TW200815501A - Wettable silicone hydrogel contact lenses and related compositions and methods - Google Patents

Abstract

Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

Description

200815501 IX. INSTRUCTIONS: Before and after the relevant application, reference is made to the US Patent Application No. 6 lion 4,91 i ' filed on June 31, 2007. U.S. Patent Application Serial No. 60/894,609, the entire disclosure of which is hereby incorporated by reference. TECHNICAL FIELD OF THE INVENTION The present invention is directed to a silicone hydrogel ophthalmic device and related compositions and methods. More particularly, the present invention relates to wettable hydrogel contact lenses that can be molded by fishing and fishing, and related compositions and methods. [Prior Art] Shi Xiyu's water-condensing «shaped glasses have become popular, because the contact lens wearer wears such a lens on their eyes' compared to (4) oxygen hydrogel contact lenses, after a long time Due to the ability. For example, depending on the particular lens, the Shixi oxygen hydrogel contact lens can be worn or opened for daily wear, weekly wear, bi-weekly wear, or monthly wear. For lenses wearers, the benefits associated with silicone hydrogel contact lenses can be attributed, at least in part, to the combination of hydrophilic and hydrophobic properties of the bismuth-containing polymeric materials of contact lenses. Hydrogel contact lenses, such as non-oxygenated hydrogel contact lenses, such as 2-hydroxyethyl methacrylate _MA, are often made in non-polar resin hidden glasses; 13⁄4, for example, self-polymerized The olefin is a contact lens mold of a base resin. In other words, the lens precursor composition of the non-oxygenated hydrogel contact lens is polymerized in a non-polar resin contact lens mold to produce a HEMA-based I-composite or polymerized lens product. Due to the hydrophilic nature of the polymeric component of the lens invisible eye 121843 200815501, the HEMA-based lens is compatible on the eye and has an ocularly acceptable surface wettability, even if it is used non- The same is true for the polar resin mold. However, current helium oxygen hydrogel contact lenses from non-polar resin molds have hydrophobic lens surfaces. In other words, the surface of such a silicone hydrogel contact lens has low wettability and is therefore not compatible or ocularly acceptable on the eye. For example, such a silicone hydrogel contact lens can be combined with increased fat

Plasting, protein deposition, and stimulation of lens wearers are associated. Surface treatment or surface modification has been used on the surface of such silicone hydrogel contact lenses or lens products to increase the hydrophilicity and wettability of the lens surface. An example of the surface treatment of a helium-hydrogel lens includes coating the surface of the lens to adsorb a chemical species onto the surface of the lens, altering the chemical nature or electrostatic charge of the chemical groups on the surface of the lens. Surface treatment has been described which involves the use of a plasma gas to coat the surface of the polymerized lens or, after forming a polymeric lens, the use of a plasma gas on the surface of the contact lens mold to process the mold. The surface treatment of contact lenses requires more means and time to manufacture contact lenses than manufacturing methods that do not use surface treatment or modification. In addition, surface treated chopped aerogel contact lenses can exhibit reduced surface manageability when the lens is being worn and/or touched by the lens wearer. For example, an increased touch of a surface treated lens may result in degradation or wear of the hydrophilic surface. An alternative way to increase the wettability and eye compatibility of the Shixi oxygen hydrogel lens is to include a polysilicon, a mesh π I, 3 Α σ wetting agent such as poly Different compositions of vinyltetrahydropyrrolidone (PVP) exist in the presence of t-battery to make oxygenated hydrogel contact lens precursor 121843 200815501

The composition is polymerized. It is to be understood that these types of lenses are silicone hydrogel contact lenses having a polymeric internal wetting agent. Furthermore, it will be further appreciated that such lenses comprise an interpenetrating polymer network (IPN) comprising a polymeric denier, such as PVP. As is well known to those skilled in the art, IPN refers to a combination of two or more different polymers in the form of a network of tissues, of which two are synthesized and/or crosslinked in another form, and There are no covalent bonds between them. The IPN can be composed of two chains forming two separate network structures, but in a side-by-side or interpenetrating manner. Examples of IPNs include continuous IPN, simultaneous IPN, semi-IPN, and average-IPN. While oxy-hydrogel contact lenses containing polymeric wetting agents can avoid problems associated with surface treatment, such lenses may not retain their eye compatibility for extended periods of time, including surface wettability. For example, internal wetting agents, because they are not covalently bonded to other components that form a polymerized lens, can be filtered from the lens when worn by the lens wearer, thus causing the lens wearer over time The reduced surface is resilience and increased discomfort. As an alternative to the surface treatment or the use of polymer wetting agent pH as described above, it has been found to have acceptable surface wettability on the eye: oxygen hydrogel contact lenses, which can be replaced with polar resin molds instead of non-polar Resin mold manufacturing. For example, a silicone hydrogel contact lens formed in a mold of ethylene-vinyl alcohol or polyvinyl alcohol has the desired surface wettability. An example of an available polar resin for making a contact lens mold for an IPN-free, surface-treated, oxygen-free hydrogel contact lens that does not contain a polymeric wetting agent is an ethylene-vinyl alcohol copolymer resin. ARIJTEtm 'B' sold by Nippon Gohsei Corporation as a brand name olefin-vinyl alcohol copolymer 121843 200815501 resin. In addition to its polarity, SOARLITETM is said to have the following characteristics: Extremely high mechanical strength, antistatic properties, low shrinkage when used in molding processes, superior oil and solvent resistance, small coefficient of thermal expansion, and good wear resistance. While SOARUTET® is the base mold, it provides an alternative to the manufacture of compatible oxygenated hydrogel contact lenses for the eye without the use of surface treatments or polymeric wetting agents, but the s〇arliteTM mold is more non-polar. Resin molds, such as polypropylene molds, are less deformable or flexible and are relatively difficult to work with than non-polar resin molds. Documents relating to the manufacture of contact lenses such as silicone hydrogel contact lenses include U.S. Patent Nos. 4,121,896; 4,495,313; 4,565,348; 4?6405489, 45889?664; 4?9855186; 5,039,459; 839; 5?094?609; 5?2605000; 5?607?518; 5J60J00; 558505107; 5,935,492; 65099?852; 6,367,929; 6,822,016; 6,867,245; 6,869,549; 6,939,487; and U.S. Patent Publication No. 20030125498; 20050154080; 20050191335. The above-mentioned 'Compared with the 矽oxygel contact lenses from S〇ARLITEtm contact lens molds' still requires an eye-compatible compatible Shiva Oxygen hydrogel contact lens that can be more easily manufactured without surface treatment Or use a polymeric smear IPN ' including PVP IPN to achieve eye compatibility. An existing problem relates to obtaining contact-compatible oxygenated hydrogel contact lenses from non-polar resins or polyolefin-based materials, such as having wettability on the compatible surface of the eye. Oxygen hydrogel contact lenses without the use of surface treatments or polymeric wetting agents. SUMMARY OF THE INVENTION 121843 200815501 The present invention i1 emergency glasses, lens production ^, Γ,, and the enemy compound and method are attempting to find gray ash determinants of the current 矽 hydrogel barrier" 八, ~, 升 y glasses are associated Needs and problems. Ρ It’s surprisingly found that the 4 矽 oxygen hydrogel contact lenses on the eyes can be dreamed of providing a relatively large amount of brothers. “Jesus gathers...” (4) Objects before extraction and hydration: Water-reducing invisible Obtained in the lens product to cause sand oxide water to contact the contact lens.水 〃 j 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私 私

, the heart P to 乂 10% (w / w) of the weight of the polymerized rock-oxygen hydrogel lens product before extraction, can be extracted and hydrated to form an oxygen-absorbing surface with acceptable ocular surface Hydrogel contact lenses, such as oxygen gas permeability, surface wettability, modulus water 5 liters, ion flux and design, allow the lenses of the present invention to be comfortably worn by patients In the eyes, after a long period of time, for example, at least one day, at least - weeks, at least (four), or about one month, without removing the lens from the eyes. The oxygenated hydrogel contact lenses of the present invention comprise a lens object having an eye that is aesthetically acceptable, such as a front surface and a back surface. The surface wettability of the iodoxyhydrogel contact lens is related to the amount of removable component present in the oxygenated/coiled contact lens product present prior to extraction. The lens objects of the oxygenated hydrogel contact lenses of the present invention do not require surface treatment or polymeric wetting agents to achieve acceptable surface wettability on the eye. The silicone hydrogel contact lenses of the present invention do not require the use of a mold of a polar resin mold such as S〇ARLITEtm as a base material to obtain an eye-acceptable surface wettability. In addition, the lens of the present invention does not require further mechanisms after the aging process or the removal of the mirror 121843 10 200815501. However, it will be appreciated that certain embodiments of the invention may optionally include surface treatment, polymeric wetting agent IPN, and/or use of a polar resin mold or post-maturing mechanism or a post-lens removal mechanism, if desired. One aspect of the invention relates to a helium oxygen hydrogel contact lens. The oxygenated hydrogel contact lenses of the present invention comprise lens objects having acceptable surface wettability on the eye. In some embodiments, it will be apparent that the lens object comprises a hydrogel hydrogel material and that the dry weight is no greater than 90/ of the dry weight of the lens prior to extraction. . It is clear that the dry weight is the weight of the lens object that does not contain significant amounts of water or any amount of water. In certain other embodiments, it will be appreciated that the lens system is a lens object obtained from a pre-extracted polymerized hydrogel contact lens product having a removable component in an amount of at least 1% (w/ w). In other words, the pre-extracted polymerized hydrogel contact lens product has a removable component content of at least 10% (w/w). In other embodiments, it is apparent that the lens system is a lens object produced in the following manner, and the extractable component is extracted from the polymerized hydrogel contact lens product prior to extraction to produce an extracted polymerized oxygen. The hydrogel contact lens product, and hydrated, and the second extract hydrated; the 5 Oxygen Water Glue contact lens product to produce a silicone hydrogel contact lens having an ocularly acceptable surface wettability. The pre-extracted bismuth-polymerized Shixi oxygen hydrogel contact lens product has an extractable component content of at least 1 〇〇/ of the pre-extracted lens object. (w/w). In certain embodiments, the content of the removable component is at least 10 Å/. The (W/W) pre-extracted polymerized hydrothermal hydrogel contact lens product is substantially or completely free of non-reactive additives such as diluents. For example, the 121843 200815501 uranium extract product can be obtained from a polymerizable composition that does not contain a diluent, compatibilizer or other non-reactive additive. As used herein, a polymerizable composition that does not contain a diluent, compatibilizer, or other non-reactive additive can be referred to as a "total formulation" or "total composition." The overall formulation does not include non-reactive An additive, and capable of forming the pre-extracted polymerized hydroxyl hydrogel contact lens product of the present invention, having an extractable component content of at least 10% (w/w) of the pre-extracted lens object.

Other formulations or polymerizable compositions may contain one or more additives as compared to lens products derived from the overall formulation, thereby causing a greater amount of extractable components to be present in the polymerized lens product prior to extraction. For example, when the pre-extracted polymerized lithothere hydrogel contact lens product obtained from the overall formulation has an extract component content of i 5%, it can be understood that the diluent is obtained from the same formulation and the amount of 5% (four) is added. The second pre-extracted polymerized Shixi oxygen hydrogel contact lens product has a extractable component content (4). After extraction and hydration, the dry weight of the oxygenated hydrogel contact lens obtained from the extraction of Hg + A匕 was obtained as the dry weight of the lens product before extraction. Another aspect of the invention is the product of the (IV) hydrogel barrier lens which is polymerized prior to extraction. It will be appreciated that such lens products are, for example, in the mold cavity of the mold, the self-curing procedure or the polymerization procedure, the process of not yet feeding, or the product that has not been contacted with the composition of the stroke. In some embodiments, the contact lens product comprises an object member prior to extraction having a dry weight of: 1% by weight greater than subjecting the member member to an extraction procedure to form a smattering The dry weight of the object member after the frog product. For example, the preceding object member may include 121843 -12-200815501 at least H)/〇(w/w) that can be extracted into a pre-stroke object member. In further embodiments In the middle, the extract component contains and is greater than 15% (w/w) of the member before extraction, and less than before the extraction; (in terms of). In some embodiments, the extractable component is greater than the stroke. w The object member is heard (w/w) and is less than 75% (W/W) of the object member before extraction. The pre-extracted pre-extracted object member of the present invention is extracted before the extraction. Containing - or a plurality of removable additives, such as additives that are removed during the extraction procedure. For example, the object member can be used with 3 or more compatibilizers, release aids, lens removal auxiliaries, and enhanced housekeeping properties. Agent and ion flux reducer. It is clear that the removable additive is The <reactive additive' or may be a reactive additive that is removable from the polymerized rheumatoid hydrogel contact lens product during the extraction procedure.

Another aspect of the invention pertains to a polymerizable silicone hydrogel contact lens precursor composition. The polymerizable silicone hydrogel contact lens precursor composition comprises a lens forming component, such as a monomeric material, and one or more optional additives, as described herein, which are formed to have a real f amount. In addition to the knowing,,, and work together with oxygen hydrogel contact lens products. In some embodiments, the polymerizable silicone hydrogel contact lens precursor composition comprises a polymerizable 3 stone and a polymerizable non-containing stone component. The two components are combined into a polymerizable silicone hydrogel contact lens precursor composition. A portion of the precursor composition can be removed from the polyoxygenated hydrogel contact lens product made from the precursor composition. This fraction is present in an amount of at least the chamber (w/w) of the polymerized oxygenated hydrogel contact lens product prior to extraction. In some embodiments, the precursor composition comprises a first monomer having a first reactivity ratio, and a second single 121843 having a second reactivity ratio less than the first reactivity ratio. 13 - 200815501 Group. As is well known to those skilled in the art, the reactivity ratio can be determined by the ratio of the rate constant of the individual species of the monomer to the rate constant of the other monomer. Such compositions may also comprise a crosslinking agent having a reactivity comparable to that of the first reactivity. In certain embodiments, the lens precursor composition can comprise one or more removable additives. For example, a particular embodiment of a specular precursor composition can include one or more compatible

Agent, handle release aid, lens removal aid, wettability enhancer and ion flux reducer. I

Yet another aspect of the invention relates to a method of making a compatible oxygenated hydrogel contact lens on the eye. In some embodiments, the method of the present invention comprises forming a lens object comprising a helium oxygen hydrogel material having an ocularly acceptable surface permeable recording and a dry weight no greater than the dry weight of the lens object prior to extraction 90%. The method may also include agglomerated hydrogenated water before extraction

The contact lens product extracts the extractable component, wherein the extractable component comprises at least 10% of the polymerized hydrogel contact lens product prior to extraction. The method can also include forming a polyoxygenated hydrogel contact lens precursor composition useful in the manufacture of the oxygenated hydrogel (tetra) shaped lens product of the present invention and the inventive oxygenated hydrogel contact lens. The lenses, lens products of the present invention will be described in the following detailed description and claims from the following description, the drawings, the foregoing description and the accompanying claims. As can be described in this article

And each combination is included, and each of two or more such features are within the scope of the invention, and the features in which the strips are included in such a combination are not mutually exclusive. In addition, any feature or combination of features may be excluded from any particular embodiment of the invention, particularly 121843 200815501. Other aspects and advantages of the present invention are set forth in the description which follows, in conjunction with the claims. DETAILED DESCRIPTION Figure 1 illustrates a method of making a silicone hydrogel contact lens. The method shown is a method of casting a molded hydrogel contact lens. The molded contact lenses can be made in a form suitable for placement on the eyes of a person. For example, cast molded contact lenses do not require any further mechanism to modify the lens to make a lens suitable for use on the eye. It is clear that the casting molding process is used, as shown in the figure! The procedure shown in the above, the present invention is a hydrothermal gel contact lens of the present invention which is a cast-molded invisible ophthalmoscope. In addition, it will be apparent that the lenses of the present invention are fully molded 7 oxygen hydrogel contact lenses if no further mechanism is used to modify the lens design. As used herein, the term "hydrogel" refers to a network or matrix of polymeric chains, some or all of which may be water soluble and which may contain a high percentage of water. Hydrogel refers to Polymeric materials, including contact lenses, which are water swellable or swellable by water. Thus, the hydrogel may be unhydrated and water swellable, or the hydrogel may be partially hydrated and swelled by water. , or the hydrogel may be fully hydrated and swelled by water.,, 矽 水 hydrogel "or, 矽 水 朦 ' ' ' 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语 术语. For example, the 'Shixi oxygen hydrogel kicking line includes one or more hydrophilic stone-containing polymers. Hydroxyl hydrogel contact lenses are contact lenses comprising a silicone hydrogel material, including vision correcting contact lenses. The composition containing the milk is a component containing at least one group in the form of a single body or a prepolymer of 121843 200815501. The attached layer may be present in the stone containing oxygen, and the amount thereof is an oxygen-cutting component. The total molecular weight is greater than 2% by weight, such as greater than 30% by weight. The diabase-containing component which can be used comprises a polymerizable functional group such as acrylic acid, methyl acetoacetate, acrylamide, methacrylamide, decyl vinylamine, N-vinylamine and Styryl functional group. Examples of some of the compositions containing the sulphur-containing oxygen used in the lenses of the present invention can be found in U.S. Patents 3,8,8,178; 4,12,57,4,136,25(); 4,153,641; 4,740,533 ; 5,034,461 and 5,070,215

And ΕΡ 080539. A further example of an oxime 3 oxirane monomer is a polydecyloxyalkyl (meth) acrylic acid monomer 'including but not limited to methyl propyl methoxy methoxy phenyl (trimethyl sylvestre oxy) ) Dream Burning, Pentamethyl Di-Oxyalkyl Methacrylic Acid Brewing and Methyl-(Dimethyldecyloxy)methacryloxymethoxymethylnonane. One type of helium-containing component can be used as a poly(organosiloxane) prepolymer such as 4-dimethacryloxycarbonyl-propylpolydimethyloxane. Another example is mPDMS (monomethacryloxypropyl-terminated mono-n-J-terminated polydimethyloxane). Another type of oxygen-containing component can be used, including 3 oxyethylene carbonate or vinyl urethane monomers, including but not limited to U_bis [4·(vinyloxy oxygen) ))·1·yl]tetramethyl oxazide 3-(vinyloxycarbonylthio)propyl _[ s (trimethyl decyloxydecane); 3 _ gin (trimethyl decyloxy) ) 石 ] ] ] ] 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 Base ethylene-based carbonated vinegar; and trimethyl-stone-based vinyl vinyl carbonate. Examples of suitable materials include the following formula: 12J843 16 200815501 〇ch3 ch3

II 1 I CH2=CH —〇0〇(CH2)4—Si—〇一—Si—Ο CH3 [CH3 25 CH3 〇 I. ii Si — (CH2)4CO—CH=CH2 ch3 ch3 〇

I II

Si - (ch2)4qco~ch=ch2 ch3

u

Another example of a suitable material includes an agent represented by the following formula: 〒H3 "ch3 · CH2= CH—〇C〇(CH2)4 — Si—Ο- -Si—Ο Ι LCH3 J In addition to bismuth-containing components In addition, the lenses, lens products and compositions of the present invention may comprise one or more hydrophilic components. The hydrophilic component includes those which, when combined with the remaining reactive components, are capable of providing at least about 20%, e.g., at least about 25%, water to the lens formed. Suitable hydrophilic components may be present in an amount between about 1 Torr and about 6 Torr, based on the weight of all reactive components. From about 15 to about 50 weight. /〇, for example between about 2 〇 and about 40% by weight. A hydrophilic monomer which can be used to produce a polymer for use in the lens of the present invention has at least one polymerizable double bond and at least one hydrophilic functional group. Examples of the polymerizable double bond include acrylic acid, methacrylic acid, acrylamide, methyl acrylamide, fumaric acid, maleic acid, styryl, isopropenylphenyl, fluorene - vinyl carbonate, alpha vinyl urethane, allyl, hydrazine - vinyl ethyl fluorenyl and hydrazine - vinyl decylamine and a group of vinyl guanamine double bonds. Such a hydrophilic monomer itself can act as a crosslinking agent to cause hydrazine. , "acrylic" or "acrylic" single system is a monomer containing an acrylic group (CRfH=CRc〇x), wherein R is Η or CH3 'R' is H, alkyl or a few groups, and]^ It is also known that it can be easily polymerized, such as N, N_: methacrylamide (dma), C. 121843 200815501 2-hydroxyethyl enoate, glyceryl methacrylate, hydroxyethyl hydrazine Propylene amine, polyethylene glycol monomethacrylate, methacrylic acid, acrylic acid, and mixtures thereof.

Hydrophilic vinyl-containing monomer that can be incorporated into the materials of the lenses of the present invention, can include some monomers, such as a group of vinyl decylamine (eg, a group of vinyl tetrahydrophyllin (NVP)), N- Vinylmethylacetamide, N-vinylethylacetamide, N-vinylethylformamide, bad vinylformamide, N_2-ethylethyl urethane, N - Carboxy-ethyl acetinate N-vinyl ester. In one embodiment, the hydrophilic vinyl-containing monomer is NVP. Other hydrophilic monomers which may be employed in the lenses of the present invention include polyoxyethylene polyols having one or more terminal hydroxyl groups replaced by a functional group containing a polymerizable double bond. Examples include polyethylene glycols having one or more terminal hydroxyl groups replaced by a functional group containing a polymerizable double bond. Examples include polyethylene glycol reacted with one or more molar equivalents of a capping group such as isocyanatoethyl methacrylate ("deletion") propylene (tetra), chlorinated methacrylic acid Anthracene, vinyl benzamidine chloride or the like to produce a polyethylene polyterpene alcohol having one or more terminally polymerizable olefin groups through a linking moiety such as a urethane ester a group, bonded to the polyethylene polyol. Other examples are the hydrophilic vinyl acetonate or urethane urethane monomers disclosed in U.S. Patent No. 5,070,215, the disclosure of which is incorporated herein by reference. Other suitable hydrophilic single systems are known to those skilled in the art. More preferred hydrophilic monomers which may be incorporated into the polymers of the present invention include some hydrophilic monomers such as dimethyl methacrylate (DMA), C 121843 18 200815501 2-hydroxyethyl enoate, hydrazine Glyceryl acrylate, hydroxyethyl decyl acrylamide, N-vinyl tetrahydropyrrolidone (NVP), polyethylene glycol monodecyl acrylate, and polyethylene glycol dimercapto acrylate. In some embodiments, hydrophilic monomers comprising DMA, NVP, and mixtures thereof are employed. Other examples of materials for making a silicone hydrogel contact lens include those disclosed in U.S. Patent No. 6,867,245.

None of the methods include the step of placing the lens precursor composition on or in the contact lens mold member. With respect to the present application, it is understood that the lens precursor composition is a polymerizable hydrogel lens precursor composition 2, as shown in Fig. 2. It is understood that the polymerizable lithothere hydrogel lens precursor composition is a prepolymerized or pre-cooked composition suitable for polymerization. As used herein, the polymerizable compositions of the present invention may also be referred to as monomer blends or inverse mixtures. Preferably, the polymerizable composition or lens precursor composition is not polymerized prior to the group or: the reaction. However, the polymerizable composition or mirror, and the sigma may be partially polymerized prior to the aging process. Prior to the present ===ization or polymerization procedure, the lens precursor composition of the invention is in the form of a barn, a dispensing device or a contact lens. Responding to the reference Fig.: Surface: The composition is placed on the contact lens master member to form the lens. The mold member is used as the first contact lens. For example, the contact lens parent broadcast has a lens-forming surface that is bounded to the front or front surface of the lens. Invisible from the U-glass mold The first contact lens mold member is placed in contact with the member to form a contact lens mold having a contact lens forming cavity. 121843 -19- 200815501 Therefore, the way shown in Figure 1 is that the two two = 1 1 contact lens mold step _, the mirror mold member is placed in the contact lens forming cavity to contact the 'to form a J-heart The Shixi gas hydrogel mirror is located in the contact lens forming cavity. 2 〇 2 pieces are contact lens gong ', a solid contact lens constitutive pull member or rear contact lens mold member 〇 “ 一个 隐 隐 隐 隐 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个 一个The surface behind the contact lens. "Boundary 4 In step 106, Tai, and soil 4 1 include aging the polymerizable silicone hydrogel lens precursor composition to form a precursor product before extraction, as shown in Figure 2. In the middle of it. ^^^ Hydrogel contact lens During the formation of the lens precursor composition, the polymerizable Shixi oxygen hydrogel brothers are polymerized to form a polymerized mirror. b, it can also be understood that the curing step is a polymerization step. Mature 鸠 can be packaged == lens precursor composition exposed to effective lens precursor composition = two light shot. For example, aging 106 can include heat or ultraviolet light in which the lens precursor composition is exposed, in particular, to a polymerization amount. Cooked

U: may also include aging the composition in an oxygen-free environment. For example, curing can occur in the presence of nitrogen or other inert gases. The pre-polymerized hydrothermal hydrogel contact lens product 2〇4 refers to the T-co-product prior to the extraction procedure for the imposition of the mash and removal of substantially all extractable components. The pre-extracted polymerized diarrhea gelatin contact lens product can be provided on or in a contact lens mold, extraction = or other device prior to contact with the extracted composition. For example, 'the pre-extracted polymerized stone-oxygen condensation: the contact lens product can be provided in the lens forming cavity of the contact lens mold after the ripening process', after being released from the contact lens mold, it is provided in a 121843 -20- 200815501 Contact lens φ extraction procedure on the contact lens module... ί After the tax removal lens procedure and the stroke Qin order, it is provided in the extraction tray or other device to obtain the polymerized Shixi oxygen hydrogel invisible The lens is made into a component, such as a lens-like network containing a stone-like polymer. The lens can be removed from the components of the lens, and the "18 or matrix" and the lens are removed. It includes unreacted monomers, and the oligomers do not become covalently linked or otherwise deuterated (4). It will also be appreciated that the removable component includes one or "additives, including organic additives, including diluents, and lens product extraction from the polymerization during the stroke procedure, as discussed herein. Thus, the material of the removable component may comprise a linear, uncrosslinked, crosslinked or branched polymer of the extractable material relative to the polymer backbone, network or matrix of the lens object. Or otherwise fixed. After curing the polymerizable lens precursor composition, the method includes the step of demolding the contact lens mold. Demolding refers to the separation of two mold members (e.g., male and female mold members) containing a contact lens product that has been polymerized prior to extraction or a mold that passes through a polymerization device. The polymerized diaphorite hydrogel contact lens product prior to extraction is tied to one of the demolded mold members. For example, the polymerized Shishi oxygen water reduced contact lens product can be placed on the male mold member or the female mold member. Then, the pre-extracted polymerized hydrogen peroxide hydrogel contact lens product 2〇4, «excluding the lens step During the period 110, the contact lens mold member placed thereon is knife-away, as shown in FIG. The contacted polymerized contact lens product can be removed from the mold member or master mold member, depending on which mold member the polymerized contact lens product remains adhered to during the release of the contact lens mold. After removing the lens of the oxygenated hydrogel contact lens product prior to extraction, the method comprises extracting the extractable material from the 7-oxygen hydrogel contact lens product prior to the extraction. 4. The H step 112 H step 112 causes extraction. Shixi oxygen hydrogel contact lens product 2G6' is shown in Figure 2. Extraction step 112 refers to the process in which the extracted W-polymerized hydroxyl hydrogel contact lens product is contacted with one or more extraction compositions. For example, a polymerized oxygenated hydrogel contact lens product or a batch of a polymerized hydroxyl hydrogel contact lens product can be contacted with a liquid extraction medium or a plurality of liquid extraction media or a plurality of liquid extraction media. Includes solvent. For example, the extraction medium may include ethanol, ff Θ & alcohol beta extraction medium may also include a mixture of alcohol and water "5G/. A mixture of B and deionized water, or a mixture of 7 (10) ethanol and 30% deionized water, or a mixture of ethanol and deionized water. Or I, the extraction medium may be substantially or completely free of alcohol, and may include one or more of the hydrophobically unreacted components to be removed from the polymerized rheumatoid hydrogel lens product: 丨 乍. For example, the extraction medium can comprise, consist essentially of, or completely encapsulate, buffer bath, and the like. The extraction step 112 can be performed at different temperatures, for example, extraction can occur at room temperature (e.g., about 2 G ° C), or it can occur at elevated temperatures (e.g., about to about 峨). Moreover, in some (four) embodiments, the extraction step 112 can include the step of contacting the lens product with alcohol and water, which can be the final step of the multi-step extraction procedure. After extracting the extracted hydrazine hydrogel contact lens product, step 114 of hydrating the polymerized hydroxyl hydrogel contact lens product 121843-22-2218015. The hydration step 114 can include contacting the extracted polymeric oxygenated hydrogel contact lens product or one or more batches of such product with water or an aqueous solution to form a hydrated oxygenated hydrogel contact lens 2〇8, As shown in Figure 2. For example, the extracted polymeric oxygenated hydrogel contact lens product can be hydrated, including deionized water, by being placed in two or more separate volumes of water. In some methods, the hydrating step 114 can be combined with the extraction step 112 such that the two steps are performed on a single workstation in the contact lens line. In some methods, the hydrating step 114 can be carried out in the valley at room temperature or at elevated temperatures, and the right is required at high pressure. For example, hydration can occur in water at a temperature of about 120 ° C (e.g., 121 ° C) and a pressure of 103 kPa (15 psi). In view of the above, it is clear that the polymerized hydroxyl hydrogel contact lens product and the extracted polymerized hydroxyl hydrogel contact lens product are water swellable products or components and hydrated by oxygen. Hydrogel contact lenses are products or components that have been swollen with water. As used herein, a zeolitic hydrogel contact lens refers to a helium oxygen hydrogel element that has undergone a hydration step. Thus, it can be appreciated that the oxyhydrogel contact lens is a fully hydrated zephyr hydrogel contact lens, a partially hydrated oxime hydrogel contact lens or a dehydrated oxime hydrogel contact lens. A dehydrated oxygenated hydrogel contact lens refers to a contact lens that has undergone a hydration procedure and has been subsequently dehydrated to remove water from the lens. After hydrating the extracted oxygenated hydrogel contact lens product to produce a silicone hydrogel contact lens, the method includes the step 116 of packaging the silicone hydrogel contact lens 208. For example, the helium oxygen hydrogel contact lens 208 can be placed in a suitable container containing a volume of liquid, including a buffered saline solution, in a suitable container containing a volume of liquid. Examples of liquids suitable for the lenses of the present invention include phosphate buffered saline and borate buffered saline. The ^I wave or valley can be sealed and then sterilized as shown in step 118. For example, the packaged lithothere hydrogel contact lens can be exposed to a sterile amount of &s', including heat', such as by autoclaving, 7 radiation, electron beam radiation, or ultraviolet radiation. The Moonlight Oxygen Hydrogel Contact Lens can be obtained by providing a relatively large amount of removable material in the polymerized Stone Oxygen Hydrogel contact lens product prior to extraction. Pre-extracted polymerized with a removable component! Oxygenated water-cured lens product 'The removable component is - or a plurality of removable materials 2 includes a drawable substance 其', which is polymerized before extraction The helium hydrogel lens product weighs at least 10% (w/w) of the product, and the lens product can be hydrated by extraction to form an eye-acceptable surface wettability: gel contact lens . The lens of the invention has oxygen permeability, surface moistureability,

U number of turns, water content, ion flux, design, and combinations thereof, which allow the lens of the present invention to be comfortably worn on the eye of a patient> + _ m over a long period of time, for example, At least one day, at least one, to >, two weeks, or about one month, remove the lens from the eye. 'Women use < eye-compatible compatible oxygen hydrogel contact lenses', which means that the fingers can be worn on people's eyes, and no one will experience or report uncomfortableness, including eye irritation, etc. The stone-compatible oxygenated water contact lens. The compatible oxygenated hydrogel contact lens on the eye has a surface that is dragon-like on the eye and is typically not caused or will not be accompanied by significant $121843-24 - 200815501 Membrane swelling, corneal dehydration (,, dry eye), epithelial arc injury ("SEAL") or other significant discomfort. It can be understood that the surface of the eye that can be accepted by the eye can be used to refer to the Shixia oxygen hydrogel contact lens, which does not adversely affect the tear film of the lens wearer. Causes the lens wearer to experience or report the degree of discomfort associated with placing or wearing a Shixia oxygen hydrogel contact lens on the eye. Eyes of the main μ 1 ^ ... 1 good eyesight compatible Shishi oxygen hydrogel invisible eye lens system meets the requirements for clinical acceptance of daily wearing or turf, ’ long-term wear contact lenses. The Asthma Hydrogel Contact Lens of the present invention comprises a lens object having an eye-acceptable surface that is permeable to the eyes, such as a front surface and a back surface. Moistureability refers to the hydrophilicity of the contact lens or surfaces. As used herein, the surface of the lens may be considered to be wettable or ocularly acceptable if the lens has a knives on (1) in the mobility test as described below. Wettability. Soak the contact lens in the steaming water, and measure the time it takes for the water film to retreat from the surface of the lens (Mr. Water Breaking Day $ (Water Βυτ)). This test is based on a linear ruler 'grading the lens' where a score of 10 refers to a lens in which the droplet takes 20 seconds or more to retreat from the lens. Hydroxyl hydrogel contact lenses having a water BUT greater than 5 seconds, such as at least 1 Torr or at least about 15 seconds, may have an eye-cooling effect on the eye. Sexual oxygenated hydrogel invisible eyelids. The sapability can also be measured by measuring the contact angle on the surface of the lens or the two lenses. The γ π angle can be a dynamic or static contact angle. The lower contact angle, fen, refers to the increased wettability of the invisible surface of the mirror. For example, a silicone hydrogel may have a contact angle of less than about 120 degrees. However, in certain embodiments of the present invention, the lens has a contact angle that is not square, 90 degrees. In further embodiments, the oxygenated hydrogel contact lens of the present invention has advance contact. The angle is less than about degrees. It has been found that by controlling the polymerizable composition of the present invention, such as the polymerizable composition of the present invention: 1 oxygen hydrogel contact lens precursor composition, and the polymerized composition of the present invention & extraction, such as The amount or type of reactive component or combination of reactive and non-reactive components in a hydrogel contact lens product can be obtained ('^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ The present invention provides a surface-wettable surface wettability of the present invention, which does not require a surface treatment or polymeric wetting agent IPN to provide surface wettability and does not require polar resin contact lenses. Manufactured in a mold to provide surface wettability. For example, the present invention can be obtained from non-polar resin contact lens molds or hydrophobic resin contact lenses having ocularly acceptable surface wettability. Mold without the need for surface treatment or polymeric wetting agent IPN. 非 For use herein, non-polar resin contact lens molds, or "hydrophobic resin contact lens molds", refers to the formation or generation of non-polar Or a lens mold of a hydrophobic resin. Therefore, the contact lens mold in which the non-polar resin is a base may comprise a non-polar or hydrophobic resin. For example, the contact lens mold may comprise one or more polyolefins, or may be self-polymerized. Olefin resin material. As far as the present application is concerned, examples of non-polar resin contact lens molds used include polyethylene contact lens molds, polypropylene contact lens molds, and polystyrene contact lens molds. Non-polar resin is invisible to the base material. The lens mold typically has a hydrophobic surface. For example, when measured using the trapping bubble method, the non-polar resin mold or hydrophobic 121843 -26-200815501 = can have a static contact angle of (four) degrees or greater. An unacceptable surface for the use of a custom-made hydrogel contact lens made on a bed in a mold. + Provided by providing a relatively slow reactive monomer to the polymerizable composition Different reactivity ratios of two or more monomer types in the same composition can be controlled in the pre-extracted polymerized stone-oxygen hydrogel contact lens product. The amount of slow reaction monomer, such as in the aggregation

"And the early body in the mouth, which does not completely crosslink into a network during the ripening procedure," provides a relatively large amount of removable component in the polymerized hydrogel contact lens product. Completely cross-linked (4), such as unreacted, reacted or partially reacted monomers, oligomers, linear polymers, 经, 至成成成, etc., self-polymerized shixi oxygen hydrogel The polymerized component of the contact lens product is extracted. In certain of the polymerizable compositions of the present invention and the polymerized hydrogel hydrogel contact lens product, a removable additive is present. For example, some of the polymerizable compositions of the present invention are polymerized. The hydroxyl hydrogel contact lens product comprises one or more additives which are removable from the polymerized hydrogel contact lens product during the extraction procedure. For the purposes of this application, the term "additive" means a compound or chemical agent provided in the polymerizable silicone hydrogel contact lens precursor composition or the polymerized hydrogen peroxide water-rotating contact lens product prior to extraction, but which is not in the form of a silicone hydrogel invisible Glasses office However, the addition of a removable additive compared to a silicone hydrogel contact lens obtained from the same precursor composition without the additive or combination thereof can help the contact lens be processed during its manufacture period 121843 -27. 200815501 It can enhance the invisible shape of the hydrogel hydrogel. It can be self-extracted, m ^ bp ^ ^ ^ , , , , Glue L, shaped eyeglass product removal. For example, the addition of AJ is a periplasmic non-reactive, = other components of the polymerizable explosive gel lens precursor composition:: the di-two additive does not substantially become formed by polymerization The lens product is a complete part. According to its molecular weight and shape μ, most, if not all, of the additives of the present invention can be drawn from the hydrogel contact lens product. Therefore, in the combination of the present invention The additive may be extracted from the polymerized aerogel hydrogel contact lens product during the extraction private sequence. In some embodiments, the additive may be referred to as a diluent, a substantially non-reactive agent, or an extractable material. .dilution It can be used as a riding or non-alcoholic agent. The diluent can be stored in the amount of about 1% to about the secret (w/w) of the lens precursor composition, and the other non-diluent based additives can be less than 10% ( W/W) is present. The additive provided in the composition of the present invention can aid in aggregation compared to contact lenses obtained from lens products that do not contain an additive.

The formation of a CJ combined oxygen hydrogel contact lens precursor composition, for example, by aiding in the formation of a homogeneous composition or a non-phase separation composition; enhancing the invisible shape of the extract I and the di 5 of the present invention The processing properties of the lens product, for example, by assisting in the release of contact lens molds containing contact lens products, and/or in assisting the release of the contact lens product from contact lens molds; in individual groups of contact lenses, for example, in different In batch contact lenses, the control of the physical parameters of the improved contact lens, for example by reducing the textuality in the physical parameters of the contact lens; enhancing the wettability of the contact lens, for example by enhancing the wettability of the contact lens surface Sexuality; can positively affect the modulus of contact lenses, 譬121843 -28- 200815501 If the error is reduced by the modulus or increase the modulus, as needed; and can positively affect the contact lens ion pass 4, # by Reduce the invisible (four) ion pass. Therefore, it can be understood that the additives provided in the composition of the present invention are a compatibilizer, a mold release aid, a lens removal aid, a physical parameter control agent, a usable enhancer, a modulus influencer, an ion pass. A reducing agent or a combination thereof.

The same polymerizable hydroxyl hydrogel contact lens precursor composition or the pre-extracted polymerized hydroxyl hydrogel contact lens product lacking such an additive, or derived from such a polymerizable composition or polymerized product Enhancements or improvements obtained with the additives of the present invention are apparent when comparing hydroxyl hydrogel contact lenses. Compatibilizers disclosed herein modify or enhance the miscibility of the ingredients of the precursor compositions of the present invention. For example, a compatibilizer can reduce phase separation associated with inclusions and other lens-forming components as compared to formulations that do not use a compatibilizer. The provision of a removable additive in certain of the polymerizable compositions of the present invention and the polymerized product aids in the manufacture of indolent hydrogel contact lenses, particularly having an eye-compatible surface: wettability. There is no need to expose the invisible eye or lens product to the surface treatment, or to add a polymeric wetting agent such as the IPN of PVP. For example, the additives are all distributed from the ground throughout the polymerization composition and are substantially, if not completely, removed from the product of the hydrazine polymerization during the extraction procedure. Further, the additives described herein are not polymeric emollients which are mixed with the prepolymerized composition and then mixed into the polymerized object to form an IPN. The contact lenses of the present invention can be manufactured batchwise without physical or dimensional variability to improve the yield of compatible oxygenated hydrogel contact lenses on the eyes that are clinically acceptable 121843 -29-200815501. The additive may be in liquid or solid form' and includes a hydrophobic or amphiphilic compound or agent. Additives useful in the compositions of the present invention and lens products, including diluents, may have a hydrophilic group attached to a hydrophobic group, such as a hydroxyl group having an alkyl chain, a oxoxane molecule attached to a hydrophilic PEG segment. Examples of two additives such as a main chain include, but are not limited to, a molecular weight of about 1 Torr, a dolphalium or a less polydimethyl methoxy oxane _*_PEG polymer, ethylene glycol stearate, and a single laurel Diethylene glycol acid ester, C2_C24 alcohol and/or C2_C24 amine. The additive may also contain one or more polar or hydrophilic end groups such as, but not limited to, hydroxyl, amine, thiol, phosphate and carboxyl groups to aid in the miscibility of the additive with other materials present in the composition. Sex. The additive may be present in the polymerizable hydroxyl hydrogel precursor composition in an amount from about 2% (w/w) to about 60% (for example, the composition may comprise from about 5% to about 50% ( The amount of w/w) is present in the amount of - or a plurality of additives. The step-by-step example of the polymerizable composition comprises about 鄕, ^^25〇/〇, ^„30〇/〇. ^^35〇/〇,^ „4〇% , ^ ^ 45% 〇 5〇%, or about 55% of the presence of one or more additives. The oxime hydrogel contact lenses of the present invention comprise lenses having an ocularly acceptable surface wettability For example, the lens object of the present invention can have a front surface and a back surface, each surface having an ocularly acceptable surface wettability. In one embodiment, the oxygen water is The lens object of the gel contact lens is purely containing a second oxygen hydrogel material. The lens object has a dry weight of not more than 9〇% of the dry weight of the lens object before extraction. For example, the polymerized Shixi oxygen hydrogel contact lens before extraction The lens object of the product may have a dry weight χ. After the extraction procedure, 121843 -30 - 200815501, two extraction / κ combined stone oxygen gel The lens system of the contact lens product has a dry weight of less than or equal to 0.9%. As discussed herein, the polymerized hydroxyl hydrogel contact lens product can be contacted with a plurality of organic solvents in several volumes and hydrated. To produce a hydrogenated hydrogel contact lens. The hydrated oxygenated hydrogel contact lens can then be dehydrated and weighed to determine the dry weight of the Moon Moon oxygen gel contact lens. In some methods, the pre-extracted polymerized oxygenated hydrogel contact lens product is removed from the contact lens mold member and weighed to provide a polymerized hydrogel gel-like lens product prior to extraction. The dry weight is then contacted with the alcohol for about 6 hours, followed by hydration with water. The hydrated lens is then dried at about 8 (TC for about 丨 hours, then under vacuum, at about 8 (dry for about 2 hours under rc. The dried lens is weighed to determine the dry weight of the lens object of the helium-oxygen hydrogel contact lens. The dry weight is compared to determine the polymerization of the oxygenated water present before the extraction. Glue contact lens product The amount of extractable material in the process. The pre-extracted polymerized lens product having an extractable component content of about 40% produces a lens having a dry weight of about 6% hydroxyl hydrogel contact lens of the pre-extracted lens product. An object having a extractable component content of about 7 〇 σ /. The pre-extracted polymerized lens product produces a lens object having a dry weight of about 30% of the oxygenated hydrogel contact lens of the pre-extracted lens product. The amount of extractable material or extractable component in the previously polymerized hydrogel contact lens product can be measured using the following equation: Ε = ((dry weight of lens product before extraction - extracted and hydrated invisible) Dry weight of the lens) / dry weight of the lens product before extraction) χ 1〇〇Ε is the percentage of extractable material present in the lens product before extraction. 121843 -31 - 200815501 For example, a polymerized oxygenated hydrogel contact lens product prior to stroke can have a dry weight of 20 grams. The hydrogenated hydrogel contact lens obtained from the product has a dry weight of about 17 oz. The hydrogel contact lens comprises a lens object having a dry weight of 85% of the dry weight of the pre-extracted lens product. It is clear that the pre-extracted lens product has an extractable ingredient content of about 15% (w/w). As a further example, the pre-extracted polymerized hydrogel contact lens product can have a dry weight of about 18 mg, while the dehydrated hydrogel contact lens from the lens product has a dry weight of about At 13 mg, the helium-hydrogel contact lens comprises a lens object having a dry weight of about 72% of the pre-extracted lens product. The pre-extracted polymerized hydrothermal hydrogel contact lens product has an extractable ingredient content of about 28% (w/w). In some embodiments, the dry weight of the lens object of the helium oxygen hydrogel contact lens (ie, the oxygenated hydrogel contact lens that has been subjected to the extraction and hydration procedure) is greater than the dry weight of the lens object prior to extraction. 25%. For example, the dry weight of the lens object after extraction may be from about 25 〇/〇 to about 90% of the dry weight of the lens object prior to extraction. Some embodiments of the lenses of the present invention comprise lens objects having a dry weight of from about 50% to about 85% of the dry weight of the lens object prior to extraction. As discussed herein, when the extractable component content in the pre-extracted lens product is greater than 10%, such as at least 15%, at least 20%, at least 25%, or more, the lens is obtained from a lens that does not contain a removable additive. Oxidized hydrogel contact lenses (e.g., from the lens formulation of the overall formulation '', which can have ocularly acceptable surface wettability, or a pre-extracted oxime hydrogel contact lens product. . Compared to the overall formulated lens product, the addition of one or more removable additives to the precursor composition or the lens product prior to polymerization extraction will increase the extractable content of 121843 -32-200815501 and will result in an ocularly acceptable The surface wettability of the hydrogel contact lens. Therefore, it can be understood that the oxygenated water b of the present invention is a plastic L, $ eyeglass comprising a lens object having a dry weight of not more than 90% of the dry weight of the lens before extraction, which is a contact lens obtained from the overall formulation, and The invisible eye of a formulation or lens product comprising one or more removable agents is comparatively described in the description of a hydrogel contact lens containing a diluent formulation, and does not include a high extractable component content. Formulation with diluent. Such lenses often require a surface treatment or polymeric IpN to provide an acceptable surface wettability to the eye upon the hydrogel contact lens. Although the pre-extracted polymerized hydrogel contact lens product of the present invention has a relatively large amount of extractable material, the extracted form of the hydroxyl hydrogel contact lens of the present invention has a very small amount of extractable material in the lens object. . In certain embodiments, the extractable material remaining in the extracted lens is from about 0.1% to about 4%, such as from about 4% to about 2% (w/w). These other extractable materials can be measured by contacting the extracted contact lens with another volumetric strong solvent such as a gas imitation. & When the lens of the oxygenated hydrogel contact lens has a dry weight of no more than 90% of the dry weight of the lens before extraction, the hydrated lens system of the hydrogenated water contact lens is compatible on the eye, and It has an acceptable surface wettability on the eye. In comparison, when the pre-extracted neohydrogen hydrogel contact lens product has a removable component content less than 10% (w/w) of the lens product, such as about 5. (w/w), is obtained from In the case of non-polar resin contact lens molds, the water-cut oxygenated hydrogel contact lenses thus produced do not have an eye-acceptable wettability of the lens surface of the table 121843-33 - 200815501 comprising 92%. Therefore, it can be understood that such a non-wettable lens has a dryness of 9% by weight of the dry weight of the lens object before extraction (single lens of the object).

, in addition, since the extractable component is present in and distributed throughout the polymerizable rock-oxygen hydrogel lens precursor composition and the polymerized oxygenated hydrogel contact lens product towel before extraction, the invention w product and hidden (d) The mirror can be distinguished from the treated hydrogel contact lens. The lens product and contact lens of the present invention can be distinguished from the lithothere hydrogel contact lens having a polymeric wetting agent ipn due to extractable tablet product extraction and substantially absent from the hydrated contact lens. The oxygenated hydrogel contact lenses of the present invention may comprise lens objects derived from a non-polar resin contact lens mold having substantially the same surface morphology when tested for hydration and dehydration. In addition, such hydrated lens bodies may have a surface roughness that is slightly lower than the surface roughness of the dehydrated lens body. For example, the lens object of the lens of the present invention may have a surface comprising a large peak of a nanometer size, which is apparent when analyzing the root mean square (RMS) roughness data of the lens surface. The lens object can be included in the region between such peaks, which is differentially swollen to provide a reduced roughness compared to the peak, but a similar surface morphology on the babe. For example, although the height of the spike can be lowered when the lens object is hydrated, the shape of the spike remains substantially the same. Additionally or alternatively, a specific embodiment of the oxygenated hydrogel contact lens molded by the non-polar resin of the present invention, when viewed as an electron microscope, such as a scanning electron microscope, a transmission electron microscope, or a scanning transmission electron display 121843 -34- 200815501 Xuejue Erzhen:: Rich her domain and lack (4) Can be larger than the surface treated oxygenated water, lacking in the field of Nen Cong's "Hydration = reading glasses or containing polymer body, lacking Shi Xi The phase domain = the size of the _ in the middle of the phase. It is rich in the stone phase phase device, and the size can be used with the conventional image analysis software.

The image is divided into two AI = Bir-^ contours, and the measurement ==: the product is rich (4) lacking the edge of w (four), the cross-sectional area 'diameter, volume, etc. In some of the eight/& columns, the lack of the Shixi phase system has a cross-sectional area of at least 50%, ^60/. 'At least 7〇%' at least _, 丨 at least 鄕 is greater than the lack of 矽 phase of other Shihe oxygen hydrogel contact lenses.

In the ":" specific embodiment, the 'oxygenated hydrogel contact lens comprises a lens object derived from a polymerized oxygenated hydrogel contact lens product having a removable component content of at least a lens product. 1〇% (w/w). The lens object of the polymerized hydroxyl hydrogel contact lens product prior to extraction may contain no or no removable or non-reactive additives such as diluents, compatibilizers, and the like. Such lens objects can be obtained from the overall formulation, as discussed herein. These lens systems have a removable component content of at least 10% (W/W), while in certain embodiments the 'lens object has a removable component content of at least 15% (w/w) 'at least 2 〇% (w/w) 'At least 25% (w/w), Joo. (d) w) or more. For example, in certain embodiments, the pre-extracted polymerized contact lens product has an extractable ingredient content of from 10% (w/w) to about 30°/q (w/w) and is free of non-reactive additives. . In other specific embodiments, the pre-extraction polymerization is 121843-35-200815501

The feta product has an extractable ingredient content of from 丨5% (w/w) to about, such as % (w/w)' and is free of non-reactive additives. In other embodiments, the mirror object may comprise one or more non-reactive additives and may have an amount of removable component greater than that present in a similar lens object free of non-reactive additives. In some embodiments, the removable component content is no greater than 75% (w/w) of the lens product. Accordingly, a specific embodiment of the oxygenated hydrogel contact lens of the present invention comprises a lens object obtained from a pre-extracted polymerized hydrogel contact lens product having a removable component content greater than 1% (w/ w), not greater than 75% (w/w). For example, some pre-extracted polymerized hydrogel contact lens products can have a removable component content of from about 15% (w/w) to about 65% (w/w). Removable ingredients include extractables or extractables that are extracted during the extraction procedure. In addition, the removable component can comprise other materials, such as volatile materials, which can be passively or actively removed from the polymerized oxyhydrogel contact lens product prior to extraction prior to extraction. For example, the portion of the 'removable component' can be smeared between the demolding step and the extraction step. In some embodiments, the removable component of the polymerized hydroxyl hydrogel contact lens product prior to extraction comprises at least one removable additive. As discussed herein, the removable additive can be a non-reactive additive, or a reactive additive that produces a product that can be removed from the polymeric oxygenated hydrogel contact lens product prior to extraction. An example of a removable additive included in a specific embodiment of the polymerized rock-heated hydrogel contact lens product of the present invention, including a compatibilizer, a release aid, and a lens removal aid. Agent, incompatibility enhancer, ion flux reducer, modulus influencer, chain transfer sword and 121843 -36- 200815501 combination thereof. In some embodiments, the amphiphilic additive or the pot ingredient comprises a hydrophobic additive, an additive, s3 / '4 °, for example, the 'removable component can include - or a multi-polymer and a complex. ... [natively known, non-reactive hydrophilic bismuth oxyepoxy acid glycol: as a further example of the 'additive can be selected from the group consisting of hard amines, polydimers; base: = ethylene glycol S. In one example, the additive was PEG and a combination thereof. In some specific implementations of oxy-co-column, ethoxyethanol, and polydimethyl sulphate, the additive system is: It is clear that at least some specific implementations of μ, "", ", An agent other than the composition of the poly-mouth composition, the lanthanide is in the process of mixing the shovel with the polymerizable "hydrogel contact lens precursor group: sex = Γ methyl (the genus is hydrophilic and too) It is called Shixi Oxygen Oil. As usual, these relatives are soluble in water fish, and can be used for the hydrophilicity of the human lens product of the composition of the present invention. The agent is a compatibilizer. In addition, it can be understood that the agent is a release aid and a lens removal aid. For example, a poly-cut oxygen hydrogel contact lens product made of a hydrophilic oxygen-cutting agent, Selectively adhere to a single-mold member, such as a male mold structure of a contact lens mold, and it is easier to remove the lens from the mold member. In addition, compared with a mirror made from a composition that does not have a silicone oil, rA b , lx hair cream can reduce the water content in the oxygenated hydrogel concealed glasses can help keep the stone water The contact lens of the contact lens can reduce the ionic flux of the contact lens. Typically, the diarrhea oil provided in the formulation of the present invention and the lens product has a molecular weight of less than 121843 200815501 of about 3,000 Torr. For example, the compositions of the present invention and the heliox oils in the product may have a molecular weight of from about 1 Dow to about 3 Dow. In some embodiments, the helium oxide has a molecular weight of about 300 Dows. Swallowing about 1000 dolphins. In some specific embodiments, the oxime oil has a molecular weight of about 6 〇〇 呑 呑 ' and has a non-azepine content of about 75%. It can be understood that the oxime oil is a surfactant. It is also apparent that the agent is a ruthenium-containing backbone having a coupling to a long PEG chain. In another embodiment, the oxime hydrogel contact lens comprises a lens object made by a method, the method The method comprises the steps of extracting the extractable component from the polymerized hydroxyl hydrogel contact lens product before extraction to produce the extracted polymerized hydrogel contact lens product. The extractable component is a pre-extracted polymerized hydrogel. Invisible eye Providing at least 10% (w/w) of the mirror product. The method of making a lens object further comprises hydrating the extracted polymeric oxygenated hydrogel contact lens product to produce an ocularly acceptable surface wettability Oxygen hydrogel contact lenses. As discussed herein, the extractable component can be present in an amount from 1% to about 75% (w/w) of the previously polymerized hydrogel contact lens product. It can be understood that the polymerized hydrogenated hydrogel contact lens product has an extractable component content of 10% to about 75% (w/w). For example, the component can be extracted before the polymerization of the polymerized oxygenated water. The amount of the contact lens product is present in an amount from about 15% to about 65% (w/w).

In some embodiments, the tomb run A J r is the extractable point S of the polymerized hydrothermal hydrogel contact lens product, to: >, a removable additive, as described herein. For example, the extractable point/eight J can be found to include a compatibilizer, a release aid, 121843-38-200815501 lens removal aid, Kouyuan, and α w μ +, a crumbly enhancer Ion flux reduction agent % and combinations thereof, as described herein. Some specific embodiments of the lenses of the present invention include a non-surface treated lens body that provides an acceptable operability on the eye. The lens object of the Moonlight Oxygen Silicone Contact Lens can be a lens object that has not been processed by the face. Alternatively, the lens system is manufactured without:: surface treatment of the lens object to provide an acceptable surface moisturization on the eye. For example, a lens object of a particular embodiment of the lens of the present invention does not include a plasma treatment or another coating that is provided to provide an ocularly acceptable surface to the lens object. However, because the lenses of the present invention have an ocularly acceptable surface wettable property, this is due to the amount of removable material present in the polymerized dialysis hydrogel contact lens product prior to extraction. Needed, then - some embodiments may include surface treatment. Further, a specific embodiment of the lens of the present invention comprises a lens object of an interpenetrating polymer network comprising no polymeric wetting agent. The emollient provides an ocularly acceptable surface. In other words, the lens system of a particular embodiment of the lens of the present invention has an ocularly acceptable surface manageability and a 3 polymer wetting agent such as polyvinyltetrahydropyrrolidone (PVP). For example, the lens object of the lens of the present invention can be fabricated without the contact of the precursor of the fluorescein hydrogel lens with the polymeric wetting agent to form an interpenetrating polymer network. Some specific embodiments of the lenses of the present invention comprise a lens object which is a cast molded component of a non-polar resin contact lens mold. It will be appreciated that the polymerized lithothere hydrogel contact lens product is the product of polymerization or ripening in a non-polar resin occlusion 121843-39-200815501 lens mold. Alternatively, in another way, the 'polymerized oxygenated hydrogel contact lens product line' is made in a non-polar resin contact lens mold. As discussed herein, such contact lens molds are made of, or based on, a non-polar or hydrophobic resin material. Such materials typically have a relatively large contact angle on the surface on which the lens is formed. For example, the non-polar resin or hydrophobic resin mold can have a contact angle greater than about 90 degrees. Examples of suitable non-polar resin mold materials that can be used in these particular embodiments of the lens include resin materials that include one or more (iv) cigarettes. Some examples of suitable resin materials include polyethylene, polypropylene, and polystyrene, as well as other materials having similar hydrophobic properties. Non-polar resin-based molds are not based on polar resins such as polyvinyl alcohol or ethylene vinyl alcohol copolymers. In the specific embodiment, the lens of the present invention comprises a lens object comprising the above features. For example, 'oxygenated hydrogel contact lenses may include lens surfaces that are surface-treated and do not contain poly(4), ..., 3" agents. As another example, the invisible eye of Shixi oxygen hydrogel has Surface treatment, without poly-, (four) lens objects, which does not require the IPN of the zero limb wetting agent, and is a cast molded component obtained from a non-polar resin contact lens mold. - Oxygen reading contact lens - The specific embodiment of the one or more comfort enhancers, each of the oxygen hydrogel contact lenses, which enhances the comfort of the contact lens perceived by the group of f-adhesive enhancers, and the comfort is increased _ m, &, 3 in the lens of the present invention, another item of the enhancer = water action reducer. Comfort is a phase fixer. Another example of the comfort enhancer is 121843-40-200815501. An agent that reduces dehydration and stabilizes the tear film of the eye upon which the contact lens is placed. The comfort enhancer comprises a polymeric material having an affinity for water. In some embodiments, the polymeric material is derived from Unit of amphiphilic material. Appropriate material Examples include polymerizable serolipids, such as materials comprising a phosphonium choline component. In certain embodiments, the lenses of the present invention comprise a lens object comprising methacrylate choline _ monomer units. In a specific embodiment, the lens object comprises 2-mercaptopropenyloxyethylphosphonium choline (Mpc). MPC is available from some companies, such as Wire Co., Ltd. (UK) and Liao Company (Tokyo, _Japan). , ^ T ^ ^ ® # ,.J 5,981,786 ; 6,420,453 ; A 6,423,761 t ^ 〇 "As discussed herein, the comfort of the present" oxygen hydrogel lens can also be achieved by adding one or more removable comforts. The sex enhancer is enhanced in the lens precursor group and the pre-extracted 7 oxygen hydrogel contact lens product. ^ Some of the removable materials described herein include reducing the ion flux of the lens of the present invention. The agent is compared to a lens obtained from the same composition without a removable substance. The reduction of the ion flux of the low lens can help reduce the corneal dehydration of the lens and reduce the wear of the lens. Caused by corneal color 0 = text As discussed, the lenses of the present invention have the characteristics of allowing the lens to be worn. For example, the lenses of the present invention can be worn daily with lenses, maternal wear lenses, and goddess, 'female two-week wear lenses or monthly fits. The lens is worn. The lens of the present invention comprises a sleek fishery, a modulus, an ion-passing enthalpy, a turbulent venting property, and a water content, which are used to aid in sheet comfort and usability. In some embodiments, the invention 121843 41 200815501 The lens comprises a hydrated lens object having characteristics selected from the group consisting of a forward contact angle of less than about 95 degrees, a tensile modulus of less than about 16 coffee, an ion flux of less than about 7 X 103 square millimeters per minute, and oxygen reading. The milk permeability (Dk) is at least about 70 Barr (b-, water content of at least about 30% by weight, and combinations thereof. However, in a potted embodiment, the ionic flux can be greater than 7 and 3 square millimeters per minute without causing corneal dehydration staining or other clinical problems. For example, when the _oxygel contact lens contains a comfort enhancer,

For example, the ionic flux can be about 25 χ ι〇_3 mm 2 /min, which is still clinically acceptable. The present invention: The lens may comprise a hydrated lens object having an advancing contact angle of less than (10) degrees on the front surface, the back surface or the front and back surfaces. In some embodiments, the mirror object and the ancient # μ t gauge object have a lens surface advancing contact angle of less than 90 degrees 'eg, the lens object is a right pound Η矣乂 eight lens surface contact angle of about 85 degrees, about 80 degrees 'about 75 degrees, about 70 degrees, about 65 degrees, about (eight) degrees, about % degrees, or about % degrees. The lens object may also have a lens surface reverse contact angle of less than 8 degrees, and the lens lens version may have a lens surface reverse contact angle of about 75 degrees, about 70 degrees, and a force of 65 degrees 'about 60 degrees 'about 55 degrees 'about 5 〇, or about 45 degrees. Hysteresis, which means that the difference between the advancing contact angle and the retreating contact angle can be from about 5 degrees to about %. However, in some embodiments, the hysteresis may be greater than %, while still being acceptable on the g bed. For example, when a hydrogenated hydrogel contact lens contains a comfort enhancer, such as a DPP component such as Mpc, the hysteresis can be about 60 degrees and the lens can still be clinically acceptable. The contact angle can be measured using a routine method known to those skilled in the art. For example, the contact angle and the reverse contact angle of the spectacles can be measured by the drop shape method, such as a fixed drop method or by using a 121.42-42-200815501 method. The method of capturing bubbles. Kruss DSA 1〇〇 instruments (Kruss GmbH, Hamburg) and DA Brandreth: Dynamic Contact Angle and Contact Angle Hysteresis in the front and back water contact angles of the hydrogel contact lenses, Colloid and Interface Science Journal, Vol. 62, 1977, pp. 205-212, and R. Knapikowski, M. Kudra: Kontaktwinkel messungen nach dem Wilhelmy-Prinzip-Ein statistischer Ansatz zur Fehierbeurteilung'', Chem. Technik, Vol. 45, 1993, 179- 185 pages, and as described in U.S. Patent No. 6,436,481. As an example, the advancing contact angle and the reverse contact angle can be determined using a trapped bubble method using phosphate buffered saline (PBS; pH = 7.2). The lens was flattened on the surface of the quartz and rehydrated for 10 minutes in PBS. The bubble was placed on the surface of the lens using an automated syringe system. The size of the bubble can be increased and decreased to obtain a retreat angle (the plateau obtained when the bubble size is increased) Zone) and the angle of advancement (the plateau zone obtained when the bubble size is reduced). The lens of the invention may additionally or alternatively A lens object exhibiting a water break time (BUT) greater than 5 seconds. For example, a specific embodiment of the lens of the present invention comprising a lens object having a water BUT of at least 15 seconds, for example 20 seconds or more, may be ocularly acceptable Surface wettability. The lens of the present invention can comprise a lens object having a modulus of less than 1.6 MPa. In some embodiments, the lens object has a modulus of less than 1.0 MPa. For example, the lens object can have a modulus of about 0.9 MPa. , about 0.8 MPa, about 0.7 MPa, about 0.6 MPa, about 0.5 MPa, about 0.4 MPa, or about 0.3 MPa. One example of the oxygenated hydrogel contact lens of the present invention has a modulus of 0.55 MPa. -43 - 200815501 : The modulus is selected to provide a comfortable lens when placed on the eye' and the compliant lens is treated by the lens wearer. The modulus of the lens object can be used as usual. Known routines t test, for example, a piece of contact lens having a width of about 4 mm can be removed from the mirror, and the tensile modulus (unit; _ can be measured from the initial slope of the stress strain line, The curve is tested by tension , At a rate of 10 mm / minute, in air, at a level of at least 75% of the Cheng 'at the pit, using Instron 3342 (Instron Corporation) is obtained.

U The ionic flux of the lens object of the lens of the present invention may be less than 5 χ妒 square mm/min. Although, the lens objects of the lenses of the present invention may have an ion flux of up to about 7 to 10 -3 square millimeters per minute, when the ion flux is less than about 5 x 103 square millimeters per minute, and when the contact lens is not included At the time of Cong, corneal dehydration and staining can be reduced. In some embodiments, the ionic flux of the lens object is about 4.5 Χ 10·3 mm 2 /min, about 4 χ 10-3 mm 2 /min 'about 3.5 χ 10 · 3 mm 2 /min, about 3 χΐ〇 _ 3 square Mm / min ' or smaller. However, 离子' as described herein, the ion flux can be greater than 7χ10.3 mm 2 /min without causing corneal dehydration, staining or other clinical problems. For example, when the Shixi oxygen hydrogel contact lens contains a comfort enhancer, such as a silky ingredient, the ion flux can be about 25 x 10-3 square millimeters per minute while still being clinically acceptable. The ionic flux of the lens object of the present month lens can be determined using a method known to those skilled in the art. For example, the ion flux of a contact lens or lens object can be measured using a technique similar to the "ion flux technology" described in the U.S. patent. For example, the lens 121843-44-200815501 to be measured can be placed. The lens is held between the male and female parts. The flexible sealing ring, j: # e + a human part contains the mountain seal, which is positioned in the lens and the individual male or female lens is positioned in the lens to maintain Between the files. There will be a threaded shackle. The lid will be spiraled in the chamber cum ml (H Mo... Define the donor chamber. Donor cc... C1 solution filling. Receiving chamber can be 8. Completion u ^ Electric ♦ Handcuffed wire Immerse the deionized water f in the receiving chamber, and add the stirring rod to the joint. 4. The mountain husbandry team will place the receiving chamber in the constant two and keep the temperature under the pit. Finally, the donor chamber will be dipped. = = in the chamber. The conductivity can be measured every 2 minutes, after (4) knife I in the donor chamber immersed into the receiving chamber 1 minute after the start. Conductivity versus time data should be substantially linear. The lens object of the lens of the present invention typically has high oxygen permeability For example, the lens object has an oxygen permeable melon of not less than 6 〇 勒 ( (4). A specific embodiment of the lens of the present invention includes having about 8 baht, about % baht, about: 〇 勒 勒 ' 请 巴 巴, about Baller, about 13 baht, about 14 baht or larger lens object. The Dk of the lens of the present invention can be determined using routine methods known to those skilled in the art. For example, the Dk value can be determined using the Mocon method. As described in U.S. Patent No. 5,817,924, the Dk value can be determined using a commercially available instrument under the mode indication of the M〇c〇n (four) coffee system. The lenses of the present invention also include lens objects having an ocularly acceptable water content. For example, a particular embodiment of the lens of the present invention comprises a lens object having a water content of not less than 30%. In some embodiments, the lens system has a water content of about 35°/., about 40%, about 45%, About 50%, about 55%, about 60%, 121843-45 -

200815501 or about 65%. The water content of the lenses of the present invention can be determined using routine methods known to those skilled in the art. Example #, the hydrated cuvette hydrogel contact lens can be removed from the hydrophobic liquid, wiped to remove excess surface water, and weighed. The weighed lens can then be dried in an oven under vacuum at 8 Torr and the dried lens can then be weighed. The difference in weight is measured by subtracting the weight of the dried lens from the weight of the hydrated lens. The water content (%) is (weight difference / hydrated weight) X 100. In addition to the specific values identified above, the lenses of the present invention may have values within the range between any combination of the particular values identified above. For example, the present contact lenses can have a water content of from about 45% to about 55%, an ion flux value of from about 3.9 to about 5.3, a static contact angle of from about 35 degrees to about 45 degrees, and an advancing contact angle of from about 55 degrees to about 75 degrees. The retrogressive contact angle is about 47 degrees to about (10), the hysteresis is about 11 degrees to about 25 degrees, the Young's modulus is about 4747 MPa to about 〇51 bribes, the elongation is about 140% to about 245%, and combinations thereof. In some specific embodiments of the present invention, the lens system has a water BUT greater than 20 seconds, a modulus less than 〇·5na, an ion flux of less than 5, and a water content of about 55%. . The present invention provides a hydrogel contact lens for contact lenses. The lens can be a spherical lens focus lens or a multifocal lens, including, in the embodiment, the lens of the present invention is a toroidal contact lens that is rotated. The contact lens of the lens object that rotates the stabilizer is a visually corrected or visually enhanced or aspherical lens. The lens can be a single bifocal lens. In some specific lenses, such as rotationally stabilized contact lenses may be included. For example, the lens object can have ribs 121843-46-200815501 mirror settings, surrounding fixtures, and/or one or more thinned upper and lower regions. The lenses of the present invention also include lens objects containing peripheral edge regions. The surrounding edge region may include a rounded portion. For example, the peripheral edge region can include a circle T trailing edge surface, a rounded front edge surface, or a combination thereof. In some embodiments, the peripheral edge is completely rounded from the front surface to the back surface. Therefore, it is apparent that the lens object of the invention (4) may include rounded peripheral edges. The lenses of the present invention can include lens objects having a thickness profile that seeks to address the problems associated with current Shihe oxygen hydrogel contact lenses, which are still comfortable for lens wearers. By varying the thickness of the lens object, the modulus of the lens object can be controlled by the rigidity of the lens object. For example, the stiffness of a region of a contact lens can be defined as the product of the Young's modulus of the lens and the square of the thickness of the lens over the designated area. Thus, certain embodiments of the lenses of the present invention can include a central stiffness (e.g., a stiffness at the center of the lens or the center of the optical zone) of less than about _7 hall square Ai Mi, and a lens joint stiffness of less than about 0.03 MPa. Square millimeters or a combination thereof: a lens object. The lens junction can be defined as a beveled lens region: the junction, or for a lens without a bevel, about a point from the edge of the lens (see U.S. Patent No. 6, 71). In other embodiments, the lens of the present invention may comprise a lens object having a "rigidity greater than 7 _ square millimeters, a rigid junction stiffness greater than about .03 slightly _ square millimeters, or a combination thereof. Hydrogel contact lenses can be used in the lens or in batches of lenses, in physical reading, such as physical dimensions, etc., with little variability. For example, 'in some embodiments, additives can be added to the polymerizable stone eve. Oxygen 121843 200815501 Hydrogel contact lens precursor composition to reduce the physical property variability of the lens. Using this physical parameter to control the additive, the variability between the batches of the lens can be low (4). For example, for - or multiple Batch: The variability of the inventive lens can range from about % to about 19%. For example, the diameter and basic curve of the lens of the present invention can be controlled within a predetermined value (10). More specifically, the diameter of the contact lens of money is (10) Millimeter, and if the actual diameter of the contact lens in the contact lens batch varies from about 136 mm to about H.4 mm, then _ or a variety of additives can be used during the manufacture of the contact lens. Variability and manufacture of contact lenses having a diameter ranging from about (10) mm Μ 2. 2 mm. Similar controls can be provided to reduce variations in lens thickness, sagittal ice base curvature, etc. Additives can be diluents or compatibilizers. And may be up to about 5% (in quantities provided. Thus, the addition of diluents or other additives may be used to reduce or control the deformation in the contact lenses of the present invention. Further, diluents or additives, as well as modifications present in the polymerizable composition ^ The active or reactive component can be used in different batches of lenses, taking the physical properties of the lens as a standard, such as modulus. The present invention, the oxygenated hydrogel contact lens can be provided in a sealed package, For example, the present invention can be provided in a sealed bubble wrap or other similar container suitable for transport to a lens wearer. The lens can be stored in an aqueous solution in a package, such as a salt. Aqueous solution. Some suitable solutions include phosphate buffered saline solution and borate buffered solution. ^ If necessary, the solution may contain a bactericide or may not contain disinfectant. Preservative: If necessary, the solution may also contain a surfactant, such as a polyoxygen (ρ〇ι_), etc. 0 121843 -48- 200815501 In the sealed package, the error H u^, the brother of the car is not _. For example, the lens can be sterilized before sealing the package, or a sterilized in the package to be sealed. The sterilized lens can be a lens that has been exposed to sunlight. Pressure treatment clock H+ ^ <lens, 7* radiation lens, exposed lens, etc.. For example, the lens is irradiated by ultraviolet radiation, and the other aspect is about the pre-extracted polymerized Shishi oxygen hydrogel hermit 艮The mirror product W, such as a lens product that has been polymerized but has not been subjected to an extraction procedure, as described herein. As described above, a relatively high amount of a removable material, such as an extractable material, is used to produce a pre-extraction The polymerized (iv) hydrogel contact lens product results in an ophthalmic hydrogel contact lens with acceptable surface wettability for the eye' even when the lens is made using a non-polar resin contact lens mold and does not include a polymer Table of wetting agents EVEN process. A specific embodiment of the present invention for extracting a hydrolyzed hydrogel contact lens product comprising a polymerized body comprises a pre-extracted object member having a dry weight of at least 1% greater than that the object member is subjected to an extraction procedure to form an extracted polymerization. The dry weight of the object component after the oxygen hydrogel contact lens product. For example, the oxygenated hydrogel contact lens product that is polymerized prior to extraction has an extractable component content of at least 10 Å/〇 (w/w) of the lens product. In some embodiments, the pre-extracted polymerized hydrogel contact lens product has an extractable ingredient content of no greater than 75% of the lens product. In further embodiments, the extractable component is present in an amount from about 15% to about 65% (w/w) of the extracted lens product. In yet another embodiment, the extractable ingredient is present in an amount from about 15% to about 50% (w/w) of the extracted lens product. 121843 -49- 200815501 Since the lens of the present invention can be obtained from a non-polar resin contact lens mold member, the specific embodiment of the pre-extracted Shishi oxygen hydrogel contact lens product of the present invention includes such a non-polar resin contact lens. The mold member contacts the product provided. For example, a specific embodiment can be a pre-extraction product provided in a sealed contact lens mold, or a pre-extraction product provided on a mold member of a release contact lens mold. In some embodiments, the lens product prior to extraction is in contact with the contact lens male mold member. Specific embodiments of the oxygenated hydrogel contact lens products of the present invention prior to extraction also include object members containing - or a plurality of removable additives, such as non-reactive additives. Additives include each of the above and each additive, including combinations of such additives. Therefore, it is clear that the lens product before extraction may comprise one or more additives selected from the group consisting of compatibilizers, debonding aids, lens removal auxiliaries, preparation enhancers, ionic lower agents, comfort agents and Its combination. A 酉匕 ^ some specific. In the examples, the lens product comprises a unit containing methyl methacrylate, which is an element of pre-extraction, such as 2-methylpropanyloxyethylphosphonate. Another aspect of the quality relates to polymerizable lithothere hydrogel contact lenses first, and - and s. The precursor composition of the present invention can be polymerized non-containing; the L 汆 汆 矽 矽 与 与 与 与 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 被 。 。 。 。 。 。 。 。 。 。 。 。 。. A portion of the precursor composition can be removed from the product of the prior polyoxygenated canister. Removable amount: one of the oxygen hydrogel contact lens products 121843 - 50 - 200815501. In certain embodiments, the non-especial component of the precursor composition comprises a first reactivity ratio A monomer that is a second monomer having a second reactivity ratio lower than the first reactivity ratio. For example, if the first monomer has a reactivity ratio of about 3, the second monomer has a reactivity ratio of less than about 3. The second reactivity ratio may be less than about 1%, less than about 2%, less than about 3〇0/〇, less than about 40%, about 50% lower than about 60% lower, about 70% is below, about 80% is lower than 'or about 90% lower than the first reactivity ratio. In a specific embodiment, the second single system has a reactivity ratio of 〇·5, and the first monomer has a reactivity ratio of 3. The lens products and lenses of the present invention can be made using reactive components having different reactivity ratios during the formation of the polymerized product. It is clear that the component having a higher reactivity ratio is generally more reactive than the component having a lower reactivity ratio, and therefore the first component having a higher reactivity ratio will be within a certain amount of time. reaction. In some embodiments, the precursor composition also comprises a crosslinking agent having a reactivity ratio that is more similar to the first reactivity ratio than the second reactivity ratio. Thus, the type of reactive component in the precursor composition of the present invention can affect the amount of removable component present in the polymerized regrown product, the dry weight of the oxygenated hydrogel contact lens of the present invention, and the lens. Wettability. Furthermore, the precursor compositions of the present invention may comprise one or more initiators. It can be understood that the thermal initiator has "starting, temperature." By selecting a thermal initiator having a higher starting temperature, and using a relatively lower amount of initiator, the ion flux of the lens of the present invention can be reduced. The amount of the removable component described herein: For example, one of the thermal initiators used in the precursor composition of the present invention is azobis(2,4-dimethylvaleronitrile) (νΑζα52) having a starting temperature It is (10) 121843 -51 - 200815501 °c 'At this time' the reactive component begins to polymerize. The second thermal initiator used in the precursor composition of the invention is azobisisobutyronitrile (vaz_, which has a beginning A temperature of about 9 (TC. Eye compatible hydroxyl hydrogel contact lenses can be obtained from a precursor composition comprising about 0.2 parts VAZa52 or about Q1 parts vaz〇_88. Further, as disclosed herein The curing step of the polymeric polymerizable composition may include one or more temperature steps. Specific embodiments of the precursor composition of the present invention may comprise one or more hydrophobic or amphiphilic additives that may be removable or extractable, such as The above specific additives. One or more additives may It is present in an amount from about 1% to about 60% (w/w). In some embodiments, one or more additives are present in an amount from about 30% (w/w) to about 60% (w/w). In certain compositions, at least two different additives are provided. Certain specific embodiments of the precursor compositions of the present invention comprise a polymerizable silicone hydrogel invisible in a non-polar resin contact lens mold. The lens precursor composition. Other embodiments include such a composition in a storage container such as a bottle or the like, or in a dispensing device such as a manual or automated pipetting device. An example of a precursor composition of the present invention comprises Polymerized cerium-containing component, which comprises a fluorenyl fluorenyl sulfonium-containing oxo-monoxide, A-bis (nonyl acryloyloxyethyl imino carboxyethyloxy propyl group) Alk)-poly(trifluoropropyldecyloxyl)-poly(ά>methoxy-poly(ethylene glycol) propylmethyloxirane) (M3U) 'with a polymerizable non-ruthenium containing component, It includes the team vinyl·methylacetamide (VMA), isodecyl methacrylate (IBM), ethoxylated ethoxyethyl acrylate (EOEMA) Di-mercaptoacrylic acid tris(ethylene glycol) hydrazine (TEGDMA), triethylene hydride 121843 200815501 alcohol divinyl ether (TEGDVE) and 2,2'-azobis(2,4-dioxyl valeronitrile) (VAZO -52). The roM line in this composition is shown to increase the stiffness of the extracted hydroxyl hydrogel contact lens as compared to a lens that is substantially identical to IBM without the lens. 30-40% (w/w), rather than bismuth-containing components, may comprise from about 60% to about 70% (w/w) of the composition. In some embodiments, the M3U is provided in an amount of about 30-40% The VMA is supplied in an amount of about 45-50%, the MMA is supplied in an amount of 15-20%, the EBM is supplied in an amount of about 5%, the EOEMA is provided in an amount of 15%, and the TEGDMA or TEGDMA and the TEGDVE are Approximately 0.2% is provided, and VAZO-52 is provided in an amount of about 0.5%. Another example of the precursor composition of the present invention comprises the aforementioned components and an ultraviolet absorber, and a microdye which may be a reactive dye or pigment particle. The UV absorber can be provided in an amount of about 0.9%, and the microdye can be provided in an amount of about 0.1%. The UV absorber can be a strong UV absorber which exhibits a relatively high absorption in the UV-A range of about 320-380 nm, but is relatively more transparent than about 380 nm. For example, the UV absorber may include photopolymerizable hydroxydibenzophenones and photopolymerizable benzotriazoles, such as 2-hydroxy-4-propenyloxy which is commercially available from Cytec Industries as CYASORB8 UV416. Ethoxybenzophenone, 2-hydroxy-4-(2-hydroxy-3-mercaptopropenyloxy)propoxydibenzophenone, and commercially available from Noramco as NORBL® C®7966 Photopolymerizable benzotriazole. Other photopolymerizable UV absorbers may include polymerizable vinyl-based unsaturated tri-till, salicylate, aryl-substituted acrylates, and other polymerizable variants of effective UV absorbers, and such UV absorbers. a mixture. Another embodiment of the precursor composition of the present invention comprises a polymerizable 121843-53 - 200815501 ruthenium-containing component comprising M3U, and a polymerizable non-ruthenium-containing component comprising VMA, methacrylate methacrylate (MMA) ), TEGDMA and VAZO-52. Another example of the precursor composition of the present invention is a composition comprising the components of the foregoing specific examples and an ultraviolet absorber and a microdye. This embodiment may also comprise a block copolymer of polydimethyl siloxane (PDMS) and polyethylene glycol (PEG). This block copolymer is abbreviated herein to PDMS-co-pEG. An example of PDMS-co-PEG has a PEG content of 75% and a molecular weight of about 1400. Other examples of PDMS-co-PEG materials that can be used have molecular weights from about 300 to about 3,000 dolphins. PDMS-co-PEG may be present in an amount from about 10% (w/w) to about 40% (w/w). For example, the precursor composition may comprise PDMS-co-PEG in an amount of 12% (w/w), 20% (w/w), 25% (w/w), 29% (w/w), or 30% (w/w). Another embodiment of the precursor composition of the present invention comprises a polymerizable ruthenium-containing component comprising M3U, and a polymerizable non-ruthenium-containing component, which comprises VMA, IBM, MMA, TEGDMA, UV absorber, micro-dye And VAZO-64. Particular embodiments of such compositions may have a modulus greater than other specific embodiments disclosed herein. Another embodiment of the precursor composition of the present invention comprises a polymerizable ruthenium-containing component comprising M3U, and a polymerizable non-ruthenium-containing component comprising 1-vinyl-2-tetrahydropyrrolidone (NVP) , MMA, TEGDMA and VAZO-52. In such embodiments, the cerium-containing component comprises from about 30% to about 40% (w/w) of the composition, and the non-containing cerium component comprises from about 60% to about 70% (w/w) of the composition. For example, M3U can be present in an amount from about 35% to about 38%. NVP can be present in an amount of about 45-50%, MMA can be present in an amount of about 15-20%, TEGDMA can be present in an amount of about 〇·1-〇·8% 121843-54-200815501, and VAZO-52 can be about 0.1- 0.6% of the amount exists. Another embodiment includes previously identified ingredients and sterols. The sterol may be provided in an amount of from about 5% (w/w) to about 30% (w/w). For example, specific embodiments may comprise decyl alcohol in an amount of about 5% (w/w), about 10% (w/w), about 15% (w/w), about 20% (w/w), about 25% (w/w), or about 30% (w/w). Sterols are effective as both a compatibilizer and a diluent. Thus, sterols can help reduce the phase separation of the components of the photographic precursor composition. A particular example of a sterol-containing formulation comprises 35% M3U, from about 45% to about 55% NVP, from about 13% to about 20% MMA, about 0.1% TEGDMA, about 0.6% (VAZO-52), and about 30. % sterol or lower. The NVP-containing precursor composition of the present invention may also comprise a release aid, such as a release aid comprising a hydrophilic oxime component, a polyoxyalkylene component or a combination thereof. The NVP-containing precursor composition of the present invention may further comprise a diluent selected from the group consisting of hexanol, ethoxyethanol, isopropanol (IPA), propanol, decyl alcohol, decane oil, and combinations thereof. The diluent can be present in an amount from about 10% to about 30% (w/w). A composition having a relatively high concentration of diluent exhibits a lower ionic flux value, a reduced modulus, an increased elongation, and a water BUT greater than 20 seconds. Some specific embodiments of the NVP-containing precursor composition containing a diluent comprise units of methacrylate choline-monomer, such as 2-methylpropenyl methoxyethyl. The MPC can be present in an amount from about 1% (w/w) to about 15% (w/w) of the composition. For example, when the composition of the invention comprises about 2.5% MPC, about 5°/. MPC, about 7% MPC, about 10% MPC, or about 12% MPC, can be made into an eye-compatible neon hydrogel contact lens. Such compositions may also contain an alcohol based diluent. For example, some compositions may contain 121843 '55 - 200815501 containing about 5°/. Sterol. Specific examples of the NVP-containing composition of the present invention, including the above specific examples, also include (3-methacryloyl-2-hydroxypropyloxy)propylbis(tridecyldecyloxy)methyl Decane (SiGMA). Another aspect of Benming is a method for making a Shixia oxygen hydrogel contact lens. In certain embodiments, the method of the invention comprises forming a dry weight of no more than 10% (w/w) of the pre-extracted oxygenated hydrogel contact lens product having a removable component content greater than or equal to the dry weight of the lens product. 90% of the dry weight of the lens object before extraction and the acceptable surface of the eye can be used to treat the contact lens object. The step of forming the method may include the step of extracting the extractable material from the oxygenated hydrogel invisible ophthalmic product prior to extraction. The oxime method can also include maturation of the polymerizable silicone hydrogel contact lens precursor composition to form at least a portion of the lens product having a removable component content. As discussed herein, the ripening can be thermal curing or UV curing. The ripening can be carried out in a non-polar resin contact lens 槿 φ | 4 ^ ^ ^ ,, such as a polyolefin-based contact lens mold. The method can also include combining the polymerizable Schiffon component with the polymerizable non-stone component to form a polymerizable silicone hydrogel contact lens precursor composition. This method can also include the step of adding a removable additive to the polymerizable spectacles precursor composition. The additive may be added to the final monomer mixture or it may be added to either of the two components in a mixed bismuth-containing component and a non-ruthenium-containing component (121843-56-200815501). Any of the additives described in the additive, including combinations of such additives. The ',' can also include the addition of UV absorbers, micro-dyeing agents, and bovine precursors in the composition of the hairpins τ 6 ^ , , and . The steps to the mirror ι. As can be seen from the description of the article, these methods can be applied to manufacture a silicone hydrogel contact lens without a lens, a lens having a polymeric wetting agent, or a polar resin mold or combination.

The contents disclosed in this article can be found in the book, the body of the body, including the lens object, which has been subjected to an extraction procedure to effectively mold from (4) (4), nitrogen curing Hydrolyzed by Polymerization: The contact lens product removes extractable material, the contact lens product is a self-polymerizable lithothere hydrogel contact lens precursor composition having a distribution throughout the composition and lens product The wettability enhances the monomer, promotes compatibility, or a plurality of additives and a high amount of extractable material. The lens system has a second acceptable surface for lubricity. Use of the compositions and methods of the present invention 'invented eye-compatible oxygenated hydrogel contact lenses' _ avoiding problems associated with the use of pure resin molds, such as in the polymerization reaction, on the separation of the mold half隹; problems associated with ingenious and expensive post-polymerization procedures such as plasma etching, irradiation, chemical modification; and problems associated with polymer lubricants. The following examples are intended to illustrate some aspects of the invention and are not intended to be limiting. 121843 -57· 200815501 The following conventional chemicals are cited in the examples and may be referred to by their abbreviations. PP : Polypropylene PEG : Polyethylene glycol IBM : Isodecyl methacrylate VMA : N-vinyl mercaptoacetamide (just distilled under vacuum) M3U : M3-U ; 仏 6 > bis (decyl propylene ) Mercaptooxyethyliminocarboxylate: ethoxypropyl)-poly(dimethyloxane)-poly(trifluoropropylmethyloxirane)-poly(ά>曱oxy- Poly(ethylene glycol) propyl fluorenyl oxane); dimethyl methacrylate fluorene-containing macromolecules are represented by the following formula M3U used in the following examples, wherein η is 121, m is 7.6, and h is 4.4, and Μη = 12,800, and Mw = 16,200. C3H6(OC2H4)pOCH3 ch3 ch3 ch3 c2h4cf3 ch3 ch3 1 111 1 1 H2C= CCOOC2H4 NHCOOC2H4OC3H6SiO-( SO }n- ( SrO }m- ( SiO > h-SiC3H6OC2H4〇CONHC2H4OCOC=CH2

If 111 ch3 ch3 ch3 ch3 ch3 EOEMA : ethoxyethyl decyl acrylamide

Vazo-52 : 2, azobis(2,4-dioxyl valeronitrile) (V-52; thermal initiator) I; , Vazo-64 : azobisisobutyronitrile (V-64; thermal initiator PDMS: polydidecyloxane PDMS-co-PEG: block copolymer of polydimethyloxane and PEG, containing 75% PEG, and MW 600 (DBE712, available from Gelest) HEMA :曱2-Hydroxyethyl acrylate NVP : 1-vinyl-2-tetrahydropyrrolidone (distilled under vacuum) HOB : 2-hydroxybutyl methacrylate FM0411M: FM-0411M; a-mercapto propylene fluorenyl Ethoxyethyliminocarboxyl 121843-58-200815501 Ethoxypropyl-poly(dithiocarbazone oxy)-butyl fluorenyl sulphate was used in the following examples to express FM0411M , where η = 13-16 and Mw is 1500. Ch3 ch3 ch3 ch3

i I ) I

H,C= CCOO€2H4 NHCOOQH^OC^HgSiO-i SiO }n~Si€4H9 ' I I I ch3 chz ch3 TAIC : 1,3,5-Triallyl 4,3,5-three tillage - 2A6(1H,3H,5H)-trione (triallyl isocyanurate) f ' AOT : aerosol OT; bis(2-ethylhexyl) sulfosuccinate sodium salt TP〇: biphenyl Base (2Λ6-trimercaptobenzylidene)phosphine oxide ΙΡΑ: isopropanol N,N-DMF : DMF ; Ν,Ν-dimercaptoamine ΗΜΡ : 4-hydroxy-4-mercapto-2- Pentanone TEGDMA: Triethylene glycol dimethacrylate TEGDVE: Triethylene glycol diethylene ether oxime: decyl methacrylate (j VM : vinyl methacrylate PTA: pentaerythritol triacrylate TPTMA: Trimethyl methacrylate, propylene oxide, SiGMA : (3-methylpropenyloxy-2-hydroxypropyloxy)propyl bis(trimethyldecyloxy)methyl decane, Pr: propanol Hx: Hexanol DA: decyl alcohol 121843 -59- 200815501 DVG: divinyl glycol EE: ethoxyethanol U^416 · two dibasic acid 2-(4-benzylidene-3-phenylphenoxy) Ester M3U U dye ··· Wan Cu_ phthalicin dispersion in Shaowu (% w/w) Cu-phthalicin can be Heliogen Blue K7090 Available from BASF. Example 1 Hydroxyl Hydrogel Contact Lens Manufacturing The chemical compounds set forth in Example 2-55 were weighed and mixed to form a mixture. The mixture was filtered through a 〇2-5.〇micron syringe filter into a bottle. Store the mixture for up to about 2 weeks. It should be understood that these mixtures are polymerizable hydrogel hydrogel contact lens precursor compositions. In Examples 2-55, except for their individual weight percentages (expressed by weight; w In addition to /w), the unit is provided in each of the chemical substances. In the final oxygenated hydrogel contact lens, the weight percentage of the chemical compound is more closely related to the unit amount present in the precursor composition. a precursor composition in contact with a lens defining a surface of the non-polar resin master member, such as a polypropylene mold member. A non-polar resin male mold member, such as a polypropylene male mold member, is placed in contact with the female mold member to form an invisible shape. The contact lens mold for the lens forming cavity contains the precursor composition. The contact lens mold is placed in a nitrogen rinsed oven to allow the precursor composition to be cured thermally. The contact lens mold is exposed to a temperature of about 8 Torr for about 1 hour or longer. After the precursor composition is polymerized, the contact lens mold is demolded, and the polymerized oxygenated hydrogel contact lens is extracted before extraction. The product was removed from one of the mold members 121843-60-200815501 lenses. The lens product removed before extraction was weighed to determine its dry weight. The removed lens product is then extracted and hydrated by contacting the lens product with a plurality of volumes of alcohol such as ethanol and deionized water. The hydrated hydrogen peroxide gel contact lens was weighed, then dehydrated in an oven and weighed again to determine the dry weight of the dehydrated hydrogel hydrogel contact lens. Some properties, such as contact angles, including dynamic and static contact angles, oxygen permeability, ionic flux, modulus, elongation, tensile strength, water content, etc., are determined as described herein. It is also tested that the hydration/oxygen gel contact lens can be used to measure the water breakage time of the lens. During the formulation study, the eye compatibility was tested in an iterative manner in which the contact lens was placed in one of the eyes i, i, 3 hours or 6 hours or more, and clinical evaluation was performed. Example 2 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and incubated in Example 1 of Example 1. Compound (shrinking unit weight % 〇Λ ν;) M3U μ_35 34.6 ~~ NVP 45 44.5—^ MMA ～-20 20 ---- 19.8~^ TEGDMA '^ 0.5 -—--- Circle—&quot ;---——. 0.5 V-52 ~^ 0.6 --- ---.>·_ ---- The oxygenated hydrogel contact lenses from this formulation are relatively easy to handle and are acceptable Compatibility. These contact lenses have an equilibrium water content of about 54%, a water scent of more than 20 seconds, and a static contact angle of about sen. = 121843 -61 - 200815501 is about 0.38 angstrom modulus of about 0.5 MPa and an elongation of about 227%. These helium-hydrogel contact lenses have an extractable amount of 16.9 + Λ 3%.3%. Example 3 The polymerizable diarrhea hydrogel 11⁄2 glasses precursor composition was obtained from the following chemical compound (abbreviation) unit weight % M3U 35 34.6 NVP 50 49.5 MMA 1 15 14.9 TEGDMA 0.8 0.8 V-52 0.2 0.2 Formulated neohydrogen hydrogel contact lenses are relatively easy to handle,

And has acceptable compatibility. These contact lenses have an equilibrium water content of about 54%, a water BUT of greater than 30 seconds, and a static contact angle of about 34. The forward contact angle is 78. The reverse contact angle was 48 〇, the ion flux was about 6, the Young's modulus was about 〇7 MPa, and the elongation was about 186%. These helium-hydrogel contact lenses have an extractable amount of 17.5 +/- 0.5%. Example 4 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % 〇/w) One M3U 35 33.0 One NVP 47 44.3 MMA One --- 18 17.0 TEGDMA 0.5 0.5 V-52 ---- 0.6 0.6 L_ da 5 5.7 121843 -62 - 200815501 The dream oxygen hydrogel contact lens of this formulation is relatively easy to handle and is compatible with mPC. The (tetra) shaped glasses have an equilibrium water content of about 52%, a water BUT of greater than 18 seconds, and a static contact angle of about %. , the advancing contact angle is %. , the reverse contact angle is 49. The ion flux was about 6, the Young's modulus was about 〇, and the elongation was about 167%. Example 5 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition was prepared by mixing and filtering the following chemical compounds as described in Example 1 of Jin Yu, Yu &, +,, B. Obtained compound (abbreviation) unit weight M3U 35 3〇Τ^—~ NVP 47 41.4 MMA 18 —.— 15.9 TEGDMA 0.5 0.4 V-52 0.5 0.4 DA 12.5 ^^—丨丨· 11.0 Get 0 from this formula Hydroxyl hydrogel contact lenses are relatively easy to handle and are compatible with mPC. These contact lenses have an equilibrium water content of about 54%, a water BUT of greater than 20 seconds, and a static contact angle of about 37. The forward contact angle is s, and the reverse contact angle is 48. The ion flux is about 35 and the Young's modulus is about Ο·. And the elongation is about 304%. Example 6 The hydratable hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example i. 0 121843 -63 - 200815501 Compound (abbreviation) unit Weight % (wAvf M3U 35 --- 26.8 ^ NVP 47 ------- 36.0 ~ MMA 18 13.8 ^ TEGDMA 0.1 0.01 ^ V- 52 0.6 ' ------ 0.5 ~ da 25 19.1 ~ DBE 5 ------ 3.8 ~ -- The oxygenated hydrogel contact lenses from this formula show that the piles can be retracted and removable. These contact lenses have balanced water. Mandan, containing ^ is about 53%, water BUT is greater than 20 seconds, static contact angle is about 34 〇, from j item _ wang · Ma about 5, Yang phase: number is about 〇 · 4 MPa ' and elongation Is about ip?%. Example 7 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition Obtained 0 compound (abbreviation) by mixing the following chemical compounds in the specified amounts and as described in Example 1 Unit weight % M3U 35 26.6 NVP 47 35.7 ' MMA 18 13.7 TEGDMA 1 — 0.8 V-52 0.6 DA 30 22.8 得 from this recipe Hydrogel contact lens having a modulus of from about 〇.6MPa to about 0.9 MPa. Example 8 The polymerizable silicone hydrogel contact lens precursor composition of the system via the following -64-200815501 121843

The compounds were obtained in the amounts specified and mixed and transitioned as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 26.8 NVP 47 36.0 ' MMA 18 1 13.8 TEGDMA 0.1 0.08 V-52 0.6 0.5 " DA 30 23.0 J---- ---— From this formulation Oxygenated hydrogel contact lenses have an acceptable surface wettability to the eye. These contact lenses have an equilibrium water content of about, a water BUT of greater than 2 sec seconds, a contact angle of about 42 〇 'advance contact angle of about 73 〇, and a receding contact angle of about 48. The ion flux* is about 3.9, the Young's modulus is about 〇·5 MPy, and the elongation is about 242%. These Shixi oxygen hydrogel contact lenses have an extractable amount of 43.4 +/- 3.1%. Example 9 Polymerizable Hydroxyl Hydrogel Contact Lens Ginseng 5 Brother Becker Composition

The compound is obtained in the amount specified and obtained by mixing and filtering as described in Example 1.

Compound (abbreviation) M3U

MMA

TEGDMA V- 52

IPA

% by weight (w/w) 31.6 42.5 16.3 0.1 0.5 9.0 The gelatin contact lens product obtained by the pre-extraction of this formulation was 121,634-65 - 200815501 having an extractable ingredient content of about 26%. The Shixi oxygen hydrogel contact lenses from this formulation have acceptable surface wettability on the eye. Example 10 A polymerizable rock oxide hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 26.8 NVP 47 36.0 MMA 18 13.8 TEGDMA 0.1 0.1 V-52 0.6 0.5 — IPA 30 23.0 Ingot of the polymerized hydrogel before extraction from this formulation The lens product has an extractable ingredient content of about 45%. Oxygenated hydrogels from this formulation have an eye-acceptable surface wettability. These contact lenses have an equilibrium water content of about 56%, a water BUT of greater than 20 seconds, a contact angle of about u 45°, an ion flux of about 5.3, a Young's modulus of about 〇·3 MPa, and an elongation of about 351% 〇 Example 11 A polymerizable oxime hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. 121843 -66- 200815501 Compound (abbreviation) Unit weight % (w/w) M3U 35 26.8 NVP 47 36.0 MMA 18 13.8 TEGDMA 0.1 0.1 V-52 0.6 0.5 DA 15 11.5 DBE712 15 11.5 Oxygenated water from this formulation Glue contact lenses have an acceptable surface moisturization on the eye. Example 12 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example i. Compound (abbreviation) Unit weight % (w/ w) M3U 35 26.8 NVP 47 36.0 MMA 18 13.8 TEGDMA 0.1 0.1 V-52 0.6 0.5 EE 30 23.0 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. Example 13 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. 121843 -67- 200815501 (abbreviation) Unit weight% (w/w) __M3U 35 26.8 47 36.0 18 13.8 ___TEGDMA 0.1 0.1 ^_^52 0.6 0.5 The pre-extracted polymerized oxygenated hydrogel obtained by this formulation is invisible The lens product has an extractable ingredient content of about 17%. Example 14

The polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit quantity Weight% (w/w) _ M3U 35 29.0 NVP 47 38.9 MMA 18 14.9 TEGDMA 0.1 0.1 V-52 0.6 0.5 IPA 20 16.6

The pre-extracted polymerized oxygenated hydrogel contact lens product from this formulation has an extractable ingredient content of about 36%. The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. Example 15 A polymerizable silicone hydrogel contact lens precursor composition was obtained by combining the following chemical compounds in the specified s and as described in Example 1. 121843 -68 - 200815501 —------- -------- Compound (abbreviation) Unit ί M3U 35~ NVP 45~ —~~^~~—------—- MMA 20 ^ ------------ —-~~~—------- TEGDMA 1 V-52 0.6, —— -----~ (w/w)

19.7 seconds. Example 16 A polyoxygenated hydrogel invisible spectacles precursor composition was obtained by substituting: compound in a specified amount and by mixing and filtering to obtain a compound of 0 seconds (abbreviation) unit amount ^ ^__ S $ % (w/w) M3U 35 34.4 NVP 45 '—— 44.3 — ΜΜΑ 20 *—--- 19.7 DVG 0.5 0.5 TEGDMA 0.5 0.5 V-52 0.6 0.6 Oxygen hydrogel invisible from this formulation The glasses showed a water BUT of less than 5. Example 17 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. 121843 -69- 200815501 Compound (shrink ~~ unit weight% (w/w) M3U 35 34.4 NVP --- —47 46.3 ΜΜΑ 18 17.7 DVG 1 I, 1---- V-64 0.6 0.6 from this formula The hydrothermal gel contact lens system showed a water BUT of less than 5 seconds.Example 18 A polymerizable hydroxyl hydrogel contact lens precursor composition was prepared by combining the following chemical compounds in the amounts specified and as described in Example 1. Obtained by filtration. Compound (abbreviation) Unit weight % (ν/Λν^) M3U ---.^ 35 30.1 NVP —------ 47 40.4 15.5 A__ MMA 18 ------ __ TEGDMA 0.2 __ 0.2 ___ V-64 0.6 0.5 micro-dye 0.1 0.1 _ UV416 0.9 0.8 __ Hx -------—-- 15 12.9 Example 19 Polymerizable Fried Oxygen Hydrogel Contact Lens Precursor Composition (d) The following chemical compounds were obtained by mixing and filtering as described in Example 1. 121843 -70- 200815501 Compound (abbreviation) Unit weight% (w/w) M3U 35 30.0 NVP 47 40.3 MMA 18 15.5 TEGDMA 0.4 0.3 V- 64 0.1 0.1 M3U micro-dye 0.1 0.1 UV416 0.9 0.8 EE 15 12.9 Example 20 Polymerizable hydrogel hydrogel invisible The spectroscopic composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 30.1 NVP 47 40.4 MMA 10 8.6 IBM 8 6.9 TEGDMA 0.1 0.1 V-64 0.2 0.2 M3U microstain 0.1 0.1 UV416 0.9 0.8 EE 15 12.9 Example 21 Polymerizable hydroxyl hydrogel contact lens precursor composition via the following chemical compounds in the specified amount And obtained by mixing and filtering as described in Example 1. 121843 -71 - 200815501 Compound (abbreviation) - Unit weight% (w/w) A---------- M3U --. --^ 35 30.1 , --- ' ----- NVP ····**__ a ****" 47 40.4 —--·" — MMA - a ^ 12 10.3 a "···- IBM 6 5.2 TEGDMA 0.1 0.1 V-64 —-____^***-*1· 0.2 0.2 M3U micro-dye 0.1 0.1 —----- """~ A UV416 ------- ---- 0.9 0.8 — --- EE a __-- 15 ____— 12.9 —-~---—1 Example 22 Polymerizable Hydrogen Hydrogel Contact Lens Precursor Composition is based on the following chemical compounds The amount specified and press The mixing and filtration described in Example 1 were obtained. Compound (abbreviation) ------ Unit weight% (w/w) M3U —.— 35 30.0 NVP ———-— 47 40.3 ___ MMA 12 10.3 IBM —— 6 5.2 __ TEGDMA 0.3 0.3 ^__V-64 0.2 0.2 — M3U micro-dye -_ 0.1 0.1 ___ UV416 0.9 0.8 ~~ L_ EE 15 12.9 Example 23 The polymerizable hydrogel contact lens precursor composition is characterized by the following: the compound is in the amount specified By example! 121843 -72- 200815501 Compound (abbreviation) Unit Quantity---! Weight % (w/w) M3U 35 23.2 NVP 52^^ 34.5 MMA 8 5.3 mPC 5 3.3 TEGDMA 0.1 0.07 V- 52 0.6 0.3 Pr 5 3.3 DA 45 29.9 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. These contact lenses have an equilibrium water content of about 63%, a water BUT of greater than 19 seconds, and a static contact angle of about 39. , the advancing contact angle is %. The reverse contact angle was 46, the Young's modulus was about 〇·4 MPa, the elongation was about 1〇9%, and the tensile strength was about 0.2. Example 24 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemically mashed materials in the amounts specified and as described in the Examples. Compound (abbreviation) ------ J M3U ^ --—— Unit quantity" Weight % --------- 24.0 35 __ NVP ^ 47 32.3 MMA ~ ——-- --- 2 1.4 DMA 3 2.1 _ mPC ____^ 8 ^ 1 ~ ---- 5.5 TEGDMA —~———____ 0.1 0.07 V-52 ~——___ 0.6 0.4 Pr --* —~~_______ ___-' 8 5.5 .——- -—------___ DA ^~ 1------ - ------- -------J 42 ______- 28.8

121843 -73 - 200815501 Oxygenated hydrogel contact lenses known from this formulation have an ocularly acceptable surface wettability. Example 25 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing the following compounds in the amounts specified and mixed as described in Example 1 to obtain a 0 compound (abbreviation) unit weight % ( w/w) M3U 27.8 18.8 SIGMA 16.4 Bu 1U NVP 47.2 32 MMA 1.7 1.2 mPC 7.7 5.2 ~ TEGDMA 0.17 0.1 V-52 0.46 0.3 Pr 7.7 5.2 DA 31.4 21.3 ACN ^ 7 4.7 Oxygen hydrogel invisible from this formulation The glasses have an acceptable U surface wettability on the eye. Example 26 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1 to obtain 0 121843 -74 - 200815501 compound (abbreviation) unit amount Weight% (;w/w丨M3U 23 15.9 SIGMA 15 --——---- 10.4 NVP 52 35.9 ~ MMA 2 1.4 mPC ^^^ —--- 10 --——~___ 6.9 TEGDMA 0.2 0.1 V- 52 0.6 0.4 DA 22 15.2 Hx "---- 10 ---------- 6.9 Pr 10 ------ 6.9 Hydroxyl hydrogel contact lenses from this formula have eyes Acceptable surface wettability. Example 27 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition Obtained 0 by compounding and filtering the following chemical compounds in the amounts specified and as described in Example 1. (abbreviation) Unit weight % (w/v4 M3U 23 15.3 SIGMA 15 9.9 NVP 52 34.5 mPC 10 6.6 — TEGDMA 0.2 0.1 _ V-52 0.6 0.4 ~ Pr 10 6.6 ~ Hx 40 26.5 Oxygenated water from this formulation Glue contact lenses have an acceptable surface mountability on the eye. These contact lenses have an equilibrium water content of about 6 3%, 121843 -75- 200815501 Water BUT is greater than 25 seconds, ion flux is about 17, static contact angle is about 43°, advancing contact angle is 94., reverse contact angle is 48., Young's modulus is about 〇 .3 MPa, elongation is about 166%, and tensile strength is about 〇·3. Example 28 Polymerizable lithothere hydrogel contact lens precursor composition is obtained by placing the following chemical compounds in the amount specified It is obtained by mixing and filtration as described in the example. Compound (abbreviation) Unit weight (%) (w/w) — M3U 25 16.6 — SIGMA 13 8.6 NVP 47 31.2 mPC 15 9.9 _ TEGDMA 0.2 0.1 — V-52 0.6 0.4 Pr 15 9.9 Hx 35 23.2 Π 矽 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. Example 29 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Compositions The chemical compound was mixed and filtered in the amount specified and as described in Example 1 to obtain 0 121843 -76 - 200815501 ------- (abbreviation) unit weight% (w/w) ___ M3U 30 23.0 ~ ~ __ NVP —---------- 52 39.8 — tBMA 18 13.8 ___JEGDMA 0.1 0.1 -_ T AIC 0.2 0.2 __- D1173 0.4 0.3 ___ DBE712 30 23.0 Oxygenated hydrogel contact lenses of this formulation, which are cured by uv radiation, have ocularly acceptable surface wettability. Example 30 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. __^ compound (abbreviation) unit weight% (w/w) M3U 35 32.7 NVP 47 43.9 —--------- MMA 18 16.8 _____________ mPC 0.5 0.5 -----_________ TEGDMA 0.5 0.5 -- ---__----- V-52 0.6 0.6 Pr 0.5 0.5 DA 5 4.7 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. Example 31 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition Obtained 0 compounds (abbreviation) units by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1 to obtain 121843-77-200815501 Quantity ^ 26.3 M3U 35 NVP 47 __ 35.3 MMA 18 ^~----.___ mPC 1.25 0.9 ~~ tegdma 0.1 0.1 V-52 0.6 0.5 Pr 1.25 0.9 H DA 30 ~''''' II----- 22.5 Oxygenated hydrogel contact lenses from this formulation have surface wettability on the eye. These contact lenses have an equilibrium water content of about %%, a water BUT of greater than 17 seconds, a static contact angle of about 36 angstroms, and an advancing contact angle of 87. , the reverse contact angle is 44. The ion flux is about 8, the Young's modulus is about, the elongation is about 335%, and the tensile strength is about 〇4. Example 32 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1.

121843 -78- 200815501 Oxygenated hydrogel contact lenses from this formulation have an eye-acceptable surface wettability. These contact lenses have an equilibrium water content of about 66%, a water BUT of greater than 17 seconds, a static contact angle of about 33°, an advancing contact angle of "o, a reverse contact angle of 45., and a Young's modulus of about 0.4 MPa. The elongation is about 131%, and the tensile strength is about 〇.3. Example 33 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition is via the following chemical compounds in the amounts specified and as described in Example 1. Mixing and transition to obtain 0 compound (abbreviation) Unit weight% M3U 23 16.3 SIGMA 15 10.7 NVP 52 36.9 mPC 10 7.1 — TEGDMA 0.2 0.1 V-52 0.6 0.4 Pr 10 7.1 Hx 30 21.3 " Oxygen from this formulation Hydrogel contact lenses have an ocularly acceptable surface wettability. These contact lenses have an equilibrium water content of about 63%, a water BUT of greater than 19 seconds, an ion flux of about 18, and a static contact angle of about 37. The contact angle is 1〇1〇, the reverse contact angle is 46〇, the Young's modulus is about 4 MPa, the elongation is about 155%, and the tensile strength is about 〇·4. Example 34 Polymerizable stone Oxygen hydrogel contact lens precursor composition via the following chemistry The compound was obtained in the amounts specified and mixed and filtered as described in Example 1 to obtain 121843 -79 - 200815501. Compound (abbreviation) Unit weight % (w/w) M3U 35 26.6 NVP 47 35.7 MMA 18 13.7 TEGDMA 0.1 0.1 V- 52 0.6 0.5 micro-dye 0.1 0.1 UV 0.9 0.7 DBE-712 30 22.8 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability which is present in the polymerized lens product. The amount of extractable material is greater than 10% and is estimated to be from about 4 to 42%.Example 35 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Compositions by the following chemical compounds in the amounts specified and by example Mixing and filtering as described in 1 to obtain 0 compound (abbreviation) unit weight% (w/w) M3U 35 27.8 NVP 47 37.4 MMA 17 13.5 TEGDMA 0.2 0.2 _ V-52 0.5 0.4 micro dye 0.1 0.1 a UV 0.9 0.7 DBE-712 25 19.9 Oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface mountability. The extractable material present in the polymerized lens product is 121843-80. The 200815501 quantity is greater than ίο. %, and estimated It is about 40 to 42%. Example 36 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. __ Compound (abbreviation) Unit weight % (w/w) M3U 35 34.8 VMA 45 44.7 IBM 5 5.0 EOEMA 15 14.9 X-MIX3 0.2 .2 V-52 0.5 0.5 The oxygenated hydrogel contact lens from this formulation has Acceptable surface wettability on the eye. These helium-hydrogel contact lenses have an equilibrium water concentration of 61·3 +/- 〇.〇5% ’ and an extractable amount of 17·5 + 八·5〇/〇. Example 37 A χ χ 矽 矽 hydrogel contact lens precursor composition was obtained by mixing and filtering the following hydration rations in the amounts weighed and as described in Example 1. Compound (abbreviation) Unit weight % €\νΛν) M3U^^~ 35 34.8 _YUA^^— 45 44.7 IBM __ —_ 5 5.0 eoema ~ , —---~---- 14 13.9 X-MI5G - 0.2 .2 V^52^^— 0.5 0.5 UV41?^— ------- 0.9 0.9 micro-dye 0.1 0.1 121843 -81- 200815501 From this formulation; ^ tn ^Lip hydrogel contact lenses have an eye-acceptable surface wettable Sex.癸 癸 A〆, l This special oxygen hydrogel contact lens has an equilibrium water concentration of 61.3 +/- 〇 〇 5%, u Ή 丄 • and an extractable amount of 17.5 +/- 〇·5%. Example 38 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 34.8 VMA 47 46.7 ΜΜΑ 18 17.9 TEGDMA 0.2 0.2 V-52 0.5 0.5 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface. Wettability. These helium-hydrogel contact lenses have an equilibrium water concentration of 5 6 +/- I·27% and an extractable amount of 23·6 +/- 0.1%. Example 39 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 34.8 VMA 47 46.7 MMA 17 16.9 TEGDMA 0.2 0.2 V-52 0.5 0.5 UV416 0.9 0.9 —*-—1— _ Microdye 0.1 0.1 121843 -82- 200815501 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. These contact lenses have an equilibrium water content of about 5:, an ion flux of about 7, and a static contact angle of about 34. The advancing contact angle is about 65 〇 and the reverse contact angle is 50. The Young's modulus is about 6 Mpa, the elongation is about 238%, and the Dk is about 109. These oxime oxygen gel contact lenses have an extractable enthalpy of 23.6 +/- 0.1%. Example 40 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in the Examples. Compound (abbreviation) Unit weight % 〇/w〇M3U 35 27.8 VMA 47 37.4 ΜΜΑ 17 13.5 TEGDMA 0.2 0.2 V-52 '0.5 0.4 UV416 0.9 0.7 Micro-dye 0.1 0.1 DBE712 25 19.9 Oxygen from this formulation Hydrogel contact lenses have an acceptable surface wettability on the eye. These hydrogel contact lenses have an equilibrium water concentration of 47.6 +/- 0.5% 'and an extractable amount of 48·9 +/_ 〇·7〇/〇. Example 41 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in the Examples 0 0 121843 -83 - 200815501 Compound (abbreviation) Unit weight % (w/w) M3U _35 29.0 ~ VMA 47 38.9 '~~ MMA 17 14.1 TEGDMA 0.2 0.2 V-52 0.5 0.4 ~ UV416 0.9 0.7 Micro-dye 0.1 0.1 — DBE712 20 16.6 From this formula Oxygen hydrogel contact lenses have an acceptable surface moisturization on the eye. These contact lenses have an equilibrium water content of about 55 Å/〇, an ion flux of about 6, and a static contact angle of about 35. The advancing contact angle is about. The reverse contact angle is 49°, the Young's modulus is about 〇·3 MPa, the elongation is about 265%, and the Dk is about 98. Example 42 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1 to obtain a compound (abbreviation) unit weight percent (w/ w) M3U 35 27.0 VMA 47 36.2 MMA 17 13.1 TEGDMA 0.2 0.2 V, 52 0.5 0.4 UV416 0.9 0.7 Micro-dye 0.1 0.1 DBE712 29 22.4

The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable 121843-84-200815501 surface (iv). These contact lenses have an equilibrium water content of about gen, an ion flux of about 4, a static contact angle of about 4 〇 0, an advancing contact angle of about, a reverse contact angle of about 54°, and a Young's modulus of about 〇· 4 Mpa, elongation is about 219%, and Dk is about 129. These helium-hydrogel contact lenses have an extractable amount of 50.2 +/- 0.8%. Example 43 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/ w) M3U 35 31.1 VMA 47 41.7 MMA 17 15.1 TEGDMA 0.2 0.2 V-52 0.5 0.4 UV416 0.9 0.8 Micro-dye 0.1 0.1 DBE712 12 10.6 Oxygenated hydrogel contact lenses from this formulation have an eye-acceptable surface It can be used for fishing. Example 44 A polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. 121843 -85- 200815501

1 case of 45 total polymerizable oxygenated water « contact lens first f composition was obtained by the following: compound was obtained in the specified amount and mixed and filtered as described in Example 1.

U compound (abbreviation) wt% (wAv>

Dream oxygen hydrogel contact lenses derived from this formulation have acceptable surface wettability on the eye. Example 46 A polymerizable lithothere hydrogel contact lens precursor composition was obtained by mixing and filtering as described in pp. 121,843-86-200815501. Calculate the compound in the specified amount and in accordance with Example 1 f) / (Λ 1 7 /tl compound (abbreviation) unit weight% (w/w) —— -----------' M3U_ _一35 34.〇^一^7 45 44. / 6.0 IBM ____ 6 13 12.9 —^-·<- TEGDMA _. 0.2 0.2 — V-64 _____ 0.4 0.4 ------^—UV416 0.9 0.9 _—-—A micro-dye 0.1 0.1 The oxygenated hydrogel contact lens of this formulation has an eye-acceptable surface wettability. Example 47 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition Obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Ο 121843 Compound (abbreviation) Unit weight % (w/w) M3U 27 20.0 FMM 10 7.4 NVP 46 34.1 PC 6 * 4.4 IBM 6 4.4 HOP 4 3.0 Mix4 0.4 0.3 V-52 0.5 0A~~ ~ Pr — 35 25.9 The Shixi Oxygen Hydrogel Contact Lens from this formulation is ocularly acceptable -87- 200815501 Surface Wettability These contact lenses have an equilibrium water content of about 6%, an ion flux of about 11, and a static contact angle of about 46. The advancing contact angle is about 102. The retrogressive contact angle is about 51. The Young's modulus is about 〇·2 Mpa, the elongation is about 150%', and the tensile strength is about 0.2. Example 48 Polymerizable Hydrogen Hydrogel Contact Lens The composition is obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in the Examples. Compounds (abbreviations) Unit weight % (w/w) M3U 23 16.4 SIGMA 15 10.7 NVP 45 32.2 PC 10 7.1 IBM 6 4.3 Mix3 0.4 0.3 V-52 0.5 0.4 Pr 40 28.6 矽 The oxygenated hydrogel contact lenses from this formulation have an eye-acceptable surface wettability. These contact lenses have an equilibrium water content of about 61%, ion flux is about 14, static contact angle is about 40. Advancing contact angle is about 106° 'reverse contact angle is about 52. Young's modulus is about 〇.2 Mpa, elongation is about 224. %, tensile strength is about 〇.3, and Dk is about 69. Example 49 Polymerizable lithothere hydrogel contact lens precursor composition is based on the following chemical compounds in the specified amount and in Example 1. Mixing and filtering to obtain 0 121843 • 88 - 200815501 Compound (abbreviation Unit weight% (w/w) M3U _ 35 ------ 30.3 VMA 45 --------- 39.0 IBM 8 6.9 MMA 11 9.5 TEGDMA 0.2 0.2 V-64 03 0.3 UV416 0.9 0.8 micro Dye 0.1 0.1 DBE712 _ 15 13.0 The oxygenated hydrogel contact lenses from this formulation have an ocularly acceptable surface wettability. Example 5: Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition Obtained 0 compound (abbreviation) unit weight percent by weighting the following chemical compounds in the amounts specified and as described in Example 1 (w) /w) M3U 35 -34.8 —————— ------ NVP 47 42.5 -------__--- MMA 18 16.3 ~—------ __ TEGDMA 0.1 0.1 —-— V-52 — 0.6 _____ 0.5 1 9.0 u- -- "---1 ____ HMP 10 __—^ Example 51 Polymerizable hydrogel hydrogel contact lens precursor, composition via the following chemical compounds The amount specified is obtained by this combination and filtration as described in Example 1. 121843 -89- 200815501 Compound (abbreviation) Unit weight % (w/w) M3U 35 26.8 NVP 47 36.0 MMA 18 13.8 TEGDMA 0.1 0.1 V-52 0.6 0.5 HMP 30 23.0 Example 52 (: polymerizable hydrogel hydrogel invisible The glasses precursor composition was obtained by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 35 0.24 NVP 47 32.3 MMA 2 1.4 DMA 3 2.1 mPC 8 5.5 TEGDMA 0.1 0.1 V-52 0.6 0.4 Pr 50 34.3 Example 53 u Polymerizable hydroxyl hydrogel contact lens precursor composition via the following chemical compounds in the specified amount and in Example 1 The mixture was mixed and filtered to obtain 0 121843 •90-200815501 compound (abbreviation) unit weight% (w/w) M3U 27.88 18.9 SIGMA 16.4 11.1 NVP 47.2 32.0 MMA 1.7 1.2 mPC 7.7 5.2 TEGDMA 0.17 0.1 V-52 0.46 0.3 DA 31.4 21.3 Pr 7.7 5.2 DMSO 7 4.7 Example 54 Polymerizable Hydroxyl Hydrogel Contact Lens Precursor Composition was prepared by mixing and filtering the following chemical compounds in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 20 14.2 TRIS 15 10.7 VMA 30 21.3 mPC 4 2.8 HEMA 10 7.1 MMA 10 7.1 DMA 15 10.7 TEGDMA 0.1 0.1 V52 0.6 0.4 Pr 6 4.3 DA 30 21.3 Example 55 The polymerizable silicone hydrogel contact lens precursor composition was obtained by mixing and filtering the following compound in the amounts specified and as described in Example 1. Compound (abbreviation) Unit weight % (w/w) M3U 25 16.6 SIGMA 13 8.6 NVP 47 31.2 mPC 15 9.9 TEGDMA 0.2 0.1 V52 0.6 0.4 Pr 15 9.9 DA 35 23.2 Example 56 Polymerizable Hydrogen Hydrogel Contact Lens Precursor Composition via the following chemistry The compound was mixed and filtered as specified in Example 1 to give 0 compound (abbreviation) unit weight % (w/w) M3U 25 16.6 SIGMA 8 5.3 NVP 52 34.5 mPC 15 9.9 TEGDMA 0.2 0.1 V52 0.6 0.4 Pr 15 9.9 Hx 35 23.2 Example 57 〇Polymerizable hydrogel contact lens precursor composition was prepared by mixing the following chemical compounds in the amounts specified and as described in Example 1. Filtered to get. 121843 -92- 200815501 Compound (abbreviation) Unit weight % (w/w) M3U 30 23.0 One NVP 52 39.8 One tBMA 18 13.8 One EGDMA 0.1 0.1 One TAIC 0.2 02 One D1173 0.4 0.3 One DBE814 30 23.0 One example 58 feet 3 The lens had an equilibrium water content of 56% and showed a water BUT of 18 seconds after 24 hours and 2 seconds after 4 days. The lens product has an extractable ink, and the spoon 26/〇°R3 lens has a contact angle of 34.1 ° C, an advancing contact angle of 1〇6 3 c, a reverse contact angle of 52 4 r, and a hysteresis of 53 9 C> c, the ion flux is 121843

The hydroxyl hydrogel contact lenses were obtained from a non-polar resin lens mold and prepared from the lens precursor composition obtained by mixing and filtering the following chemical compounds in the amounts specified, as described in Example 1. ^_ _ Code R1 R3 R7 R8 R9 R0 M3U —--- 35 35 35 35 35 35 _ VMA 45 45 45 45 45 45 IBM ---- 6.5 5 5 8 8 5 One EOEMA 13.5 15 15 12 12 15 TEGDMA 0.2 0.6 0.2 0 0 0.1 TEGDVE ---— 0.2 0 0 0.2 0.6 0.1 V52 ^---- 0.5 0.5 0.5 0.5 0.5 0.5 R1 lens has an equilibrium water content of 63.1%, and shows that water BU is 4.7 seconds after 24 hours. And 9 seconds after 4 days. The R1 lens product has an extractable content of about 16%. -93 - 200815501 5_5 Η)·3 mm 2 /min, the modulus is 〇·42 Mpa, the elongation is gland, and the tensile strength is 0.27 MPa. , lens /, with balanced water containing 畺 6 〇 8 〇 /. And it shows that the water is 20 seconds in % hour and 2G seconds in 4 days. The R7 lens product has an extractable: about 25%. The R7 lens has a contact angle of 33.7. The advancing contact angle is 1〇3.7. The retrograde contact angle is 53.9. The latent image is ·, the ion flux is 8.1 10 mm 2 /min, the modulus is 〇·33, the elongation is 1%%: and the tensile strength is 0.24 MPa. The R8 lens had an equilibrium water content of 642% and showed water but was 4.3 seconds after % hours and 9 seconds after 4 days. The lens-like product has an extractable content of about 15°/〇. The rib lens had an equilibrium water content of 63.9% and showed water BUTs of 1.3 seconds after 24 hours and 7 seconds after 4 days. The R9 lens product has an extractable content of about 13%. ^ The R0 lens has an equilibrium water content of 63 8% and shows that the water buTk is 15 seconds after 24 hours and 2 seconds after 4 days. The R〇 lens product has an extractable amount of about 22%. The R0 lens has a contact angle of %. The advancing contact angle is 101.3. The reverse contact angle is 48·7. The hysteresis phenomenon is Yisuke, the ion flux is 11.7ΗΤ3 mm 2 /min, the modulus is 42 MPa, the elongation is ΐ9%, and the tensile strength is 0.35 MPa. Example 59 The effect of different crosslinkers on the extractable component content was also evaluated. Shixi Oxygen Gel contact lenses are made in a non-polar resin lens mold without surface treatment and without the use of polymer IPN. The ingredients of the lens formulation are provided in the following table 121843 -94- 200815501. The type and concentration of the crosslinker were varied and the extractable component content was determined. Name M3U VMA IBM EOEMA Crosslinker type crosslinker % V-52 EWC% Extraction in EtOH % T31 35 45 5 15 TAIC 0.2 0.5 63.4 9.88 T31A 35 45 6 14 TEGDVE 0.3 65 10.3 T31B 35 45 6 14 VM 0.3 58.7 9.62 T31C 35 45 5 15 TEGDMA 0.2 0.5 54.06 25.85 T31C1 35 45 5 15 TEGDMA 0.4 0.5 53.38 24.66 T31C2 35 45 5 15 TEGDMA 0.8 0.5 51.58 24.14 T31E 35 45 5 15 PTA 0.2 0.5 53.5 25.13 T31F 35 45 5 15 TPTMA 0.2 0.5 53.36 25.72 T31G 35 45 5 15 MIX# 3 0.2 0.5 61.6 16.9 MIX#3 : 1 : 1 ratio of TEGDMA to TEGDVE These results confirm the oxygenated hydrogel contact lenses, which contain units derived from VMA and IBM, and A cross-linking agent based on di-mercapto acrylate or tri-decyl acrylate is derived from a hydroxyl hydrogel contact lens product having a high extractable ingredient content (eg, greater than 16.9%). For comparison, a lens product derived from VMA and IBM, which utilizes a copolymer of vinyl methacrylate or triallyl cyanurate, has a lower extractable component content (eg, Less than 10%). The lens product using triethylene glycol divinyl ether as a crosslinking agent has an extractable component content of 10.3%. In this study, 80% of the contact lenses obtained with each of the formulation names T31A; T31C; T31C1; T31C2; T31E; T31F; and T31G showed a water BUT greater than 20 seconds. In the T31 lens, 60% showed a water BUT of 10 seconds. In the T31B lens, only 40% showed a water BUT of 5 seconds. Therefore, for these lens formulations, the di-methacrylate and tri-decyl acrylate-based crosslinkers consistently provide a high-extractable composition containing 121843-95-200815501 Contact lens products. It is derived from this 4-lens hydrogel contact lens that has the desired surface wettability. These data also support the following findings: When these Zeolite oxygen gels have an extractable amount of more than 10%, or when they obtain an oxygenated hydrogel contact lens, the dry weight is no greater than the individual lens product dry. At the time of weight, the oxygenated hydrogel contact lenses can have an acceptable surface wettability on the eye. Example 60

An example of the present invention is compared to current Shixi oxygen hydrogel contact lenses, as shown in the following table. The lenses are Acuvue Advance contact lenses (Johnson &Johnson); lens B is Acuvue Oasys contact lenses (Johnson & Johnson), lens C is 〇2 Optix contact lenses (Ciba Vision); and lens D is Biofinity contact lenses (CooperVision) ). Nature Lens A Lens Β Lens c Lens D Example 8 Example 40 Example 27 EWC 47 38 33 47 54 46 54 Dk 60 103 110 128 120 129 109 Ion Flux 3.5 ΝΑ 1.8 4.5 4.5 4.0 6.8 Modulus 0.37 0.73 0.97 0.75 0.4 0.35 0.56 % elongation 197 222 186 130 222 219 238 ACA 96 67 70 56 65 78 65 RCA 49 54 51 46 49 54 50 —----- Hysteresis 47 13 19 10 16 24 15 % extractable in PSHCLP before extraction Substance ΝΑ 16 ΝΑ 8 16 25 25 % extractable material in SHCL 6.5 1 4.9 4.1 3.9 15 1.6 0 EWC : equilibrium water content (percentage) 121843 -96- 200815501 aca : advancing contact angle (degrees) RCA : reverse contact angle (degrees) PSHCXP: Polymerized Shixi oxygen hydrogel invisible eyepiece mirror product SHCL · Shixi oxygen hydrogel contact lens (after extraction and hydration) Example 61 The present invention Shishi oxygen hydrogel contact lens The comparison between the lens and the lens precursor composition using Bi〇fmity hydrogel contact lens is obtained from a non-polar resin hidden p-glass lens. A lens precursor composition for use in the manufacture of Biofinity hydrogel contact lenses is produced by pre-extraction polymerization having an extractable amount of less than 10% (w/w), such as about 8% (w/w). Shixi oxygen hydrogel contact lens product. When the precursor composition is matured and extracted and hydrated in a non-polar tree contact lens mold, the formed Shixi oxygen hydrogel contact lens has a lens object which has an approximate pre-extraction lens product: . The hydrated contact lenses thus produced have surface wettability which is inconspicuous on the eye. In comparison, the lenses of the present invention comprise a lens (4) having a dry weight no greater than 90% of the dry weight of the polymerized hydrogel contact lens product prior to extraction and having an ocularly acceptable surface wettable Sex, as mentioned above. The present disclosure is intended to be illustrative of specific embodiments, and it is understood that the specific embodiments are presented by way of example However, all modifications, alternatives, and equivalents of the specific embodiments are intended to be included within the scope of the invention. Φ wrong by 121843 -97- 200815501 Many publications and patents have been cited above. Each of the cited publications and patents is hereby incorporated by reference in its entirety. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a flow chart illustrating the steps of making a silicone hydrogel contact lens. Figure 2 is a flow diagram illustrating the compositions, lens products, and hidden lenses of the present invention. ...eye [main component symbol description]

102 placing the lens precursor composition on the contact lens mold member or step 104 of closing the contact lens mold in the step 104. aging step 108 demolding step 11 removing the lens step 112 extracting step 114 hydrating step 116 packaging step 118 sterilizing Step 202 polymerizable helium hydrogel lens precursor composition 2〇4 pre-extracted polymerized oxygenated hydrogel contact lens product 206 extracted helium oxygen hydrogel contact lens product 208 hydrated helium oxygenated water Glue contact lens 121843 -98-

Claims (1)

200815501 X. Patent application scope: 1. Seed stone oxygen gel contact lens, which comprises: 90% of the body dry weight, the lens object of the main oxygen-transfer material, the lens object has an acceptable surface on the eye t The m and the dry weight are not greater than the pre-extraction lens 2·^ request item R dream oxygen hydrogel contact lens, wherein the lens system does not contain 3 surface treatments which are acceptable for surface wettability on the eye. 3. The stone-oxygen gel contact lens of item 1 or 2, wherein the lens system is not 3, and the eye-catching polymer of the polymer moisturizing agent is acceptable on the surface of the eye. organization. 4. The oxygenated hydrogel contact lens of any one of clauses 1 to 3, wherein the lens limb is a cast molded component obtained from a non-polar resin contact lens mold. The hemohydrogel contact lens of any one of 4, wherein the lens system is hydrated and comprises one or more features selected from the group consisting of: advancing contact angle less than about 120 degrees 5 tensile modulus less than about 1.6 MPa, ion The flux is less than about 7 Χ 1 (Γ 3 mm 2 /min, oxygen gas permeability of at least about 70 barrer, and water content of at least about 30 wt. / 〇. 6. Seed stone oxygen gel contact lenses, It comprises a lens object obtained from a pre-extracted polymerized hydrogel contact lens product having a removable component comprising at least 10% (w/w), wherein the lens object has an ocularly acceptable surface moisturizing Wetness. Into the oxygenated hydrogel contact lens of claim 6, wherein the lens object is a lens object that has not been surface treated. 121843 200815501 8·If the request is 6弋7, the special 7 stone oxygen invisible gel Glasses, in which the lens system does not contain private: ρ 0 main buckle /, on the moon An interpenetrating polymer network of a polymeric wetting agent that accepts surface wettability. 9. If the item 6 δ δ, the main 8 of any of the oxygenated hydrogel contact lenses, straight-through The stone 々 々 水 水 水 水 水 水 水 水 水 水 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 〜 Hydrating, and including one or more features selected from the group consisting of: advancing contact angle less than about 120 degrees, tensile modulus less than about 16 Mpa, ion flux less than, force 7 X 10 3 square millimeters per minute, oxygen permeability at least about 70 Å, and a water content of at least about 30% by weight. U. The oxygenated hydrogel contact lens of any one of claims 6 to 1 wherein the polymerized hydrogel contact lens product is removable. In addition to the component comprising at least one non-reactive additive. 12. The oxygen hydrogel contact lens of claim 11, wherein the at least one non-reverse Q additive is selected from one or more of the following: a compatibilizing agent, Mould additive, lens removal aid, wettability enhancer and ion A reducing agent. 13. The diarrhea oxygen gel contact lens of claim 11 wherein the at least one non-reactive additive is a hydrophobic or amphiphilic additive. 14. The oxygen hydrogel of claim 11. a contact lens, wherein the at least one non-reactive additive is a non-reactive alcohol, a non-reactive hydrophilic anthracene polymer, or a combination thereof. 15) A request for a cerium oxygen hydrogel contact lens, wherein the at least one The non-reactive additive is selected from one or more of the following: ethylene glycol stearate, single 121843 200815501 diethylene glycol laurate, CyC: 24 alcohol, CyC24 amine, and polydidecyl fluorene-co- PEG. 16. The oxygenated hydrogel contact lens of claim 11, wherein the at least one non-reactive additive is decyl alcohol, polydimethyl methoxyalkane-co-PEG or a combination thereof. The hemohydrogel contact lens of any one of clauses 6 to π, wherein the lens system comprises units derived from thiol choline-monomer. 18. The oxygenated hydrogel contact lens of claim 1, wherein the lens system comprises f, a unit of 2-methylpropenyloxyethylphosphonium choline. 19. A pre-extracted polymerized hydrothermal hydrogel contact lens product, comprising: an object member of extraction 4 having a dry weight of at least 1% greater than an extraction process of the object member to form an extracted polymer. The dry weight of the component of the object after the oxygen hydrogel contact lens product. 20. The polymeric oxygenated hydrogel contact lens product of claim 19, wherein the object member of extract A has a removable component content of from 1% (w/w) to about 75% of the member of the object (w) /w) 〇Q 2L The polymeric oxygenated hydrogel contact lens product of claim 19 or 20 is provided in contact with a non-polar resin contact lens mold member. The polymeric oxygenated hydrogel contact lens of any one of clauses 19 to 21 wherein the extracting other object member comprises at least one non-reactive additive. 23. The polymeric oxygenated hydrogel contact lens product of claim 22, wherein the non-reactive additive is selected from the group consisting of one or more compatibilizers, mold release aids, lens removal aids, Wettability enhancer and ion flux reducer. The polymerized diarrhea hydrogel contact lens product of Item 22, wherein the non-reactive additive to 121843 200815501 is a hydrophobic additive or an amphiphilic additive. 25. The polymeric hydrogel contact lens product of claim 22, wherein the at least one non-reactive additive is a non-reactive alcohol, a non-reactive hydrophilic oxo conjugate or a combination thereof. 26. The polymeric hydrogel contact lens product of claim 22, wherein the at least one non-reactive additive is selected from one or more of the following: ethylene glycol stearate, diethyl laurate Alcohol esters, alcohols, c2_Ch amines and polydimethyloxane-co-PEG. (27) The polymeric hydrogel contact lens product of claim 22, wherein the at least one non-reactive additive is decyl alcohol, polydidecyl fluorene oxide _ pEG or a combination thereof. The polymeric hydrogel contact lens product of any one of claims 19 to 27, wherein the object component prior to extraction comprises a unit of methacrylate phospha-choline-monomer. 29. A polymerizable silicone hydrogel contact lens precursor composition comprising: a polymerizable non-ruthenium containing component and a polymerizable rhodium containing component combined into a polymerizable hydrogen peroxide/coiled contact lens precursor composition, One portion of the polymerizable silicone hydrogel contact lens precursor composition can be removed from the polymerizable silicone hydrogel contact lens W, the composition of the polymerized stone shower & hydrogel contact lens product. And present in an amount of at least 1% (w/w) of the polymerized rock hydrogel contact lens product. 30. The polymerizable silicone hydrogel contact lens precursor composition of claim 29, wherein the polymerizable non-containing stone component comprises a first type of body having a reaction ratio of ten and a ratio of less than One reactivity is more than the second reactivity compared to 121^43 200815501 second monomer. 31. The polymerizable silicone hydrogel contact lens precursor composition of claim 30, wherein the polymerizable & non-s? component further comprises a crosslinking agent having a reactivity ratio similar to the first reactivity ratio. 32. The polymerizable silicone hydrogel contact lens precursor composition of claim 29, wherein the polymerizable & έ石夕 component is M3U, and the polymerizable non-stone component comprises a group of vinyl methyl hydrazine Amine, methyl methacrylate, tris(ethylene glycol) vinegar, and an initiator. The polymerizable silicone hydrogel contact lens precursor composition according to any one of claims 29 to 32, wherein the non-garium-containing component further comprises an ultraviolet absorber and a micro-dye. The polymerizable silicone hydrogel contact lens porch composition of any one of the items 29-33 further comprising a block copolymer of polydidecyloxyne and polyethylene glycol. 35. The polymerizable silicone hydrogel contact lens precursor composition of claim 29, wherein the polymerizable inclusion component is M3U and the polymerizable non-containing component comprises μ ethylene-2-tetrahydrop Turbinone, methyl methacrylate, tri(ethylene glycol) dimercaptoacrylate, and initiator. 36. The polymerizable silicone hydrogel contact lens precursor composition of claim 35, wherein the non-containing stone component further comprises decyl alcohol. 37. The polymerizable silicone hydrogel contact lens precursor composition of claim 36, wherein the sterol is present in an amount from about 5% (w/w) to about 3% (w/w) of the composition. . 38. The polymerizable silicone hydrogel contact lens precursor composition of claim 35, further comprising a block copolymer of polydidecyloxane and polyethylene glycol. 121843 200815501 39. According to claim 38, the singularity of the singularity of the sulphuric acid-containing contact lens or the s Alkylene oxide release aid. 40. According to claim 35, the human ♦ B hard oxygen hydrogel contact lens precursor composition, wherein the non-containing bismuth component is incorporated into the oxen ^ human ^ V 匕 containing a diluent, selected from the group consisting of hexanol and ethoxylate. Ethanol, isopropanol, propionic acid > Known, sterol and combinations thereof. 41. A human, % & oxygenated hydrogel contact lens precursor composition according to claim 40, further comprising a unit of methacrylate choline _ monomer. 42. In the case of claims 29 to 41 A polymerizable silicone hydrogel contact lens is a precursor composition that contains at least half of a hydrophobic additive or an extractable amphiphilic additive. 43. The method of claim 42, wherein the additive is selected from the group consisting of the following: ^ ^ ', one or more of the following: stearic acid Ethylene glycol ester, diethylene glycol monolaurate @, rr ^ ^ sterol, CyC: 24 amine and polydimethyl decane co-PEG. 44. The polyoxygenated hydrogel contact lens precursor composition of claim 42, wherein the additive is decyl alcohol, polydimethyl oxalate-co-pEG or a combination thereof. 45. The method of claim 44, wherein the additive comprises a polydioxanoxane having a molecular weight in the range of from about 300 to about 30,000 doxantane. - co-PEG. 46. The polymerizable lithothere hydrogel stealth ophthalmic degrading composition of claim 44, wherein the additive comprises polydimethicone-co-molecular having a molecular weight of less than about 3, doldorfal- PEG. 47. The polymerizable silicone hydrogel contact lens precursor composition of claim 42, wherein the additive is present in an amount ranging from about 1% to about 6% (w/w) of the composition. 121843 200815501 . 48. The polymerizable hydrogen peroxide hydrogel contact lens precursor composition of claim 42, which comprises at least two different additives. 49. The polymerizable 11 oxygen hydrogel contact lens precursor composition of claim 42 which is provided in a non-polar resin contact lens mold. 50. A method of making a silicone hydrogel contact lens comprising: a pre-stroke oxygenated hydrogel contact lens product having a removable component content of at least 1% (w/w) of the lens product The helium-hydrogel contact lens is formed to have a dry weight no greater than 90% of the dry weight of the lens object prior to extraction, and an acceptable surface wettability on the eye. 51. The method of claim 5, wherein the forming system comprises extracting the extractable material from the sulphuric oxygen/coluent contact lens product prior to extraction. 52. The method of claim 5 or 51, further comprising aging the polymerizable silicone hydrogel contact lens precursor composition to form at least 10% of the lens product having a removable component content (w/ w) The polymerized hydrogenated hydrogel contact lens product prior to extraction. 53. The method of claim 52 wherein the polymerizable lithothere hydrogel contact lens precursor composition is cured in a non-polar resin contact lens mold. 54. The method of claim 52, further comprising adding a removable additive to the polymerizable silicone hydrogel contact lens precursor composition. 55. The method of claim 54, wherein the removable additive is selected from the group consisting of a compatibilizer, a mold release aid, a lens release aid, a wettability enhancer, a modulus reducer, and a reduced ion flux. Agents and combinations thereof. 56. The method of any of clauses 52 to 55, further comprising the step of adding an agent 121843 200815501 to the lens precursor composition, the collector, the microdye, and combinations thereof. The agent is selected from the group consisting of ultraviolet light absorbers 57. According to any one of claims 50 to 56, the mirror is manufactured without the need for a surface treatment lens or an interpenetrating polymer of the contact lens 4 Lens of the reticular tissue. 50% with polymer wetting 121843