TW200616967A - Novel indazole carboxamides and their use - Google Patents
Novel indazole carboxamides and their useInfo
- Publication number
- TW200616967A TW200616967A TW094120713A TW94120713A TW200616967A TW 200616967 A TW200616967 A TW 200616967A TW 094120713 A TW094120713 A TW 094120713A TW 94120713 A TW94120713 A TW 94120713A TW 200616967 A TW200616967 A TW 200616967A
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- directed
- ikk2
- treatment
- activity
- Prior art date
Links
- DITBWPUMEUDVLU-UHFFFAOYSA-N 1h-indazole-3-carboxamide Chemical class C1=CC=C2C(C(=O)N)=NNC2=C1 DITBWPUMEUDVLU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 abstract 3
- 101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 abstract 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 101100508533 Drosophila melanogaster IKKbeta gene Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58265504P | 2004-06-24 | 2004-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200616967A true TW200616967A (en) | 2006-06-01 |
Family
ID=35782386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094120713A TW200616967A (en) | 2004-06-24 | 2005-06-22 | Novel indazole carboxamides and their use |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8501780B2 (zh) |
| EP (1) | EP1758578B1 (zh) |
| JP (1) | JP5017105B2 (zh) |
| KR (1) | KR20070043940A (zh) |
| CN (1) | CN101005836A (zh) |
| AR (1) | AR050253A1 (zh) |
| AT (1) | ATE493396T1 (zh) |
| AU (1) | AU2005258332A1 (zh) |
| BR (1) | BRPI0512533A (zh) |
| CA (1) | CA2571712A1 (zh) |
| DE (1) | DE602005025632D1 (zh) |
| ES (1) | ES2358579T3 (zh) |
| IL (1) | IL179747A0 (zh) |
| MA (1) | MA28727B1 (zh) |
| MX (1) | MXPA06014481A (zh) |
| NO (1) | NO20070076L (zh) |
| PE (1) | PE20060373A1 (zh) |
| RU (1) | RU2007102576A (zh) |
| TW (1) | TW200616967A (zh) |
| WO (1) | WO2006002434A2 (zh) |
| ZA (1) | ZA200609759B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI380973B (zh) * | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
| US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| EP1948187A4 (en) * | 2005-11-18 | 2010-11-03 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
| WO2007091107A1 (en) * | 2006-02-10 | 2007-08-16 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| JP5019768B2 (ja) * | 2006-03-23 | 2012-09-05 | 独立行政法人科学技術振興機構 | 新規低分子化合物およびその製造方法 |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| GB0715087D0 (en) * | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| GB0804591D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| GB0804592D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| AU2009298981B2 (en) | 2008-10-02 | 2012-09-27 | Asahi Kasei Pharma Corporation | 8-substituted isoquinoline derivative and use thereof |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| WO2010120854A1 (en) * | 2009-04-15 | 2010-10-21 | Glaxosmithkline Llc | Chemical compounds |
| JP2015214492A (ja) * | 2012-09-07 | 2015-12-03 | 大日本住友製薬株式会社 | ３−（４−ピペリジル）−インダゾール誘導体 |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| CN109715608B (zh) | 2016-09-23 | 2022-08-05 | 诺华股份有限公司 | 在肌腱和/或韧带损伤中使用的吲唑化合物 |
| JOP20210324A1 (ar) * | 2019-06-27 | 2023-01-30 | Biogen Ma Inc | مشتقات من 2h-indazole واستخدامها في علاج مرض |
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| DE3342632A1 (de) | 1983-11-25 | 1985-06-05 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
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| JP2963288B2 (ja) | 1992-01-14 | 1999-10-18 | 株式会社海洋バイオテクノロジー研究所 | 水中有害付着生物防除剤 |
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| CN1249051C (zh) | 2000-04-28 | 2006-04-05 | 阿卡蒂亚药品公司 | 毒蕈碱性激动剂 |
| EP1293206A4 (en) | 2000-05-15 | 2005-09-21 | Kissei Pharmaceutical | LIQUID PREPARATION BASED ON WATER |
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-
2005
- 2005-06-22 TW TW094120713A patent/TW200616967A/zh unknown
- 2005-06-22 PE PE2005000715A patent/PE20060373A1/es not_active Application Discontinuation
- 2005-06-22 AR ARP050102576A patent/AR050253A1/es unknown
- 2005-06-24 BR BRPI0512533-2A patent/BRPI0512533A/pt not_active IP Right Cessation
- 2005-06-24 CA CA002571712A patent/CA2571712A1/en not_active Abandoned
- 2005-06-24 AT AT05769167T patent/ATE493396T1/de not_active IP Right Cessation
- 2005-06-24 RU RU2007102576/04A patent/RU2007102576A/ru not_active Application Discontinuation
- 2005-06-24 EP EP05769167A patent/EP1758578B1/en not_active Expired - Lifetime
- 2005-06-24 MX MXPA06014481A patent/MXPA06014481A/es unknown
- 2005-06-24 US US11/570,060 patent/US8501780B2/en not_active Expired - Fee Related
- 2005-06-24 JP JP2007518364A patent/JP5017105B2/ja not_active Expired - Fee Related
- 2005-06-24 WO PCT/US2005/022870 patent/WO2006002434A2/en not_active Ceased
- 2005-06-24 AU AU2005258332A patent/AU2005258332A1/en not_active Abandoned
- 2005-06-24 CN CNA200580028413XA patent/CN101005836A/zh active Pending
- 2005-06-24 DE DE602005025632T patent/DE602005025632D1/de not_active Expired - Lifetime
- 2005-06-24 KR KR1020067027143A patent/KR20070043940A/ko not_active Withdrawn
- 2005-06-24 ES ES05769167T patent/ES2358579T3/es not_active Expired - Lifetime
-
2006
- 2006-11-23 ZA ZA200609759A patent/ZA200609759B/en unknown
- 2006-11-30 IL IL179747A patent/IL179747A0/en unknown
- 2006-12-29 MA MA29580A patent/MA28727B1/fr unknown
-
2007
- 2007-01-05 NO NO20070076A patent/NO20070076L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI380973B (zh) * | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005258332A1 (en) | 2006-01-05 |
| EP1758578B1 (en) | 2010-12-29 |
| CA2571712A1 (en) | 2006-01-05 |
| AR050253A1 (es) | 2006-10-11 |
| US8501780B2 (en) | 2013-08-06 |
| CN101005836A (zh) | 2007-07-25 |
| ES2358579T3 (es) | 2011-05-11 |
| JP2008504296A (ja) | 2008-02-14 |
| WO2006002434A3 (en) | 2006-06-15 |
| RU2007102576A (ru) | 2008-07-27 |
| MXPA06014481A (es) | 2007-03-01 |
| NO20070076L (no) | 2007-02-26 |
| ZA200609759B (en) | 2007-10-31 |
| ATE493396T1 (de) | 2011-01-15 |
| WO2006002434A2 (en) | 2006-01-05 |
| EP1758578A2 (en) | 2007-03-07 |
| PE20060373A1 (es) | 2006-04-29 |
| IL179747A0 (en) | 2007-05-15 |
| US20070281933A1 (en) | 2007-12-06 |
| DE602005025632D1 (de) | 2011-02-10 |
| KR20070043940A (ko) | 2007-04-26 |
| BRPI0512533A (pt) | 2008-03-25 |
| EP1758578A4 (en) | 2009-05-27 |
| MA28727B1 (fr) | 2007-07-02 |
| JP5017105B2 (ja) | 2012-09-05 |
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