-04 | 2006-09-05 | Bayer Aktiengesellschaft | Substituted aromatic thiocarboxylic acid amides and their use as herbicides |
| ES2238679T3 (es) * | 1994-05-04 | 2005-09-01 | Bayer Cropscience Ag | Amidas de acidos tiocarboxilicos aromaticas substituidas y su empleo como herbicidas. |
| NZ289498A (en) * | 1994-07-15 | 1998-02-26 | Meiji Seika Co | Piperidinylpiperazine derivatives such as various piperidinylpiperazinylacetylphenoxy acetic acid derivatives, pharmaceutical compositions |
| JPH10511357A (ja) * | 1994-12-22 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | フィブリノゲン受容体拮抗物質 |
| ZA951822B (en) * | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
| FR2728901B1 (fr) * | 1994-12-28 | 1997-03-28 | Sanofi Sa | Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| IL116893A (en) * | 1995-02-10 | 2000-02-29 | Yamanouchi Pharma Co Ltd | Piperazine derivatives and pharmaceutical compositions containing them |
| WO1996024583A1 (en) * | 1995-02-10 | 1996-08-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzamidine derivatives and medicinal composition thereof |
| US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| DE19516483A1 (de) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| GB9511989D0 (en) * | 1995-06-13 | 1995-08-09 | Glaxo Group Ltd | Chemical compounds |
| WO1997002245A1 (en) * | 1995-07-06 | 1997-01-23 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
| PL329053A1 (en) * | 1996-03-30 | 1999-03-01 | Roche Diagnostics Gmbh | Novel derivatives of oxazolydine, method of obtaining them and therapeutic agents containing such compounds |
| TW403745B (en) * | 1996-05-30 | 2000-09-01 | Yamanouchi Pharma Co Ltd | Novel substituted -amidinobenzene derivative and pharmaceutical compositions thereof |
| AR008245A1 (es) * | 1996-06-21 | 1999-12-29 | Glaxo Group Ltd | Derivados de acido acetico, uso de los mismos en la fabricacion de un agente terapeutico y proceso para preparar dichos derivados |
| WO1997049698A1 (en) * | 1996-06-21 | 1997-12-31 | Glaxo Group Limited | Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders |
| DE19643331A1 (de) * | 1996-10-21 | 1998-04-23 | Thomae Gmbh Dr K | 1-(4-Piperidinyl)-piperidinylene, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19652919A1 (de) * | 1996-12-19 | 1998-06-25 | Solvay Pharm Gmbh | Piperazinophenyl- und Piperazinophenyloxy-carbonsäure-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| AR013693A1 (es) * | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
| WO1999033805A1 (en) * | 1997-12-26 | 1999-07-08 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
| JP2003504301A (ja) | 1998-04-01 | 2003-02-04 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | インテグリンアンタゴニスト |
| PL346795A1 (en) * | 1998-09-22 | 2002-02-25 | Yamanouchi Pharma Co Ltd | Cyanophenyl derivatives |
| US6204282B1 (en) | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
| ES2258642T3 (es) | 2001-07-02 | 2006-09-01 | Astrazeneca Ab | Derivados de piperidina utiles como moduladores de la actividad del receptor de quimiocina. |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| US7635698B2 (en) | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| JP2008530216A (ja) | 2005-02-16 | 2008-08-07 | シェーリング コーポレイション | Ｃｘｃｒ３アンタゴニスト活性を有する、複素環で置換された新規のピリジンまたはフェニル化合物 |
| MX2007009947A (es) | 2005-02-16 | 2007-09-26 | Schering Corp | Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3. |
| WO2006088837A2 (en) * | 2005-02-16 | 2006-08-24 | Schering Corporation | Heterocyclic substituted piperazines with cxcr3 antagonist activity |
| KR20070107056A (ko) | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Ｃｘｃｒ３ 길항제 활성을 지닌 피리딜 및 페닐 치환된피페라진-피페리딘 |
| AU2006216941B2 (en) | 2005-02-16 | 2009-12-03 | Pharmacopeia, Llc | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity |
| MX2007010068A (es) | 2005-02-16 | 2007-10-10 | Schering Corp | Piperazino-piperidinas con actividad antagonista de cxcr3. |
| WO2007011293A1 (en) | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | Novel piperidine derivatives |
| KR101351454B1 (ko) * | 2005-08-31 | 2014-01-14 | 아메데온, 인코포레이티드 | 위장 및 중추 신경계 장애의 치료에 유용한 입체이성질체 화합물의 합성 방법 및 중간 생성물 |
| EP1996577B1 (en) | 2006-03-21 | 2016-02-10 | Merck Sharp & Dohme Corp. | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
| CA2658417A1 (en) * | 2006-07-14 | 2008-01-17 | Schering Corporation | Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity |
| DE102007038250A1 (de) | 2007-08-13 | 2009-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Herstellverfahren |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| EP3760202A1 (en) | 2017-02-28 | 2021-01-06 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP3589627A4 (en) * | 2017-02-28 | 2020-08-05 | Morphic Therapeutic, Inc. | (ALPHA-V) (BETA-6) INHIBITORS INTEGRIN |
| EP3617206A1 (en) | 2018-08-29 | 2020-03-04 | Morphic Therapeutic, Inc. | Integrin inhibitors |
| PL3844162T3 (pl) | 2018-08-29 | 2025-06-09 | Morphic Therapeutic, Inc. | Inhibitory integryny alfa v beta 6 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2095239B (en) * | 1981-02-27 | 1985-03-06 | Torii & Co Ltd | Novel amidine compounds |
| US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
| PT84171B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem |
| GB9122016D0 (en) * | 1991-10-16 | 1991-11-27 | Glaxo Group Ltd | Chemical compounds |
-
1992
- 1992-11-10 AU AU29158/92A patent/AU2915892A/en not_active Abandoned
- 1992-11-10 TW TW081108989A patent/TW221996B/zh active
- 1992-11-10 EP EP92923116A patent/EP0612313A1/en not_active Withdrawn
- 1992-11-10 JP JP5508956A patent/JPH07501063A/ja active Pending
- 1992-11-10 EP EP19920203442 patent/EP0542363A3/en not_active Withdrawn
- 1992-11-10 WO PCT/EP1992/002588 patent/WO1993010091A2/en not_active Ceased
- 1992-11-13 CN CN92114388A patent/CN1073169A/zh active Pending
- 1992-11-13 IL IL103746A patent/IL103746A0/xx unknown
- 1992-11-13 IS IS3945A patent/IS3945A/is unknown
- 1992-11-13 AP APAP/P/1992/000447A patent/AP330A/en active
- 1992-11-13 MX MX9206541A patent/MX9206541A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0612313A1 (en) | 1994-08-31 |
| EP0542363A2 (en) | 1993-05-19 |
| CN1073169A (zh) | 1993-06-16 |
| AU2915892A (en) | 1993-06-15 |
| WO1993010091A2 (en) | 1993-05-27 |
| MX9206541A (es) | 1993-04-01 |
| EP0542363A3 (en) | 1993-07-14 |
| AP330A (en) | 1994-03-30 |
| IS3945A (is) | 1993-05-15 |
| JPH07501063A (ja) | 1995-02-02 |
| IL103746A0 (en) | 1993-04-04 |
| WO1993010091A3 (en) | 1993-06-24 |
| AP9200447A0 (en) | 1993-01-31 |