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WO2000043791A3 - Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases - Google Patents

Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases Download PDF

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Publication number
WO2000043791A3
WO2000043791A3 PCT/US2000/001997 US0001997W WO0043791A3 WO 2000043791 A3 WO2000043791 A3 WO 2000043791A3 US 0001997 W US0001997 W US 0001997W WO 0043791 A3 WO0043791 A3 WO 0043791A3
Authority
WO
WIPO (PCT)
Prior art keywords
rapid
species
neurodegenerative diseases
sensitive detection
protein aggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/001997
Other languages
French (fr)
Other versions
WO2000043791A9 (en
WO2000043791A2 (en
Inventor
Cynthia Carol Bamdad
R Shoshana Bamdad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minerva Biotechnologies Corp
Original Assignee
Minerva Biotechnologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minerva Biotechnologies Corp filed Critical Minerva Biotechnologies Corp
Priority to JP2000595161A priority Critical patent/JP5122705B2/en
Priority to AU34741/00A priority patent/AU3474100A/en
Priority to CA002361013A priority patent/CA2361013A1/en
Priority to EP00913266A priority patent/EP1169646A2/en
Publication of WO2000043791A2 publication Critical patent/WO2000043791A2/en
Anticipated expiration legal-status Critical
Publication of WO2000043791A3 publication Critical patent/WO2000043791A3/en
Publication of WO2000043791A9 publication Critical patent/WO2000043791A9/en
Priority to US10/823,097 priority patent/US20050112607A1/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis of disease, as well as for screening of candidate drugs for treatment of neurodegenerative disease. The techniques are simple, extremely sensitive, and utilize readily-available components. Binding species, capable of binding a neurodegenerative disease aggregate-forming or fibril-forming species, are fastened to surfaces of electrodes and surfaces of particles, or provided free in solution, to bind fibril-forming species and/or be involved in aggregation.
PCT/US2000/001997 1999-01-23 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases Ceased WO2000043791A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2000595161A JP5122705B2 (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of abnormal protein aggregation in neurodegenerative diseases
AU34741/00A AU3474100A (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
CA002361013A CA2361013A1 (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
EP00913266A EP1169646A2 (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
US10/823,097 US20050112607A1 (en) 1999-01-23 2004-04-13 Rapid and sensitive detection of protein aggregation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11712699P 1999-01-25 1999-01-25
US60/117,126 1999-01-25
US13228899P 1999-05-03 1999-05-03
US60/132,288 1999-05-03
US15593799P 1999-09-24 1999-09-24
US60/155,937 1999-09-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US60268900A Continuation-In-Part 1999-01-23 2000-06-23

Publications (3)

Publication Number Publication Date
WO2000043791A2 WO2000043791A2 (en) 2000-07-27
WO2000043791A3 true WO2000043791A3 (en) 2001-07-26
WO2000043791A9 WO2000043791A9 (en) 2002-03-28

Family

ID=27381935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001997 Ceased WO2000043791A2 (en) 1999-01-23 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases

Country Status (5)

Country Link
EP (1) EP1169646A2 (en)
JP (2) JP5122705B2 (en)
AU (1) AU3474100A (en)
CA (1) CA2361013A1 (en)
WO (1) WO2000043791A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252595B2 (en) 2008-05-13 2012-08-28 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

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CA2413884A1 (en) * 2000-06-23 2002-01-03 Minerva Biotechnologies Corporation Rapid and sensitive detection of protein aggregation
JP4223804B2 (en) 2000-10-03 2009-02-12 ミナーヴァ・バイオテクノロジーズ・コーポレーション In situ dilution with magnetic force
ATE426807T1 (en) 2000-11-01 2009-04-15 Minerva Biotechnologies Corp PROTEOM ANALYSIS METHOD FOR DRUG COMPARISON
US20020164611A1 (en) * 2000-11-15 2002-11-07 Bamdad R. Shoshana Oligonucleotide identifiers
WO2002056022A2 (en) 2000-11-27 2002-07-18 Minerva Biotechnologies Corp Diagnostics, drug screening and treatment for cancer
US20030044843A1 (en) * 2001-01-09 2003-03-06 Mitsubishi Pharma Corporation Novel proteome analysis method and devices therefor
US7166471B2 (en) 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
WO2003020279A2 (en) 2001-09-05 2003-03-13 Minerva Biotechnologies Corporation Compositions and methods of treatment of cancer
EP1550862B1 (en) 2002-10-04 2012-01-25 Protosera Inc. Method of identifying an analyte by gel electrophoresis-mass spectrometry
JP2007531505A (en) 2002-11-27 2007-11-08 ミネルバ バイオオテクノロジーズ コーポレーション Techniques and compositions for diagnosis and treatment of cancer (MUC1)
JP2006517674A (en) 2002-12-20 2006-07-27 ミネルバ バイオテクノロジーズ コーポレーション Optical devices and methods comprising nanoparticles
MXPA06001588A (en) 2003-08-13 2006-08-25 Chiron Corp Prion-specific peptide reagents.
JPWO2005095958A1 (en) 2004-03-31 2008-02-21 アンジェスＭｇ株式会社 Assay methods for identifying drug candidates
DE102004040119A1 (en) * 2004-08-18 2006-04-27 Heinrich-Heine-Universität Düsseldorf Agent, useful for e.g. inactivating infectious prion and decontaminating device, instrument or appliance infected with prion, comprises a nano-particle
CA2594840A1 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Elisa assays using prion-specific peptide reagents
ATE528649T1 (en) * 2005-02-15 2011-10-15 Adlyfe Inc METHOD FOR DETECTING MISFOLDED PROTEINS AND PRIONS
AU2006287299B2 (en) 2005-09-09 2012-08-23 Novartis Ag Prion-specific peptoid reagents
CA2657503C (en) 2006-07-28 2014-10-21 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
KR20140101876A (en) 2008-10-09 2014-08-20 미네르바 바이오테크놀로지 코포레이션 Method for inducing pluripotency in cells
WO2012017739A1 (en) * 2010-07-31 2012-02-09 エレコン科学株式会社 Amyloid assay device and amyloid assay method
JP6196163B2 (en) 2011-03-17 2017-09-13 ミネルバ バイオテクノロジーズ コーポレーション Methods for producing pluripotent stem cells
KR101352849B1 (en) * 2012-01-03 2014-01-21 주식회사 나노엔텍 Method for Differentially Detecting Multimeric Form of Multimer-Forming Polypeptides
US10895571B2 (en) * 2013-06-06 2021-01-19 Siemens Healthineers Nederland B.V. Reagents, methods and devices to prevent aggregation in particle based tests for the detection of multimeric target molecules
AU2016219350A1 (en) 2015-02-10 2017-08-24 Minerva Biotechnologies Corporation Humanized anti-MUC1* antibodies
JP6630972B2 (en) * 2015-03-24 2020-01-15 学校法人甲南学園 Biosensor for electrochemical measurement of amyloid β peptide
WO2017138696A1 (en) * 2016-02-12 2017-08-17 주식회사 캔티스 Detection method and electrochemical detection kit for aggregate form of protein, and diagnostic method and electrochemical diagnostic kit for diseases associated with abnormal protein aggregation by using same
US11167283B2 (en) 2018-05-04 2021-11-09 University Of South Carolina Dot blot box and use thereof
WO2021263227A2 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Anti-nme antibody and method of treating cancer or cancer metastasis
CN119317447A (en) 2022-04-12 2025-01-14 米纳瓦生物技术公司 Anti-variable MUC1* antibodies and their uses

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Patent Citations (9)

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US4945045A (en) * 1984-07-06 1990-07-31 Serono Diagnostics Ltd. Electrochemical methods of assay
WO1994009364A1 (en) * 1992-10-13 1994-04-28 Duke University Method of inhibiting binding of amyloid precursor protein to beta-amyloid protein
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252595B2 (en) 2008-05-13 2012-08-28 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US8278111B2 (en) 2008-05-13 2012-10-02 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9096652B2 (en) 2008-05-13 2015-08-04 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Also Published As

Publication number Publication date
AU3474100A (en) 2000-08-07
JP5122705B2 (en) 2013-01-16
WO2000043791A9 (en) 2002-03-28
JP2012230124A (en) 2012-11-22
CA2361013A1 (en) 2000-07-27
EP1169646A2 (en) 2002-01-09
JP2002540383A (en) 2002-11-26
WO2000043791A2 (en) 2000-07-27

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