TW200730494A - Novel compounds - Google Patents

Novel compounds

Info

Publication number: TW200730494A
Authority: TW; Taiwan
Prior art keywords: novel compounds; prodrug; solvate; diseases; modulation
Prior art date: 2005-10-10

Application number

TW095136986A

Other languages

English (en)

Inventor

Giuseppe Alvaro

Markus Bergauer

Roberto Profeta

Riccardo Giovannini

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-10

Filing date

2006-10-05

Publication date

2007-08-16

2005-10-10 Priority claimed from GB0520581A external-priority patent/GB0520581D0/en

2005-11-11 Priority claimed from GB0523045A external-priority patent/GB0523045D0/en

2006-02-27 Priority claimed from GB0603900A external-priority patent/GB0603900D0/en

2006-09-18 Priority claimed from GB0618336A external-priority patent/GB0618336D0/en

2006-10-05 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-08-16 Publication of TW200730494A publication Critical patent/TW200730494A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

TW095136986A 2005-10-10 2006-10-05 Novel compounds TW200730494A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0520581A GB0520581D0 (en)	2005-10-10	2005-10-10	Novel compounds
GB0523045A GB0523045D0 (en)	2005-11-11	2005-11-11	Novel compounds
GB0603900A GB0603900D0 (en)	2006-02-27	2006-02-27	Novel compounds
GB0618336A GB0618336D0 (en)	2006-09-18	2006-09-18	Novel compounds

Publications (1)

Publication Number	Publication Date
TW200730494A true TW200730494A (en)	2007-08-16

Family

ID=37546777

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095136986A TW200730494A (en)	2005-10-10	2006-10-05	Novel compounds

Country Status (20)

Country	Link
US (2)	US7655693B2 (zh)
EP (1)	EP1934177B8 (zh)
JP (1)	JP5139305B2 (zh)
KR (1)	KR101282464B1 (zh)
AR (1)	AR056575A1 (zh)
AT (1)	ATE556049T1 (zh)
AU (1)	AU2006301470B2 (zh)
BR (1)	BRPI0616944B8 (zh)
CA (1)	CA2625642C (zh)
CR (1)	CR9898A (zh)
EA (1)	EA015736B1 (zh)
ES (1)	ES2387405T3 (zh)
IL (1)	IL192627A0 (zh)
MA (1)	MA29817B1 (zh)
NO (1)	NO20082145L (zh)
NZ (1)	NZ567051A (zh)
PE (1)	PE20070592A1 (zh)
PL (1)	PL1934177T3 (zh)
TW (1)	TW200730494A (zh)
WO (1)	WO2007042239A1 (zh)

Families Citing this family (22)

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Publication number	Priority date	Publication date	Assignee	Title
DE602006015215D1 (de) *	2005-10-10	2010-08-12	Glaxo Group Ltd	Prolinamidderivate als natriumkanalmodulatoren
US8143306B2 (en) *	2005-10-10	2012-03-27	Convergence Pharmaceuticals Limited	Methods of treating bipolar disorders
GB0701365D0 (en) *	2007-01-24	2007-03-07	Glaxo Group Ltd	Novel pharmaceutical compositions
GB0706630D0 (en) *	2007-04-04	2007-05-16	Glaxo Group Ltd	Novel compounds
WO2011015537A1 (en) *	2009-08-05	2011-02-10	Glaxo Group Limited	Co-therapy for the treatment of epilepsy and related disorders
ES2536694T3 (es) *	2009-09-14	2015-05-27	Convergence Pharmaceuticals Limited	Procedimiento para preparar derivados de alfa-carboxamida
ES2786298T3 (es)	2011-03-03	2020-10-09	Zalicus Pharmaceuticals Ltd	Inhibidores de benzimidazol del canal de sodio
GB201122113D0 (en)	2011-12-22	2012-02-01	Convergence Pharmaceuticals	Novel compounds
GB201209015D0 (en)	2012-05-22	2012-07-04	Convergence Pharmaceuticals	Novel compounds
CN106255679B (zh)	2014-02-27	2019-09-06	默克专利有限公司	用作nav通道抑制剂的杂环化合物及其用途
GB201417499D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417500D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417497D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
ES2912881T3 (es)	2014-12-23	2022-05-30	Convergence Pharmaceuticals	Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
SG11201903667XA (en) *	2016-11-02	2019-05-30	Biogen Inc	Novel dosage regimen
WO2018213686A1 (en) *	2017-05-19	2018-11-22	Biogen Inc.	Novel crystalline forms
CA3076823A1 (en)	2017-10-05	2019-04-11	Biogen Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
EP3694510A4 (en)	2017-10-10	2021-06-30	Biogen Inc.	SPIRO DERIVATIVE PREPARATION PROCESS
CA3093401A1 (en) *	2018-04-16	2019-10-24	Biogen Ma Inc.	Methods of treating neuropathic pain
WO2020210485A1 (en) *	2019-04-10	2020-10-15	Biogen Ma Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
US20220162164A1 (en) *	2019-04-10	2022-05-26	Biongen Inc.	Processes for preparing alpha-carboxamide pyrrolidine derivatives
WO2021154631A1 (en)	2020-01-30	2021-08-05	Javed Mohammad	Combination drug therapies for cns disorders

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IL94466A (en)	1989-05-25	1995-01-24	Erba Carlo Spa	Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en)	1994-06-27	2001-03-13	Cytomed Incorporated	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9727523D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Alpha-aminoamide derivatives useful as analgesic agents
US6136131A (en) *	1998-06-02	2000-10-24	Instrument Specialties Company, Inc.	Method of shielding and obtaining access to a component on a printed circuit board
BR0009322A (pt)	1999-03-26	2002-04-30	Euro Celtique Sa	Pirazóis, imidazóis, oxazóis, tiazóis e pirróis substituìdos com arila e o uso dos mesmos
GB9923748D0 (en)	1999-10-07	1999-12-08	Glaxo Group Ltd	Chemical compounds
GB0115517D0 (en)	2001-06-25	2001-08-15	Ferring Bv	Novel antidiabetic agents
TW200404796A (en) *	2002-08-19	2004-04-01	Ono Pharmaceutical Co	Nitrogen-containing compound
TWI286132B (en)	2002-09-20	2007-09-01	Hoffmann La Roche	4-pyrrolidino-phenyl-benzyl ether derivatives
MY142651A (en)	2003-03-18	2010-12-15	Merck Sharp & Dohme	Biaryl substituted triazoles as sodium channel blockers
US7589116B2 (en)	2003-04-03	2009-09-15	Merck & Co. Inc.	Biaryl substituted pyrazoles as sodium channel blockers
AU2004232936B2 (en) *	2003-04-18	2008-10-30	Merck & Co., Inc.	Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
WO2005000309A2 (en)	2003-06-27	2005-01-06	Ionix Pharmaceuticals Limited	Chemical compounds
EP1524265A1 (en)	2003-10-15	2005-04-20	Newron Pharmaceuticals S.p.A.	Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors
WO2005100334A1 (en)	2004-04-14	2005-10-27	Pfizer Products Inc.	Dipeptidyl peptidase-iv inhibitors
WO2006119451A1 (en)	2005-05-04	2006-11-09	Vertex Pharmaceuticals Incorporated	Pyrimidines and pyrazines useful as modulators of ion channels
JP2008540438A (ja)	2005-05-04	2008-11-20	バーテックスファーマシューティカルズインコーポレイテッド	イオンチャネルのモジュレーターとして有用なピリジン
WO2006124865A2 (en)	2005-05-19	2006-11-23	Vertex Pharmaceuticals Incorporated	Biaryls derivatives useful as modulators of ion channels
CN101305011B (zh)	2005-09-09	2011-03-02	史密丝克莱恩比彻姆公司	吡啶衍生物及其在治疗精神障碍中的用途
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
DE602006015215D1 (de) *	2005-10-10	2010-08-12	Glaxo Group Ltd	Prolinamidderivate als natriumkanalmodulatoren
GB0701366D0 (en)	2007-01-24	2007-03-07	Glaxo Group Ltd	Novel pharmaceutical compositions
GB0701365D0 (en)	2007-01-24	2007-03-07	Glaxo Group Ltd	Novel pharmaceutical compositions
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
GB0706630D0 (en)	2007-04-04	2007-05-16	Glaxo Group Ltd	Novel compounds

2006
- 2006-10-05 TW TW095136986A patent/TW200730494A/zh unknown
- 2006-10-06 PE PE2006001225A patent/PE20070592A1/es not_active Application Discontinuation
- 2006-10-06 CA CA2625642A patent/CA2625642C/en active Active
- 2006-10-06 JP JP2008534910A patent/JP5139305B2/ja not_active Expired - Fee Related
- 2006-10-06 PL PL06806110T patent/PL1934177T3/pl unknown
- 2006-10-06 ES ES06806110T patent/ES2387405T3/es active Active
- 2006-10-06 NZ NZ567051A patent/NZ567051A/en unknown
- 2006-10-06 EP EP06806110A patent/EP1934177B8/en active Active
- 2006-10-06 KR KR1020087011271A patent/KR101282464B1/ko not_active Expired - Fee Related
- 2006-10-06 BR BRPI0616944A patent/BRPI0616944B8/pt not_active IP Right Cessation
- 2006-10-06 EA EA200801054A patent/EA015736B1/ru not_active IP Right Cessation
- 2006-10-06 US US11/570,560 patent/US7655693B2/en active Active
- 2006-10-06 WO PCT/EP2006/009731 patent/WO2007042239A1/en not_active Ceased
- 2006-10-06 AU AU2006301470A patent/AU2006301470B2/en not_active Ceased
- 2006-10-06 AT AT06806110T patent/ATE556049T1/de active
- 2006-10-09 AR ARP060104441A patent/AR056575A1/es not_active Application Discontinuation
2008
- 2008-03-31 MA MA30797A patent/MA29817B1/fr unknown
- 2008-04-18 CR CR9898A patent/CR9898A/es not_active Application Discontinuation
- 2008-05-07 NO NO20082145A patent/NO20082145L/no not_active Application Discontinuation
- 2008-07-03 IL IL192627A patent/IL192627A0/en active IP Right Grant
2009
- 2009-12-17 US US12/641,111 patent/US8153681B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20100105754A1 (en)	2010-04-29
BRPI0616944B1 (pt)	2020-04-14
WO2007042239A1 (en)	2007-04-19
CA2625642C (en)	2013-12-24
NO20082145L (no)	2008-05-07
EA200801054A1 (ru)	2008-08-29
EP1934177B8 (en)	2012-09-05
BRPI0616944B8 (pt)	2021-05-25
IL192627A0 (en)	2011-08-01
JP2009511519A (ja)	2009-03-19
ES2387405T3 (es)	2012-09-21
EP1934177B1 (en)	2012-05-02
BRPI0616944A2 (pt)	2011-07-05
ATE556049T1 (de)	2012-05-15
US7655693B2 (en)	2010-02-02
EA015736B1 (ru)	2011-10-31
MA29817B1 (fr)	2008-09-01
PL1934177T3 (pl)	2013-03-29
JP5139305B2 (ja)	2013-02-06
PE20070592A1 (es)	2007-06-23
AU2006301470A1 (en)	2007-04-19
EP1934177A1 (en)	2008-06-25
AU2006301470B2 (en)	2012-06-14
NZ567051A (en)	2011-03-31
CA2625642A1 (en)	2007-04-19
US8153681B2 (en)	2012-04-10
AR056575A1 (es)	2007-10-10
KR20080059296A (ko)	2008-06-26
KR101282464B1 (ko)	2013-07-04
US20080280969A1 (en)	2008-11-13
CR9898A (es)	2008-07-29

Publication	Publication Date	Title
TW200730494A (en)	2007-08-16	Novel compounds
UA94833C2 (en)	2011-06-10	Substituted bicyclolactams
TW200716606A (en)	2007-05-01	Chemical compounds
TW200800963A (en)	2008-01-01	Chemical compounds
SI1853602T1 (sl)	2010-11-30	Kemične spojine
PT1853588E (pt)	2008-08-25	Compostos químicos
NO20063479L (no)	2006-10-02	Fosfonater, monofosfonamidater og bis-fosfonamidater for behandling av virussykdommer
EA201000886A1 (ru)	2011-02-28	Органические соединения
TW200508228A (en)	2005-03-01	Biaryl heterocyclic compounds and methods of making and using the same
MX2007007845A (es)	2008-01-22	Sulfonilpirrolidinas, metodo para producir las mismas y su uso como medicamento.
TW200612911A (en)	2006-05-01	Compounds for the treatment of inflammatory disorders
WO2007079199A3 (en)	2007-09-13	Substituted bis-amide metalloprotease inhibitors
CY1109911T1 (el)	2014-09-10	Πυρρολοβενζοδιαζεπινες
PT2385053E (pt)	2013-12-17	Intermediários para a preparação de compostos bicíclicos condensados como inibidores mtor
UA85559C2 (en)	2009-02-10	Aminobenzophenone compounds
TW200740429A (en)	2007-11-01	Methods and dosage forms for reducing side effects of carbamate compounds
TW200728258A (en)	2007-08-01	Novel compounds
TW200616977A (en)	2006-06-01	Enantiomers of selected fused heterocyclics and uses thereof
NO20064344L (no)	2006-10-19	Caspaseinhibitorer og anvendelser derav
MX2010001303A (es)	2010-09-07	Compuestos terapeuticos.
TW200745039A (en)	2007-12-16	Isotopically substituted pantoprazole
EA200801366A1 (ru)	2008-10-30	Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
MX2010001304A (es)	2010-09-07	Compuestos terapeuticos.
NO20063293L (no)	2006-07-14	Farmasoytiske forbindelser
UA93887C2 (ru)	2011-03-25	Производные пролинамида kak модуляторы натриевых каналов