NO20064344L - Caspaseinhibitorer og anvendelser derav - Google Patents
Caspaseinhibitorer og anvendelser deravInfo
- Publication number
- NO20064344L NO20064344L NO20064344A NO20064344A NO20064344L NO 20064344 L NO20064344 L NO 20064344L NO 20064344 A NO20064344 A NO 20064344A NO 20064344 A NO20064344 A NO 20064344A NO 20064344 L NO20064344 L NO 20064344L
- Authority
- NO
- Norway
- Prior art keywords
- caspase inhibitors
- compounds
- formula
- present
- provides
- Prior art date
Links
- 102000011727 Caspases Human genes 0.000 title 1
- 108010076667 Caspases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Foreliggende oppfinnelse tilveiebringer en forbindelse med formel I: hvori variablene er som definert heri. Foreliggende oppfinnelse tilveiebringer også fremgangsmåter for fremstilling av forbindelsene med formel I, og intermediater derav, farmasøytiske sammensetninger som innbefatter disse forbindelsene og fremgangsmåter for anvendelse av forbindelsene og sammensetningene.
Applications Claiming Priority (4)
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| US54861004P | 2004-02-27 | 2004-02-27 | |
| US62974304P | 2004-11-19 | 2004-11-19 | |
| US62966104P | 2004-11-19 | 2004-11-19 | |
| PCT/US2005/006540 WO2005085236A2 (en) | 2004-02-27 | 2005-02-28 | Caspase inhibitors and uses thereof |
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| NO20064344L true NO20064344L (no) | 2006-10-19 |
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| NO20064344A NO20064344L (no) | 2004-02-27 | 2006-09-26 | Caspaseinhibitorer og anvendelser derav |
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| NO20064351A NO20064351L (no) | 2004-02-27 | 2006-09-26 | Caspaseinhibitorer og anvendelser derav |
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| EP (2) | EP2270004A1 (no) |
| JP (3) | JP2007525503A (no) |
| KR (1) | KR20060129069A (no) |
| CN (1) | CN102161656B (no) |
| AR (1) | AR047981A1 (no) |
| AU (1) | AU2005219861B2 (no) |
| BR (1) | BRPI0508102A (no) |
| CA (1) | CA2557645C (no) |
| IL (1) | IL177709A0 (no) |
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| RU (1) | RU2382780C2 (no) |
| TW (2) | TWI362381B (no) |
| WO (1) | WO2005085236A2 (no) |
| ZA (1) | ZA200607634B (no) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ID27002A (id) * | 1998-03-19 | 2001-02-22 | Vertex Pharma | Penghambat-penghambat kaspase |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| HUE024556T2 (hu) * | 2004-03-12 | 2016-02-29 | Vertex Pharma | Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására |
| US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| US7531570B2 (en) * | 2004-05-27 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Treatment of diseases using ICE inhibitors |
| US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| SG11201609256SA (en) | 2014-05-12 | 2016-12-29 | Conatus Pharmaceuticals Inc | Treatment of the complications of chronic liver disease with caspase inhibitors |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| US20190022043A1 (en) | 2015-12-31 | 2019-01-24 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| CN105853408B (zh) * | 2016-04-15 | 2018-12-04 | 浙江大学 | 苯酰胺衍生物在制备Caspase-1抑制剂中的应用 |
| WO2018065902A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| WO2024044098A2 (en) * | 2022-08-23 | 2024-02-29 | Alexion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
Family Cites Families (20)
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| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| AU702346B2 (en) * | 1994-07-22 | 1999-02-18 | Altana Pharma Ag | Dihydrobenzofuranes |
| AP624A (en) * | 1995-06-06 | 1997-12-19 | Pfizer | Substituted n-(indole-2-carbonyl)-b- alanimamides and derivatives as antidiabetic agents. |
| ATE310528T1 (de) * | 1996-09-12 | 2005-12-15 | Idun Pharmaceuticals Inc | Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie |
| CN1234038A (zh) * | 1996-09-12 | 1999-11-03 | 伊邓药品公司 | 作为ICE/ced-3类半胱氨酸蛋白酶抑制剂的C-末端修饰的(N-取代)-2-吲哚基二肽 |
| FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
| ID27002A (id) * | 1998-03-19 | 2001-02-22 | Vertex Pharma | Penghambat-penghambat kaspase |
| US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6630473B1 (en) | 1999-01-29 | 2003-10-07 | Senju Pharmaceutical Co., Ltd. | Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives |
| EP1278737B1 (en) | 2000-04-24 | 2010-06-30 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
| PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AP2002002407A0 (en) | 2000-05-23 | 2002-03-31 | Vertex Pharma | Caspase inhibitors and uses thereof. |
| DE60131160T2 (de) | 2000-06-07 | 2008-08-07 | Vertex Pharmaceuticals Inc., Cambridge | Caspase-inhibitoren und ihre verwendungen |
| JP2004509120A (ja) | 2000-09-13 | 2004-03-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤およびそれらの用途 |
| MXPA03009647A (es) | 2001-04-19 | 2004-01-29 | Vertex Pharma | Heterociclildicarbamidas como inhibidores de caspasa. |
| US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| HUE024556T2 (hu) * | 2004-03-12 | 2016-02-29 | Vertex Pharma | Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására |
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2005
- 2005-02-28 NZ NZ549665A patent/NZ549665A/en not_active IP Right Cessation
- 2005-02-28 WO PCT/US2005/006540 patent/WO2005085236A2/en not_active Ceased
- 2005-02-28 CN CN2010106215884A patent/CN102161656B/zh not_active Expired - Fee Related
- 2005-02-28 KR KR1020067019903A patent/KR20060129069A/ko not_active Ceased
- 2005-02-28 AR ARP050100737A patent/AR047981A1/es unknown
- 2005-02-28 EP EP10013186A patent/EP2270004A1/en not_active Withdrawn
- 2005-02-28 BR BRPI0508102-5A patent/BRPI0508102A/pt not_active IP Right Cessation
- 2005-02-28 JP JP2007500824A patent/JP2007525503A/ja active Pending
- 2005-02-28 RU RU2006134258/04A patent/RU2382780C2/ru not_active IP Right Cessation
- 2005-02-28 AU AU2005219861A patent/AU2005219861B2/en not_active Ceased
- 2005-02-28 EP EP05724143A patent/EP1718639A2/en not_active Withdrawn
- 2005-02-28 US US11/069,895 patent/US7652153B2/en not_active Expired - Fee Related
- 2005-02-28 CA CA2557645A patent/CA2557645C/en not_active Expired - Fee Related
- 2005-03-01 TW TW094106099A patent/TWI362381B/zh not_active IP Right Cessation
- 2005-03-01 TW TW101100244A patent/TW201217332A/zh unknown
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2006
- 2006-08-27 IL IL177709A patent/IL177709A0/en not_active IP Right Cessation
- 2006-09-12 ZA ZA2006/07634A patent/ZA200607634B/en unknown
- 2006-09-26 NO NO20064351A patent/NO20064351L/no not_active Application Discontinuation
- 2006-09-26 NO NO20064344A patent/NO20064344L/no unknown
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2009
- 2009-12-03 US US12/630,350 patent/US20100105914A1/en not_active Abandoned
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2011
- 2011-04-21 JP JP2011095553A patent/JP2011144203A/ja not_active Withdrawn
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2014
- 2014-05-09 JP JP2014097786A patent/JP2014140385A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005085236A2 (en) | 2005-09-15 |
| KR20060129069A (ko) | 2006-12-14 |
| EP1718639A2 (en) | 2006-11-08 |
| CA2557645A1 (en) | 2005-09-15 |
| JP2014140385A (ja) | 2014-08-07 |
| AR047981A1 (es) | 2006-03-15 |
| CN102161656A (zh) | 2011-08-24 |
| WO2005085236A3 (en) | 2005-10-20 |
| RU2006134258A (ru) | 2008-04-10 |
| TW200540152A (en) | 2005-12-16 |
| BRPI0508102A (pt) | 2007-07-17 |
| NZ549665A (en) | 2010-09-30 |
| AU2005219861B2 (en) | 2011-08-11 |
| RU2382780C2 (ru) | 2010-02-27 |
| IL177709A0 (en) | 2006-12-31 |
| NO20064351L (no) | 2006-11-20 |
| TW201217332A (en) | 2012-05-01 |
| HK1159614A1 (en) | 2012-08-03 |
| ZA200607634B (en) | 2008-01-08 |
| HK1099757A1 (en) | 2007-08-24 |
| EP2270004A1 (en) | 2011-01-05 |
| US7652153B2 (en) | 2010-01-26 |
| US20100105914A1 (en) | 2010-04-29 |
| CA2557645C (en) | 2013-09-24 |
| CN102161656B (zh) | 2013-02-20 |
| US20050233979A1 (en) | 2005-10-20 |
| JP2007525503A (ja) | 2007-09-06 |
| JP2011144203A (ja) | 2011-07-28 |
| TWI362381B (en) | 2012-04-21 |
| AU2005219861A1 (en) | 2005-09-15 |
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