TR200201797T1 - Detection of anti-hepaptit B drug resistance - Google Patents
Detection of anti-hepaptit B drug resistanceInfo
- Publication number
- TR200201797T1 TR200201797T1 TR2002/01797T TR200201797T TR200201797T1 TR 200201797 T1 TR200201797 T1 TR 200201797T1 TR 2002/01797 T TR2002/01797 T TR 2002/01797T TR 200201797 T TR200201797 T TR 200201797T TR 200201797 T1 TR200201797 T1 TR 200201797T1
- Authority
- TR
- Turkey
- Prior art keywords
- drug resistance
- detection
- hbv
- hepaptit
- patient
- Prior art date
Links
- 206010059866 Drug resistance Diseases 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 abstract 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000011896 sensitive detection Methods 0.000 abstract 1
- 238000011895 specific detection Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Bir mevcut bulus, bir hastadaki anti-HBV ilaci direncinin, bu hastadaki bir biyolojik örnekte bulunan HBV irklarinin DNA polimerazindaki L528M, M552V/I ve/veya V/L/M555I mutasyonlarindan en azindan birinin genetik saptanmasi sayesinde görüntülenmesi için olan bir metot ile ilgilidir. Mevcut bulus anti-HBV ilacinin direncinin çok belirgin ve duyarli bir saptanmasina olanak tasiyan yeni sondalarin tasarimi için kullanilan yeni HBV DNA polimeraz sekanslarini saglamaktadir.A present invention relates to a method for imaging anti-HBV drug resistance in a patient by genetic detection of at least one of the L528M, M552V / I and / or V / L / M555I mutations in the DNA polymerase of HBV breeds in a biological sample in this patient. The present invention provides new HBV DNA polymerase sequences used for the design of new probes, which allow a very specific and sensitive detection of anti-HBV drug resistance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99870148 | 1999-07-08 | ||
| US14354699P | 1999-07-13 | 1999-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200201797T1 true TR200201797T1 (en) | 2003-05-21 |
Family
ID=30129296
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00689T TR200100689T1 (en) | 1999-07-08 | 2000-07-05 | Detection of anti-hepatitis B drug resistance |
| TR2002/01797T TR200201797T1 (en) | 1999-07-08 | 2000-07-05 | Detection of anti-hepaptit B drug resistance |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00689T TR200100689T1 (en) | 1999-07-08 | 2000-07-05 | Detection of anti-hepatitis B drug resistance |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1144693A3 (en) |
| JP (1) | JP2003505021A (en) |
| CN (1) | CN1384888A (en) |
| AR (1) | AR028149A1 (en) |
| AU (1) | AU6431700A (en) |
| BR (1) | BR0006899A (en) |
| CA (1) | CA2339422A1 (en) |
| TR (2) | TR200100689T1 (en) |
| WO (1) | WO2001004358A2 (en) |
| ZA (1) | ZA200101680B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6583279B1 (en) * | 2001-01-26 | 2003-06-24 | Becton, Dickinson And Company | Sequences and methods for detection of hepatitis B virus |
| GR1003878B (en) * | 2001-03-13 | 2002-04-24 | Γεωργακοπουλος Ελευθεριος Δρ. | Plastic vineyard-covering fabric |
| EP1513958B1 (en) | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
| US7186700B2 (en) | 2002-09-13 | 2007-03-06 | Idenix Pharmaceuticals, Inc. | β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies |
| KR100650162B1 (en) * | 2003-08-05 | 2006-11-27 | 주식회사 진인 | Microarray for detecting drug-resistant hepatitis virus containing a quality control probe and a negative control probe and a method for detecting drug-resistant hepatitis virus using the same |
| US20100292471A1 (en) * | 2006-12-18 | 2010-11-18 | Panagene Inc. | Peptide nucleic acid oligomers comprising universal bases,preparation methods thereof, and kits, devices and methods for the analysis, detection or modulation of nucleic acids using the same |
| JP2008283977A (en) * | 2008-06-09 | 2008-11-27 | Toshiba Corp | Genotype of target nucleic acid and method for determining mutation, method for immobilizing nucleic acid fragment on insoluble support, method for purifying and amplifying desired nucleic acid, and genotype assay kit |
| CN101812537B (en) * | 2009-10-27 | 2012-08-08 | 重庆医科大学 | Method and reagent kit for simultaneously detecting resistance site of three nucleotide analogues of hepatitis B virus |
| US9045803B2 (en) | 2012-02-29 | 2015-06-02 | Abbott Molecular Inc. | Hepatitis B virus typing and resistance assay |
| TW201831684A (en) * | 2016-11-11 | 2018-09-01 | 美商艾洛斯生物製藥公司 | Oligonucleotide targeting strategy for cccdna |
| CN109609694B (en) * | 2018-12-29 | 2022-03-01 | 上海昂朴生物科技有限公司 | Kit and method for detecting hepatitis B typing and multidrug resistance sites based on Illumina sequencing technology |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2167056A1 (en) * | 1993-07-13 | 1995-01-26 | Uwe Spies | Nucleotide sequences and process for amplifying and detection of hepatitis b virus |
| US5667974A (en) * | 1995-06-07 | 1997-09-16 | Abbott Laboratories | Method for detecting nucleic acid sequences using competitive amplification |
| ZA973367B (en) * | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
-
2000
- 2000-07-03 AR ARP000103391A patent/AR028149A1/en unknown
- 2000-07-05 CA CA002339422A patent/CA2339422A1/en not_active Abandoned
- 2000-07-05 CN CN00801329A patent/CN1384888A/en active Pending
- 2000-07-05 BR BR0006899-3A patent/BR0006899A/en not_active IP Right Cessation
- 2000-07-05 AU AU64317/00A patent/AU6431700A/en not_active Abandoned
- 2000-07-05 WO PCT/EP2000/006306 patent/WO2001004358A2/en not_active Ceased
- 2000-07-05 TR TR2001/00689T patent/TR200100689T1/en unknown
- 2000-07-05 EP EP00951337A patent/EP1144693A3/en not_active Withdrawn
- 2000-07-05 TR TR2002/01797T patent/TR200201797T1/en unknown
- 2000-07-05 JP JP2001509556A patent/JP2003505021A/en active Pending
-
2001
- 2001-02-28 ZA ZA200101680A patent/ZA200101680B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001004358A2 (en) | 2001-01-18 |
| CA2339422A1 (en) | 2001-01-18 |
| CN1384888A (en) | 2002-12-11 |
| AR028149A1 (en) | 2003-04-30 |
| AU6431700A (en) | 2001-01-30 |
| ZA200101680B (en) | 2003-05-28 |
| EP1144693A2 (en) | 2001-10-17 |
| EP1144693A3 (en) | 2001-11-28 |
| BR0006899A (en) | 2001-06-12 |
| TR200100689T1 (en) | 2002-04-22 |
| WO2001004358A3 (en) | 2001-08-30 |
| JP2003505021A (en) | 2003-02-12 |
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