TW200813102A - Wettable silicone hydrogel contact lenses and related compositions and methods - Google Patents

Abstract

Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

Description

200813102 IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention is particularly directed to helium oxygenated hydrogel ophthalmic devices and related compositions and methods. More particularly, the present invention relates to molded wettable hydrogel hydrogel contact lenses and related compositions and methods. [Prior Art] 〇

Shixi oxygen hydrogel contact lenses have become popular because of the ability of contact lens wearers to wear these glasses for longer periods of time than non-shixi oxygen hydrogel contact lenses. For example, depending on the particular lens, the oxygenated hydrogel contact lens can be worn daily, worn weekly, bi-weekly or worn on a monthly basis or worn or worn every day. Wear it in two weeks or wear it every month. The wearer of the lens wearer associated with the oxygenated hydrogel contact lens can be at least partially attributed to the combination of the hydrophilic component of the contact lens and the hydrophobic character of the ruthenium containing polymeric material. Non-oxygenated hydrogel contact lenses, such as 2-hydroxyethyl methacrylate (HEMA based hydrogel contact lenses), are often found in non-polar resin contact lens molds (eg, contact lens molds derived from polyolefin-based resins). Produced in. In other words, the lens precursor composition for non-stone-oxygen hydrogel contact lenses is polymerized in a non-polar resin contact lens mold to produce a wealth-based polymeric eye lens product. Due to the hydrophilic nature of the polymeric component of the HEMA-based contact lens, the hema-based spectacles are compatible on the eye and have an ophthalmically acceptable surface wettability, even though produced using a non-polar resin mold. In contrast, the current cut oxygen hydrogel contact lenses obtained from non-polar resin molds have hydrophobic eyeglass surfaces. In other words, the (a) oxygen hydrogel 121841.doc 200813102 has a low wettability on the surface of the contact lens, which is therefore incompatible with the eye or unacceptable to the eye. For example, such lyophilized hydrogel contact lenses can be associated with increased lipid deposition, protein deposition, combination of spectacles and ocular surfaces, and general stimuli for spectacles wearers. • In an effort to overcome these problems, attempts have been made to surface or surface-modify the helium-oxygen hydrogels; 11-eye glasses or lens products to increase the hydrophilicity and wettability of the lens surface. Examples of surface treatments of silicone hydrogel lenses include coating the surface of the lens, adsorbing the chemical onto the surface of the lens, and surface treating, including coating the surface of the polymeric lens with a plasma gas, or using it on the surface of the contact lens mold. The plasma gas is used to treat the mold prior to forming the polymeric glasses. Unfortunately, several drawbacks are associated with this approach. The surface treatment of contact lenses requires more mechanical and time to produce contact lenses than manufacturing methods that do not use surface treatment or modification. In addition, the surface treated hydroxyl hydrogel invisible eyepiece can exhibit reduced surface wettability when the lens is worn and/or touched by the lens wearer. For example, increasing the touch on the U-treated glasses can result in degradation or wear of the hydrophilic surface. Another way to increase the wettability and eye compatibility of the oxygenated hydrogel glasses is to polymerize the oxygen in the presence of a first: composition comprising a polymeric wetting agent such as polyvinylpyrrolidone (pvp). Hydrogel contact lens precursor composition. Such types of spectacles are referred to herein as diarrhea hydrogel contact lenses having a polymeric internal humectant, and typically comprise an interpenetrating polymer network (IPN) comprising a high molecular weight polymer such as pvp. As is generally understood by those skilled in the art, IPN refers to the synthesis of two or more different polymers in a network form. 121841.doc 200813102:, at least one polymer is synthesized in the presence of another polymer and/ 'There is no covalent bond between the two. Cong can consist of two chains that form two adjacent or interpenetrating networks. (d) Examples include step-by-step synchronization of 1PN, half (four) and average 1PN. Although including polymeric humectants IPN, the lithohydrate hydrogel contact lenses avoid problems associated with surface treatment, such lenses may not retain their eye compatibility over a prolonged period of time, including (or Since the internal humectant is not covalently bonded to form = other components of the spectacles', so when worn by the spectacles wearer, it can be self-mirror/removal, and thereby the surface wettability is lowered over time. And the discomfort of the wearer of the lens increases. As an alternative to the surface treatment or the use of polymeric wetting agent IPN as described above, it has been found that a polar resin mold can be used instead of a non-polar resin mold to produce an ophthalmically acceptable surface that is wettable. Hydroxyl hydrogel contact lenses. For example, hydroxyl hydrogel contact lenses formed in ethylene-vinyl alcohol based or polyvinyl alcohol based molds have the desired surface wettability. An example of a polar resin which produces a non-polymerized humectant IPN which is not surface-treated oxime water/spinner fe: contact lens mold of a type of spectacles is a resin of ethylene-vinyl alcohol copolymer Such as ethylene vinyl alcohol copolymer resin sold by Nipp〇n G〇hsei, Ltd under the trade name soarliteTM. In addition to its polarity, SOARLITETM is described as having the following characteristics: · High mechanical strength, antistatic property, when used Low shrinkage during molding, excellent oil and solvent resistance, low coefficient of thermal expansion and good wear resistance. Although SOARLITETM based molds produce an eye on the surface without the use of surface treatment or polymeric wetting agent IPN. Rongzhi Oxygen Hydrogel Contact Lens 121841.doc 200813102 provides an advantageous alternative, but the SOARLITETM mold has less deformability or flexibility than non-polar resin molds (such as polypropylene molds) and is non-polar Resin molds are relatively difficult to work with. From the above, it can be seen that there is a need for an oxygen compatible hydrogel contact lens Y that is more compatible with the oxygenated hydrogel contact lenses obtained from the s〇ARLITETM contact lens mold. Easily produced without the need for surface treatment or the use of polymeric wetting agents IPN (including PVP IPN) to achieve eye compatibility. In addition, it is highly desirable to provide a self-polar tree Or a hydrocarbon-based contact lens mold member for producing an eye-compatible oxygenated hydrogel contact lens, such as a hydroxyl hydrogel contact lens having an eye-compatible surface wettability, which overcomes existing methods Disadvantages, that is, there is a need for an improved method for preparing a compatible lens on the eye which does not require surface treatment of the resulting contact lens product and does not require the use of a polymeric wetting agent (4) as a polymerizable shi A portion of a hydrogel contact lens precursor composition. The present invention satisfies such needs. SUMMARY OF THE INVENTION The present invention provides contact lenses, eyeglass products, compositions, and methods for solving contact with existing lithothere hydrogel contact lenses and their present The need and problems associated with the production method. It has been surprisingly found that 'eye-compatible Shishi oxygen hydrogel contact lenses can provide phase shifting in the pre-extracted polymeric rock hydrogel contact lens product. In addition to the material, the product is then extracted to remove the removable materials and hydrated to produce a sulphuric hydrogel contact lens. Pre-extracted polymeric oxaxy hydrogel lens products having a removable component (i.e., one or more removable materials, including extractable materials and the like) typically contain about 10 weight less to 121841.doc 200813102. /〇Removable components. s ^ Λ u 177 The saddle will extract the polymerized hydrogel lens product from the pre-stroke (to remove the extractable component by this means) and hydrate it to form an eye for use as described herein. A chopped hydrogel contact lens that can be attached to the surface of the f. The Shi Xi Dong: silk _ night / 7 milk water / spin-on spectacles of the present invention have a time for allowing the patient to comfortably wear the glasses for a prolonged period of time, such as at least one day, at least weeks to V two weeks or about one month without self- The eye removes oxygen permeability, surface wettability, modulus, water content, ion flow and design.

In one aspect, the invention is directed to a polymerizable oxalate hydrogel contact lens precursor composition. The precursor compositions are effective to form a broken oxygen hydrogel contact lens. After polymerization, the precursor formulation results in the formation of an extractable hydratable contact lens preform. The precursor composition comprises the following: (1) at least about 20% by weight of a reactive fluoropropenyl fluorene macromonomer, at least about 45% by weight of a monomer composition free of sulphur, which comprises hydrophilicity A vinyl-containing monomer, an acrylic monomer, and an acrylate-functionalized ethylene oxide oligomer, and (iii) a polyoxyalkylene oxide extractable component. In one embodiment, the polymerizable silicone hydrogel contact lens precursor composition comprises at least about 25% by weight, and preferably from about 25% to about 35% by weight, of reactive fluorine-containing dimethyl propylene fluorenyl hydrazine. Oxygen macromonomer. An exemplary reactive fluorine-containing dimethyl propylene fluorenyl oxalyl macromonomer of the present invention is α_ω_bis(methacryloxyethyliminocarboxycarbonylpropyl) poly(dimethylhydrazine) Oxime)-poly(trifluoropropylmethyloxirane)-poly(ω-methoxy-poly(ethylene glycol) propylmethyloxane) (also referred to herein as M3U, and CAS Registration No. 697234-74-5). In another embodiment, the polymerizable silicone hydrogel contact lens of the present invention 121841.doc -10- 200813102 then the body composition comprises about 45-55 wt% A monomer composition containing ruthenium. Particularly preferred is a hydrazine-free hydrophilic component comprising decyl vinylmethyl acetamide, methacrylate methacrylate and triethylene glycol methacrylate. In one embodiment, the polymerizable silicone hydrogel contact lens precursor composition comprises from about 10 weight percent to about 30 weight percent polyoxyalkylene oxide extractable, in an even more specific embodiment. The polyoxyalkylene oxide-extractable component optionally comprises from about 1 to 6 parts of a chain transfer agent and from about 99.9 to 94 parts of a polyoxyalkylene oxide. The polyoxyalkylene oxime extractable component comprises a dimethyloxane-ethylene oxide block copolymer, such as a dimethyl methoxy olefin-ethylene oxide block copolymer containing about 75% by weight of ethylene oxide. The dimethyloxoxime-oxyethylene block copolymer is Dbe 712 (Ge]lest, M〇rrisviUe, PA). The chain transfer reagents used in the compositions, glasses and methods described herein include mercaptans, Thioether, organic halide, allyloxy ether and allyloxy alcohol. In a particularly preferred embodiment, the chain transfer reagent is allyloxyethanol. In other embodiments of the invention, the polymerizable helium oxygen The hydrogel contact lens precursor composition may also comprise one or more of the following: a UV absorber, a colorant or an initiator. The UV absorber may, for example, be a photopolymerizable hydroxybenzophenone such as 2-hydroxyl. 4 propylene methoxy ethoxy benzophenone. The chromogen used in the present invention may, for example, be a phthalocyanine pigment, such as ugly cyanine blue. In addition, the polymerizable silicone hydrogel contact lens precursor formulation is included The initiator can be, for example, a thermal initiator such as 2 , 2, _ azobis(2,4-dimethylvaleronitrile) (VAZO-52). Soil 12184 Ldoc -11 - 200813102 In a more specific embodiment, the polymerizable silicone hydrogel contact lens precursor of the present invention The composition comprises α-ω·bis(methacryloxyethylethylimidocarboxyethoxypropylpoly(dimethyloxane)-poly(trifluoropropylmethyloxime)- Poly(ω·methoxy-poly(ethylene glycol) propylmethyl decane), Ν_vinyl _. Ν-methyl acetamide, methyl methacrylate and triethylene methacrylate In a preferred embodiment, the precursor composition of the present invention comprises a core... bis(methacryloxyethylethylimidocarboxyethoxypropyl)-poly (dimethyl texa Oxane)-poly(trifluoropropylmethyloxirane)-poly(ω-methoxy-poly(ethylene glycol) propylmethyloxirane), fluorene-vinylmethylacetamide, The component may be extracted by methacrylic acid, triethylene glycol dimethacrylate and dimethyl oxalate-oxyethylene block copolymer. In another embodiment, the extractable component comprises DBE 712, optionally containing allyloxyethanol. In a more specific embodiment of the polymerizable silicone hydrogel contact lens precursor composition, 'α-ω-bis(methacryloxyethylethylimidocarboxyethoxypropyl)-poly(dimethyl)矽 ) _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The ratio of the combination of amine, methyl methacrylate and triethylene glycol dimethyl acrylate is in the range of about 〇·50 to about 〇·65 by weight. In an embodiment, the polymerizable silicone hydrogel contact lens precursor composition comprises alpha-omega-bis(methacryloxyethyliminocarboxycarbonylpropyl)-poly(dimethyloxime) Alkane;)_poly(trifluoropropylmethyloxirane poly(ω_methoxy-poly(ethylene glycol) propylmethyloxirane), Ν_vinyl_Ν_曱基乙121841.doc -12- 200813102 Amine amine, methyl methacrylate, bis-f-propylglycolic acid triethylene glycol vinegar, 2-pyridyl-4-propenyloxyethoxybenzophenone, phthalocyanine blue, 2, 2, _ azobis(2,4-dimethylvaleronitrile) and DBE 712 (as appropriate The propoxyethanol combination) is particularly preferred in the exemplary polymerizable hydrogel contact lens precursor composition. The weight/weight percentage is about (weight ratio) heart 1-bis (methyl) Propylene oxiranylethylimidoyl yloxypropyl)-poly(dimethyloxane)-poly(difluoropropylmethyloxirane)-poly(1-methoxy-poly (Ethylene glycol) propylmethyl oxime), about 37% (by weight) Ν _ vinyl _ ν _ methyl acetamide, force 13.5% (heavy ratio) methyl methacrylate , about 16% by weight of triethylene glycol dimethacrylate, about 7% by weight of 2-hydroxypropyl ethoxyethoxy benzophenone, about 1% by weight (weight ratio) Cyanine blue, about 〇/〇 (heavy ratio) 2,2丨-azobis(2,4·dimethylvaleronitrile) and about 2〇% DBE 712 (as appropriate with allyloxyethanol) According to another aspect, the present invention provides a hydrogenated hydrogel contact lens produced from any of the above polymerizable lens precursor compositions. In another aspect, the invention provides a freezer as described herein. Non-existible polymerizable component The ophthalmic hydrogel contact lens obtained by the reaction of the lens precursor composition. According to another aspect, the present invention is directed to a latex contact lens produced by the following steps: polymerizing a polymerizable lens as described herein Precursor group mouth to form a pre-extracted polymeric hemohydrogel contact lens, extracting the extractable component from pre-opening glasses to form an extracted polymeric lens product, and hydrating the extracted polymeric lens product Forming a hemorrhagic hydrogel 121841.doc • 13 - 200813102 Glue contact lens. The resulting extracted hydrated contact lens product typically has an equilibrium water content in the range of from about 40 weights to about 48% by weight and within about ι〇〇_ιΐ5 barrer Oxygen permeability (Dk X 1〇-"). In an embodiment of this aspect of the invention, a helium oxygen hydrogel contact lens is produced according to the above method, wherein the polymerizable lens precursor composition comprises a thermal initiator and the polymerization step further comprises polymerizing the lens precursor The body composition is heated to a temperature greater than about 50 °C. In another embodiment, a helium oxygen hydrogel contact lens is produced by polymerizing a polymerizable lens precursor composition as described above to form a pre-extracted polymeric hemohydrogel contact lens, wherein DBE and The allyloxyethanol combination extracts the polyoxyalkylene oxime extractable component from the pre-extracted polymeric oxime hydrogel contact lens to form an extracted polymeric spectacles product, and hydrates the extracted polymeric spectacles product to form a Batching of one or more of the following characteristics of low-variability helium hydrogel contact lenses: equilibrium water content, oxygen permeability, static contact angle, dynamic contact angle, hysteresis, refractive index, ion current, modulus and tensile strength . For example, depending on the particular characteristics of the lens product, the variability of any one or more of the foregoing lens features is typically less than about 2%, and preferably less than about 10%. In one or more embodiments, the variability of any one or more of the spectacles diameter, equilibrium water enthalpy and/or ion current is about 5% or less, more preferably about 3% or less than 3%. And even more preferably about 2% or less than 2%. In another aspect, the present invention provides an equilibrium water content of at least about 4% and an oxygen permeability (Dk X 1〇·η) of about 9〇. _12〇barrer's oxygen hydrogel contact lens. 121841.doc -14 - 200813102 In the above-mentioned _ 誊 Α, 贯 轭 , , , , 本文 本文 本文 本文 本文 本文 & & & & & & & & & & & & & & & & & & & & & & & & & & & & & Gel contact lenses: The contact angle is about 7 inches. To about 75. The tensile modulus is less than about 〇·7 3 and the ion current is about 1.5-5 (xl 〇 -3 mm 2 /min). In the case of the present invention, the oxygenated hydrogel contact lens of the present invention may have a circular outer peripheral edge, and may be one of the following: · spherical glasses, aspherical glasses, early focus glasses or Rotating stable toric contact lenses. In a practical example, the present invention provides a heralloy hydrogel contact lens as described herein in a sealed package. In another embodiment, the oxygenated hydrogel contact lenses of the present invention are not surface treated.

In another aspect, the present invention provides a method of producing a polymerizable silicone hydrogel contact lens precursor composition. The method comprises combining the following: (1) at least about 25% by weight of a reactive fluorine-containing dimethyl propylene fluorenyl siloxane macromonomer, and (ii) at least about 45% by weight of a fluorene-free macromonomer a composition and (iii) a polyoxyalkylene oxide extractable component to thereby produce a polymerizable hydrogel hydrogel contact lens precursor composition, wherein the high molecular weight monomer composition excluding the Shixia comprises hydrophilicity A vinyl-containing monomer, an acrylic monomer, and an acrylate functionalized ethylene oxide oligomer. In one embodiment of this aspect of the invention, the above method further comprises combining a macromonomer, a monomer composition free of bismuth and an extractable component, an ultraviolet absorber, and a color former. Exemplary colorants include phthalocyanine pigments such as phthalocyanine blue. Preferred UV absorbers are photopolymerizable hydroxydibenzophenones such as 2-hydroxy-4-propenyloxyethoxybenzophenone. 121841.doc 200813102 In a particular embodiment of the method, the amount of the reactive fluorine-containing dimethyl propylene geranyl macromonomer is in the range of from about 25% by weight to about 35% by weight. In another embodiment of the method, the amount of the bismuth-free monomer composition is in the range of from about 45 to about 55% by weight. In another embodiment of the method, the polyoxyalkylene oxide extractable component is present in an amount from about 10% by weight to about 3% by weight. / within the scope of 〇. In a preferred embodiment of the method, the reactive fluorine-containing dimethyl propylene fluorenyl oxy-enlarge macromonomer is a core-bis(methyl propyl methoxyethyl imino decyl ethoxy group) Propyl poly(dimethyloxane)-poly(trifluoropropylmethyloxirane)-poly(ω-methoxy-poly(ethylene glycol) propylmethyl decane) (M3U) In another embodiment of the method, the ruthenium-free monomer component comprises glacial vinylmethyl acetamide, methyl methacrylate, and triethylene glycol dimethacrylate S. In another embodiment, the polyoxyalkylene oxime extractable component further comprises a chain transfer agent such as a thiol, an n organic halide or a diloxypropanol. In a particularly preferred embodiment, the chain transfer reagent In the preferred embodiment of the method, the polyoxygen oxide extractable component comprises from about 0.05% by weight to about 7% by weight of decyloxyethanol. The extractable component is a dimethyl ethoxylated ethylene oxide block copolymer, for example, a dimethyl oxirane ethylene oxide copolymer copolymer containing 75% by weight of ethylene oxide. Particularly preferred for use as the polyoxygen-oxygen extractable component is DBE 712. 121841.doc _ 16 _ 200813102 In another embodiment of the method, the combining step further comprises combining the initiator with the other components. Preferably, it is a thermal initiator such as 2,2,-azobis(2,4-dimethylvaleronitrile) (VAZO-52). In another aspect, provided herein is a method for producing polymerizable helium oxygenated water. A method of a gel contact lens precursor composition comprising: α_ω_bis(methacryloxyethyliminocarboxycarbonylpropyl)-poly(dimethyloxane poly(trifluoropropane) (曱-based oxane)-poly(ω_methoxy-poly(ethylene glycol) propylmethyl decane), Ν-vinyl-Ν-methyl acetamide, methyl methacrylate and

Triethylene glycol dimethacrylate is combined to thereby produce a polymerizable silicone hydrogel contact lens precursor composition. In one embodiment of the above method, the combining step further comprises combining the dimethyloxane-ethylene oxide block copolymer extractable component (eg, dbe with other components. In one embodiment of the above method, 'ene The relative amount of propoxyethanol and dbe 712 is in the range of about (M to about 5 parts of diloxypropoxyethanol and about 9. Spoon 95 - in another embodiment of the foregoing method, the combination step further comprises Combining the cyanine blue with the other components. The M example + 'M combined step-in step comprises combining the ethoxylated ethoxybisbenzophenone with the other components. In another embodiment of the method, The combining step comprises adding 2,2, azobis(2,4-monomethylvaleronitrile) to the combination. One of the foregoing methods, ethyl imino, carboxyl group, preferred embodiment +, bis(methacrylic)醯Oxyethoxypropyl)-poly(dimethyloxane)_poly(trifluoro-121841.doc •17·200813102 propyl-decyloxyl)-poly(ω-decyloxy-poly(B) Glycol) propyl mercapto oxime) with Ν-vinyl-Ν-mercaptoacetamide, methyl methacrylate and triethylene glycol dimethacrylate The ratio of combinations is in the range of from about 〇·5〇 to about 〇·65. In another aspect, a method of producing a polymerizable silicone hydrogel contact lens precursor composition is provided herein, wherein The method comprises the steps of: bis(methacryloxyethylethylimidocarboxyethoxypropyl)-poly(dimethyloxoxane poly(trifluoropropylmethyloxirane)-poly( Ω_methoxy-poly(ethylene glycol) propylmethyl oxalate, Ν-vinylmethyl acetamide, methyl methacrylate, triethylene glycol dimethacrylate, 2- Hydroxy_4_acryloxyethoxybenzophenone, phthalocyanine blue, 2,2,-azobis(2,4-dimethylvaleronitrile) and dbe 712 (optionally containing allyloxy) Ethanol) is combined to thereby produce a polymerizable oxalate hydrogel contact lens precursor composition. In one embodiment, the above method comprises the following relative amounts of components: about 28% by weight alpha-omega- Bis(methylpropoxymethoxyethyliminocarboxyethoxypropyl)-poly(dimethyloxane)-poly(trifluoropropylmethyloxirane)-poly(ω-曱Oxy-poly (ethylene Alcohol) propylmethyl oxime), about 3 7% by weight of Ν-vinylmethyl acetamide, about 13.5% by weight of 甲基S曰 methacrylate, about 16% (%) Weight ratio) triethylene glycol dimethacrylate, about 7% by weight of 2-hydroxy-4-propenyloxyethoxybenzophenone, about 0.1% by weight of phthalocyanine blue , about 0.4% by weight of 2,2,-azobis(2,4•dimethylvaleronitrile) and about 20% DBE 712 (including allyloxyethanol as appropriate). In an embodiment, the combining step results in the formation of a component combination 'and the method further comprises combining the mixed components to form a mixture 121841.doc -18-200813102. In another embodiment, the method further comprises filtering the mixture. In another embodiment, the method comprises polymerizing a polymerizable lens precursor composition to form a pre-extracted polymeric oxygenated hydrogel contact lens. In another embodiment, the method further comprises placing the polymerizable lens precursor composition in a non-polar resin contact lens mold prior to the polymerizing step.

In another embodiment, the foregoing method comprises extracting a pre-extracted polymeric contact lens to form an extracted polymeric lens product in the absence of an extractable component, and hydrating the extracted polymeric lens product to form a helium oxygen hydrogel contact lens In another aspect, the present invention provides a method of improving the efficacy of a dimethyloxane-ethylene oxide block copolymer for use in the preparation of a hydrogel contact lens. The method comprises from about 1% by weight to about 1% by weight. a step of adding allylicoxyethanol to a dimethyloxane-ethylene oxide block copolymer to provide an allyl mercaptoethanol-dimethyloxoxime for preparing a hydroxyl hydrogel contact lens product Alkylene oxide block copolymer. The amount of diloxypropoxyethanol used in the addition step is preferably effective to produce a t-water-cut oxygen hydrogel having a swelling coefficient in the range of from about G.9G to about 0 (such as from about Q% to Q5). Contact lens products. In at least embodiment, the coefficient of expansion is from about 98 98 to about 1 〇 2 . The spectacles of the present invention are intended to be exemplified by the following "combination, composition, and other embodiments of the method. The following description, the drawings, the 。& It is to be understood that the individual and each feature described herein, and each of the two or more features of the features, such as 121841.doc -19-200813102, and each of the combinations are included in the present invention. Within the scope, the constraints are that the features included in the combination are mutually exclusive. Furthermore, any feature or combination of features may be specifically excluded from any embodiment of the invention. In particular, other aspects and advantages of the present invention are set forth in the following embodiments and in the claims. [Embodiment] The present invention will now be described more fully in the following A. However, the present invention may be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Instead, the embodiments are provided so that this disclosure will be thorough and complete and fully conveyed to those skilled in the art. The scope of the invention. DEFINITIONS It should be noted that the singular forms """ &""""""" Thus, for example, 'reference|, contact lens" includes a single eyeglass and two or more identical or different glasses, reference to "precursor composition" refers to a single composition and two or two The same or different compositions above, and analogs thereof. In describing and claiming the present invention, the following terms will be used in accordance with the definitions set forth below. As used herein, the term "hydrogel" refers to a polymeric material that is typically a polymer chain network or matrix capable of swelling or swelling with water. The network or matrix may or may not be crosslinked. A poly-a shell that is water-swellable or water-swellable, including contact lenses. Therefore, a hydrogel may (1) be unhydrated and swellable with water, or (ii) partially hydrate and expand with water, or (丨(1) Complete water 121841.doc -20- 200813102 Combined with water swelling. As the term, for example, "substituted alkyl,", substituted, is substituted by one or more non-interfering substituents. Part (eg, alkyl) such as, but not limited to, CrC8 cycloalkyl (eg, cyclopropyl, cyclobutyl, and the like), halo (eg, fluoro, chloro, bromo and Iodo), cyano, alkoxy, lower phenyl, substituted phenyl and the like. For substitution on the phenyl ring, the substituent can be in any orientation (ie, ortho, in between, or in the opposite). The term "Shixi oxygen hydrogel" or "hydroxyl hydrogel material" is meant to include bismuth (Si) a specific hydrogel of a bismuth component or a bismuth component. For example, a hydrazine hydrogel is usually prepared by combining a hydrazine-containing substance with a conventional hydrophilic hydrogel precursor. A contact lens is a contact lens comprising a silicone hydrogel material, including a contact lens for correcting vision. The characteristics of a silicone hydrogel contact lens are different from those of conventional hydrogel-based glasses. ''Oxygen-containing component, In order to contain at least one [-Si-O-Si] linkage component in a monomer, a macromonomer or a prepolymer, each of the oxime in # may have one or more of the same or different The organic group substituent (R1, R2) or the substituted organic group substituent, for example, -SiRihO-. The term "bonding agent" as used herein refers to an atom used to bond the interconnecting moiety: or A collection of atoms, such as polymer ends and repeating unit blocks. Bonding agent: > may be hydrolytically stable or tau include physiologically hydrolyzed or enzymatically degradable linkages. Preferred linkages are hydrolytically stable. "recognised or as appropriate" means that the events described later may or may not occur, so that this The description includes the occurrence of the event and the occurrence of the event. 121841.doc 21- 200813102 For example, when referring to a collection of atoms having a specific atomic length (for example, a length ranging from 2 to 50 atoms) in a bonding agent, the term , , length, based on the number of atoms in the longest chain of the set of atoms, independent of the substituent. For example, 5, since the hydrogen atom is a substituent on carbon and is not considered in the approximate overall length of the chain, it is considered - CHaCH2· has a length of two carbon atoms, even though each methylene group itself contains a total of three atoms. Similarly, the linking agent-0-C(0)-CH2CH2C(0)NH- is considered to have 6 underlines The chain length of an atom. The "molecular mass" in the context of the polymer of the invention refers to the nominal average molecular mass of the polymer, which is often by size exclusion chromatography, light scattering techniques or at 1, 2, 4 - Intrinsic velocity measurement in dichlorobenzene. The molecular weight in the case of a polymer can be expressed as a number average molecular weight or a weight average molecular weight, and in the case of a material supplied by a manufacturer, it will depend on the supplier. The basis for any such molecular weight determination can be readily provided by the supplier if it is not provided in the form of an encapsulating material. Generally, the molecular weight of a macromonomer or polymer as referred to herein means the weight average molecular weight. The molecular weight determination of the number average molecular weight and the weight average molecular weight can be measured using a gel permeation chromatography technique or other liquid chromatography techniques. Other methods of measuring molecular weight values may also be used, such as using end group analysis or measurement dependencies (eg, freezing point drop, boiling point increase, or osmotic pressure) to determine the number average molecular weight, or using light scattering techniques, ultracentrifugation, or Viscosity measurement to determine the weight average molecular weight. The "network" or "matrix" of a hydrophilic polymer generally means cross-linking formed by covalent bonds or physical bonds (e.g., hydrogen bonds) between polymer chains. 121841.doc -22· 200813102 π non-interfering substituents, 'are those groups which are normally not reactive with other functional groups contained in the same molecule when present in the molecule. The hydrophilic π substance is a water-repellent substance. These compounds have a pro-spraying effect on water and are often charged or have polar side chain groups that attract water. . The "hydrophilic polymer" of the present invention is defined as a polymer which is capable of swelling in water but soluble in water. @ Ο "Hydrophilic component" is a hydrophilic substance which may or may not be a polymer. Hydrophilic The sexual component comprises, when combined with the remaining reactive components, capable of providing at least about 20% (e.g., at least about 25%) water content to the resulting water: spectacles: a quaternary component such as 7 or the like." As used herein, "Oxygen-compatible hydrogel contact lenses" refers to dream oxygen hydrogel contact lenses that can be worn on the human eye without human experience or substantial discomfort (including eye irritation and similar discomfort). Compatibility: Hydroxyl hydrogel contact lenses have an ophthalmically acceptable surface wettability and usually do not cause significant corneal swelling, corneal dehydration ("dry eye disease,), upper angle: epithelial arch lesion (&quot ;SEAL") or other significant discomfort or related to these diseases. ^ "Substantially" or "basically" or "about," means that the stomach is almost all or completely, such as 95% or more of a certain given amount. / Burning base is usually about ι20 in length. Smoke bonds in the atomic range. = The light chain is preferably but not necessarily saturated, and although the direct bond is generally preferred, it may be branched or straight chain. Exemplary alkyl groups include methyl, ethyl, propyl, and butyl groups. When pentyl, nonylbutyl, ethylpropyl, 3-methylpentyl and similar alkyl 1 refer to three or more carbon atoms, as used herein, 121841.doc-23-200813102 alkyl π includes a cycloalkyl group. ''Oligomer'' is a molecule composed of a limited number of monomeric subunits, and usually consists of from about 2 to about 8 monomeric subunits. ''Lower alkyl' refers to An alkyl group having 1 to 6 carbon atoms, and may be a straight chain or a branched chain such as a methyl group, an ethyl group, a n-butyl group, an isobutyl group, or a t-butyl group.

The "efficiency" of a particular batch of polyoxyalkylene oxide (e.g., eucalyptus) as used herein is believed to provide a contact lens mold diameter of 98.98 to 1 () at a given concentration (and all other factors being the same). The ability of the final extracted hydrated lens product in a diameter within 2 fold. The diameter of the final glasses product is reduced: the larger the polyoxyalkylene is, the greater the efficiency, the larger the term "expansion coefficient" as used herein refers to the outer diameter and heart of the water-cut oxygen hydrogel contact lens. The ratio of the outer diameter of the lens-shaped insert of the lens forming surface forming the contact lens mold. Therefore, when the contact lens mold insert has a 142 mm eyeglass having a 14.2_, the barrier is invisible 1 〇〇. The expansion coefficient of two L-shaped glasses is also found in the following sections. Summary of the Invention As previously discussed, the Wang Wang, 7 to 03 夕# points provided in this article are based on the following findings. Use the method of avoiding complicated and expensive polar trees with the polar tree... to avoid the need for the post-sequence and to solve the problem of taking in the relevant problems to prepare the compatible Shishi, Er... ΙΡΝ 镜 。 。 。 令人 令人 令人 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 841 - 200813102 Eyewear products Remove (four) Saki (with other non-reverse kiosks), thereby producing a compatible contact lens product on the eye. In particular, the inventors have discovered that one can be removed by relatively large amounts or ones. A method of incorporating a substance into a polymerizable silicone contact lens precursor composition to provide an ophthalmically compatible hydroxyl hydrogel contact lens. While such materials impart the desired characteristics to the resulting final contact lens product, in practice The contact lens product is provided, for example, by extraction therefrom to provide an extracted contact lens product, which is then hydrated to produce a final enamel having an ophthalmically acceptable surface wettability, and other gain characteristics as described herein. Oxygen hydrogel contact lens product. In a related aspect, the invention provides a method for improving the performance of dimethyl oxaxiglass I oxyethylene block copolymer used in the preparation of a lithothermic hydrogel contact lens. The hydrazine method comprises adding from about 0.1% by weight to about 5% by weight of allyloxyethanol to the dimethyl oxalate ethylene oxide block copolymer to provide a hydroxyl hydrogel for use in the preparation of a helium oxygen hydrogel. Contact lens Isopropoxyethanol dimethyl oxa oxide oxyethylene block copolymer. It has been advantageously found, for example, to dimethyl methoxyoxane prior to mixing with other components of the polymerizable contact lens precursor composition. - The addition of allyloxyethanol to the ethylene oxide block copolymer is effective to achieve any potential adverse effects from the use of a particular batch or grade or similar dimethyloxane-oxyethylene block copolymer or analog thereof" Normalize " to thereby provide a final lens product that is acceptable to one or more eyeglass sizes or variations in various physical properties. These and other important aspects of the invention are described and illustrated in detail in the following section. Μ 121841.doc 25- 200813102 Composition of Polymerizable Oxygenated Hydrogel Contact Lens Precursor Compositions The hydroxyl hydrogel contact lenses of the present invention are generally referred to herein as "polymerizable silicone hydrogel contact lens precursors" The composition "or" precursor composition is produced. The precursor composition is a mixture of various reagents for preparing the invisible eye of the australis hydrogel, that is, in the reaction (in the state of the present invention) The reaction mixture before the polymerization reaction. The precursor composition of the present invention usually comprises at least the following components: (1) at least about 25% by weight of a reactive fluorine-containing dimethyl methacryloyloxyl macromonomer mono-body And preferably from about 25% by weight to about 35% by weight of the reactive fluorine-containing dimethyl propylene fluorenyl siloxane macromonomer, and (ii) at least about 45% by weight of the quinone-free monomer composition, And (iii) a polyoxyalkylene oxime extractable component. The ruthenium-free monomer composition comprises a hydrophilic vinyl-containing monomer, an acrylic monomer, and an acrylate functionalized ethylene oxide polymer. Fluoropropyl thiol oxy macromonomer As described above, the self-contained reactive fluoropropenyl fluorenyloxy macromonomer "precursor composition" is used to prepare the oxime contact lens of the present invention. Although not essential, the macromonomer is usually represented by a siloxane block. The copolymer or triblock \5 is also composed of two or two different oxaxy-oxygenated polymers "post-stage" or zone slaves and has at least one at one end of the linear macromonomer. The propylene oxime group and preferably the macromolecular monomer having a reactive acrylonitrile group at both ends. The fluorine-containing fluorenyloxy macromonomer used in the present invention usually has at least one fluorine substituent. The fluorine substituent is preferably. Existing on one of the repeating units of the block polymer such that the overall macromonomer has more than one fluorine atom. Preferably, the fluorine-containing macromonomer of 121841.doc -26 - 200813102 has about 1% by weight to A macromonomer of about 5% by weight of fluorine and preferably having from about 1% by weight to about 5% by weight of fluorine. Generally, at least one of the blocks of the 'copolymer or triblock polymer. Have a repeating unit -[Si(CH3)2〇]-, and at least The other blocks comprise a halogen atom which has a fluorine-containing substituent, preferably has a fluoroalkyl substituent, preferably wherein the alkyl group is a lower alkyl group. In the case where the macromonomer is a triblock polymer' Preferably, one block has a repeating unit 4Si(CH3)2〇]_, and the second block is a block in which a halogen atom has a fluoroalkyl substituent, preferably wherein the alkyl group is a low-cracking group, and the third inlay The segment has a ruthenium atom substituted with an alkyl group comprising a hydrophilic component (eg, a short polyethylene glycol (PEG) chain (CH2CH2 〇) p). The third block mentioned above preferably comprises covalently attached to the poly A ruthenium atom substituted with an alkyl group-bonding agent of ethylene glycol, wherein PEG is optionally blocked with a blocking group such as a lower alkyl group or a benzyl group and the alkyl group-bonding moiety is closest to the ruthenium atom. The polyethylene glycol segment typically has from about 1 to about 25 subunits, and more preferably from about 2 to about 12 subunits. The PEG segment preferably has from about 4 to about 1 unit subunit. The three oxoxane blocks mentioned above may be in any order. The above-described exemplary aerobic macromonomers are described in U.S. Patent No. 6,867,245, the disclosure of which is incorporated herein by reference. Any one or more of the macromonomers described therein are suitable for use in the compositions and contact lenses of the present invention, and especially those having a (_si〇_) block of a macromonomer having A substituent which is an exothermic or other hydrocarbon chain substituted with one or more fluorine atoms. For example, a representative alkoxy macromonomer comprises the weight of the following triblocks. 121841.doc -27- 200813102 Complex unit:

Wherein R1, R2, R3, R4, and RdR6 are each independently selected from the group consisting of _H and a lower alkyl group, and P (the number of ethylene oxide repeating units) is in the range of from about 1 to about 25, and Y is ruthenium and low carbon. Alkyl or phenyl fluorenyl. The variables n, m &h correspond to the number of repeats 7 各 of each defeated segment; and are each independently within the range of about 3 to about 2 。. Preferably, at least one R group of the Si_〇 which is covalently bonded to each block n, m&h is a lower alkyl group, and even more preferably a fluorenyl group. That is, preferably, in the block η, at least one of 1 or 2 is a methyl group; in the block m, at least one of the group or R4 is a methyl group; and in the block h In the middle, at least one of r5 or the ruler 6 is a methyl group. Preferably, at least one of the blocks n, h has a repeating unit -Si(CH3)2?-, wherein the two r groups covalently bonded to the oxime are methyl. For example, preferred macromonomers comprise the following polymer triblocks:

Wherein Ri, R3 and R5 are each independently selected from -H, lower alkyl, fluoroalkyl (including difluoroalkyl and trifluoroalkyl) and (-CHOJOCH^CHdpO-Y, wherein 〇 is in the range of 1 to 10 In the range, p (the number of ethylene oxide repeating units) is in the range of from about 2 to about 12, and Y is an anthracene, a lower alkyl group or a benzoinyl group, the limitation being at least one of (1) I, R3 and Rs Is _Η or lower alkyl, 121841.doc -28- 200813102 (··) 1 At least one of R3 and R5 is a fluoroindolyl group, and at least one of (out) 1, 3, and 3 is ( -ch2)0(〇ch2ch2)p〇_y, wherein the value of the specific variable is as described above. A macromonomer for use in a particularly preferred macromonomer t 3 or more than a Xinnu polymer structure of the present invention, Wherein R1 is a fluorenyl group, R3 is a fluoroalkyl group, and R5 is (-CH2)0(OCH2CH2)pO-Y, and η is in the range of 50 to 200, 茁 is in the range of 2 to 50, and h is Range of 1 to 15 • Within the reference to the fluoropropenyl fluorenyl oxy macromonomer, the macromonomer f; sl-0-sla 卩 is the "occupying oxime macromonomer component The total molecular weight is greater than about 20% by weight, for example greater than 3 〇 The oxime macromonomer of the present invention comprises an acrylonitrile group, and preferably has two propylene fluorenyl groups, that is, one at each end, wherein one of the propylene sulfhydryl moieties or a plurality of olefin carbons is optionally organic. Substituted by a group such as an alkyl group. The propylene fluorenyl moiety is a moiety derived from acrylic acid, such as R7\ /R9 R/c=c\,

II U ° 'wherein in acrylic acid, r8 and r9 are each Η. However, according to the present invention, the fluorenyl fluorenyl moiety is one in which R9 is fluorene or alkyl, preferably lower alkyl, and the heart and heart are each independently Η, alkyl or carboxyl, but The restriction is that only one of R7*R8 can be sewed. W is oxygen or nitrogen. In the case of hydrazine nitrogen, the corresponding propylene sulfhydryl moiety is referred to as acrylamide. In a preferred embodiment, the core is each hydrogen and R9 is a lower alkyl group such as methyl, ethyl or propyl. & is preferably a fluorenyl group, and the above-mentioned acryl-based moiety is present on both ends of the linear macromonomer 121841.doc • 29-200813102. Among the propylene groups contained in the macromonomer, the values of I, R8 and R9 are independent. That is, for macromonomers having more than one propylene fluorenyl group, the values of the heart, heart and heart of each propylene thiol moiety are independently selected. However, in the preferred embodiment, the values of R7, R8 and I in the respective acrylonitrile groups are the same, and thus the macromonomer is regarded as a homobifunctional group - meaning that the reactive groups at the terminal are the same. Where the reactive groups at the ends are different, the macromonomers are considered to be heterobifunctional. Illustrative acryl-based polymerizable functional groups which may be present at the end of the oxime macromonomer include methacrylate groups, acrylamido groups and methacrylamide groups. Further examples of suitable oxo-containing monomers are polydecyloxyalkyl (meth) acrylate monomers which include, but are not limited to, fluoro substituted methacryloxypropyl thiols (dimethyl) Shi Xi alkoxy, Shi Xizhuo, pentamethyl oxalyl alkyl methacrylate and methyl bis(trimethyl decyloxy) methacryloxymethyl ketone. One type of suitable rhodium-containing component is a poly(organosiloxane) prepolymer such as L bis methacryloxy-propyl polydimethyl decane substituted by fluorine. Another example is a fluorine-substituted mPDMS (mono-n-butyl propyleneoxy propyl-terminated mono-n-butyl-terminated polydimethyl methoxy oxane). The oxy-fired polymer portion of the knives of the knives (i.e., one or more oxy-fired polymer blocks) is typically bonded to the propylene thiol end by insertion of a linking agent. Each of the linking agents typically has a length of from about 4 atoms to about 20 atoms, wherein the illustrative linking agent can include one or more of the following: _〇_c(〇)_, O-^-C(〇) -NH. . . . . . . . (( ( ( ( ( ( ( ( ( ( ( ( ( (0)(0)-(CH2)b-〇-(CH2)c-, -〇-C(〇)-〇-(CH2)a-,-0-C(0)-0-(CH2)aNH -C(0)(0)-(CH2)b and analogs thereof, wherein a, b and c are each independently in the range of from 1 to about 10. That is, a, b&c are each independently selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and ι. The linking agent is preferably a straight chain rather than a branched chain, and optionally contains one or more heteroatoms 或 or N. Thus, in addition to comprising one or more alkylene chain segments, the linking agent may optionally contain one or more functionalities selected from, for example, a carboxyl group, a guanylamino group, a urethane group, and a carbonate group. base. The molecular weight of the osmolality component is typically in the range of from about 8,000 Daltons ((1:11:11) to about 25,000 Daltons, and preferably about 1 Torr, 〇〇〇Door Up to about 20,000 Daltons. A particularly preferred oxoxane macromer for use in the present invention has a molecular weight of about 16,000 Daltons. A particularly preferred class of oxirane macromonomers has the following Triblock polymer of the general formula: 0 ch3 ο ϋ 〒Η3 CS-Λ -ch3 . Si—〇.1 ch3 ch3 j and continuous structure CH2CH2CF3 continued -Sj—0-|4si-Ο ch3 ch2ch2ch2(〇ch2ch2) Poch3 oo /CH3 II || ch3 *Si^~(CH2)3〇(CH2)2〇CNH(CH2)2OC—i=CH2 CH3 where n, m, h and p have the same values as above. The monomer is called heart ω-bis (oxyethyl imido thioglycol methacrylate) · poly (dimethyl methoxy oxane) _ poly (trifluoropropyl methyl oxa oxide) _ poly (still _ methoxy-poly (B 121841.doc -31 _ 200813102

Glycol) propyl decyl oxane or M3U. In a particularly preferred embodiment, η is about 121, m is about 7.6, h is about 4.4, and p is about 7.4. The M3U can be easily synthesized according to the procedure set forth in Example 1 of International Patent Publication No. WO 2006/026474. The polymerizable hydroxyl hydrogel precursor compositions provided herein typically comprise at least about 20% by weight of a fluoropropenyl fluorene macromonomer, and preferably at least about 25% by weight of a fluoropropenyl group. Oxygen macromonomer. The compositions of the present invention preferably comprise from about 25% to about 4% by weight of the fluorine-containing fluorenylfluorenyloxy macromonomer, and more preferably from about 25% to about 35% by weight of the macromonomer. Non-aerobic monomer composition The glasses, lens products and compositions of the present invention, in addition to the oxime macromonomer, further comprise a ruthenium-free monomer component or a composition-free monomer comprising a plurality of additives. The composition typically comprises more than one hydrophilic combination of hydrophilicity [the biopsy includes the ability to provide at least about 2% (or even at least about 25%) of the water hydration to the resulting hydrated eyeglass when combined with other precursor formulation components. 4 components. The inorganic monomer composition (meaning each compound constituting the monomer composition) generally comprises at least about 45% by weight of the lens precursor composition, based on the molecular weight of each precursor composition component. The inert monomer composition preferably comprises from about 45% to about 55% by weight of the precursor composition. The ruthenium-free monomer composition of the present invention excludes a hydrophilic compound containing one or more ruthenium atoms. Thus, the monomer composition of the present invention is referred to herein as a composition free of ruthenium. The monomers which may be included in the monomer composition of the ruthenium-free monomer generally have at least one of 121841.doc-32-200813102 Polymerized double bond and at least one hydrophilic functional group. Examples of polymerizable double bond include acrylic acid, methacrylic acid, vinyl, fluorene-vinyl ethyl fluorenyl and N-vinyl decylamine, N-vinyl decylamine Base double bonds and analogs thereof. These hydrophilic monomers may be, but are not necessarily, cross-linking agents. It is considered to be a subset of the acryl-based moiety as described above, acrylic type, or "acrylic-containing" or The acrylate monomer is a monomer containing an acrylic group (CR, H = CRCOW), wherein R is hydrazine or CH3, R is H, an alkyl group or a carbonyl group, and W is 0 or N. Hydrophilicity of the present invention The component generally comprises the following components which do not contain bismuth, and one or more components of D are hydrophilic. The monomer containing hydrophilic vinyl (CH2=CH-), acrylic monomer and acrylic acid Ester-functionalized ethylene oxide (_(〇CH2CH2)n) oligomer. Illustrative acrylic monomers including N, N - dimethyl propyl decylamine (DMA), 2-hydroxyethyl acrylate, glyceryl methacrylate, 2-hydroxyethyl methacrylamide, methacrylic acid, propionic acid, methacrylic acid The composition (MMA) and mixtures thereof. As described above, the monomer/\ composition comprising all of the individual hydrophilic and non-hydrophilic components comprises at least about 45% by weight of the precursor composition. Thus, the composition of the monomer composition The weight percentage of each component will vary within this range. The mono-body composition preferably comprises from about 45% to about 55% by weight of the precursor composition 'and thus the weight percent of each component from the precursor The composition varies from about 0.05% to about 40% by weight or from about 5% to about 5% by weight to achieve the desired total weight percent of the precursor composition. The acrylic monomer component is preferred. Existing in an amount of from about 7 wt% to about 20 wt%/❶ of the precursor composition of the precursor composition for the preparation of the xenon glasses product, and even more preferably about 10% of the precursor composition of the first 12l841.doc-33-200813102 5% by weight to about 18% by weight. Served with total precursor The illustrative weight percentage of the acrylic monomer includes the following: about 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17% or 18%. As described above, the monomer composition Also included is a hydrophilic vinyl-containing monomer. Hydrophilic vinyl-containing monomers which can be incorporated into the spectacles of the present invention include the following: N-vinyl decylamine (e.g., N-ethylene fluorene oxime _ (NVP)), N-vinyl-N-methylacetamide (VMA), N-vinyl-N-ethylacetamide, N-vinyl-N-ethylformamide, N-B Mercaptocarboxamide, N 2 -hydroxyethyl vinyl carbamate, N-carboxy-β-alanine N-vinyl ester. A particularly preferred vinyl containing monomer is fluorenyl-vinyl-indole-methylacetamide (VMA). The structure of the VMA corresponds to CH3C(0)N(CH3)-CH=CH2. The vinyl-containing monomer component of the monomer composition is preferably present in an amount ranging from about 20% by weight to about 5% by weight of the precursor composition prior to the preparation of the hydrogen spectacles product, and even more preferably in the precursor The bulk composition is present in an amount ranging from about 25% to about 42% by weight. A representative weight of the vinyl-containing monomer includes the following weights: about 25% by weight, 26% by weight, 27% by weight, 28% by weight, 29% by weight, 30% by weight, 31% by weight, of the precursor composition, 32% by weight, 33% by weight, 34% by weight, 35% by weight, 36% by weight, 37% by weight, 38% by weight, 39% by weight, 40% by weight, 41% by weight or 42% by weight The bulk composition additionally comprises an acrylate functionalized ethylene oxide oligomer 'i.e., having from about 2 to about 8 continuous ethylene oxide (ch2CH20-) monomeric subunits and terminally reactive groups (such as acrylate groups) ) Functionalized Oxidation 121841.doc -34- 200813102 Ethylene oligomer. One or both ends of the polymer can be functionalized with an acrylate group. Examples include reagents with one or more molar equivalents capable of introducing one or more reactive acrylonitrile groups to either or both ends of the nutrient (eg, isocyanatoethyl methacrylate (nIEMn), methacrylic anhydride) The methyl propyl sulfhydryl gas or the like is reacted to produce an ethylene oxide condensate of an ethylene oxide oligomer having a propionate group at one or both ends. Representative polymer: It is described by the following formula: R7\ = /R9

〇 R/C—,/(Shen Mailcan-F

- II, wherein s is in the range of 2 to about 8, preferably 2 to about 4, and 1 is 1 or an alkyl group, preferably a lower alkyl group, and the heart and the ruler 8 are each independently H, an alkyl group or a carboxyl group, with the proviso that only one of R7 or Rs may be a carboxyl group. & is preferably a lower alkyl group such as a methyl group, and each of R? and Rs is H. The variable F is selected from the group consisting of 〇H, a capping group such as an alkoxy group or a (iv) vinegar c group as shown below. The following structure shows a homo-functional ethoxylated ethoxylate oligomer having the same acrylate group at each end. However, in theory, the acetoacetate moieties at each end may be the same or different.

/C=C ,R9

A II ο , (〇ch2ch2): C-II o / c==c r8 Preferred for use in the acrylate functionalized ethylene oxide oligomer of the present invention includes 121841.doc -35- 200813102 oligo-oxyethylene oxide monoterpene Acrylate and oligo-ethylene oxide dimethyl acrylate. The acrylate functionalized oxyethylene oligomer preferably used in the present invention is a thioglycolic acid propylene glycol.

The acrylate functionalized ethylene oxide polymer is typically present in the precursor composition in relatively small amounts. For example, the polymeric polymer is present in the precursor composition in an amount ranging from about 5% by weight to about 10% by weight, preferably from about 0.075% by weight to about 5% by weight. A representative amount of the polymer component includes the following amounts: about 1% by weight of the precursor composition, 0.2% by weight, 3% by weight, 0.4% by weight, 〇·5% by weight, 〇·8 by weight %, 〇9 wt%, 1 wt%, 2 wt❽/. 3 wt%, 4 wt% or 5 wt〇/〇. Polyoxyalkylene Oxide Extractable Components As previously described, the precursor compositions of the present invention specifically include polyoxyalkylene oxide (PAOS) removable or extractable components. (The terms "removable" and "extractable are used interchangeably herein and refer to a component that is removed after polymerization of the lens precursor composition. The PA〇s extractable component of the present invention is represented by polyoxygen oxide, and the polyoxyalkylene in the oxime may be polyethylene glycol, polypropylene glycol, copolymer of ethylene glycol and propylene glycol, polyethylene glycol and polypropylene glycol. Terpolymer, including a segment of the copolymer and a three-stage polymer. Such polyoxy(tetra)oxygens may sometimes be referred to herein as lycopene; as the term is used herein, lithium oil " is intended to encompass any such polyoxyalkylene oxime. In general, polyoxonite oxygen is characterized by having a polydimethylene (PDMS) backbone in which a certain hundred moles of sulfhydryl groups are replaced by a polyalkylene group as described above. In a preferred embodiment, the T terpene fluorenyl group is attached to the oxane backbone via a spacer. The intervening spacers are typically from about 2 to about 121,841.doc • 36 to 200813,102 atoms and are typically used to facilitate attachment of the polyoxyalkylene chain to the siloxane backbone. Exemplary spacers include extended alkyl chains, substituted alkyl groups, amino acids, and the like. Preferred spacers are lower alkyl groups such as ethyl, propyl, butyl, pentyl, hexyl and the like. Alternatively, the polyoxyalkylene oxide used herein may be a dimethyloxane oxyethylene block copolymer such as those available from Gelest (Morrisville, PA). In general, the polyoxygen oxides of the present invention will contain at least about 25 weight percent polyoxydioxide, and more typically will comprise from about 30 weight percent to about 90 weight percent polyoxyalkylene. Preferably, the polyoxyalkylene oxide contains about 50% by weight or more of the polyoxyalkylene. It is said that the solar polyoxygen oxide contains about 25% by weight of polyoxyalkylene, 40% by weight, 50% by weight, 60% by weight, 70% by weight, 75% by weight, 8% by weight or 85% by weight. Polyoxyalkylene. In general, materials having about 55% by weight or more by weight of ethylene oxide are water soluble. Particularly preferred for use in the present invention are polyoxyalkylene oxides in which the polyoxyalkylene is a polyethylene glycol or a propylene oxide-ethylene oxide block copolymer. Exemplary polyoxyalkylene oxides are available from Gelest (PA, USA). Representative polyoxyalkylene oxime includes dimercapto oxane (75% ethylene oxide) block copolymer (PDMS-co-PEG); dimercapto oxime [65-70% (60% propylene oxide / 40) % ethylene oxide) block copolymer (PDMS-co-PPO-PEG); dimercapto oxirane (25-30% ethylene oxide) block copolymer (PDMS · co-PEG); Alkane [50-55% (60% propylene oxide / 40% ethylene oxide)] block copolymer (PDMS-co-PPO-PEG); dimethyloxane (50-55% ethylene oxide) block copolymer (PDMS-co-PEG); dimethyloxane (80-85% ethylene oxide) block copolymer (PDMS-co-PPO-PEG) and dimercapto oxime 121841.doc -37- 200813102 alkane ( 8 〇 / q ethylene oxide) block copolymer (Pdms_co-PEG). The above-mentioned polyoxygen oxides correspond to the following abbreviations (Gelest): DBE-712, DBP-732, DBE-224, DBP-534, DBE-621, DBE-821 and DBE·814. The preferred polyoxyalkylene oxime is dimethyl oxirane ethylene oxide) post-copolymer (DBE-712). While the PAOS extractable component may be present in the precursor composition in any amount, preferably the extractable component is present in an amount ranging from about 2% by weight to about 3% by weight, preferably from about 1% by weight to about 3% by weight. The amount exists. The extractable component is more preferably present in an amount ranging from about 10% by weight to about 28% by weight. Exemplary amounts of the extractable component in the precursor composition include the following weight % ••about 1〇weight/〇, force 12% by weight, about 15% by weight, about 20% by weight, about 25% by weight, about 29% % by weight or about 3 〇 〇 / 〇. In some cases, the PAOS removable component also contains a chain transfer reagent in addition to the polyoxyalkylene oxide. The chain transfer reagent is an agent that promotes a reaction between a radical species and a non-radical species. Exemplary chain transfer reagents for use in the present invention include thiols, disulfides, organic compounds, and allylooxylates.

Things. Some illustrative examples of chain transfer agents include mercaptans such as butanol, lauryl mercaptan, octyl thioglycolate, ethylene glycol bis(thioglycolate), M-butanediol bis(thiopropyl) Acid ester), trihydrocarbyl propane ginseng (thioglycolate), trimethylolpropane ginseng (β-thiopropionate), pentaerythritol thiopropionate) and the like; Disulfide, such as di-p-butyl disulfide; a complex such as tetra-carbonized carbon, four-alkaline carbon, gas-like, dioxane, and the like; and an allyloxy compound, such as allyloxy alcohol And its analogues. These chain transfer agents can be used individually or in the form of a mixture of any of the foregoing. 121841.doc -38· 200813102 :. Preferred compounds for use in the present invention that are allylicoxylated to a plurality of diloxyoxyl moieties, β P "- or a compound comprising at least one diloxyoxy moiety, have the following generalized knot h2c:

:CH 〇r〇

ο 八中框付部分 corresponds to the dilute propoxy moiety, and Q represents the parent molecule's = or residue, such as an alcohol or any small organic molecule, when it is connected to the susceptor Acts as a chain transfer agent. Q is preferably derived from: 'such as ethanol, propanol, butanol and the like or a substituted oxime thereof, preferably a residue of ethanol, and having the structure (_CH2CH20H), = corresponding to the chain transfer reagent 2. Allyloxyethanol. It has been found that the addition of a chain transfer reagent to an extractable component, such as the extractable components described herein, as appropriate, effectively provides an extracted hydrated 3 oxygen contact lens having reduced size and haste variability. body. Because the chain transfer agent is added to "normalize" or, the precursor lens composition is fine-tuned such that the resulting extracted hydrated contact lens population typically has a variability of less than 20% - or more of the following characteristics: Equilibrium water content, oxygen permeable static contact angle, dynamic sad contact angle (forward contact angle or receding contact angle 'lag, refractive index, ion current, modulus, tensile strength, and the like. For example, the specificity of the spectacles product Depending on the characteristics, the variability of any one or more of the aforementioned spectacles features is typically less than about 20%, and preferably less than about 10 Å. In one or more embodiments, the spectacles diameter, equilibrium water content, and/or 121841. D〇<-39- 200813102 The variability of any one or more of the ion currents is about 5% or less, more preferably about 3% or less than 3%, and even more preferably about 2% or less. 2%. Glasses The diameter of the lens in the body preferably has a variability of less than about 1.5%. The batch or group system as used herein refers to a plurality of contact lenses. Yes, when the contact lens is in a batch or group When the number of contact lenses is sufficient to provide a standard error of t, A modified statistical value is achieved. In some cases, a batch of contact lenses refers to at least 10 contact lenses, at least 100 contact lenses, at least 1000 contact lenses or more. n Because A, in one aspect The present invention provides a method for improving the oxygenation of polyoxyalkylene by adding a chain transfer agent of from about 01% by weight to about 10% by weight, preferably an allyloxy compound, More preferably, it is an oxyl alcohol to provide a chain shift of 4 doses of polyoxyalkylene oxide for the preparation of a hydroxyl hydrogel contact lens product. Preferably, it is from about 01% by weight to about 6% by weight dry circumference. 1 Addition of a chain transfer agent. It is considered that the specific batch of polyemulsified rare earth oxide (such as Shixia oil) as used herein, the efficiency, is at a given concentration (and all / /, the same number) Providing a lens-forming surface having a contact lens mold 2 The final extracted water of the outer diameter of the mold-forming surface of the lens-shaped insert of the L-shaped lens insert is about 〇·卯 to an outer diameter in the range of (such as, 々0.95 to about le05 times) ' The ability to see the product. At least - Example +, hydrated glasses 7 is the contact lens mold used or the mold to form the contact lens mold, and the object is G!, about G·98 to 1 · 〇 2 times. The final glasses product glasses directly control to reduce the number of people The greater the "efficiency" of 丨〆-大和t oxyalkylene oxime. Although the final = mirroring technique is to provide the chain transfer agent with the desired properties of the above-mentioned clinically acceptable " An amount of product capacity 121841.doc 200813102 measured 'but mixed with other components of the precursor composition

Adding a chain transfer agent to additionally provide the most dioxane: olefinic, large-to- _ can be changed C 〇 · ι to about 5 parts of chain transfer agent and about dad chain transfer agent · polyoxidation The mixture may contain any. Also, the amount of chain transfer agent: 0.2, 〇.3, G.4, Q 5 1

Oh,. Ι ^.5 + 2.5^3.5+4:5-: 97.5, 97, 96.5, 96, 95.5 or 95. Additional Components of the Oxygenated Hydrogel Contact Lens Precursor Composition The lens precursor compositions of the present invention may also include additional components, exceptional line (UV) absorption (four) or uv radiation or energy absorption (four) butterfly colorants, absorbents It can be, for example, a relatively high absorption value exhibiting a relatively high absorption value in the range of 320ν·Α of about 320 380 nm, but relatively transparent at about 380 nm. Examples include photopolymerizable benzophenones and photopolymerizable clumole triazoles such as 2-hydroxy-4-propenyloxyethoxybenzhydryl (purchased from Cytec Industries by CYASORB® UV416) 2, via — 4 (2hydroxy-3-methylpropenyloxy)propoxybenzophenone and photopolymerizable albendazole (purchased from Noramco as NORBLOC® 7966). Other photopolymerizable UV absorbers suitable for use in the present invention include polymerizable ethylenically unsaturated tris, salicylates, aryl substituted acrylates, and mixtures thereof. In general, the UV absorber, if present, is provided in an amount corresponding to about 5% by weight of the precursor 121841.doc -41 - 200813102 composition to about 1.5% by weight of the composition. Particularly preferred are compositions comprising from about 0.6% by weight to about 1% by weight of the UV absorber. The precursor compositions of the present invention may also include colorants, although encompassing colored eyeglass products and clear lens products. The colorant is preferably a reactive dye or pigment that effectively provides color to the resulting lens product. The reactive dyes are dyes that are bonded to the materials of the spectacles and do not bleed. Exemplary colorants include the following materials: benzoquinic acid, 4-(4,5-dihydro-4-((2-methoxymethyl-4-((2-(sulfooxy)ethyl))) Sulfhydryl)phenyl)azo-3-methylxyloxy_1Η-σΛ. sit-1-yl); [2-naphthoic acid, 7-(ethinyl)-4-yl group _3_ ((4_((sulfoethyl) fluorenyl)phenyl)azo)_] ; [5_((4,6-dichloro-1,3,5-diin-2-yl)amine 4--4-yl-3-((1-Drytyl-2-naphthyl)azo-2,7-naphthalene-disulfonic acid, trisodium salt]; [copper, 29H, 31H_phthalocyanine (2-)-N29, N30, N31, N32)·, sulfo((4((2-sulfo)oxy)ethyl)indolyl)phenyl)amino)sulfonyl derivatives] and [2, 7-naphthalenesulfonic acid, 4-amino-5-hydroxy-3,6-bis((4-((2)(sulfooxy)ethyl) fluorenyl)phenyl)azo)-tetrasodium salt] Particularly preferred colorants for use in the present invention are phthalocyanine pigments such as phthalocyanine blue and phthalocyanine green, chromium oxide-alumina-cobalt oxide, chromium oxide, and various iron oxides of red, yellow, brown, and black. An opacifier such as titanium dioxide may also be incorporated. For some applications, a mixture of colors may be employed. More preferably, the appearance of the natural iris is simulated. Furthermore, the precursor composition of the present invention may comprise one or more initiator compounds, i.e., compounds capable of initiating polymerization of the precursor composition. Preferably, the thermal initiator 'i. Start the "temperature initiator" by selecting a thermal initiator having a souther decomposition temperature and using a relatively low amount of initiation 121841.doc -42 - 200813102 to reduce the ion current of the glasses of the present invention, thereby affecting The amount of removable material removed or extracted in the extraction step. For example, one exemplary thermal initiator used in the precursor composition of the present invention is 2,2,-azobis (2,4-dimethyl) Valeronitrile) (VAZO-n-52). VAZO®-52 has a beginning of about 50°c.. Knife-degree is 'μ degree as the reactivity of the reactive component in the body composition begins. The thermal initiator of the composition of the present invention is azobisisobutyronitrile (VAZO8-88) having a decomposition temperature of about 9 ° C. A suitable initiator is VAZO®-64, 2, 2, - Azobisisobutyronitrile. The additional thermal initiators described herein include nitriles such as 1 1, 1, azobis(cyclohexanecarbonitrile) and 2,2,_ azobis(2-mercaptopropionitrile), and other types of initiators, such as those available from Sigma Aldrich. A compatible oxygenated hydrogel contact lens may comprise from about 0.2 to about 0.7 parts of VAZO-52 (or from about 1 to about 8% by weight) or from about 0.1 part to about 0.6 parts of VAZO-88. 0.05 to about 5% by weight) obtained from the precursor composition. The precursor compositions of the present invention may also comprise a release aid, i.e., effective to make the cured contact lens of Ij easier to remove one or more compounds from its mold. Exemplary release aids include hydrophilic crushed oxygen, polyyttrium oxide, and combinations thereof. The precursor composition may additionally comprise a diluent selected from the group consisting of hexanol, ethoxyethanol, and iso Propanol (IPA), propanol, decyl alcohol, and combinations thereof. If a diluent is used, it is usually present in an amount ranging from about 10% to about 30% by weight. Compositions having relatively high concentrations of diluent tend to (but are not required to) have lower ion current values, reduced modulus, and increased elongation and water BUT greater than 20 seconds. Other materials suitable for the preparation of a second oxygen hydrogel contact lens are described in U.S. Patent No. M67,245.

The term "additive" in the present application is provided in the polymerizable silicone hydrogel contact lens precursor composition of the present invention or the pre-extracted polymeric helium oxygenated gel-shaped lens product. A compound or any chemical agent necessary for hydrogel (tetra) glasses. Although not necessarily necessary for the preparation of a hydrogel contact lens, this does not in any way indicate that the composition of the present invention does not include a precursor to one or more additives. The body composition or the resulting lens product imparts one or more advantages. For example, the inclusion of a removable additive can, for example, facilitate processing of the contact lens during manufacture, and in combination with the (four) precursor in the absence of added enamel. The obtained hydroxyl hydrogel contact lens can enhance the _ or a plurality of characteristics of the hydroxyl hydrogel contact lens: or a combination thereof. The additive used herein is a self-pre-extracted polymeric oxime oxygen gel. An additive that is removed from the contact lens product. For example, the additive may be substantially non-reactive or may not be combined with a polymerizable oxygen-reducing lens precursor composition. The component reacts such that the additive is essentially: a covalently bonded constituent of the resulting polymeric lens product. Depending on the molecular weight and shape, most, if not all, of the additives can be self-polymerized in the dream hydrogel contact lens product. Extraction. Therefore, during the extraction procedure, the additive in the composition can be drawn from the polyoxygenated hydrogel contact lens product. Because & is also considered to be a removable or extractable component as previously described. Polyoxyalkylene oxime is an "additive," as used herein. Examples of additives other than the PAOS extractable component include, but are not limited to, 121841.doc • 44- 200813102 ethylene glycol stearate, diethylene glycol monolaurate, C2_Cm alcohol, and/or

CrC24 amine. The additive may also contain one or more polar or hydrophilic end groups such as, but not limited to, a hydroxyl group, an amine group, a sulfhydryl group, a phosphate group, and a carboxylic acid group to facilitate mixing of the additive with other materials present in the composition. Dissolved. The additive may be in liquid or solid form and includes a hydrophobic or amphiphilic compound or agent. In certain embodiments, the additive may be referred to as a diluent, substantially a non-reactive agent or an extractable agent. In addition to the previously described PAOS extractable components, the precursor compositions of the present invention may also contain an alcohol or non-alcohol diluent. If such other diluents are used, they may generally provide one or more of the following functions in an amount of less than about 10% by weight of the present invention provided in the compositions of the present invention, for example, Promoting the formation of a homogeneous composition or a composition that is not phase separated to aid in the formation of a polymerizable silicone hydrogel contact lens precursor composition; (ii) demolding, for example, by promoting contact lens molds containing contact lens products And/or promoting the release of the contact lens product from the contact lens mold to enhance the processability of the pre-extracted polymeric rock-oxygen hydrogel invisible, brother product, (U1), such as by reducing contact lens populations (eg, different In a batch of contact lenses, the variability of the physical parameters of the contact lens improves the control of the physical parameters of the contact lens; (iv) enhances the wettability of the contact lens, such as by enhancing the wettability of the surface of the contact lens; (7) Hunting by actively reducing the modulus or increasing the modulus and actively affecting the contact lens model (4) can reduce the invisibility compared to the target hi glasses obtained from the glasses product that does not include the additive. Mirror ion flow and positive influence qe invisible, see ion flow. Therefore, the additive provided in the composition of the present invention can be used as a compatibilizer, a mold release aid, a mirror release aid, a physical parameter control agent, a wettability enhancer, a modulus influencer, and the like. 121841.doc -45-200813102 Ion flow reducing agent or a combination of any one or more of the foregoing. The compatibilizing agent can improve or enhance the miscibility of the components of the precursor composition of the present invention. The compatibilizer can reduce the formation of the polymer and other glasses in comparison with the formulation without the compatibilizer. Component related phase separation. The additive is preferably evenly distributed throughout the polymeric composition and is substantially (if not completely) removed from the polymeric product during the extraction procedure. Thus, the contact lenses of the present invention are preferably produced by small physical or dimensional variability between batches' thereby improving the yield of clinically acceptable ocular oxygen-compatible hydrogel contact lenses. Exemplary precursor compositions of the present invention are provided in Examples 1, 3 and 4. Certain embodiments of the precursor compositions of the present invention comprise a polymerizable silicone hydrogel contact lens precursor composition provided in a non-polar resin contact lens mold. Other embodiments include such compositions in storage containers such as bottles and the like, or in dispensing devices such as manual or automatic pipetting devices. Method of Forming a Hydroxyl Hydrogel Contact Lens In general, in the production of a helium oxygen hydrogel contact lens, the components of the Shiqi Oxygen Hydrogel Contact Lens Precursor Composition are each weighed and then assembled. The resulting precursor composition is then typically mixed, for example, using magnetic or mechanical mixing and optionally filtered to remove particulates. The spectacles of the present invention can be produced, for example, as illustrated in Figure 。. The figure is a block diagram illustrating a method of producing a helium oxygen hydrogel contact lens. Specific Orders, 121841.doc • 46- 200813102 Figure 1 illustrates a method of casting a silicone hydrogel contact lens. The cast molded contact lens can be self-produced in a form suitable for direct placement on the human eye' without the need for further processing to modify the lens to make the lens suitable for use on the eye. The hydroxyl hydrogel contact lenses of the present invention produced using a casting process such as the procedure illustrated in Figure 1 are herein considered to be, cast, and formed as the aerogel contact lens. The glasses of the present invention are understood to be "fully formed hydroxyl hydrogel contact lenses, if no processing is used to alter the design of the lens that causes the lens product to be removed from the mold member. Illustrative methods for producing contact lenses, such as neohydrogenated hydrogel contact lenses, are described in U.S. Patent Nos. 4,121,896, 4,495,313, 4,565,348, 4,640,489, 4,889,664. , 4, 985, 186, 5, 39, 459, 5, 〇 80, 839, 5, 094, 609, 5, 26, 5, 607, 5 18, 5, 760, 100, 5, 85 , No. 1, No. 5, No. 5, 935, 492, No. 6, 099, 852 E, No. 6, 367, 929, No. 6, 822, 016, No. 6, 867, 245, No. 6, 869 549, No. 6, 939, 487, and U.S. Patent Publication No. 2, pp. 20050154080 and 20050191335. Returning to Figure 1, the method outlined in the block diagram will now be briefly described. The illustrated method includes the step of step 2, i.e., placing the polymerizable silicone hydrogel lens precursor composition (202, as shown in Figure 2) on or in the contact lens mold member. The polymerizable silicone hydrogel lens precursor composition refers to a prepolymerized or precured composition suitable for polymerization. The polymerizable composition of the present invention as used herein may also be referred to as a "monomer mixture" or "reaction mixture," a polymerizable composition or a lens precursor prior to curing or polymerization of the combination of ^121841.doc-47-200813102. Preferably, the composition is not polymerized to any significant extent. However, in some cases, the polymerizable composition or lens precursor composition can be partially polymerized prior to being subjected to curing. Prior to curing or polymerization procedures, the lens precursor of the present invention The body composition can be provided in a container, dispensing device or contact lens mold. Returning to step 102 of Figure 1, the lens precursor composition is placed on the lens forming surface of the concave invisible • eyepiece mold member. Concave invisible Eyeglass molds generally refer to a first contact lens mold member or a front contact lens mold member. For example, a concave contact lens mold member has a lens forming surface that defines an invisible shape produced by a contact lens mold. a front surface of the lens. The first contact lens mold member is placed in contact with the second contact lens mold member to form a contact lens-like space The contact lens mold of the cavity. Therefore, the method of the month in the figure includes the step 1〇4, that is, the contact lens mold is closed by placing the two contact lens mold members in contact with each other to form a contact lens-like cavity. The hydroxyl hydrogel lens precursor composition 2〇2 is located in the hidden mirror cavity. The second contact lens mold member refers to a convex contact lens mold member or a rear contact lens mold member. For example, the second The contact lens mold member includes a lens forming surface that defines a contact lens: a rear surface of the contact lens produced in the mold. As used herein, a non-polar resin contact lens mold or a "hydrophobic resin contact lens mold" Refers to a contact lens mold formed or produced from a non-polar or hydrophobic resin. Thus, non-polar resin based contact lens molds can be included in non-polar or aqueous resins. For example, the contact lens molds may comprise one or more polyolefins, or may be formed from a polyolefin resin material. Examples of non-polar resin contact lens molds for use in the context of the present application include polyethylene contact lens molds, polypropylene contact lens molds, and polystyrene contact lens molds. Non-polar resin based contact lens molds typically have a hydrophobic surface. For example, the non-polar resin mold or the hydrophobic resin mold may have about 9 Torr as determined by the trapping bubble method. Or a larger static contact angle. At these contact angles, the conventional Shihee hydrogel contact lenses produced in such molds have clinically unacceptable surface wettability. 1 - The method further comprises curing the l-body composition to form a pre-extracted polymeric oxime hydrogel contact lens product 204 (as shown in Figure 2). During curing, the lens forming components of the polymerizable oxalate hydrogel lens precursor composition are polymerized to form a polymeric lens product. Therefore, curing can also be understood as a polymerization step. Curing 1 〇 6 can include exposing the polymerizable lens precursor composition to a light shot, such as a thermal light shot or any other component that effectively polymerizes the lens precursor composition. For example, "106" can include exposing the polymerizable lens precursor composition to a polymeric 'hot or ultraviolet (UV) light. Curing can be carried out in an oxygen-free environment as appropriate. Cattle! 1 and SMb can be inert The atmosphere T is carried out, for example under nitrogen, argon or other inert gas. The pre-extracted polymeric hydrogel contact lens product 204 means substantially all of the removable/extractable components are removed from the self-polymerized product. The polymerization product prior to the extraction procedure. The pre-extracted polymeric oxime hydrogel contact lens product can be provided on or within the contact lens mold, extraction tray or other device prior to contact with the extraction composition. For example, in curing After the procedure, 121841.doc -49- 200813102 pre-extracted polymeric 7 oxygenated contact lens product can be provided in the lens-like cavity of the contact lens mold; after the contact lens mold is released, it can be provided in a contact lens mold member Upper or inner; or after the devitrification procedure and prior to the extraction procedure, may be provided on or in the extraction tray or other device. Pre-extracted polymeric 7-oxygen hydrogel invisible The mirror product comprises a lens forming component (such as a enamel-containing polymeric network or matrix in the form of a spectacles) and a removable component that can be removed from the spectacles forming group. The removable component is in addition to the PA 〇s extractable component. Also includes unreacted monomers, oligomers, partially reacted monomers or relative

C Other agents that are not covalently attached or immobilized to the lens forming component. The removable component may also include - or a plurality of additives, including organic additives, including diluents' which may be extracted from the polymeric lens product during the extraction procedure as previously discussed. Thus, a substance which may comprise a removable component includes not only a polyoxygen oxide extractable component but also an extractable or unremovable extractable relative to the polymer backbone, network or matrix of the lens body. Linear uncrosslinked, crosslinked, and/or branched polymers of the material. Further, the second removable component may include other materials, such as volatile materials, which may be passively or actively removed from the pre-extracted polymeric hydrogen peroxide water (IV) contact lens product after extraction. For example, the -partial removable component can evaporate between the demolding step and the extraction step. After the polymerizable lens precursor composition is singulated, the release lens 108 of the contact lens mold is performed. Demolding refers to the method of separating two mold members (such as male and female: mold members) of a wedge or polymerization device containing a pre-extracted polymeric contact lens product. The pre-extracted polymeric rock-oxygen hydrogel contact lens product is located on the four members of the demolded mold. For example, 'polymerization shi shi 121841.doc -50- 200813102 oxygen water; the edge contact lens product can be located on the male mold member or the concave mold and the member. 'Next, during the de-mirror step 110 (shown in Figure 1), the pre-extracted polymerized stone-oxygen-condensed female-shaped rabbit-mirror-Jr Weng 4 words ^: '定'位-之-取取Eye ~ mirror mold its separation of the pieces. The pre-extracted polymeric contact lens product can be removed from the convex mold member or the female mold member depending on the mold member that the polymeric contact lens product remains adhered during the release of the contact lens mold. After the pre-extracted deoxygenated hydrogel contact lens product is demired, the method comprises extracting 112 extractable material from the pre-extracted neohydrogen hydrogel contact lens product. Extraction step 112 results in an extracted oxygenated hydrogel contact lens product 206 (shown in Figure 2). Extraction step 112 refers to the process of contacting the pre-extracted polymeric hydrogel contact lens product with one or more extraction compositions, and may include a single extraction step or several sequential extractions. For example, the polyaerogel hydrogel contact lens product or a batch of polymeric hydrogel hydrogel contact lens product is contacted with one or more volumes of liquid extraction media. The extraction medium typically includes one or more solvents. For example, the extraction medium includes ethanol, methanol, propanol, and other alcohols. The extraction medium may also include a mixture of an alcohol and water, such as a mixture of 5 % ethanol and 50% deionized water, or 7 % ethanol and 30. /. A mixture of deionized water, or 9 (%) ethanol and deionized water 112 can be carried out at various temperatures including room temperature. For example, the extraction can be in the mixture. Alternatively, the extraction medium can be substantially or completely alcohol free and can include one or more agents that facilitate removal of the hydrophobic unreacted component from the polymerized hydrogel hydrogel lens product. For example, the extraction medium can comprise, consist essentially of, or consist entirely of water, a buffer solution, and the like. Extraction 121841.doc -51- 200813102 occurs at room temperature (e.g., about 20 ° C) or it can occur at elevated temperatures (e.g., from about 25 Torr to about 100 C). In addition, in some embodiments, the extracting step 1 η may include contacting the lens product with a mixture of alcohol and water, and in some cases, - _ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ . -------------~------------- - Extraction of pre-extracted polymeric hydrogel contact lens products to provide extracted polymeric ground milk After the water/spinning contact lens product, the method comprises the step of: extracting the polymerized hydroxyl hydrogel contact lens product. The hydrating step 114 can, for example, comprise contacting the extracted polymeric hydrogel head contact lens product p or one or more batches of the product with water or an aqueous solution to form a hydrated rock oxygen hydrogel contact lens 208 (as in Figure 2). Shown). For example, the extracted polymeric oxyhydrogel contact lens product can be hydrated by being placed in two separate volumes or two separate volumes of water, including deionized water. In certain embodiments, the hydrating step 114 is combined with the extraction step 112 such that the two steps are performed at a single location in the contact lens production line. The hydration step 114 can be carried out in a container at room temperature or elevated temperature and, if necessary, under high pressure. For example, hydration can occur in water at a temperature of about 120 ° C (e.g., a temperature of 121 ° C and a pressure of 1 〇 3 kPa (15 psi). Therefore, as apparent from the above, it is considered that the pre-extracted polymer is oxygenated. Hydrogel: (4) Shaped glasses products and extracted polymeric Weishui «contact lens products" & water-swellable products or components, money for hydrated water hydrogel contact lenses are water-swellable products or components. As used herein, a Shixia oxygen hydrogel contact lens refers to a Shixia oxygen hydrogel element that has undergone a hydration step. Therefore, the Shixi oxygen hydrogel contact lens can be a fully hydrated Shixia oxygen hydrogel contact lens, Partially hydrated Shixia Oxygen Hydrogel Contact Lens or Dehydrated Stone Oxygen Condensate 121841.doc -52- 200813102 Glue Contact Lens. Dehydrated Oxygen Hydrogel Contact Lens means that it has undergone a water human procedure and subsequently Dehydration to remove water contact lenses from the glasses. In the hydration of the extracted hydrogel hydrogel contact lens products to produce Shi Xi oxygen water - Gongjia Pu Di Niang Weng ~ ^ ^ ^ Ge • brackets to speak ^ Guang Oxygen ^ seeking through the plastic - shape - eye - mirror one by one • 208 steps 116. For example, the hydroxyl hydrogel contact lens 2〇8 can be placed in a blister pack or other suitable container that includes a volume of liquid, such as a physiological saline solution, including a buffered physiological saline solution. Examples of the liquid of the spectacles of the present invention include phosphate buffered physiological saline 疒 and monoacid buffered physiological saline. Then, as shown in step 118, the hair/package or the granule is sealed, and then sterilized. For example, The encapsulated oxime hydrogel contact lens can be exposed to a sterilizing amount of radiation, including heat radiation, such as by autoclave treatment, gamma radiation, electron beam radiation, or ultraviolet radiation. The characteristics of the oxygenated hydrogel glasses are as described above. Disclosed, the compositions and methods provided herein provide an eye-compatible Shishi oxygen hydrogel contact lens. Pre-extracted polymeric rock-enriched hydrocele gel product extraction with a removable component as described herein. And hydrating to form an Oxime Hydrogel contact lens having an ophthalmically acceptable surface wettability. The glasses of the present invention have oxygen permeability, surface wettability, modulus, water content, Ion μ and combinations thereof - which make the spectacles of the present invention suitable for the patient's eye to be properly worn for extended periods of time, such as at least one day, at least one week, at least two weeks, or scoop months without the need to remove the spectacles from the eye. The < eye-catching compatible oxygenated hydrogel contact lens" means: the human eye does not experience or report substantial discomfort (including eye irritations and similar discomfort) Glue contact lenses. Eyes compatible 121841.doc •53- 200813102 Essence water gel contact lens has eye damage that does not cause significant corneal swelling, and epithelial arch disease is sputum, water (" dry eye disease "), the upper corner of the sacral arch disease k (, SEAL) or other sacred temples can be said that K weeks U flu symptoms are not compatible with the production of ^ ^ sexual culmination :: adversely affect the lens of the wearer's eye tear film to lead the glasses to wear the guide to the eye or put on the eye or wear Shixia oxygen hydrogel contact lens wide-ranging private oxygen hydrogel contact lens . The eye is compatible with the blister contact lens to meet the clinically acceptable needle (4). Wearing or long-wearing contact lenses 2 Ming 7 oxygen hydrogel contact lenses comprise a mirror body having a surface with an ophthalmic surface wettability (0ASW), such as a front surface and a rear surface. The hydrophilicity of one or more surfaces of the contact lens. In a measuring method, if the spectacles obtain 6 amps on 3 or X in the wettability test performed as follows, the surface of the spectacles may be considered to be wettable, or it may be considered to be wettable for ophthalmology. Sex. Immerse the contact lens in the steaming water C; remove it from the water and measure the length of time it takes for the water film to recede from the surface of the lens (eg water dispersal time (water bribe or WBUT)). The test provides the level of the glasses in the linear range of the shape, where the 1〇 point refers to the glasses in which the water droplets need to glow or take longer to retreat from the glasses. Although the in vitro evaluation of (4) is only for the OASW method or indication, it can be considered to have an invisible hydrogel of water BUT of more than $second (such as at least 10 seconds or more preferably at least about 15 seconds). The glasses have an ophthalmically acceptable surface wettability. Alternatively, the 0 class can be evaluated in vivo. If the eyewear can be worn on the patient's eye for at least 6 hours and the patient does not report discomfort or irritation, the eyeglass is considered to have a 〇ASW. 121841.doc -54- 200813102 λ, 〖, can also be measured by measuring the contact angle on the surface of one or two glasses to detect the contact angle can be a sad or static contact angle. A lower contact angle generally refers to an increase in the wettability of the contact lens surface. For example, the hydroxyl hydrogel is hidden: the number of the lens is the best of the 贡12-〇.σ. In some embodiments of the glasses of the present invention, the glasses have a size of no more than 9g. The contact angle' and in other embodiments, the oxygenated hydrogel contact lenses of the present invention have a thickness of less than about 80. And even more preferably less than about 75. Before entering the contact angle. The hydroxyl hydrogel contact lenses of the present invention comprise a lens body having an ophthalmically acceptable surface wettability. For example, the mirror body of the helium oxygen hydrogel contact lens of the present invention typically has a front surface and a back surface, each surface having an acceptable surface wettability for the eye. In one embodiment, the lens body of the helium oxygen hydrogel contact lens comprises a hydroxyl hydrogel material. The mirror body has a dry weight of not more than 9〇% of the dry weight of the lens body before extraction. For example, the mirror body of the pre-extracted polymeric hemohydrogel contact lens product can have a dry weight X. After the extraction procedure, the mirror of the extracted polymeric hydrogel hydrogel contact lens product has a dry weight of less than or equal to 0.99 。. As noted above, during the extraction step, the pre-extracted polymeric hydrogel hydrogel contact lens product can be contacted with a wide variety of organic solvents, followed by a hydration step to produce a helium oxygen hydrogel contact lens. Next, the hydrated hydrogel hydrogel contact lenses were dehydrated and weighed to determine the dry weight of the lens body of the hydroxyl hydrogel contact lenses. For example, in some methods, the pre-extracted polymeric hemohydrogel contact lens product is removed from the contact lens mold member and weighed to provide a pre-extracted polymeric hydrogel contact lens product. weight. The pre-extracted 121841.doc -55-200813102 lens product was contacted with the alcohol for about 6 hours and then hydrated with water. The hydrated spectacles are then dried at about 80 ° C for about 1 hour and then dried under vacuum at about 80 ° C for about 2 hours. The dried glasses were weighed to determine the dry weight of the mirror body of the Shihe oxygen hydrogel contact lens. The dry weights are then compared to determine the amount of extractable material present in the polymerized lyophilized hydrogel contact lens product. The pre-extracted polymeric lens product having a level of extractable component of about 40% produces a lens body having a dry weight of about 60% of the oxygenated hydrogel invisible eyeglasses of the pre-extracted lens product. The pre-extracted polymeric lens product having an extractable component content of about 70% produces a lens body having a dry weight of about 30% of the oxygenated hydrogel contact lens of the pre-extracted lens product, and the like. The amount of extractable material or extractable component present in the pre-extracted polymeric hydrogel contact lens product can be determined using the following equation: Dry weight of the pre-extracted lens product - extracted and hydrated contact lens Dry weight) / pre-extracted dry weight of the lens product) X 1〇〇. Ε is the percentage of extractables present in the pre-extracted lens product. For example, the pre-extracted polymeric oxygenated hydrogel contact lens product can have a dry weight of about 20 mg. If the hydrogenated hydrogel contact lens obtained from the product has a dry weight of about 17 mg, the hydrogenated hydrogel contact lens comprises a lens body having a dry weight of 85% of the dry weight of the pre-extracted lens product. It will be appreciated that the pre-extracted lens product has an extractable component content of about 15% by weight. As another example, the pre-extracted polymeric hydrogel contact lens product can have a dry weight of about 18 mg, and if the dehydrated oxaxy hydrogel contact lens obtained from the lens product has about 13 mg For dry weight, the Shixi oxygen hydrogel contact lens comprises a mirror body having a dry weight of about 72% of the pre-extracted lens product. The 121841.doc -56-200813102 pre-extracted polymeric rock hydrogel contact lens product has an extractable component content of about 28% by weight. In certain embodiments, the mirror body of the helium-oxygen hydrogel contact lens (i.e., the oxygenated hydrogel contact lens that has been subjected to the extraction and hydration procedures) is substantially more than 40% of the dry weight of the lens in the extraction. For example, the dry weight of the lens body after extraction can be from about 4% to about 9% by weight of the pre-extracted lens body. The lenses of the present invention: Certain embodiments comprise a lens body having a dry weight of from about 50% to about 80% of the dry weight of the pre-extracted lens body. (a) as discussed herein, when the extractable component content of the pre-extracted lens product (eg, unreacted reagents, such as polymer backbone, network or matrix relative to the lens body, is not crosslinked or fixed) The linear uncrosslinked, crosslinked or branched polymer of the extracted material) is greater than 10%, such as at least 15%, at least 2%, at least 25 / Torr or more, from the non-polyoxyalkylene oxime extractable component The ophthalmic hydrogel contact lens obtained from the lens precursor composition or the pre-extracted oxygenated hydrogel contact lens product (for example, the lens product obtained from the "mass formulation") can be ophthalmically acceptable Surface wettability. Applicants have discovered that

The Cj bulk formulation lens product includes one or more removable/extractable additives in the precursor composition or the polymerized pre-extracted lens product to increase the extractable component content and produce an ophthalmically acceptable surface Wettable. Hydroxyl hydrogel contact lenses. Although the pre-extracted polymeric hydrogel contact lens product of the present invention has a relatively large amount of extractable material, the extracted form of the As-Silicon hydrogel contact lens of the present invention has very little extractable material in the resulting lens body. . In some embodiments, the amount of extractable material remaining in the extracted spectacles is from about 121841.doc -57 to 200813102 from 0.1% to about 4%, such as from about 4% to about 2% by weight. The additional extractable material can be determined by contacting the extracted contact lens with an additional volume of a strong solvent such as chloroform. In addition, since the extractable component is present and distributed throughout the polymerizable silicone hydrogel lens precursor composition and the pre-extracted polymeric oxygenated hydrogel contact lens product, the lens product and contact lens of the present invention can be Different from surface treated helium hydrogel contact lenses. Since the extractable component can be extracted from the lens product and is substantially absent from the hydrated contact lens, the lens products and contact lenses of the present invention can be distinguished from the oxygenated hydrogel contact lens having the polymeric wetting agent IPN. The silicone hydrogel contact lenses of the present invention may comprise lens bodies obtained from non-polar resin contact lens molds having substantially the same surface morphology upon inspection in the hydrated and dehydrated state. Further, the hydrated mirror bodies may have a surface roughness slightly smaller than the surface roughness of the dehydrated mirror body. For example, the lens body of the glasses of the present invention may have a surface comprising a nanometer size peak, which is apparent when analyzing the root mean square (RMS) roughness data of the surface of the lens. The mirror body may contain regions between the unbalanced peaks of the differential ridges between the peaks to provide reduced roughness and substantially similar surface morphology. For example, although the peak height can be reduced when the lens body is hydrated, the peak shape remains substantially the same. Alternatively or additionally, embodiments of the non-polar resin molded oxygenated hydrogel contact lenses of the present invention may comprise visually visible when viewed with an electron microscope such as a scanning electron microscope, a transmission electron microscope, or a scanning transmission electron microscope. Identify the mirrors of the rich and poor areas. Based on the analysis of the chemical points 121841.doc -58- 200813102, it can be understood that the pelagic area is a region of the eyeglasses that is substantially or completely free of stone. The plutonium area may be larger than the surface treated zephyrheal hydrogel contact lenses or those in the oxidizing agent brain containing the polymeric humectant. Conventional image analysis software and devices, such as the image analysis system available from Tennessee, can be used to determine the size of the rich zone, the barren zone, or both. The image analysis software system can be used to outline the cross-sectional area, diameter, volume, and the like of the rich boundary area and the peat area. In certain embodiments, the prickly 々P* g 士 ^ T贞 ^ ^ has at least 鄕, at least 70%, at least 70%, at least 70% smaller than other anaerobic hydrogel concealed glasses. 80% or at least 90% of the cross-sectional area. The untreated surface of the present invention generally provides surface wettability acceptable to the eye. In other words, in the embodiment, the mirror body of the Shixia oxygen hydrogel contact lens of the present invention is a mirror body which is not surface-treated. In other words, the mirror body is produced to provide moisture without surface treatment of the mirror body. For example, the illustrative mirror body does not include a plasma treatment or additional coating 1 to make the == 胄 more acceptable, due to the pre-extraction of the polymerized stone hydrogel contact lens product There is a "removable amount of material" to provide the spectacles of the present invention with an ophthalmically acceptable surface wettability, as certain embodiments may include surface treatment if necessary. Some embodiments of the lenses of the present invention comprise a wash-molded component mirror body obtained from a non-polar resin contact lens cookware. Polyoxygenated Hydrogel Contact Lens The product refers to a product that is polymerized or cured in a non-polar resin contact lens mold. Alternatively, in another manner, the polymeric rock oxide hydrogel contact lens product is produced in a non-polar resin contact lens mold. As discussed herein, 121841.doc-59-200813102 4 is a mold produced using a non-polar or hydrophobic resin material or based on a non-polar or hydrophobic resin material. These materials typically have a relatively large contact angle on their lens forming surface.

矽 The oxygenated hydrogel contact lens of the present invention may also include one or more comfort enhancers that enhance the feel of the lens wearer or the wearer of the eyeglasses relative to the silicone hydrogel contact lens without the comfort enhancer. The comfort of contact lenses. Examples of comfort enhancers include dehydration to reduce the tear film stabilizer or to reduce > dehydrate and stabilize the tear film of the eye placed by the contact lens. These comforts include a polymeric substance that has an affinity for water. In some embodiments, the 'polymeric substance' contains _ or a plurality of amphiphilic groups. Examples of the substance which is suitable as a relaxing enhancer include a polymerizable structure such as a substance including choline citrate, and which is damaged. In certain embodiments, the precursor composition comprises a methyl aceto-acid citrate monomer such that in this case the amphiphilic choline choline is included in the resulting cross-linked network. As discussed herein, the comfort of the 9-oxygel eyeglasses of the present invention may also include - or a plurality of removable comfort enhancements in the front (4) composition of the lens and the 7 oxygen water (four) contact lens. Agent to enhance. By way of example, some of the removable materials described herein include an agent that reduces the flow of ions of the lenses of the present invention as compared to a krypton mirror of a non-removable material. Reduce the barrier of the glasses; a brother's ion flow can help reduce the lens dehydration of the lens and reduce the cornea stain caused by wearing the eye. As discussed herein, the period of the invention... "The glasses of the moon have the ability to allow the glasses to be worn extended. gp ^ ° The glasses of this month can be used as glasses for daily wear, glasses for maternal week, glasses for laughter or mater Wearing glasses for the month 121841.doc -60 - 200813102 酉己戴. The date of the hair, 、,, brothers and sisters have surface wettability, handyman, * Zuo Bu, which contributes to the comfort and usability of the glasses. Hydrating mirror body of number, ion & oxygen permeability and water content. In certain embodiments, the wood, Τ毛毛明 glasses comprise a hydrated mirror body having a characteristic selected from the group consisting of: About 95. Previously: 2] at a tensile modulus of about 1,6 MPa, less than about 7 X ΙΟ.3: 111 ions, flow, at least about 70 barrer oxygen permeability (Dk at least about 3 ( The water content and its combination are set. However, in other embodiments, the ion current may be greater than 7 X 1 (r3 mm 2 /min, but still does not cause corneal dehydration staining, _ or other clinical problems. May include a front surface, a back surface, or a front contact angle of less than 120 on the front and back surfaces. In some embodiments, the mirror body has a contact angle of 90 on the surface of the mirror, such as a mirror body having about 85., a spoon 80 of about 75, about 70, about 65, and about 60. A mirror surface advancing contact angle of about 55. or about 50. The mirror body may also have a mirror surface receding contact angle of less than 80. For example, the mirror body may have about 75., about 7 〇, about 65., about 6 〇., about 55°, about 5〇, or about 45. The mirror surface recedes the contact angle. The hysteresis as the difference between the advancing contact angle and the receding contact angle may be about 5 to about 35. However, 'in some In some embodiments, the hysteresis can be greater than 25. However, it is still clinically acceptable. The advancing contact angle can be determined using conventional methods known to those skilled in the art. For example, conventional droplet shape methods can be used. (such as the fixed droplet method or the trapping bubble method) to measure the contact angle and the receding contact angle of the contact lens. The front and back water contact angles of the oxygenated hydrogel contact lens can be used.

Kruss DSA 100 appliance (Kruss GmbH, Hamburg) and as D. A. 121841.doc -61 - 200813102

Brandreth: "Dynamic contact angles and contact angle hysteresis*', Journal of Colloid and Interface Science, Vol. 62, 1977, pp. 205-212 and R. Knapikowski, M. Kudra:

Kontaktwinkelmessungen nach dem Wi lhel my-Pr inzip-Ein statistischer Ansatz zur Fehierbeurteilung'', Chem. Technik, Vol. 45, 1993, pp. 179-185 and U.S. Patent No. 6,43,481. For example, the advancing contact angle and the receding contact angle can be measured using a capture bubble method using phosphate buffered physiological saline (PBS; pH = 7.2). The glasses were spread on a quartz surface and rehydrated with PB S for 1 minute before testing. Use the Auto/Main System to place the bubbles on the surface of the glasses. The bubble size can be increased and decreased to obtain a receding angle (a platform is obtained when the bubble size is increased) and an advancing angle (a platform is obtained when the bubble size is reduced). Alternatively or additionally, the spectacles of the present invention may comprise a lens body exhibiting a water scatter time (BUT) of greater than 5 seconds. For example, embodiments of the lenses of the present invention comprising a mirror body having a water but of at least 15 seconds (such as 20 seconds or more) may have an ophthalmically acceptable surface wettability. The spectacles of the present invention may comprise a lens body having a modulus of less than 1.6 MPa. In some practical examples, the modulus of the mirror body is less than 丨·〇 MPa. For example, the mirror body can have a modulus of about G.9 MPa, about 88 MPa, 7 Mpa, 6 Mpa, about ^ &, force 4 4 MPa or about 0.3 MPa. The modulus of the mirror body of the present invention is preferably from about 〇4 to M8 Mpa, and even more preferably between the society 4 and about ΜΡ& In one embodiment, the mirror body has a modulus between about 0.4 and 0.5 MPa. The mirror body modulus is chosen to provide a comfortable lens that can be adapted to the operation of the eyewear when placed on the eye. The modulus of the mirror body can be determined using conventional methods known to those skilled in the art. For example, a contact lens having a width of about 4 mm can be cut from the center portion of the lens, and the tensile modulus (unit: MPa) can be at least 75% humidity at 25 ° C by using Instron 3342 (Instron Corporation). The initial slope of the stress-strain curve obtained by tensile testing at a rate of 10 mm/min in air was measured. The ion current of the lens body of the glasses of the present invention is typically less than about 5 X 1 〇·3 mm 2 /min. While some of the scopes of the lenses of the present invention can have ion currents of up to about 7 X 1 〇 3 mm 2 /min, the ion current is less than about 5 X 1 〇 -3 mm 2 /min, and when the contact lenses are not Corneal dehydration staining can be reduced when MPC is included. In some embodiments, the ion current of the mirror body is about 4.5 X 10·3 mm 2 /min, about 4 X l〇-3 mm 2 /min, about 3·5 x 1 〇 -3 mm 2 /min, about 3 x 1 (T3 mm 2 /min or less. However, as described herein, the ion current can be greater than 7 x 10 · 3 mm 2 / min, but still does not cause corneal dehydration staining or other clinical problems. The ion current of the lens body of the glasses of the present invention can be used generally The method is known in the art to determine the ion flux of a contact lens or a mirror body, for example, using a technique substantially similar to the 1 'Ionoflux Technique" described in U.S. Patent No. 5,849,81. For example, the spectacles to be measured may be placed between the convex and concave portions of the device that retains the spectacles. The convex and concave portions are located between the spectacles and the respective convex or concave portions. Flexible seal ring. After positioning the glasses in the device that retains the glasses, place the device that retains the glasses in the threaded cover. Screw the cover onto the glass 121841.d〇 (-63- 200813102 tube to define Raw material chamber. The raw material chamber can be filled with NaC1 with i6 ι·1 molar concentration. Solution. The receiving chamber can be filled with 8 〇mi deionized water. The conductor of the conductivity meter is immersed in the deionized water of the receiving chamber, and the mixing cup is added to the receiving chamber. The receiving chamber is placed in the 丨1 thermostat, 2 temperature is maintained at about 3 rc. Finally, immersing the raw material chamber into the receiving chamber can start measuring the conductivity every two minutes after immersing the raw material chamber into the receiving chamber for 10 minutes. About 20 minutes. The relationship between conductivity and time should be substantially linear. The lens body of the glasses of the present invention generally has high oxygen permeability. For example, the lens body has oxygen permeability of Dk not less than 60 barrer. Embodiments of the eyeglasses include a lens body having a Dk of about 80 barrer, about 90 barrer, about 100 barrer, about 110 barrer, about 120 barrer, about 13 barrer, about 14 inches or more. Conventional methods are known for determining the Dk of the glasses of the present invention. For example, the Dk value can be determined using the Mocon method as described in U.S. Patent No. 5,817,924. The Dk value can be modeled as Mocon®-Tran System. city The lens of the present invention also comprises a lens body having an ophthalmically acceptable water content. For example, an embodiment of the eyeglasses of the present invention comprises a lens body having a water content of not less than 3 %. In certain embodiments The mirror body has a water content of about 35%, about 40%, about 45%, about 50%, about 55%, about 60% or about 65%. It can be determined using conventional methods known to those skilled in the art. The water content of the glasses of the present invention. For example, a hydrated hydrogel hydrogel contact lens can be removed from an aqueous liquid, wiped to remove excess surface water, and weighed. 121841.doc -64- 200813102 The weighed glasses can then be dried in an oven at 8 (rc vacuum, and then the dried glasses can be weighed. Determined by subtracting the dry glasses from the weight of the hydrated glasses) The difference in weight. The water content (%) is (weight difference / hydration weight) χ 100. : In addition to the specific values determined above, the spectacles of the invention may have a range between any combination of the specific values determined above. By way of example, the contact lens of the present invention may have a water content of from about 45% to about 55%, an ion current value of from about 3 to about 4, a static contact angle of from about 35 to about 45. — 55.至约8〇. Before entering the contact angle, about 47. to about 55. After the contact angle, about 11. to about 25. The lag, about 〇·47 MPa to about 〇·51 _ of the Young's die Number (Young's m〇duli), elongation of about 14% to about 245%, and combinations thereof. In certain specific embodiments of the present invention, the lens body has a mode of less than 0.5 MPa. Number, less than 4 ion currents and about 42_46% water content. 纟Invented Shixi oxygen hydrogel contact lenses for correction L-eye glasses for force or enhanced vision may be spherical or aspherical glasses. The glasses may be single focus glasses or multifocal glasses, including bifocal glasses. In some embodiments, the lens of the present invention is a rotationally stable eyeglass. , such as a rotationally stable toric lens; a styrofoam stable contact lens can be a contact lens comprising a mirror body comprising a ballast. For example, the mirror body can have a ballast, surrounding ballast and/or One or more thinned upper and lower regions. The spectacles of the present invention also include a mirror body including a peripheral edge region. The peripheral edge region may include a circular portion. For example, the peripheral edge region may include 121841.doc -65 - 200813102 a circular trailing edge surface, a rounded leading edge surface, or a combination thereof. In some embodiments, the peripheral edge is completely rounded from the front surface to the back surface. Thus, it can be appreciated that the mirror body of the eyeglasses of the present invention can comprise a circular perimeter The spectacles of the present invention may comprise a lens body whose thickness distribution solves the problems associated with the current (IV) oxyhydrogel: S-shaped spectacles but which is still comfortable for the wearer of the spectacles. : # = The thickness of the mirror body and the modulus of the mirror body can control the hardness of the mirror body. For example, the hardness of the contact lens-area can be defined as the product of the Young's modulus of the glasses and the square of the thickness of the glasses in the specified area. Spectacles of the invention P - some embodiments may comprise a mirror body having a central hardness (e.g., the hardness of the center of the eyeglass or the center of the viewing zone) of less than about 0.007 MPa_mm2, a lens joint hardness of less than about 〇〇3 MPa-mm, or a combination thereof. The junction can be defined as the junction of the eyeglass region and the bevel or (for non-beveled glasses) a point of about 1.2 mm from the edge of the lens (see U.S. Patent No. 6,849,671). In other embodiments, the spectacles of the present invention may comprise a mirror body having a center, a hardness greater than G•(10)7 Mpa_mm2, a lens joint hardness greater than about 0.03 MPa mm2, or a combination thereof. <, μ of 疋, in the glasses or a large number of glasses, the physical parameters of the oxygenated hydrogel' contact lenses of the present invention, such as physical dimensions and the like, have small variability. For example, in certain embodiments, an additive such as a chain transfer agent is added to the polymerizable silicone hydrogel contact lens precursor composition. The variability in the physical properties of the lens is reduced. The variability between any two batches of glasses is preferably less than 2% using such additives that control physical parameters. For example or alternatively, the variability of the lenses of the present invention may range from about 〇 5% to about I. 9%. For example, the diameter and base curve of the glasses of the present invention can be controlled within L6% of the predetermined value. More specifically, if the target contact lens diameter is 121841.doc -66- 200813102 14.0 mm, and if the actual diameter of the contact lens in a batch of contact lenses varies from about 13.6 mm to about 14_4 mm, then the contact lens can be used. One or more additives are used during production to reduce variability and produce contact lenses having a diameter ranging from about 8 mm to about i4.2 mm. Similar controls can be provided to reduce: variations in lens thickness, radial depth, base curvature, and the like. The oxygenated hydrogel contact lenses of the present invention can be provided in a sealed package. For example, the oxygenated hydrogel contact lenses of the present invention can be provided in a sealed foamed package or other similar container suitable for delivery to a lens wearer. Glasses can be (\^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ bath solution including phosphate buffered saline solution and borate buffer solution. If necessary, the solution may include disinfectant or may Disinfectant or preservative. If necessary, the solution may also include a surfactant such as poloxamer and the like. The lenses in the package are preferably sterile. For example, the glasses can be sealed in G Such as the bacterium or can be sterilized in a sealed package. The sterilized glasses can be glasses that are exposed to the sterilizing amount of radiation. For example, the glasses can be glasses treated with high-M da, gamma-radiated glasses, Glasses exposed by ultraviolet light and the like. EXAMPLES The following examples illustrate some aspects and advantages of the invention, but the invention is not considered to be limited to the specific embodiments described below. - Unless otherwise indicated, The practice of the invention will employ well-known techniques for polymer synthesis, hydrogel formation, and the like within the skill of the art. Such techniques are fully described in the literature. Unless specifically stated to the contrary, no. 121841.doc -67· 200813102 then Reagents and materials are commercially available. Methods for preparing contact lenses, such as neohydrogenated hydrogel contact lenses, are described in U.S. Patent Nos. 4,121,896, 4,495,313, 4,565,348, 4, 64〇, 489, 7889, 664, 4,985,186, 5,039,459, 5,080,839, 5,094,609, 5,26, nickname, 5,6,7,518, 5, 760, 100, 5, 850, 107, 5, 935, 492, 6, 099, 852, 6 367, 929, 6,8225016, -6, 867, 245 ^ ^ ^ ^ Publications No. 20030125498, No. 20050154080, and No. 20050191335 In the following examples, while efforts have been made to ensure accuracy with respect to the numbers used (eg, amount, temperature, etc.), certain experimental errors and deviations should be resolved. Unless otherwise noted, the temperature is in .c and the pressure is Below sea level is atmospheric pressure or near atmospheric pressure. The following well-known chemical substances are mentioned in the examples, and in some cases, are mentioned by the abbreviations mentioned below. Substances and methods, abbreviations. AE: allyloxyethanol DI: deionized HEMA: 2-hydroxyethyl methacrylate IPA: isopropanol MMA: methyl methacrylate 121841.doc .68- 200813102 M3U: M3-U; α-ω - bis(fluorenyl propylene oxyethyl imino carboxy ethoxy propyl) _ poly (dimethyl methoxy oxane poly(trifluoropropyl methyl decane) - poly (ω-methoxy - poly(ethylene glycol) propylmethyl decane; dimethyl methacrylate oxime macromonomer The M3U used in the following examples is represented by the following formula, wherein η is 121 and m is 7.6, h is 4.4, p is 7.4, and Μη=12,800, and Mw=16,200 (Asahikasei Aime Co" Ltd" Japan) 〇C3H6(OC2H4)pOCH3 CH3 〇H3 CH3 C2H4CF3 ch3 ch3 H2C=CCOOC2H4NHCOOC2H4OC3H6〒iO—(〒iO)n -10) m-〒0)h-fi-C3H6OC2H4OCONHC2H4OCOC=CH2 ch3 ch3 ch3 ch3 ch3 M3U coloring: dispersion of β copper phthalocyanine in M3U (% by weight). Copper phthalocyanine is available from BASF as Heliogen Blue® 7090. N,N-DMF : DMF ; N,N-dimethylformamide NVP: 1-vinyl-2-pyrrolidone (fresh distillation under vacuum) PDMS : polydimethyl methoxy hydride PDMS-total - PEG: block copolymer of polydimethylsiloxane and PEG, which contains 75% PEG and MW 600 (DBE712 from Gelest) PEG: polyethylene glycol PP: propyl propylene Pr: propanol TEGDMA: two Triethylene glycol methacrylate TEGDVE: triethylene glycol divinyl ether TPO: biphenyl (2,4,6-trimethylbenzylidene) phosphine oxide TPTMA: trimethyl methacrylate trimethyl Propylene g-ester 121841.doc -69- 200813102 UV416: 2-(4-phenylmercapto-3-hydroxyphenoxy)ethyl acrylate Vazo-52 : 2,2'-azobis (2,4 - dimethyl valeronitrile) (V-52; thermal initiator)

Vazo-64: azobisisobutyronitrile (V-64; thermal initiator) VMA ··N-vinyl-N-methylacetamide (fresh distillation under vacuum) VM: vinyl methacrylate characterization glasses Method of Advancing Contact Angle/Retraction Contact Angle The advancing contact angle can be determined using conventional methods known to those skilled in the art. For example, a conventional droplet shape method such as a sessile drop method or a trapping bubble method can be used to measure the contact angle and the receding contact angle of the contact lens provided herein. The Kruss DSA 100 appliance (Kruss GmbH, Hamburg) and the DA Brandreth: ''Dynamic contact angles and contact angle hysteresis'', Journal of Colloid and Interface Science, can be used for the front and back water contact angles of the hydrogel contact lenses. Vol. 62, 1977, pp. 205-212 and R. Knapikowski, M. Kudra: Kontaktwinkelmessungen nach dem Wilhelmy-Prinzip-Ein statistischer Ansatz zur Fehierbeurteilung", Chem. Technik, Vol. 45, 1993, pp. 179-185 and Measured as described in U.S. Patent No. 6,436,481. For example, the advancing contact angle and the receding contact angle can be measured using a capture bubble method using phosphate buffered physiological saline (PBS; ρ Η = 7.2). The lenses were spread on a quartz surface and rehydrated with PBS for 10 minutes prior to testing. The bubble is placed on the surface of the lens using an automatic injection system. The bubble size can be increased and decreased to obtain the receding angle (the platform is obtained when the bubble size is increased) and the advancement (the platform is obtained when the bubble size is reduced). The modulus can be determined using conventional methods known to those skilled in the art to determine the modulus of the lens. For example, a contact lens with a width of about 4 mm can be cut from the center of the lens, and the tensile modulus (in MPa) can be used by itself.

Instron 3342 (Instron Corporation) was determined by initial slope of the stress 4 strain curve obtained by tensile testing at a rate of 10 mm/min in air at least 75% humidity at 25 °C. Ion Current The ion current of the lens body of the glasses of the present invention can be determined using conventional methods known to those skilled in the art. For example, the ion current of the contact lens or lens body can be measured using a technique substantially similar to nI〇noflux Teehnique, described in U.S. Patent No. 5,849,811. For example, the spectacles to be measured can be placed between the convex and concave portions of the device that retains the spectacles. The male and female portions include a flexible sealing ring between the eyeglasses and each of the male or female portions. After positioning the glasses in the means for retaining the glasses, the means for retaining the glasses is placed in a threaded cover. Screw the cover onto the glass to define the material chamber. The raw material chamber can be filled with 16 ml of 0. 1 molar NaC1 solution. The receiving chamber can be filled with 80 ionized water, the conductor of the conductivity meter is immersed in the deionized water of the receiving chamber and the stir bar is added to the receiving chamber. The receiving chamber was placed in a constant dish 1 to maintain the temperature at about 35 °C. Finally, the raw material chamber/texture chamber is brought to the center. The conductivity can be measured every two minutes after immersing the material chamber in the receiving chamber for a period of about two minutes. The relationship between conductivity and time should be substantially linear. Oxygen Permeation 1 can be measured using conventional methods known to those skilled in the art. 121841.doc -71 - 200813102 The Dk of the glasses of the present invention is determined. For example, the Dk value can be determined using the Mocon method as described in U.S. Patent No. 5,817,924. The Dk value can be measured using a commercially available instrument of the Mocon Ox-Tran System model name. The equilibrium water content can be determined using conventional methods known to those skilled in the art to determine the water content of the lenses of the present invention. For example, a hydrazine hydrated hydrogel contact lens can be removed from an aqueous liquid, wiped to remove excess surface water, and weighed. The weighed glasses can then be dried in an oven at 8 ° C in vacuum and the dried glasses can then be weighed. The weight difference was determined by subtracting the weight of the dry glasses from the weight of the hydrated glasses. The water content (%) is (weight difference / hydration weight) χ 100. EXAMPLE 1 Preparation of a Low Modulus Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition A polymerizable silicone hydrogel contact lens precursor composition was prepared using the reagents and relative amounts specified below. Due to the low modulus of the resulting hydrated contact lens product, this formulation is referred to herein as a "low modulus formulation" or "LMF,". Table 1 Compound (abbreviation) Unit weight ° / ❶ (weight ratio) M3U 35 27.8 VMA 47 37.4 MMA 17 13.5 TEGDMA 0.2 0.2 VAZO-52 0.5 0·4 UV416 0.9 0.7 TlNT (PB15; phthalocyanine blue, m3u transport 7 0.1 0.1 DBE712 (dream oil) 25 19.9

U Weining 125.17 copies Weighing table! The ingredients are combined and mixed to form a mixture. The mixture was filtered into a vial via a 〇2 2 〇〇 microinjection filter and stored for up to about 2 weeks. 121841.doc -72- 200813102 (This mixture is referred to herein as a polymerizable lithothere hydrogel contact lens precursor composition). In the table! In addition to the respective weight percentages (expressed by weight/weight; weight ratio), a unit amount of each compound is provided. In the final oxime hydrogel contact lens, the percentage of each chemical component is more closely related to the unit amount present rather than the corresponding π ratio. Example 2 Manufacture of a Hydroxyl Hydrogel Contact Lens f) A large number of precursor compositions from Example 1 were degassed using a repeated vacuum/nitrogen rinsing procedure. The degassed precursor composition is then placed into a concave non-polar resin mold member. The filled female mold member is then closed by contact with a non-polar resin male mold member under the pressure required to achieve a tight fit. Then, the mixture was cured in a nitrogen batch oven in the following cycle: • 30 min at room temperature, 30 min & 8 at 550 C (6 sec at rc. Demold by tapping the concave mold member of the contact lens mold) So that the protruding member is released therefrom, wherein the polymeric (tetra) hydrogel contact lens product adheres to the convex mold member. The lens is removed by a floatation method or using a mechanical lens removal device. The floatation method includes containing dry glasses. The convex mold member is immersed in the bucket water. The spectacles typically leave the mold within about 10 minutes. The gas is interposed between the contact lens products by compressing and rotating the polymerized hydrogel contact lens product to its convex mold member. A mechanical vacuum is applied between the rotating male mold member and the exposed surface of the contact lens product. The separated lens is then loaded onto a plastic tray for extraction and hydration. 0 121841.doc •73- 200813102 Change the glassware containing the polymerized hydrogel contact lens product to a solvent liquid (such as industrial methyl = fine _ with 95% ethanol and 5% methanol) for 45 min at room temperatureThe solvent was then drained and the procedure was repeated with fresh <1>10 (3 times), 1:1 alcohol/water (3 times) and DI water (3 times). The hydrated spectacles are stored in a glass vial or blister pack containing the money or stored in a (4) salt buffered physiological saline solution having a pH of 7.1·7·5. The sealed vessel autoclave treatment was carried out under 12 passages. After the autoclave treatment for 24 h, the glasses were measured. The water weighs the resulting hydrated hydrogel contact lens, and is weighed again to determine the dehydrated hydrogen peroxide water and then de-gel the contact lens in an oven as described herein, 敎 glasses characteristics, such as contact Angle (including dynamic contact angle and static contact angle), sex, ion current, modulus, elongation, tensile (IV) 'water content and similar characteristics. The wettability of the water-cut oxygen hydrogel invisible eyeglasses is also detected by measuring the water dispersing time of the glasses. Eye compatibility was further tested during the dispensing study, where the contact lenses were placed on the human eye for i hours, 3 hours or 6 hours or longer, and then clinical evaluation was performed. The oxime oxygen hydrogel contact lenses produced by the formulations of the present invention have an ophthalmically acceptable surface wettability. The hydrogel contact lenses have an equilibrium water concentration (EWC) of 44% and have an extractable content of 48 9+/_〇 7%. The resulting hydrated contact lens has the following characteristics: 121841.doc -74- 200813102 Table 2 Characteristic value Balanced water content (EWC) 43-45% Oxygen permeability (Dk) 109 barrer Static contact angle (capture bubble wetting angle) 36° Dynamic Contact angle (advancing contact angle) 71° Dynamic contact angle (reverse contact angle) 49° Hysteresis (forward-reverse) 22° Refractive index L398 Ion flow 3-4 Modulus 0.4-0.5 Mpa Tensile strength 0.55-0.6 Mpa at the end In the glasses, after the extraction procedure, most, if not all, of the eucalyptus oil is extracted with the unreacted monomer or linear polymer component. In this example, no oil was detected after extraction. A series of lenses were prepared for clinical evaluation. Spectacles were prepared from the precursor composition as described in Example 1. The batch of glasses is characterized and has the following characteristics. Ο 121841.doc 75- 200813102

v£< 25C1FB07 I 43.69 ± 0.37 36.4 Soil 0.1 76.1 Soil 4·0 47.9 Soil 0.7 28.2 0.45 Soil 0.03 340.2 Soil 161.0 0.58 ± 0.26 3.04 Soil 0.10 8272 25C1FB06 43.84 ± 0.42 36.7 Soil 0·6 67.4 ± 4·4 ί 47.4士L8 20.1 0.41 土0·02 466.9土43·7 0.66 土0·04 3.04 士0.07 7883 25C1FB05 43.85士0.38 36·7 士0.5 7U 士5·5 48.4 士1.0 22.7 0·57 土0.03 508.6土93.2 1.18士0.25 3.08 soil 0· 18 6742 25C1FB04 44.37 soil 0.36 | 37.6 ± 0.366.5 ± 2.1 48.0 soil 0·4 18.5 0.53 ± 0.07 395.7 soil 60.2^ 0.78 soil 0.21 3.21 ± 0.19 8291 25C1FB03 45.52 soil 0.70 36.0 ± 0.5 | 1 72.3 Earth 1.8 1 | 46.7士 0.1 | | 25.5 1 0.39 士0·07 449.4士53.7 0.70 土 0.15 2.36 士 0.29 11148 25C1FB02 45·0 士0·51 36.3 士1.3 ί 65·5 士 1.2 | 47.7士0.7 | 17.8 0.39土0.01 302 soil 181.9 0.43 ± 0.18 3.18 ± 0.07 9855 25C1FB01 43.79 ± 0 · 33 36.0 soil 1.4 66.9 soil 2 · 8 | 47.6 soil 0.7 | | 193_I 0.47 soil 0.01 170.2 ± 100.2 0.33 soil 0.11 2.65 soil 0.13 11482 glasses static (°) (ADV,.) Back ( REC, 勹 hysteresis (〇) Modulus (mPa) Elongation (%) Tensile strength (mPa) JSS fH # GPC reading (reaction per milligram of dry glasses) I25C1FB14 43.42d=0.72 37.0 ± 0.8 70·7 ± 4.7 1 47.1 ± 0.6 I 23.6 0.49 ± 0 · 02 496.8 ± 89.4 0.92 soil 0.20 2 · 72 soil 0.14 10005 25C1FB13 44 · 48 ± 〇 · 42 38 · 1 ± 0.6 | 75.1 ± 2.2 1 48.6 ± 1.4 26.5 0.46 soil 0.03 i 340.9 ± 117.7 0·59 Soil 0.21 2.7 士 0· 14 9735 25C1FB12 42.68 土 0·70 1 36.5 地 0.9 67·8 士士 3.0 | 47.5土0·8 | [204____1 0.52 土0·12 ί 256.3土191.1 0.61 土0·50 2.60 Soil 0.04 7020 25C1FB11 43·32 ± 0.76 36.9 Soil 0.6 73.3 Soil 0.4 49.2 ±1·0 24.1 0.48±0.13 412·8 Soil 7·3 0.70 ± 0.23 1 2.62 ± 0.20 7810 25C1FB10 44.56 ± 0.39 | 35.9 Soil 1·9 i | 57.9土3.5 | | 47·7士1·2 1 1 10.2 1 0.55 士0.03 443.1±51.3 | 0.92士 0.20 | 2.81 土0.02 10879 25C1FB09 46.1 士0·37 37.5 土0·3 ί 72.5 土3.7 1 47.6 ±〇.l ] 24.9 0·43 士0·02 151.8 士100.7 0.30 土 0.12 2.65 士 0.18 11514 25C1FB08 45.14士 0.43 | | 35.9土1.0 69.6 Soil 3.7 48·1 士 0·6 21.5 0.44 士 0.05 | 412.3士63.0 | 0.63 土 0·07 3.32 土 0·29 10340 Glasses Μ Static (°) Forward (ADV,. ) Back (REC, Q) Hysteresis (0) Modulus (mPa) Elongation (%) Tensile strength (mPa) Ion flow (1 (T3 mm2/min) GPC reading (reaction per milligram of dry glasses) 121841.doc -76- 200813102 ue< 1 25C1FB18 1 43.90 soil 0·85 | 36.5 ± 0·8 II 67.5 ± 1.9 I 49.1 ± 0.5 18.4 0.41 soil 0.06 458.4 ± 85.1 0.81 soil 0.23 2.15 ± 0.15 10671 25C1FB17 43.59 soil 0.63 37.1 ± 0.7 73 ·7 soil 3.5 47.8±0.5 j 25.9 0.51±0.10 455.4 soil 43.6 0.92 ± 0.11 2.47 ± 0.09 11598 25C1FB15 43.23 soil 0.60 36.7 ± 0.3 73.5 ± 2.5 | 47.3 ± 0.2 | 26.2 I 0.43 soil 0.05 424.5 soil 22.2 0.71 soil 0.05 2.74 0.09 10741 Glasses static (°) Advance (ADV, 0) Back (REC, °) Hysteresis (.) Modulus (mPa) Elongation (%) Tensile strength (mPa) JSS Cone GPC reading (reaction per milligram of dry glasses) 121841.doc -77- 200813102 In the above tables, the GPC value is the relative reading of the residual removable content after extraction and hydration. Using chloroform as the final extraction solvent for contact with previously extracted contact lenses, extraction and hydration The total residual/extractable content afterwards is about 0.4% to Within 2% range. For each group of glasses, 3 to 5 replicate samples were measured. Example 3; Preparation of fine-tuned low modulus polymerizable silicone hydrogel contact lens precursor composition (; Reagents and amounts to prepare a polymerizable silicone hydrogel contact lens precursor composition. This formulation is attributed to the low modulus and low batch-to-batch variation in the resulting hydrated hydrogel hydrogel contact lens product. It is called π fine-tuning low-modulus formulation π or nMLMFn. Table 4 Compound (abbreviation) Unit weight% (weight ratio) M3U 35 VMA 47 MMA 17 TEGDMA 0.2 VAZO-52 0.5 UV416 0.9 TINT (PB15; Phthalocyanine blue, m3u Blue) 0.1 DBE712 (矽油) + AE1 25 121841.doc -78- 1 The ratio of AE to oyster sauce is in the range of 0.1 to 5 parts AE and 99.9 to 95 parts eucalyptus oil. Total: 125.17 parts The components in Table 4 above were weighed and mixed to form a mixture. The mixture was filtered into a vial via a 0.2-5.0 micron syringe filter and stored for up to about 2 weeks. 200813102 The composition of the blood-slurry of the body composition is different from that of the body composition described in Example 1, in which the scorpion oil component includes strontium. The heart is added to the Shixia oil, and then the Shixia oil is mixed with other chemical agents contained in the precursor formulation, and is advantageously used for the variability of the size and physical properties of the hydrated contact lens product. The dispensing of the contact lenses was carried out essentially as described in Example 2 above. The resulting hydrated contact lens has physical properties similar to those described in Example 2, with the following advantageous exceptions - the variability of either or both of the spectacles diameter, read and ion flow is generally lower than in the absence of AE Their variability in the formulations prepared. Example 4 Preparation of a finely tuned low modulus polymerizable gas condensed contact lens pre-media composition containing varying amounts of dilute propoxyethanol and characterization of the resulting dream oxygen hydrogel contact lens product The following experiment was carried out to The step study adds a different amount of dilute propoxyethyl n to the Shixia oil which reduces the effect of batch variations in the size and physical properties of the final extracted hydrated contact lens product. A monomer mixture (polymerizable hydrophobic hydrogel precursor composition) was prepared as described in Examples 1 and 3. The composition of the formulation is the same as that described in the above example 其 'The exception is that the extractable Shixia oil component contains various amounts of praline propoxyethanol·· 2、, 2, 4 and 6% in the dream oil. . Details of the formulations are provided in Tables 4 and 5 below. Various isopropoxy alcohols were added to each of the three different grades of Gelest. The monomer mixture is smashed and degassed, dispersed on the lens forming surface of the concave polypropylene contact lens 121841.doc-79-200813102, and the male mold member is engaged with the concave mold member to form the contact lens A contact lens mold containing a monomer mixture in the chamber. The EF (expansion coefficient) of the tool is about 1.1% or the outer diameter of the steel contact lens mold insert is about 14.3 mm. Curing was carried out under N2 in a batch oven. The filled mold is usually placed in an N2 batch oven, « and cleaned with N2 for 30 min to reduce the oxygen content to less than 1000 ppm, then * first heated to 55 °C for 30 min, then heated to 80 °C for 60 min 〇 Table 5 25 °C formulation with various AE concentrations 〇 chamber reference number M3U article number 矽 oil number ΑΕΛΟ / 〇 1 25C-0AE-A1 050906 5L-7902 0 2 25C-2AE-A1 050906 5L- 7902 2 3 25C-4AE-A1 050906 5L-7902 4 4 25C-6AE-A1 050906 5L-7902 6 1 25C-0AE-B1 050906 7H-11038 0 2 25C-2AE-B1 050906 7H-11038 2 3 25C-4AE -B1 050906 7H-11038 4 4 25C-6AE-B1 050906 7H-11038 6 1 25C-0AE-C1 050906 7E-10627 0 2 25C-2AE-C1 050906 7E-10627 2 3 25C-4AE-C1 050906 7E-10627 4 4 25C-6AE-C1 050906 7E-10627 6 Percentage of 烯* allyloxyethanol (AE%) means the allyloxy group contained in eucalyptus oil, the weight percentage of ethanol 121841.doc -80- 200813102 Table 6 has various Allyloxyethanol concentration 25 ° C formulation chamber reference number M3U article number 矽 oil article number 矽 oil / AE 1 25C-20SO-A1 50906 5L-7902 WITH 4% AE 20 2 25C-23SO-A1 50906 5L-7902 WITH4% AE 23 3 25C-26SO-A1 50906 5L-7902 WITH 4% AE 26 4 25C-29SO-A1 50906 5L-7902 WITH 4% AE 29 1 25C-20SO-A1 50906 10627 WITH 0.1% AE 20 25C-23SO -A1 50906 10627 WITH 0.1 %AE 23 3 25C-26SO-A1 50906 10627 WITH 0.1%AE 26 Li_ 25C-29SO-A1 50906 10627 WITH 0.1 %AE 29 1 25C-20SO-A1 040819bR 5L-7902 WITH 4%AE 20 2 25C-23SO-A1 040819bR 5L-7902 WITH 4%AE 23 3 25C-26SO-A1 040819bR 5L-7902 WITH 4%AE 26 4 25C-29SO-A1 040819bR 5L-7902 WITH 4%AE 29 1 25C-20SO- A1 040819bR 10627 WITH 0.1 %AE 20 2 25C-23SO-A1 040819bR 10627 WITH 0.1%AE 23 25C-26SO-A1 040819bR 10627 WITH 0.1 %AE 26 4 25C-29SO-A1 040819bR 10627 WITH 0.1 %AE 29 After curing, at Demolding and mirror removal on a benchtop stripper. All formulations of the glasses showed good release/off mirror characteristics. The dried glasses were loaded in a polypropylene pan, and successively washed with ethanol, ethanol-water and water for about 30 minutes to extract and hydrate, and contacted with hot water. The extracted and hydrated lenses were then placed in vials containing pH 7.2 PBS buffer (containing surfactant) and autoclaved. The glasses were measured and examined one day after the high pressure helium treatment. Only the dimensions and physical properties of the unshaped glasses are measured, including diameter, base curve, equilibrium water content, static and dynamic contact angles, tensile properties (modulus, tensile strength and elongation), and ion current. RESULTS: Various amounts of allyloxyethanol were added to the eucalyptus oil as one (1) to reduce the difference between the batches of 121841.doc -81 - 200813102 in the obtained extracted/hydrated hydrogel hydrogel contact lens products, and (ϋ A way to provide contact lenses of the desired size and physical properties. The diameter and physical properties of the high pressure enthalpy of the extracted hydrated contact lenses are provided in Table 7. The relationship between diameter, equilibrium water content, and ion current and allyloxyethanol content are shown in Figures 4, 5 and 6, respectively.

121841.doc -82 - 200813102

U g VO o TH Race <N 〇gN > Q OO r-H ON (N 41 v〇s cn 〇cn +1 β mg ? 4 g 3 οο (NO ro 00 o 跻Uij^ (N m Λ 03 σ; in 03⁄4 in PH si 鹚S o 2 rH oo et al o magnetic w inch O 00 ro o 屮cn 沄o 'OQ\ <N Ο -Η g (Ν uo CN Ό σ\ 〇Co 〇-Ή vq Ο cn ο go (Ν cn inch / g \ 羞 • Η On Os 卜〇cn S — IT) AH < ώ < o ό (NH < ώ < (N ό to CN Η < ώ < ό ό (Ν τ-Η < ώ ό CN 0 U g vo o rH 〇rH 1 (〇) AQV inch cn temple iri (N m cr; 00 1 rH rH Λ m ov o 〇 v〇msm 〇o 卜 ^ -H 〇rH TH Λ (N On in in Β U s § inchο s § C±1 inch o 屮录 (N rH c5 -Ή o cn 00 (N o rH (N r- o -H m ^s 〇tH o -H rH υ Μ (N CN o 0 -Ή ON 01 in oo O -Ή s rH v〇m S mo inch /gs ί Η 卜rH 莩rn cn cn B1 series (M3U:050906, SO:11038 < ώ < O ό in <N rH < (N ό CN Τ-Ή < ώ c inch ό (N rH < 'O ό - -83-

^s U g ν〇o 寸o (〇)Λαν m CO o? tH 卜(N rH this 00 v〇om 1—H o 岑in cn Ph 1 o (N 00 d et s rH in rH o cn 00 rH Λ in CL, so ▼-H 寸o rH oo rH in o Record <N (N 〇00 〇\ (N 00 o -H ON (N 〇-H cn in tH g 〇-Ή m cn rH UU 〇o +1 inch - inch (N cn 〇-H (N inch?; 〇(N 〇o ▼-H 〇/g\ 1 cn 00 oo rn 卜 cn rn rH A1 series (M3U:050906, 1 SO: 10627) < ώ ό ^T) (N < w <<N ΰ (N < inch ό (N rH < ό (N

121841.doc 200813102 As shown in Figure 3, 25 parts of the eucalyptus/AE mixture were used in all three formulations (Series A1, B1 &C1); the diameter of the spectacles decreased as the AE content in the mixture increased. Each series corresponds to a contact lens prepared from a given article of eucalyptus oil, wherein the eucalyptus oils used in each series of Al, B1 and C1 are different.

The glasses produced by the U A series are larger than those produced by the series B or c. Early clinical trials using 25A glasses without the addition of AE's Series A enamel resulted in glasses with a relatively high rate of dehydration dyeing, while glasses made from the series c oyster sauce had a more satisfactory (lower) dehydration dyeing rate. . Therefore, it is desirable to determine that the efficacy of Series A No. 矽 oil should be increased to achieve even more desirable clinical characteristics of the lens. (The efficacy of a particular batch of polyoxyalkylene oxide (e.g., eucalyptus) is believed to produce the final extracted hydrated spectacles product at a given concentration having a diameter that is reduced from the diameter of the contact lens mold used: the ultimate spectacles The larger the diameter of the lens of the product is, the larger the polyoxygen oxide (4) is. The better is to produce the final eyeglass product with the diameter of the contact lens mold diameter of 98.98 M.G2 times. ). For example, referring to Fig. 3, 4% ae is added to the series a Shixia oil number to produce the same diameter of the glasses as the diameter of the second pair of glasses produced by the series of the oils before the addition of allyloxyethanol. As shown in EW=6 and illustrated in Figures 4 and 5, respectively, such as EWC/ is observed. And a similar trend in the characteristics of the ion current. Thus, the addition of a polyoxyalkylene oxide extractable component (such as a toluene to a gentleman M m W shifting agent to an exemplary (iv) propoxyethanol) effectively fine-tunes the di-K-drive composition to provide similar beneficial physics. The most characteristic, the ability of wire-shaped glasses products. Particularly preferred are extracted hydrated contact lenses having an equilibrium water content in the range of from about 40,184.doc -84 to 200813102 of about 40 to about 50%, an ion current in the range of from about 2 to about 5, and a modulus of less than about 1.2 MPa. . As indicated earlier, the SO of the 5 L batch can be adjusted by adding 4% AE. For SO batches 10627 and 1 1038, it is already highly efficient, and therefore only 0.1% of AE is added for fine tuning. To further confirm this fine tuning concept, 4% AE was added to the SO 5L batch and AE of 0.1 °/〇 was added to the SO 10627 batch. Two batches of M3U were used to make 25C glasses with 20, 23, 26 and 29 fine-tuned SO (or S0/AE mixtures) as listed in Table 5. The eye f' mirror characteristics are listed in Table 8. Table 8 Characteristics of glasses with different AE-SO loads

A1 (M3U: 050906, SO: 5L-7902) D (mm) EWC% Ion flow modulus (mPA) 20SO-A1 14.52 44.47 ± 0.64 3.35 Soil 0.1 0.42 ± 0.01 23SO-A1 14.3 44.78 ± 0.39 26SO-A1 14.16 43.42 ± 0.50 2.61 ± 0.19 0.41 ± 0.03 29SO-A1 13.99 43.45 ± 0.42 B1 (M3U: 050906, SO: 10627) D (mm) EWC% Ion flow modulus (mPA) 20SO-B1 14.4 42.94 ± 0.40 3.31 ± 0.2 0 · 46 士0.04 23SO-B1 14.34 42.91 士0.66 26SO-B1 14.14 43.10 士0·77 3.23士士 0.3 0·54 士0.03 29SO-B1 13.95 43.10 土0.44

Cl (M3U: 040819bR, SO: 5L-7902) D (mm) EWC% Ion flow modulus (mPA) 20SO-C1 14,55 44.97 soil 0.38 3.56 ±0·19 0.52 ±0.03 23SO-C1 14.3 44.88士0.80 26SO -C1 14.14 44.23士0.56 2.66士0·26 0.51士0.04 29SO-C1 13.91 43.73士0·30 D1 (M3U: 040819bR, SO: 10627) D(mm) EWC% Ion flow modulus (mPA) 20SO-D1 14.44 43.89士0.69 3.16士士 0.17 0·49士士0.02 23SO-D1 14.3 44.45士0.93 26SO-D1 14.1 43.16 土0.89 2.43 土 0.11 0.55士 0.05 29SO-D1 13.85 42.06士0·97 121841.doc -85- 200813102 The diameter and s 〇 、, - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The higher the diluent loading, the greater the amount of material removed after extraction and, therefore, the smaller the diameter of the final lens. & Yu Shixi, oil loading content of 20% and 29. /. The diameter data is similar to the performance of the two fine-tuning oyster sauces. These results confirmed that the addition of 4% AE to the crushed oil extractable component effectively "fine-tuned or fine-tuned the exemplary extractable component s〇 5L to match the efficacy of SO 10627 containing only 〇·丨% AE. Γ Ο See the case of the non-fluorinated dimercaptopropenyl fluorenyloxy macromonomer M3U. The money indicates that the diameter of the glasses varies within about a batch of coffee. As can be seen in Figures 6 and 7, the slope of the lake to the lake is about _〇·〇6 reading ❻SO. With the extrapolation of this data, in order to provide glasses with similar diameters, an SO (pre-conditioning) content of about 25% and 4% is selected. 3. The general relationship between the diameter and ion current and equilibrium water volume of all 25C formulations listed in (4) 8 is shown. Referring to Figure 8, it can be seen that the diameter and water content: two are in strong correlation' and there is also a strong correlation between ion current and water content. Based on this figure, it is apparent that the ion current can generally be predicted based on the equilibrium water content. It will be appreciated by those skilled in the art to which the present invention pertains that various modifications and other embodiments of the present invention have the benefit of the teachings presented in the foregoing description. Because of the help of the _ example disclosed in this article, such as borrowing but __ example. Although the fourth embodiment is modified, replaced, and the conjugated manner is intended to cover all modifications and equivalents of the embodiments, as defined by other disclosures, may belong to the invention 121841.doc -86-200813102 Spirit and scope. Although specific terms are employed herein, they are used in a generic and descriptive sense only and not limiting. A large number of publications and patents have been cited above. The cited publications and patents are each incorporated herein by reference in their entirety. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a block diagram illustrating an exemplary method of producing a Nishui Hydrogel contact lens. Figure 2 is a block diagram showing the composition of the present invention, the lens product, and the contact lens. 囷3 is shown in the polyoxyalkylene oxime used as the extractable component for forming a hydrogen peroxide hydrogel contact lens. The effect of increasing the allyloxyethanol content as a function of the diameter of the contact lens product obtained after the extraction of the obtained hydration autoclave as described in Example 4. Figure 4 is a graph showing the invisible shape used to form the hydrogel. The effect of increasing the content of the dilute propoxyethanol in the polyoxyalkylene oxide of the extractable component of the glasses and the contact lens obtained by the extraction of the hydrated high pressure dad described in Example 4 """ The relationship between the equilibrium water content and 囷5 is to show the effect of increasing the allyloxyethanol content in the polyoxyalkylene oxide used as the extractable group for forming the helium-oxygen hydrogel contact lens. FIG. 6 is a graph showing the relationship between the ion flux of the contact lens obtained after the extraction of the hydrated high pressure dad, and the diameter of the hydrated (four) mirror (mm) and the use as described in Example 4. Specific fluorine Exemplary polyoxyalkylene oxime/ene in the polymerizable precursor composition of the acrylonitrile-based macro-monomer (stored 3MU) 121841.doc -87- 200813102 The relationship between the percentage of extractable components of propoxyethanol Graph 。7 indicates the diameter (mm) of the extracted hydrated contact lens and the polymerizable precursor composition using a specific fluorine-containing dimethyl propylene fluorenyloxyl macromonomer (yellow M3U) as described in Example 4. The relationship between the percentage of extractable components of the exemplary polyoxyalkylene oxime/allyloxyethanol. 囷8 indicates that the equilibrium water content varies with the percentage of the self-polyoxyalkylene oxime/allyloxyethanol extractable component. Various polymerizable precursor compositions

The general relationship between the diameter of the final extracted hydrated contact lens product and the ion current. [Key component symbol description] (/ 102 placement 104 sealing 106 solid > 匕 108 stripping 110 mirror 112 extraction 114 hydration 116 package 118 sealing and sterilization 202 polymerizable oxygenated hydrogel glasses precursor composition 204 pre Extraction of polymeric oxygenated hydrogel contact lenses 206 Extraction of hydrogenated hydrogel contact lens products 208 Hydrated hydrogel contact lenses 121841.doc -88-

Claims (1)

200813102 X. Patent Application Range: 1. A polymerizable silicone hydrogel contact lens precursor composition comprising (1) about 25% by weight to about 35% by weight of a reaction dimethyl propylene fluorenyl oxime a molecular monomer, (ii) at least about 45% by weight of a monomer composition containing no antimony, and (iH) a polyoxyalkylene antimony extractable component, wherein the antimony-free monomer composition comprises a hydrophilic content Vinyl monomer, acrylic monomer, and acrylate functionalized ethylene oxide oligomer. 2. The polymerizable silicone hydrogel contact lens precursor composition of claim 1, wherein the polymer lens precursor composition further comprises an ultraviolet absorber and a color former. 3. The polymerizable silicone hydrogel contact lens precursor composition of claim 1 or 2, wherein the reactive fluorine-containing dimethyl propylene fluorenyloxy macromonomer has an average molecular weight of greater than about 2,500. 4. The polymerizable silicone hydrogel contact lens precursor composition of any of claims 3 to 3 comprising from about 45 to about 55% by weight of a monomer group containing no hydrazine. 5. If requested! The polymerizable silicone hydrogel contact lens precursor composition of any of the above 4, comprising from about 10% to about 30% by weight of the polyoxyalkylene oxygen extractable component. 6. The polymerizable silicone hydrogel contact lens precursor composition of claim 2 which is such that the colorant is a phthalocyanine pigment. 7. The polymerizable silicone hydrogel contact lens precursor combination of claim 2 or 6 121841.doc 200813102 wherein the colorant is phthalocyanine blue. 8. The polymerizable silicone hydrogel contact lens precursor composition of claim 2, wherein the t outer absorbent is photopolymerizable via bis-mercapto ketone. 9. The polymerizable lithothere hydrogel invisible spectacles precursor precursor according to claim 8 wherein the δ hai ultraviolet absorbing agent is 2-hydroxy-4-acryloxyethoxy ethoxybenzene. 10. The polymerizable ♦ oxyhydrogel contact lens assembly according to any one of claims 1 to 9, wherein the reactive fluoropropenyl hydrazine macromolecular body is a ♦ double ( Methyl propylene ethoxyethyl imino ruthenyloxy group) poly(monodecyl oxynoxy) poly(trifluoropropylmethyl oxynoxy) _ poly(1-methoxy- Poly(ethylene glycol) propylmethyl decane) (Μ3υ). 11. The polymerizable 7 oxygen hydrogel contact lens precursor composition of any one of claims 1 to 1G wherein the monomer composition containing no antimony comprises N-vinyl-N-methylacetamide , methyl acetonate methyl vinegar and dimethyl propylene triacetate - alcohol vinegar. 12. The polymerizable silicone hydrogel contact lens financial composition according to any one of items 1 to 3, wherein the polyoxyalkylene hydrous extractable component further comprises a chain transfer agent. 13. The polymerizable silicone hydrogel contact lens precursor composition of claim 12 wherein the oxime chain transfer agent is selected from the group consisting of thiols, monothioethers, organic dentates, and allylic oxygen. Base alcohol. The polymerizable silicone hydrogel contact lens precursor composition of claim 13, wherein the chain transfer reagent is allyloxyethanol. 15. The composition of the polymerizable shihe oxygen hydrogel invisible spectacles precursor precursor 121841.doc 200813102 wherein the polyoxyalkylene oxime oxygen extractable component comprises about ι·ι to 6 parts ally And a polymerizable oxime hydrogel contact lens 刖 组合 组合 , , , , , , , , , , , , , , , , , , , , , , , , , , The polyoxyalkylene oxime extractable component comprises a dimethyl aristochene-oxyethylene block copolymer. 17. The polymerizable hydrogel contact lens precursor composition of claim 16, wherein the bismuth The oxo-oxyethylene block copolymer contains 75% by weight of ethylene oxide. 18. The polymerizable hydrogel contact lens, such as a body composition, according to any one of the items 17, wherein The polyoxyalkylene oxime extractable component comprises DBE 712. The polymerizable silicone hydrogel contact lens precursor composition of any of the above claims further comprising an initiator. A polymerizable silicone hydrogel contact lens precursor composition, wherein the initiator is hot 21. The polymerizable silicone hydrogel contact lens precursor composition of claim 19, wherein the initiator is a thermal initiator. 22. A polymerizable silicone hydrogel contact lens precursor composition , which comprises α-ω-bis(mercaptopropenyloxyethyliminocarboxyethoxypropyl)-poly(monomethyloxime)-poly(trifluoropropylmethyloxime) Poly(ω-methoxy·poly(ethylene glycol) propylmethyl decane), vinyl yiyimethyl acetamide, methyl methacrylate and triethylene glycol dimethacrylate. 23. The polymerizable silicone hydrogel contact lens precursor composition of claim 22, further comprising a dimethyloxane-ethylene oxide block copolymer 121841.doc 200813102 extract component. The polymerizable silicone hydrogel contact lens precursor composition of item 23, wherein the extractable component comprises DBE 712. 25. The polymerizable silicone hydrogel contact lens precursor composition of claim 24, wherein The extractable component comprises DBE 712 and allyloxyethanol. 26. The polymerizable according to any one of claims 22 to 25. A hydrazine hydrogel contact lens composition. The precursor composition further comprising phthalocyanine blue. The polymerizable oxime hydrogel contact lens 〇 precursor composition according to any one of claims 22 to 26, Further comprising 2-hydroxy-4-propenyloxyethoxybenzophenone. The polymerizable hydrogel contact lens precursor composition of any one of claims 22-27 A thermally initiating agent comprising the polymerizable hydroxyl hydrogel contact lens precursor composition according to any one of items 22 to 28, wherein the center is bis-(methacryloxyethylethylenimine) Carboxyethoxypropyl)-poly(didecyloxane)-poly(trifluoropropylmethyl, azide)> poly(ω-methoxy-poly(ethylene glycol)propyl fluorenyl The ratio of the combination of N-I vinyl·Ν_methylacetamide, methyl methacrylate and diethylene glycol dimethacrylate to a weight ratio of about 〇55 to about 〇 Within the range of 65 '. A polymerizable hydrogel contact lens precursor composition according to claim 29, which comprises α-ω-bis(methacryloxyethyliminocarboxyethoxypropyl)- Poly(dimethyloxane)-poly(trifluoropropylmethyloxirane)-poly(ω-methoxy-poly(ethylene glycol) propylmethyl oxirane), bucket vinyl _ ν•Methylacetamide, decyl methacrylate, triethylene glycol dimethacrylate 121841.doc 200813102 ester, 2-hydroxy-4-propenyloxyethoxybenzophenone, phthalocyanine blue, Thermal initiator and DBE 712, optionally combined with allyloxyethanol. The polymerizable silicone hydrogel contact lens precursor composition of claim 30, which comprises about 28% by weight of α-ω-bis(methacryloxyethylenimine carboxy group B) Oxypropyl)-poly(dimethyloxane)-poly(trifluoropropyldecyloxyl)-poly(ω-decyloxy-poly(ethylene glycol)propylmethyloxime: Alkane), about 37% by weight of ruthenium-vinyl-oxime-methylammoniumamine, about 13.5 〇/〇 (by weight) methyl methacrylate, about 0.16% by weight of dimethyl propylene fx Triethylene glycol acid ester, about 0.7% by weight of 2-hydroxy-4-propenyloxyethoxybenzophenone, about 0.1% by weight of phthalocyanine blue, about 0.4% by weight The thermal initiator and about 20% DBE 712 are optionally combined with allyloxyethanol. 3 2. A spectroscopy hydrogel contact lens produced by the polymerizable spectacles precursor composition of any one of claims 1 to 31. 33. A hydroxyl hydrogel contact lens produced by the reaction of a polymerizable lens such as a body composition according to any one of claims 1 to 3, wherein i J does not have an extractable component. 34. A hydrogenated hydrogel contact lens produced by the following steps: - Polymerizing a polymerizable lens precursor assembly according to any one of claims 1-3 to form a pre-extracted polymerization a hydrogel contact lens from which the extractable component is extracted to form an extracted polymeric lens product, and the extracted polymeric lens product is hydrated to form an equilibrium water content of about 40% by weight A sulphur oxygen hydrogel contact lens in the range of about 48% by weight and having an oxygen permeability (d匕χ 1〇_η) in the range of about 90-115 barrer. 121841.doc 200813102 35. The second embodiment of the oxygenated knee contact lens of claim 34, wherein the polymerizable lens precursor composition comprises a thermal initiator, and the polymerization further comprises the polymerizable lens precursor The body composition is heated to a temperature greater than about 55. The temperature of the mixture is 0. 36. The seeding oxygen hydrogel contact lens is produced by the following steps: polymerizing the polymerizable lens precursor composition of claim 30, a combination of a surface and an allyloxyethanol to form a pre-extracted polymeric rock-oxygen hydrogel contact lens, polymerized from a remote pre-extraction; an oxygen hydrogel contact lens to extract the polyoxyalkylene oxide-extractable group And forming a portion of the extracted polymeric lens product and hydrating the extracted polymeric lens product to form a variability of less than about 2% by weight of one or more of the lens diameter, the equilibrium water enthalpy, and the ion current. Oxygen hydrogel contact lenses. 37. A hydroxyl hydrogel contact lens having an equilibrium water content of at least about 4% and an oxygen permeability (Dkxi〇-n) of about 90-120 barrer. 3. A stone-oxygen hydrogel contact lens according to claim 37, further comprising one or more features selected from the group consisting of: the surface of the lens has a contact angle of from about 70° to about 75. The tensile modulus is less than about 〇7 MPa, and the ion current is about 1·5-7 (X 1 (Γ3 nim2/min). 39. The helium hydrogel of any one of claims 32 to 38. A contact lens, wherein the lens body comprises a circular peripheral edge. 40. A hydroxyl hydrogel contact lens according to any one of claims 32 to 38, which is a spherical mirror or an aspherical mirror. 41. as claimed in claims 32 to 38 Any of the oxime hydrogel contact lenses, which are 121841.doc 200813102 monofocal spectacles or multifocal spectacles. 42. The oxyhydrogel contact lens of any one of claims 32 to 38, which is a rotation Stabilizing a toric contact lens. 43. A hydrogenated hydrogel contact lens according to any one of claims 32 to 42 which is in a sealed package. 44. A surface treatment as claimed in claims 32 to 42 A hydrophobic 1 gel contact lens. 45. A method of producing a polymerizable hydroxyl hydrogel contact lens precursor composition, the method comprising: combining (1) at least about 25% by weight of a reactive inclusion a fluoropropenyl fluorenyloxy macromonomer, (ii) at least about 45% by weight of a hydrazine-free hydrophilic group And (iii) a polyoxyalkylene oxime extractable component, wherein the hydrazine-free hydrophilic component comprises a hydrophilic vinyl-containing monomer, an acrylic monomer crosslinking agent, and an acrylate functionalized oxidized ethylene oxide a polymer, thereby producing a polymerizable hydroxyl hydrogel contact lens precursor combination C./.. The method of claim 45, which comprises further combining the macromonomer, • a hydrophilicity free of hydrazine The composition and the extractable component, the ultraviolet absorber, and the coloring agent. The method of claim 45 or 46, wherein the reactive fluoropropenylhydrazine macromonomer is in an amount of about 25 weight The method of any one of claims 45 to 47, wherein the amount of the hydrophilic component containing no ruthenium 121841.doc 200813102 is from about 45% by weight to about 55 weight percent. The method of any one of claims 45 to 48, wherein the polyoxyalkylene oxime extractable component is present in an amount ranging from about 1% by weight to about 3% by weight. The method of claim 46, wherein the colorant is a phthalocyanine pigment. The method of claim 50, wherein the colorant is phthalocyanine blue. 52. The method of claim 46, wherein the ultraviolet absorber is a photopolymerizable hydroxybenzophenone. 53. The method of claim 52, The ultraviolet absorbing agent is a 2-hydroxy hydroxy methoxy ethoxy benzophenone. The method according to any one of claims 45 to 53, wherein the reactive propylene-containing fluorenyl oxy-oxyl macromolecule The monomer is α·bis(methylpropenyloxyethyliminomercaptoethoxypropyl)-poly(dimethyl-oxime)-poly(trifluoropropylmethyl-stone) Burning) - poly(co-methoxy-poly(ethyl: alcohol) propylmethyl-osin) (M3U). 55. 57. The method of any one of claims 45 to 54, wherein the hydrophilic component which does not contain Shi Xi includes N·Ethyl-based methyl ethylamine, methyl acrylate Vinegar and triethylene glycol dimethacrylate. The method of any one of clauses 45 to 55, wherein the polyoxynitride oxygen extractable component further comprises a chain transfer agent. The method of claim 56 wherein the chain transfer reagent is selected from the group consisting of a thiol, a disulfide bond, an organic dentate, and an allyloxy alcohol. 8. The method of claim 57, wherein the chain transfer reagent is allyloxy b. 121841.doc 200813102. The method of claim 58, wherein the polyoxygen oxide extractable component comprises about 〇·〇 5% by weight to about 7% by weight of allyloxyethanol. The method of any one of the items 45 to 59, wherein the polyoxyalkylene oxime oxygen extractable component comprises a dimethyl siloxane-ethylene oxide block copolymer. The method of claim 60, wherein the dimethyloxane-ethylene oxide block copolymer contains from about 67% by weight to about 77% by weight of ethylene oxide. 62. The method of claim 6, wherein the polyoxyalkylene oxime extractable component comprises DBE 712. The method of any one of claims 45 to 62, wherein the combining step further comprises an initiator. 64. The method of claim 63, wherein the initiator is a thermal initiator. 65. The method of claim 64, wherein the thermal initiator has about 5 Torr. The beginning of the cockroach Decomposes the temperature. 66. A method of producing a polymerizable hydroxyl hydrogel contact lens precursor composition, the method comprising: combining alpha-omega-bis(methacryloxyethyliminocarboxyl ethoxypropyl poly (dimethyloxane)-poly(trifluoropropylmethyloxirane)-poly(ω-methoxy-poly(ethylene glycol) propyl methyl oxalate), Ν-ethylene Methyl ethyl amide, methyl methacrylate and triethylene glycol dimethacrylate, to thereby produce a polymerizable silicone hydrogel contact lens precursor composition. 67. The method, wherein the combining step further comprises a dimethyloxane "deuterated ethylene block copolymer extractable component. 68. The method of claim 67, wherein the extractable component comprises DBE 712. 121841.doc 200813102 69. If the request jg > ancient, upper ^, go to 'where the extractable component contains DBE and allyloxyethanol. Eight: East 69 method 'where allyloxyethanol and DBE 712 phase 1 is in the range of about 5 parts of allyloxyethanol to about 5% of DBE 712. The method of any one of clauses 66 to 70, wherein the combining step further comprises a phthalocyanine blue. The method of any one of clauses 66 to 71, wherein the combining step further comprises 2 The hydroxy-4-propenyloxyethoxybenzophenone. The method of any one of claims 66 to 72, wherein the combining step further comprises a thermal initiator. 74. Any one of claims 66 to 73 The method of the item, the center thereof... bis(methacryloxyethylethylimidocarboxyethoxypropyl poly(dimethyloxane)_poly(trifluoropropylmethyloxirane)_ Poly(ω_decyloxy-poly(ethylene glycol) propylmethyl-oxaxane)-p-vinyl-fluorene-methylacetamide, mercaptomethyl hydrazide and trimethyl methacrylate The ratio of the combination of glycol esters is in the range of from about 0.55 to about 65.5% by weight. 75. A method of producing a polymerizable silicone hydrogel contact lens precursor composition. The method comprises: combining alpha · ω-bis(mercapto propylene methoxyethyl imino carboxy ethoxy propyl)-poly (monomethyl oxyhydrogen)-poly (trifluoropropyl A) Shixi Oxygen Burning)-Poly-methoxypoly(ethylene glycol) propylmethyl oxalate), Ν·ethylglycine methyl acetamide, methacrylate methacrylate, dimercapto acrylate Ethylene glycol vinegar, 2-alkyl-4-propenyloxy ethoxy dibenzophenone, phthalocyanine blue, thermal initiator 121841.doc -10- 200813102 and DBE 712, which optionally contain allyloxy Ethanol to thereby produce a polymerizable hydrogel contact lens precursor composition. 76. The method of claim 75, comprising combining about 28% (by weight) α_ω-bis (methacrylofluorene) Ethylethylimidocarboxyethoxypropyl)-poly(dimethyloxane)·poly(trifluoropropylmethyloxirane)-poly(still_methoxy-poly(ethylene glycol) ) propylmethyl oxirane), about 37% by weight of Ν_vinyl 沁 沁 methyl acetamide, about 13.5% by weight of methyl methacrylate, about 16% (weight ratio) ) Triethylene glycol monomethacrylate, about 7% · 7% (by weight) 2_ Luo to soil 4 propylene oxy ethoxy bisbenzoquinone _, about (weight ratio) offer ^ ^ 〇 · 4% (by weight) thermal initiator and about 20% DBL· 712 Which optionally comprising allyloxy ethanol. The method of any of the items 45 to 76, wherein the combining step results in, and is wounded, and the opening is performed, and the method further comprises mixing the component combinations to form a mixture. %. The method of claim 77, wherein the method further comprises filtering the mixture. The method of any one of claims 45 to 78, further comprising polymerizing the polymerizable lens precursor composition to form a pre-extracted polymeric oxime hydrogel contact lens. The method of claim 79, wherein the step of collecting the human comprises heating the polymerizable lens precursor composition. 81. The method of claim 79 or 8, wherein the step of including the polymerizable lens precursor composition is initially placed in a non-polar resin contact lens 121841.doc 200813102 in a mirror mold. 82. The method of claim 79 to 81, further comprising extracting the pre-extracted polymeric (four) glasses (four) into a smear-collected polymeric lens product, and hydrating the extracted polymeric spectacles The product is formed into a helium oxygen hydrogel contact lens. 83. A method for improving the efficacy of a dimethyloxane-oxyethylene block copolymer for use in the preparation of a hydrogel gel contact lens, the method comprising: from about 〇.i% by weight to about 10% by weight The allyloxyethanol is added to the dimethyloxane-ethylene oxide block copolymer to provide an allyloxyethanol-dimethyloxane ethylene oxide for use in the preparation of a hydroxyl hydrogel contact lens product. Block copolymer. 84. The method of claim 83, wherein the amount of the allyloxyethanol in the adding step is effective to produce an extracted hydrated hydrophobic water having a coefficient of expansion ranging from about 〇·9 〇 to about 11 〇. Gel contact lens product. 85. A oxime hydrogel contact lens comprising the reaction product of the polymerizable lens precursor composition of any one of claims 1-3, and substantially free of extractable components. 121841.doc -12-