[go: up one dir, main page]

TW201002265A - Detecting infection in reduced pressure wound treatment - Google Patents

Detecting infection in reduced pressure wound treatment Download PDF

Info

Publication number
TW201002265A
TW201002265A TW098118605A TW98118605A TW201002265A TW 201002265 A TW201002265 A TW 201002265A TW 098118605 A TW098118605 A TW 098118605A TW 98118605 A TW98118605 A TW 98118605A TW 201002265 A TW201002265 A TW 201002265A
Authority
TW
Taiwan
Prior art keywords
wound
fluid
infection
luciferase
reduced pressure
Prior art date
Application number
TW098118605A
Other languages
English (en)
Inventor
Amy Mcnulty
Deepak V Kilpadi
George Hutchinson
Nancy Price
Original Assignee
Kci Licensing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kci Licensing Inc filed Critical Kci Licensing Inc
Publication of TW201002265A publication Critical patent/TW201002265A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B46/00—Surgical drapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/73—Suction drainage systems comprising sensors or indicators for physical values
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/95—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with sensors for exudate composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/92—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with liquid supply means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Spectroscopy & Molecular Physics (AREA)

Description

201002265 六、發明說明： 【發明所屬之技術領域】 本發明一般係關於組織處理系統及尤其係關於偵測傷口 感染之方法與組合物。 • 該申請案主張2〇〇8年6月4曰申請之美國臨時申請案第 61/058,819號與2〇〇8年11月26曰申請之美國臨時申請案第 61/118,161號之權利’此兩案係以引用的方式併入。 【先前技術】 6™床研究與操作法已顯示一種在組織部位附近提供減壓 之系統可增加及加快該組織處新組織的生長。此現象之應 用有許夕種，但減壓之應用尤其已成功用於處理傷口。此 處理（在醫學部門通常稱爲「負壓傷口療法」、「減壓療 法」或「真空療法」）提供多種益處，包括更快愈合及肉 芽組織加快形成。通常，係由多孔墊片或其他岐管裝置於 組織上進行減壓。多孔墊片包含可分佈減壓至組織並引流 y 自組織中吸出的流體之孔洞或孔。多孔墊片通常併入包含 其他促進治療的組分之敷料中。 . 與該系統使用相關之一難點在於如何在不干擾覆蓋傷口 .的密封敷料下偵測傷口中感染之存在或類型。關於微生物 之偵測已發展多種方法。此等方法之多種形式包含使用用 於偵測微生物存在的光譜儀、色譜儀、及其他電子感測 器。其美國專利案實例包括2000丄25發佈的等人， 美國專利案案號6,017,440 ; 2001.2.13發佈的Chutjiai^ 人’美國專利案案號6,188,067;州8·^發佈的Η_Γ等 H0852.doc 201002265 人’美國專利案案號5,811，255 ; !997.3.18發佈的〇ven〇n 等人，美國專利案案號5,611，846;及1996 12 ι〇發佈的％, 美國專利案案號5,583,281。 ’ 雖然該系統在促進傷口愈合、治愈許多先前認爲不可治 療:傷口上極爲成功，但仍存在若干固難。因爲該系統的 本質需要氣密的創傷處，很難在不移動傷口敷料下倘測污 染物微生物（例如可能存在於創傷處的細菌）的存在或濃 度。為檢測細菌感染的存在或濃度’迄今仍需干擾創傷 處，進而阻礙治療。而且對創傷處的任何干擾均可能增加 該創傷處感染之可能性。另，移除傷口敷料可能引起患者 疼痛或不適。 在解決此等問題上曾採用美國專利申請公開案 uS2〇〇2/〇143286中所述的發明（其已以引用的方式併入文 Λ進展°該申請錢述感測11之使用，其以光 子式感應傷口流體中細菌劑或其他形式感染之存在。作 仍需要可專—性識別及定量感染物之其他方法。 因此’本發明之主要目 π ^ ^ ^ ;獒仏一種利用真空促進傷 口愈合t置，其所採用之方式 不干擾創傷處㈣^ 大係在應用氣讀料期間，在 傷處的敷枓下創傷處感染存在。 本發明之又一目的在於提供一 "種方式，在應用氣密敷料 期間在不干擾創傷處的敷料下， 染之性質或特殊類型。 識财在於創傷處的感 本發明之另一目的 期間，在不干擾… 式’在應用氣密敷料 ^ Γ1在不干擾創傷處的數粗Τ 、 ，下，偵測存在於創傷處的感 140852.doc 201002265 染物之濃度。 【發明内容】 f處中偵測感染之現有I具所顯示的問題可由文中 所述貝施例之方法與設㈣決。在—項實施财，提供一 種伯測由創傷處感染性生物體引起的傷σ 包括於創傷處應用減壓、隨著減壓從創傷處吸出流體、收 集從創傷處吸出的流體、及分析從創傷處收集的流體的感 染產物或感染性有機體之組分’冑而由該產物或組分之存 在顯示傷口處出現感染。 在另一實施例中，提供-種偵測創傷處傷口感染的系 統’其包含減塵源、適於傳遞該減壓至創傷處之多孔塾 片、適於在塾片與創傷處上提供實質上氣密蓋之覆蓋層、 可將流體引流到多孔墊片與減壓源之導管，藉以隨著減壓 從創傷處吸出流體’及可分析自創傷處吸出的流體以識別 感染物或感染性有機體之組分之裝置，進而由該產物或組 分之存在顯示傷口出現感染。 在另一項實施例中，提供一種適於分佈減壓至創傷處之 夕孔塾片’其中包含螢光素酶。 多考以下圖示與詳細説明，將更了解闡述性實施例之其 他目的、特徵、及益處。 【實施方式】 在以下闡述性實施例之詳細説明中，參考構成其部分之 隨附圖示。此等實施例之詳細闡述足使擅長該技術者實施 本發明’應了解可在不脫離本發明主旨或範圍下，利用其 140852.doc 201002265 他實施例及進行符合邏輯的結構、機械、電及化學變化。 為了避免擅長該技術者進行文中所述實施例時不需要的詳 述’本說明可能省略擅長該技術者咸了解的一些信息。因 此，以下詳細闡述不應視爲限制，且闡述性實施例之範圍 僅由隨附專利請求項定義。 關於圖1 ’減壓處理系統i 00之闡述性實施例提供包含傷 口 1Π的組織部位110之減壓處理，及偵測組織部位11〇之 感染。減壓處理系統1 〇〇包含將流體引流到導管1 22的減壓 源128，其經由敷料ι〇8傳遞減壓給組織部位11〇。該敷料 108包含置於傷口 U1處的墊片112 ^覆蓋層116黏附於患者 表皮114並封阻傷口 1 11周圍之液體，使傷口 1 11保持減 壓。減壓使傷口 111的流體（例如分泌液）吸至裝置丨丨8，分 析被吸出之流體或其提取物，以分析其中感染產物或感染 性有機體或有機體群之組分。 傷口 111可為位於任何組織部位11〇上或内的損傷或缺 損，包含但不限制於：骨組織、脂肪組織、肌肉組織、皮 下組織、神經組織'皮组織、血管組織、結締組織、軟 骨、腱或韌帶。傷口 1U亦可能為不一定有損傷或缺損的 任何組織，反而可能為其中需增加或促進額外組織生長的 區域。 如文中所用’「感染性有機體」為可引起傷口感染的微 生物（細菌、真菌、原生生物、古細菌、病毒）。非限制實 例包含金黃色葡萄球菌（1&?My/ococcw5 、膿鏈球菌 (Streptoco⑽s pyroge⑽）' 大陽椁菌辟咖咏心⑶的綠膿椁菌 140852.doc 201002265 (Pseudomonas aeruginosa)、奇異變形桿蛰（proteus mirabiUs)、饰炎 样 M (Klebsiella pneumoniae)、白色念珠菌（Candida albicans)反脆弱 擬桿菌/rag//句。此包含（a)具有特定特徵或製造特 疋產物的特疋種或屬之特定生物型，其中該特徵或產物可 藉由測試出例如會產生中毒休克综合症毒素^(丁^丁-丨）的 金黃色葡萄球菌、凝固酶陰性葡萄球菌、或D群鏈球菌； 及（b)具有一種以上菌種之群組，例如革蘭氏陰性細菌、棒 狀桿菌·謂)、腸球菌（Enter〇c〇cci)、腸 桿菌（五价⑽办此⑽、鏈球菌（加吻〇c〇ccw“跟）。在 一些實施例中’感染性有機體或有機體群為細菌。 如文中所用，「感染產物」為在感染期間，由宿主（即， 患者）或感染性有機體產生的可明確識別的化合物。該宿 主產物亦可在未受感染時產生，但要適用於本發明方法的 產物應在感染期間，於傷口所吸出流體中之產量比未感染 傷口所吸出流體中之產量更高。㉟染產物之非限制性實例 包含腺苷-5，-三磷酸鹽（ATP)(由細菌製造）與一些細胞活 素、纖維黏連蛋白片斷、嗜中性蛋白酶、及巨噬細胞蛋白 酶（由宿主製造）。可明確識別的化合物為一種可由其化學 組成或與特定試劑（例如，抗體或特定序列的核酸探針）之 反應性而被逐一識別的化合物。 敷料108的覆蓋層116係為可封阻液體的任何材料。例 如，覆蓋層116可為不可滲透或可半滲透之彈性材料。「彈 性」意指具有彈性體性質。其泛指具有類似橡膠性質的聚 合材料。更具體而言，數彈性體具有大於刚％之伸 140852.doc 201002265 長率及顯著恢復力。材料之恢復力係指材料從彈性變形恢 復之能力。彈性體之實例可包含’但不限於，天然橡膠、 聚異戊二稀、笨乙稀丁二烤橡膠、氯丁乙二稀橡膠、聚丁 二烯、丁腈橡膠、丁基橡膠、乙丙橡膠、乙稀丙缚二稀單 體、氯磺化聚乙烯、聚硫橡膠、聚胺酯、EVA薄膜、共聚 酯、及聚石夕氧。覆盖層11 6材料之特定實例包括聚秒氧覆 蓋層、3M Tegaderm®覆蓋層、丙烯酸覆蓋層（例如購自 Avery Dennison者）、或切口覆蓋層。覆蓋層116可包括已 插入分界面133的孔131。該分界面133成為導管122與由覆 蓋層116形成的密封空間之間的流體通道。 如文中所用的術語「墊片」泛指有助於在組織部位i 1〇 加加減壓、傳遞流體至該部位、或移除該部位的流體所提 供的物負或結構。該塾片112 —般包含複數個流道或通 道’使流體分佈至墊片U2周圍的組織部位11〇並自該處移 除。在闡述性實施例中，流道或通道相互連接，以改善流 體之分佈或自組織部位110移除。墊片112可為可與組織部 位110接觸且分佈減壓至組織部位11〇之可生物相容性材 料。墊片112之實例可包括（未限制），例如，具有形成流道 之結構元件的裝置，如，例如多孔狀發泡物、開放孔狀發 泡物、多孔組織聚集體、液體、凝膠、及已包括或經硬化 後而包括流道之發泡物。塾片1 1 2可為多孔且可由發泡 物、紗布、毯狀蓆塾片、或適合特定生物應用的任何其他 材料製得。在一項實施例中，墊片U2可為多孔發泡物且 包含複數個作爲流道的互連室或孔。多孔發泡物可為聚胺 140852.doc 201002265 酯、開放孔洞、網狀發泡物’如：由Kinetic c〇ncepts. Incorporated of San Antoni。，Texas製造的 GranuF〇am% 料。其他實施例可包含「密閉孔洞」。墊片U2之此等密閉 孔洞部分包含複數個小孔洞，其中大部分不與相鄰孔洞流 體相連。密閉孔洞可選擇性置於墊片112中’以防止流體 穿過墊片112周圍表面。有些情況中，墊片112亦可用於分 佈流體（例如醫藥品、抗細菌劑、生長因子、及各種溶液） 至組織部位110。可將其他層置於墊片丨丨2内或上，例如吸 收性材料、芯給材料、疏水材料、及親水材料。 在一些實施例中，墊片112包括可在傷口 iu中與感染性 有機體組分或感染產物反應的化合物。如上所述，感染產 物可來自宿主（例如，如：因感染產生的宿主蛋白質之化 合物，例如細胞活素、纖維黏連蛋白片斷、嗜中性蛋白 酶、或巨噬細胞蛋白酶）或來自有機體（例如，ATp)。在一 些實施例中，化合物與感染性有機體之組分或與感染產物 之間的反應產物可被吸入導管122中，由裝置118偵測。然 後，當反應產物藉由通訊線路124偵測時，裝置118可報告 數據處理系統12 6 (例如電腦p通訊線路丨2 4包括有線與無 線形式之通訊。數據處理系統126儲存數據，並可進行計 算，例如計算所測組分或產物之濃度、或感染程度。 在另一實施例中，裝置118具有反應化合物，以偵測感 木性有機體之組分或感染產物；在該實施例中，來自傷口 m的流體可穿過聲片112及進入裝置118中，使流體進入 化合物所在處。褒置丨丨8亦可具有測量反應結果的工具（例 140852.doc 201002265 電荷耦σ I置[CCD]相機，以測量微陣列、化學晶片 或微抓體裝置之結果，或光偵測器，以測量來自榮光素酶 反應之光）。 可在闡述性實施例中偵測的常見細菌感染產物為腺苷_ 5 —礤酸鹽（ATP)。在此等方法中，Ατρ可藉由技術中已 知的任何方法偵測。在一些實施例中，可在Μ,2存在下， 利用以下螢光素酶-螢光素反應偵測ATP : ATP+榮光素酶+蟹光素+〇2_^AMP+c〇2+2pi+光 光為可見光，且視需要利用例如光偵測器定量。在一項實 施例中’裝置118為光偵測器。 因此’在一些實施例中，藉由合併自傷口 u丨吸出的流 體或其提取物與螢光素酶及螢光素，然後測量隨後反應產 生的光，來偵測ATP。如果產生的光超過未感染之傷口所 產生的光’則傷口 111被感染。在多個實施例中，藉由測 1發射光來定量ATP，其中吸出的流體或其提取物中ATp i增加’表示傷口 111感染嚴重度加劇。參見，例如美國 專利4,833,〇75、5,756,3 03、與5,9lM〇2及歐洲專利申請 案002535 1A1，例如，定量ATP以確定流體中出現細菌之 方法。 在其他實施例中，感染產物為與發炎反應相關的宿主蛋 白。在此等實施例中，可藉由裝置11 8偵測任何該宿主蛋 白。其中一些此等實施例中，宿主蛋白為細胞活素、纖維 黏連蛋白片斷、嗜中性蛋白酶、或巨嗟細胞蛋白晦。象 見，例如PCT專利公開案WO 2004/086(M3與美國專利申請 140852.doc 201002265 公開案 US 2005/0079542 A1。 裝置11 8亦可藉由分析感染性有機體或有機體群之組分 來確定傷口流體或提取物之感染。如文中所用，「感染性 有機體之組分」為引起傷口感染之有機體的可明確識別部 . 分。此等組分之非限制性實例為脂多糖（LPS)、脂胞壁酸 (LTA)、抗原、及具有作為特定有機體特徵之特定序列的 DNA。 在一些實施例中，若測試革蘭氏陰性細菌時，吸出的流 < S 體或其提取物與對革蘭氏陰性細菌之脂多糖（LPS)敏感的 鱟阿米巴變形細胞溶解物組合。亦可例如藉由已知免疫測 定，利用抗體偵測LPS，該免疫測定包括藉由經過補體調 理的LPS-IgM免疫複合物致敏的宿主嗜中性白血球突發性 呼吸作用活性，測量内毒素活性之分析法（例如肉毒素活 性實驗 TM (Endotoxin Activity AssayTM)) (Hi 1 mi 等人，J. Organ Dysfunction, advanced online publication, 2009. 3· 23) ° 在偵測革蘭氏陽性細菌的多個實施例中，待偵測組分爲
U 脂胞壁酸（LTA)，其由相關技術中已知的任何方法偵測。 其中一些此等實施例中，LTA係藉由包括組合所吸出的流 體或其提取物與會特異性結合LTA的抗體，然後測定抗體 是否已與LTA結合之分析法偵測。 在一些實施例中，測試傷口流體或其提取物中會引起傷 口感染之有機體中至少一種特定屬或種，例如鏈球菌、或 月農鏈球菌pyragenes·)。此等試驗需要用在識別有 機體以決定受影響之宿主範圍較窄之感染處理法，例如當 140852.doc -11 - 201002265 需要使用宿主標靶範圍較窄之抗生素時 有些實施例中，用於可引起傷口感染之有機趙之特 或種之分析法包括裝置m，其可識別傷σ流體提取物令 有機體或有機體群所特有的核酸序列。其中有些方法中， 處理吸出的流體，使感染性有機體釋放出dna或rna;將 DNA、或從RNA反轉錄之_八以彳谓測標記物標記，並 且應用至針對至少-種特定有機體或有機體群具有專一性 之至少-種固定化核酸中；及評估該固定化核酸，以測定 該可偵測標記物是否已特異性地與其結合。本文中該可 偵測標記物與該固定化核酸之特異性結合即顯示傷口 ^ 係受到特定有機體或有機體群的感染。應明白此等試驗可 用於微陣列或微流體晶片。參見，例如Affymetrix (2〇〇5)
Application Notes ’傳染病的微陣列應用（μ^贿⑽ Applications in Infecti〇us Disease)，www affymetdx c_。 在此等貫％例中之一些態樣中，將經標記DNA或cDna應 用於包含至少5、10、20、50或100種固定化核酸之微陣 列，每種核酸針對引起傷口感染的不同有機體或有機體群 具有特異性。 在其他實施例中’可使用抗體或適體（aptamer)偵測抗原 或位於有機體或有機體群上之適體結合位置。其中一些此 等實施例中’吸出的流體或其提取物會與有機體中有機體 某屬或種所特有的抗體或適體結合，然後分析該抗體或適 體’以確定傷口 111中抗原是否與該抗體或適體結合。而 且可使用多種抗體或適體測定多種有機體。因此，其中一 140852.doc •12- 201002265 些此等方法中，吸出的流體或其提取物與—種以上抗體或 適體組合’每種抗體或適體係分別針對引起傷口感染的有 機體中不同屬或種；，然後分析該—種以上的抗體或適體， 以確定該-種以上抗體或適體中任—種是否與傷口的抗原 或適體結合部位結合。 相關技術中已知多種用於測定抗體或適體是否與抗原或 適體結合部位結合之實驗。其實例包括ELISA、免疫墨點 /刀析、及Μ引用方式併人文中之美國專利中請公開案仍 2007/0292397 Α1中所述之實驗。 在一項實施例中，裝置118包含一個隔間（未顯示卜其用 於放置包含已結合抗體之基質（未顯示），因此當流體自傷 口m吸出時’流體即流向抗體。此等方法未限制用於裝 置11 8之任何特定基質。其實例包括聚苯乙烯微量滴定 板肖化、戴、准紙、及微晶片。在進-步實施例巾，該裝置 包含鱟阿米巴變形細胞溶解物。 種偵測傷σ 111感染之方法包括使傷口 111減壓至足使 "_L體從傷σ 11卜及出。傷σ 111的流體可收集於裝置118中 ' 了刀析所吸出的流體或其提取物中之感染產物 或感木丨生有機體或有機體群之組分。該產物或組分之存在 表示k 111有感染。闡述性實施例可在無需移除傷口的 敷料108下測試傷口 lu之感染，及偵測特定的有機體 機體群。 / 在項替代性實施例中，該系統1〇〇進一步包含—種適 ；集傷机體之容器（未顯示）。該容器可利用系統i 〇〇之 140852.doc 201002265 單獨組件（例如裳置118)，收集待檢測的流體。在另一實例 中’裝置118或減壓源128可具有該容器。 圖2顯示減壓處理系統2〇〇之闡述性實施例，其包含一個 含有通往晶片235的開口 230之減壓源228。該晶片235可為 微流體或微陣列或化學晶片，及偵測器(例如CCD相機)。 該晶片235可用於偵測有機體或有機體群特有的抗原或核 酸。傷口流體藉由導管122吸出，在開口 23〇中與晶片235 相互反應。導管122之出口 237傳送傷口流體至晶片235， 使該晶片235可與傷口流體相互反應。減壓源228之組態可 以刀析微陣列或微流體數據。在利用微陣列的一些實施例 中，將有標記的DNA或cDNA應用於包含至少5、1〇、2〇、 50或100種固定化核酸之微陣列，每種核酸係分別針對引 起傷口感染之不同有機體或有機體群。然後，經由廢物導 管236去除過量流體。 視需要，系統200亦可具有裝置118與電訊電纜224。裝 置11 8或獨立的數據處理系統（未顯示）之組態可以分析微陣 列或微流體數據。在系統200中，可在開口 23〇中，對來自 裝置118與來自晶片235之傷口流體進行兩次測定。 圖3為減壓處理系統300之闡述性實施例，其包括含已浸 潰螢光素酶與螢光素334之墊片312。在一些實施例中，= 光素酶與墊片312共價結合，如美國專利號4,833,〇75中所 述。減壓源12 8吸出感染傷口 η 1中之ATP至塾片3 12，a丁p 與螢光素酶及螢光素334反應產生光。由Ατρ/螢光素酶/螢 光素反應產生的光係由裝置318偵測，該裝置包含光偵別 I40852.doc •14· 201002265 器’且光測1值可視需要經由通訊線路124傳輸至數據處 理系統126。然後該數據處理系統126記錄光測量值。以此 方式，由裝置3 1 8偵測到之光顯示ATP存在於傷口 i丨丨中。 所出示之裝置318已與覆蓋層116整合。但是，該裝置 . 318可置於系統300中可偵測到來自Ατρ/螢光素酶/螢光素 . 反應的光之任何位置。 在些貫施例中，系統3 00進一步包括與墊片3 12流體相 ρ 連的供應線345，以便自容器347中引入螢光素酶及/或螢 光素334。該供應線345亦可用於提供控制傷口 }〗丨感染的 化合物，在此情況中，該容器347將包括該化合物。 從上述顯而易見，已提供具有重要益處之本發明。雖然 僅以其形式中之一些顯示本發明，但在未限制下很容易 在未脫離本主旨細進行多種變化與修飾。 本説明書引用的所用參考係以引用併入文中文中參考 之論述僅概述作者所給出的結論及不允許任何參考構成先前 {J 技術。申請者保留質疑引用參考之準確度與適當性之權利。 【圖式簡單說明】 • 圖1為顯示用於偵測感染之減壓處理系統之闡述性實施 . 例圖之部分橫戴面； 圖2為顯示用於偵測感染之減壓處理系統之闡述性實施 例圖之部分橫截面，其中減壓源包含容納接收晶片之小隔 間；及 圖3為顯示具有包含物質之墊片的減壓處理系統之闡述 性實施例圖之部分橫截面。 140852.doc -15- 201002265 【主要元件符號說明】 100 減壓處理系統 108 敷料 110 組織部位 111 傷口 114 表皮 112 墊片 116 覆蓋層 118 裝置 122 導管 124 通訊線路 126 數據處理系統 128 減壓源 13 1 孔 133 分界面 200 減壓處理系統 224 電訊電纜 228 減壓源 230 開口 235 晶片 236 廢物導管 237 出口 300 減壓處理系統 312 墊片 140852.doc •16 201002265 318 裝置 334 螢光素酶與螢光素 345 供應線 347 容器 (
140852.doc -17-

Claims (1)

  1. 201002265 申請專利範圍： 七 !· 一種用則貞關傷處傷口❹ 減壓源； m统包含： 多1L墊片，其適於傳遞減壓至創傷處； 覆蓋層’其適於在塾片盘舍丨值♦ 遮蓋物丨 U傷處上提供實質地氣密的 導管，其將流體引流至多孔塾片與減塵 減壓從創傷處吸出流體；及 硬而隨著 用於分析從創傷處吸出的流體之I置， 物或感染性有機體組分； μ】感染產 據以該產物或细分之存在指示感染存在於該傷口。 月求員1之系統’其中該農置包含光债測器且該塾 片進一步包含螢光素酶與螢光素。 。月求項2之系統’其中該營光素酶係以共價鍵方式鍵 結至該墊片。 4·::月求項i之系統’其中該裝置包含一用以放置含有經 結合抗體的基質之隔間，如此當流體從傷口吸出時，流 體可流向該抗體。 求項1之系統，其中§亥裝置包含鱟阿米巴變形細胞 溶解物。 曰月求項1之系統’其中該裝置包含微流體晶片、化學 晶片或微陣列。 月求項6之系統，其中該微流體晶片、化學晶片或微 陣列係於減壓源中。 140852.doc 201002265 8. 9. 10. 11. 12. 13. 如請求項6之系統，豆祕 電腦。 ' 八一步包含能夠記錄分析結果之 一種適於在創傷處上分 包含螢光素酶。 布减麼之多孔墊片，其中該墊片 如請求項9之多 式鍵結至該塾片。，其中該螢光素酶係以共價鍵方 如請求項9之多孔塾片 一種如請求/ 其進一步包含螢光素。 種如請求項9之多孔墊 項1之线用於處理傷口之用途。 片用於處理傷口之用途 140852.doc
TW098118605A 2008-06-04 2009-06-04 Detecting infection in reduced pressure wound treatment TW201002265A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5881908P 2008-06-04 2008-06-04
US11816108P 2008-11-26 2008-11-26

Publications (1)

Publication Number Publication Date
TW201002265A true TW201002265A (en) 2010-01-16

Family

ID=40984785

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098118605A TW201002265A (en) 2008-06-04 2009-06-04 Detecting infection in reduced pressure wound treatment

Country Status (12)

Country Link
US (3) US8460892B2 (zh)
EP (1) EP2281199B1 (zh)
JP (1) JP2011523712A (zh)
KR (1) KR20110025811A (zh)
CN (1) CN102057275A (zh)
AU (1) AU2009256172B2 (zh)
BR (1) BRPI0909536A2 (zh)
CA (1) CA2726481C (zh)
MX (1) MX2010013321A (zh)
RU (1) RU2010146772A (zh)
TW (1) TW201002265A (zh)
WO (1) WO2009149203A1 (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011090986A2 (en) * 2010-01-20 2011-07-28 Kci Licensing, Inc. Wound-connection pads for fluid instillation and negative pressure wound therapy, and systems and methods
CN103917254B (zh) * 2011-11-21 2016-08-24 凯希特许有限公司 用于识别伤口填充物遗留在组织部位处的部分的系统、装置以及方法
DE102011055782A1 (de) * 2011-11-28 2013-05-29 Birgit Riesinger Wundpflegevorrichtung zur behandlung von wunden mittels atmosphärischem unterdruck
WO2013142372A1 (en) * 2012-03-20 2013-09-26 Kci Licensing, Inc. Targeted enzymatic degradation of quorum-sensing peptides
JP6214635B2 (ja) 2012-05-18 2017-10-18 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ カプセル化粒子
EP2849879A2 (en) 2012-05-18 2015-03-25 Basf Se An encapsulated particle
KR20150085832A (ko) 2012-11-16 2015-07-24 바스프 에스이 살충제를 함유하는 캡슐화된 비료 입자
GB201317746D0 (en) 2013-10-08 2013-11-20 Smith & Nephew PH indicator
WO2014138470A1 (en) * 2013-03-07 2014-09-12 Indicator Systems International, Inc. Detecting incipient wound infection by employing infection markers
GB201412131D0 (en) 2014-07-08 2014-08-20 Ucl Business Plc Diagnostics
JP6751076B2 (ja) * 2014-08-11 2020-09-02 ケーシーアイ ライセンシング インコーポレイテッド 陰圧閉鎖療法と一緒に使用するための、プロテアーゼ調節創傷インターフェース層
CN106714671A (zh) * 2014-09-26 2017-05-24 索弗拉狄姆产品公司 用于手术后感染的早期检测的系统和方法
CN104997583A (zh) * 2015-06-12 2015-10-28 黄蕊萍 伤口感染护理装置
CN105132272B (zh) * 2015-09-06 2017-10-20 山东省医疗器械产品质量检验中心 一种阻菌性试验装置及试验方法
WO2019238182A1 (en) 2018-06-15 2019-12-19 Coloplast A/S Data collection schemes for a wound dressing and related methods
WO2019238195A1 (en) * 2018-06-15 2019-12-19 Coloplast A/S Wound dressing system, monitor device and related methods
CN108922620A (zh) * 2018-06-20 2018-11-30 南华大学 一种手术切口感染风险评估系统
US12453513B2 (en) 2019-03-14 2025-10-28 Coloplast A/S Data collection schemes for a wound dressing and related methods
CN110124100A (zh) * 2019-05-04 2019-08-16 西北工业大学 一种可实现药物定向定量释放的载药人工骨支架及其制备方法
BR112021024419A2 (pt) * 2019-06-03 2022-01-18 Convatec Ltd Métodos e dispositivos para desfazer e confinar patógenos
CN110975025B (zh) * 2019-12-20 2022-07-05 武汉维斯第医用科技股份有限公司 一种负压治疗中创面感染检测系统及方法
US12053262B2 (en) * 2020-01-23 2024-08-06 Precision Healing LLC Skin diagnostics using optical signatures

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1355846A (en) 1920-02-06 1920-10-19 David A Rannells Medical appliance
US2547758A (en) 1949-01-05 1951-04-03 Wilmer B Keeling Instrument for treating the male urethra
US2632443A (en) 1949-04-18 1953-03-24 Eleanor P Lesher Surgical dressing
GB692578A (en) 1949-09-13 1953-06-10 Minnesota Mining & Mfg Improvements in or relating to drape sheets for surgical use
US2682873A (en) 1952-07-30 1954-07-06 Johnson & Johnson General purpose protective dressing
NL189176B (nl) 1956-07-13 1900-01-01 Hisamitsu Pharmaceutical Co Pleister op basis van een synthetische rubber.
US2969057A (en) 1957-11-04 1961-01-24 Brady Co W H Nematodic swab
US3066672A (en) 1960-09-27 1962-12-04 Jr William H Crosby Method and apparatus for serial sampling of intestinal juice
US3367332A (en) 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3520300A (en) 1967-03-15 1970-07-14 Amp Inc Surgical sponge and suction device
US3568675A (en) 1968-08-30 1971-03-09 Clyde B Harvey Fistula and penetrating wound dressing
US3682180A (en) 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
BE789293Q (fr) 1970-12-07 1973-01-15 Parke Davis & Co Pansement medico-chirugical pour brulures et lesions analogues
US3826254A (en) 1973-02-26 1974-07-30 Verco Ind Needle or catheter retaining appliance
DE2527706A1 (de) 1975-06-21 1976-12-30 Hanfried Dr Med Weigand Einrichtung zum einleiten von kontrastmittel in einen kuenstlichen darmausgang
DE2640413C3 (de) 1976-09-08 1980-03-27 Richard Wolf Gmbh, 7134 Knittlingen Katheter-Überwachungsgerät
NL7710909A (nl) 1976-10-08 1978-04-11 Smith & Nephew Samengestelde hechtstrook.
GB1562244A (en) 1976-11-11 1980-03-05 Lock P M Wound dressing materials
US4080970A (en) 1976-11-17 1978-03-28 Miller Thomas J Post-operative combination dressing and internal drain tube with external shield and tube connector
US4139004A (en) 1977-02-17 1979-02-13 Gonzalez Jr Harry Bandage apparatus for treating burns
US4184510A (en) 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4165748A (en) 1977-11-07 1979-08-28 Johnson Melissa C Catheter tube holder
US4245637A (en) 1978-07-10 1981-01-20 Nichols Robert L Shutoff valve sleeve
SE414994B (sv) 1978-11-28 1980-09-01 Landstingens Inkopscentral Venkateterforband
US4382441A (en) 1978-12-06 1983-05-10 Svedman Paul Device for treating tissues, for example skin
US4266545A (en) 1979-04-06 1981-05-12 Moss James P Portable suction device for collecting fluids from a closed wound
US4284079A (en) 1979-06-28 1981-08-18 Adair Edwin Lloyd Method for applying a male incontinence device
US4261363A (en) 1979-11-09 1981-04-14 C. R. Bard, Inc. Retention clips for body fluid drains
US4569348A (en) 1980-02-22 1986-02-11 Velcro Usa Inc. Catheter tube holder strap
US4480638A (en) 1980-03-11 1984-11-06 Eduard Schmid Cushion for holding an element of grafted skin
US4297995A (en) 1980-06-03 1981-11-03 Key Pharmaceuticals, Inc. Bandage containing attachment post
US4333468A (en) 1980-08-18 1982-06-08 Geist Robert W Mesentery tube holder apparatus
US4465485A (en) 1981-03-06 1984-08-14 Becton, Dickinson And Company Suction canister with unitary shut-off valve and filter features
US4392853A (en) 1981-03-16 1983-07-12 Rudolph Muto Sterile assembly for protecting and fastening an indwelling device
US4373519A (en) 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4392858A (en) 1981-07-16 1983-07-12 Sherwood Medical Company Wound drainage device
US4419097A (en) 1981-07-31 1983-12-06 Rexar Industries, Inc. Attachment for catheter tube
AU550575B2 (en) 1981-08-07 1986-03-27 Richard Christian Wright Wound drainage device
SE429197B (sv) 1981-10-14 1983-08-22 Frese Nielsen Anordning for behandling av sar
DE3146266A1 (de) 1981-11-21 1983-06-01 B. Braun Melsungen Ag, 3508 Melsungen Kombinierte vorrichtung fuer eine medizinische saugdrainage
US4551139A (en) 1982-02-08 1985-11-05 Marion Laboratories, Inc. Method and apparatus for burn wound treatment
US4475909A (en) 1982-05-06 1984-10-09 Eisenberg Melvin I Male urinary device and method for applying the device
EP0100148B1 (en) 1982-07-06 1986-01-08 Dow Corning Limited Medical-surgical dressing and a process for the production thereof
NZ206837A (en) 1983-01-27 1986-08-08 Johnson & Johnson Prod Inc Thin film adhesive dressing:backing material in three sections
US4548202A (en) 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
US4540412A (en) 1983-07-14 1985-09-10 The Kendall Company Device for moist heat therapy
US4543100A (en) 1983-11-01 1985-09-24 Brodsky Stuart A Catheter and drain tube retainer
US4525374A (en) 1984-02-27 1985-06-25 Manresa, Inc. Treating hydrophobic filters to render them hydrophilic
CA1286177C (en) 1984-05-03 1991-07-16 Smith And Nephew Associated Companies Plc Adhesive wound dressing
US4897081A (en) 1984-05-25 1990-01-30 Thermedics Inc. Percutaneous access device
FR2566798B1 (fr) * 1984-06-27 1986-12-12 Centre Nat Rech Scient Membrane porteuse de la luciferase pour le dosage de l'atp et son procede de production
US5215522A (en) 1984-07-23 1993-06-01 Ballard Medical Products Single use medical aspirating device and method
GB8419745D0 (en) 1984-08-02 1984-09-05 Smith & Nephew Ass Wound dressing
US4872450A (en) 1984-08-17 1989-10-10 Austad Eric D Wound dressing and method of forming same
US4655754A (en) 1984-11-09 1987-04-07 Stryker Corporation Vacuum wound drainage system and lipids baffle therefor
US4826494A (en) 1984-11-09 1989-05-02 Stryker Corporation Vacuum wound drainage system
US4605399A (en) 1984-12-04 1986-08-12 Complex, Inc. Transdermal infusion device
US5037397A (en) 1985-05-03 1991-08-06 Medical Distributors, Inc. Universal clamp
US4640688A (en) 1985-08-23 1987-02-03 Mentor Corporation Urine collection catheter
US4710165A (en) 1985-09-16 1987-12-01 Mcneil Charles B Wearable, variable rate suction/collection device
US4758220A (en) 1985-09-26 1988-07-19 Alcon Laboratories, Inc. Surgical cassette proximity sensing and latching apparatus
US4733659A (en) 1986-01-17 1988-03-29 Seton Company Foam bandage
WO1987004626A1 (en) 1986-01-31 1987-08-13 Osmond, Roger, L., W. Suction system for wound and gastro-intestinal drainage
US4838883A (en) 1986-03-07 1989-06-13 Nissho Corporation Urine-collecting device
JPS62281965A (ja) 1986-05-29 1987-12-07 テルモ株式会社 カテ−テルおよびカテ−テル用固定部材
GB8621884D0 (en) 1986-09-11 1986-10-15 Bard Ltd Catheter applicator
GB2195255B (en) 1986-09-30 1991-05-01 Vacutec Uk Limited Apparatus for vacuum treatment of an epidermal surface
US4743232A (en) 1986-10-06 1988-05-10 The Clinipad Corporation Package assembly for plastic film bandage
DE3634569A1 (de) 1986-10-10 1988-04-21 Sachse Hans E Kondomkatheter, ein harnroehrenkatheter zur verhinderung von aufsteigenden infektionen
JPS63135179A (ja) 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
GB8628564D0 (en) 1986-11-28 1987-01-07 Smiths Industries Plc Anti-foaming agent suction apparatus
GB2198789B (en) 1986-12-12 1990-10-24 Airflow Dev Ltd Extractor fan mounting
GB8706116D0 (en) 1987-03-14 1987-04-15 Smith & Nephew Ass Adhesive dressings
US4787888A (en) 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4863449A (en) 1987-07-06 1989-09-05 Hollister Incorporated Adhesive-lined elastic condom cathether
JPS6472068A (en) * 1987-09-12 1989-03-16 Seiko Instr & Electronics Reagent for immunoassay
US5176663A (en) 1987-12-02 1993-01-05 Pal Svedman Dressing having pad with compressibility limiting elements
US4906240A (en) 1988-02-01 1990-03-06 Matrix Medica, Inc. Adhesive-faced porous absorbent sheet and method of making same
US4985019A (en) 1988-03-11 1991-01-15 Michelson Gary K X-ray marker
GB8812803D0 (en) 1988-05-28 1988-06-29 Smiths Industries Plc Medico-surgical containers
US4919654A (en) 1988-08-03 1990-04-24 Kalt Medical Corporation IV clamp with membrane
US5000741A (en) 1988-08-22 1991-03-19 Kalt Medical Corporation Transparent tracheostomy tube dressing
US5059596A (en) 1989-01-16 1991-10-22 Roussel Uclaf Azabicyclo compounds
GB8906100D0 (en) 1989-03-16 1989-04-26 Smith & Nephew Laminates
US5261893A (en) 1989-04-03 1993-11-16 Zamierowski David S Fastening system and method
US5527293A (en) 1989-04-03 1996-06-18 Kinetic Concepts, Inc. Fastening system and method
US5100396A (en) 1989-04-03 1992-03-31 Zamierowski David S Fluidic connection system and method
US4969880A (en) 1989-04-03 1990-11-13 Zamierowski David S Wound dressing and treatment method
US5358494A (en) 1989-07-11 1994-10-25 Svedman Paul Irrigation dressing
JP2719671B2 (ja) 1989-07-11 1998-02-25 日本ゼオン株式会社 創傷被覆材
US5232453A (en) 1989-07-14 1993-08-03 E. R. Squibb & Sons, Inc. Catheter holder
GB2235877A (en) 1989-09-18 1991-03-20 Antonio Talluri Closed wound suction apparatus
US5134994A (en) 1990-02-12 1992-08-04 Say Sam L Field aspirator in a soft pack with externally mounted container
US5092858A (en) 1990-03-20 1992-03-03 Becton, Dickinson And Company Liquid gelling agent distributor device
US5149331A (en) 1991-05-03 1992-09-22 Ariel Ferdman Method and device for wound closure
US5278100A (en) 1991-11-08 1994-01-11 Micron Technology, Inc. Chemical vapor deposition technique for depositing titanium silicide on semiconductor wafers
US5645081A (en) 1991-11-14 1997-07-08 Wake Forest University Method of treating tissue damage and apparatus for same
US5636643A (en) 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5279550A (en) 1991-12-19 1994-01-18 Gish Biomedical, Inc. Orthopedic autotransfusion system
US5167613A (en) 1992-03-23 1992-12-01 The Kendall Company Composite vented wound dressing
FR2690617B1 (fr) 1992-04-29 1994-06-24 Cbh Textile Pansement adhesif transparent.
DE4306478A1 (de) 1993-03-02 1994-09-08 Wolfgang Dr Wagner Drainagevorrichtung, insbesondere Pleuradrainagevorrichtung, und Drainageverfahren
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US5342376A (en) 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
US5344415A (en) 1993-06-15 1994-09-06 Deroyal Industries, Inc. Sterile system for dressing vascular access site
US5437651A (en) 1993-09-01 1995-08-01 Research Medical, Inc. Medical suction apparatus
US5549584A (en) 1994-02-14 1996-08-27 The Kendall Company Apparatus for removing fluid from a wound
US5607388A (en) 1994-06-16 1997-03-04 Hercules Incorporated Multi-purpose wound dressing
US5556375A (en) 1994-06-16 1996-09-17 Hercules Incorporated Wound dressing having a fenestrated base layer
US5664270A (en) 1994-07-19 1997-09-09 Kinetic Concepts, Inc. Patient interface system
AU698477B2 (en) 1994-08-22 1998-10-29 Kci Licensing, Inc. Wound drainage equipment
DE29504378U1 (de) 1995-03-15 1995-09-14 MTG Medizinisch, technische Gerätebau GmbH, 66299 Friedrichsthal Elektronisch geregelte Niedervakuumpumpe für die Thorax- und Wunddrainage
GB9523253D0 (en) 1995-11-14 1996-01-17 Mediscus Prod Ltd Portable wound treatment apparatus
US5916802A (en) * 1997-02-19 1999-06-29 Fritz Berthold Device for measuring ATP
US6135116A (en) 1997-07-28 2000-10-24 Kci Licensing, Inc. Therapeutic method for treating ulcers
AU755496B2 (en) 1997-09-12 2002-12-12 Kci Licensing, Inc. Surgical drape and suction head for wound treatment
GB9719520D0 (en) 1997-09-12 1997-11-19 Kci Medical Ltd Surgical drape and suction heads for wound treatment
US6071267A (en) 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
GB2340235A (en) * 1998-08-05 2000-02-16 Johnson & Johnson Medical Ltd Monitoring bacterial contamination of a wound involving assay of adenosine triphosphate
US6488643B1 (en) 1998-10-08 2002-12-03 Kci Licensing, Inc. Wound healing foot wrap
US6287316B1 (en) 1999-03-26 2001-09-11 Ethicon, Inc. Knitted surgical mesh
US6856821B2 (en) 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US7799004B2 (en) * 2001-03-05 2010-09-21 Kci Licensing, Inc. Negative pressure wound treatment apparatus and infection identification system and method
US6991643B2 (en) 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
ES2220734T3 (es) 2000-02-24 2004-12-16 Venetec International, Inc. Sistema de fijacion universal para cateter.
US6540705B2 (en) 2001-02-22 2003-04-01 Core Products International, Inc. Ankle brace providing upper and lower ankle adjustment
US7108683B2 (en) * 2001-04-30 2006-09-19 Kci Licensing, Inc Wound therapy and tissue management system and method with fluid differentiation
US7004915B2 (en) 2001-08-24 2006-02-28 Kci Licensing, Inc. Negative pressure assisted tissue treatment system
GB0130720D0 (en) * 2001-12-21 2002-02-06 Serono Internat S A Proteins
US20030186299A1 (en) * 2002-02-27 2003-10-02 Cogburn Larry A. Molecular markers for identification of fat and lean phenotypes in chickens
US7976519B2 (en) 2002-12-31 2011-07-12 Kci Licensing, Inc. Externally-applied patient interface system and method
JP2007236202A (ja) * 2004-04-06 2007-09-20 Bussan Nanotech Research Institute Inc 細菌検出装置及び細菌検出方法
AU2005262701B2 (en) * 2004-06-07 2011-12-01 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
WO2006085411A1 (ja) * 2005-02-10 2006-08-17 National University Corporation Hokkaido University 免疫応答を惹起するための新規アジュバントおよびその利用
JP4999341B2 (ja) * 2005-09-06 2012-08-15 株式会社バイオエネックス 変異型ホタルルシフェラーゼ、遺伝子、組換えベクター、形質転換体、及び変異型ホタルルシフェラーゼの製造方法
US20070292397A1 (en) * 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
US7862339B2 (en) * 2006-09-21 2011-01-04 Tyco Healthcare Group Lp Negative wound pressure therapy test system

Also Published As

Publication number Publication date
KR20110025811A (ko) 2011-03-11
CA2726481A1 (en) 2009-12-10
MX2010013321A (es) 2010-12-21
CN102057275A (zh) 2011-05-11
US8986940B2 (en) 2015-03-24
CA2726481C (en) 2016-11-08
US20090326416A1 (en) 2009-12-31
US20150257686A1 (en) 2015-09-17
US20130244899A1 (en) 2013-09-19
EP2281199A1 (en) 2011-02-09
US8460892B2 (en) 2013-06-11
RU2010146772A (ru) 2012-07-20
US9215994B2 (en) 2015-12-22
BRPI0909536A2 (pt) 2019-03-06
AU2009256172A1 (en) 2009-12-10
JP2011523712A (ja) 2011-08-18
WO2009149203A1 (en) 2009-12-10
AU2009256172B2 (en) 2015-11-26
EP2281199B1 (en) 2017-03-01

Similar Documents

Publication Publication Date Title
TW201002265A (en) Detecting infection in reduced pressure wound treatment
Opal et al. Biomarkers of infection and sepsis
Morales-Narváez et al. The impact of biosensing in a pandemic outbreak: COVID-19
Puttaswamy et al. A comprehensive review of the present and future antibiotic susceptibility testing (AST) systems
Patel et al. Advancements in diagnosing periprosthetic joint infections after total hip and knee arthroplasty
JP2022002529A (ja) 感染症の検出のためのシステム及び方法
Kunze et al. Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia–an observational pilot study in critical ill patients
RU2012140430A (ru) Способы диагностики патогенов, вызывающих инфекционные заболевания и их лекарственной чувствительности
Qian et al. Metagenomic next-generation sequencing of cerebrospinal fluid for the diagnosis of external ventricular and lumbar drainage-associated ventriculitis and meningitis
Neyton et al. Metagenomic sequencing in the ICU for precision diagnosis of critical infectious illnesses
Romero-Gómez et al. Bacteraemia due to meticillin-resistant Staphylococcus aureus carrying the mecC gene in a patient with urothelial carcinoma
Singh et al. Antimicrobial resistance: Mechanisms, screening techniques and biosensors
Li et al. Evaluation of different diagnostic methods for spinal tuberculosis infection
Zhang et al. Rapid antimicrobial susceptibility testing on clinical urine samples by video-based object scattering intensity detection
JP2017207333A (ja) 細菌を検出する方法及びキット
Knabl et al. Comparison of novel approaches for expedited pathogen identification and antimicrobial susceptibility testing against routine blood culture diagnostics
Geraghty et al. Investigations on the efficacy of routinely used phenotypic methods compared to genotypic approaches for the identification of staphylococcal species isolated from companion animals in Irish veterinary hospitals
Minegishi et al. Clinical usefulness of multiplex PCR-lateral flow for the diagnosis of orthopedic-related infections
HK1157446A (zh) 檢測減壓傷口治療中的感染
Emberger et al. Nosocomial Staphylococcal scalded skin syndrome caused by intra‐articular injection
Kumar et al. Technological Advances in Sepsis Diagnosis
US11740234B2 (en) Biomarkers for detection of burkholderia pseudomallei
Kumar et al. Gene expression profiling of tuberculous meningitis
CA3099741A1 (en) Methods for microbial identification in clinical specimens by differential ribosomal rna probe hybridization
N Adam Identifying bacterial infections in synovial structures—When will the Cavalry arrive?