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MX2011011764A - Compuestos de carboxamida y su uso como inhibidores de calpaina. - Google Patents

Compuestos de carboxamida y su uso como inhibidores de calpaina.

Info

Publication number
MX2011011764A
MX2011011764A MX2011011764A MX2011011764A MX2011011764A MX 2011011764 A MX2011011764 A MX 2011011764A MX 2011011764 A MX2011011764 A MX 2011011764A MX 2011011764 A MX2011011764 A MX 2011011764A MX 2011011764 A MX2011011764 A MX 2011011764A
Authority
MX
Mexico
Prior art keywords
sup
sub
compounds
carboxamide compounds
meanings mentioned
Prior art date
Application number
MX2011011764A
Other languages
English (en)
Inventor
Wilfried Hornberger
Charles W Hutchins
Andreas Kling
Achim Moeller
Helmut Mack
Katja Jantos
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42470549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011011764(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2011011764A publication Critical patent/MX2011011764A/es

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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Abstract

La presente invención se refiere a compuestos de carboxamida novedosos y su uso para la fabricación de un medicamento. Los compuestos de carboxamida son inhibidores de calpaína (cisteína proteasas dependientes de calcio). Por lo tanto, la invención también se refiere al uso de dichos compuestos de carboxamida para tratar un trastorno asociado con una alta actividad de calpaína. Los compuestos de carboxamida son compuestos de la fórmula general I, donde R1, R2, R3a, R3b, R4, Q, Y, A y X tienen los significados que se mencionan en las reivindicaciones y la descripción, los tautómeros de los mismos y las sales de los mismos apropiados para uso farmacéutico. En particular, los compuestos tienen la fórmula general la e Ib, donde R1, r, R2b, R3a, R3b, R4, Y y X tienen los significados que se mencionan en las reivindicaciones, incluyendo a los tautómeros de los mismos y a las sales farmacéuticamente apropiadas de los mismos. De dichos compuestos, se prefieren aquellos donde Y es una unidad CH2-CH2, CH2-CH2-CH2, N(Ry#)-CH2, N(Ry#)-CH2-CH2 o CH=CH-CH=, en cada uno de los cuales opcionalmente se han reemplazado 1 ó 2 átomos de H por radicales Ry idénticos o diferentes, donde Ry y Ry# tienen los significados que se mencionan en las reivindicaciones.
MX2011011764A 2009-05-07 2010-05-06 Compuestos de carboxamida y su uso como inhibidores de calpaina. MX2011011764A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17613809P 2009-05-07 2009-05-07
US28975309P 2009-12-23 2009-12-23
PCT/EP2010/056166 WO2010128102A1 (en) 2009-05-07 2010-05-06 Carboxamide compounds and their use as calpain inhibitors

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