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TR200001973T2 - 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları. - Google Patents

11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları.

Info

Publication number
TR200001973T2
TR200001973T2 TR2000/01973T TR200001973T TR200001973T2 TR 200001973 T2 TR200001973 T2 TR 200001973T2 TR 2000/01973 T TR2000/01973 T TR 2000/01973T TR 200001973 T TR200001973 T TR 200001973T TR 200001973 T2 TR200001973 T2 TR 200001973T2
Authority
TR
Turkey
Prior art keywords
estratrienes
halogen
substituted
7alpha
manufacture
Prior art date
Application number
TR2000/01973T
Other languages
English (en)
Inventor
Bohlmann Rolf
Heinrich Nikolaus
Hofmeister Helmut
Kroll Jorg
K�nzer Hermann
Sauer Gerhard
Zorn Ludwig
Fritzemeier Karl-Heinrich
Lessl Monika
Lichtner Rosemarie
Nishino Yukishige
Parczyk Karsten
Schneider Martin
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997158390 external-priority patent/DE19758390A1/de
Priority claimed from DE1998106357 external-priority patent/DE19806357A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of TR200001973T2 publication Critical patent/TR200001973T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bulus asagidaki genel formül I' in 11 -halojen-7alfa-ile-ikame edilmis-estratrienleriyle alakalidir: (Formül (I)) Burada R11 bir flor veya klor atomudur ve diger sübstitüanlar tarfnamede ayrintili olarak açiklanmis anlamlara sahiptir. Bilesimler antiöstrojen veya doku seçici östrojen özelliklere sahiptir ve ilaç üretimi uygundur.
TR2000/01973T 1997-12-23 1998-12-23 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları. TR200001973T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997158390 DE19758390A1 (de) 1997-12-23 1997-12-23 11ß-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11ß-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE1998106357 DE19806357A1 (de) 1998-02-10 1998-02-10 11beta-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11beta-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

Publication Number Publication Date
TR200001973T2 true TR200001973T2 (tr) 2001-01-22

Family

ID=26042916

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01973T TR200001973T2 (tr) 1997-12-23 1998-12-23 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları.

Country Status (27)

Country Link
US (1) US6780855B2 (tr)
EP (1) EP1042355B1 (tr)
JP (1) JP2001527088A (tr)
KR (1) KR20010024806A (tr)
CN (1) CN1131235C (tr)
AR (1) AR015500A1 (tr)
AT (1) ATE232543T1 (tr)
AU (1) AU750801B2 (tr)
BG (1) BG104553A (tr)
BR (1) BR9814416A (tr)
CA (1) CA2316444A1 (tr)
DE (1) DE59807213D1 (tr)
DK (1) DK1042355T3 (tr)
EA (1) EA002623B1 (tr)
EE (1) EE200000380A (tr)
ES (1) ES2191371T3 (tr)
HU (1) HUP0100568A3 (tr)
ID (1) ID26207A (tr)
IL (1) IL136938A0 (tr)
IS (1) IS5526A (tr)
NO (1) NO20003286L (tr)
NZ (1) NZ505348A (tr)
PE (1) PE20000129A1 (tr)
PL (1) PL341299A1 (tr)
SK (1) SK9442000A3 (tr)
TR (1) TR200001973T2 (tr)
WO (1) WO1999033855A1 (tr)

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JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
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TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
DE102007032800A1 (de) 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2033948A1 (en) * 2007-08-30 2009-03-11 Bayer Schering Pharma Aktiengesellschaft Process for preparing Estrogen-antagonistic 11beta-Fluoro-17alpha-alkylestra-1,3,5 (10)-triene-3, 17-diols having a 7alpha-(xi-Alkylamino-omega-perfluoroalkyl)alkyl side chain and alpha-Alkyl(amino)-omega-perfluoro(alkyl)alkanes and processes for their preparation
NZ585389A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
EP2053055A1 (de) * 2007-10-24 2009-04-29 Bayer Schering Pharma Aktiengesellschaft 11.beta.-Fluoro-3-acetoxyestra-3,5-dien-17-on und Verfahren zu seiner Herstellung
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EP2070941A1 (en) 2007-12-14 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Stereoselective synthesis of selective estrogen receptor down-regulators
EP2258375A1 (de) 2009-06-04 2010-12-08 Bayer Schering Pharma Aktiengesellschaft 17B-alkyl-17alpha-oxy-estratriene
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
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CN106146599A (zh) * 2015-04-07 2016-11-23 江苏希迪制药有限公司 一种回收因亚砜构型比例不合格的氟维司群或其衍生物的方法
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Also Published As

Publication number Publication date
AR015500A1 (es) 2001-05-02
NO20003286D0 (no) 2000-06-22
NO20003286L (no) 2000-08-23
PL341299A1 (en) 2001-04-09
BG104553A (bg) 2001-02-28
AU750801B2 (en) 2002-07-25
EP1042355B1 (de) 2003-02-12
CN1131235C (zh) 2003-12-17
ID26207A (id) 2000-12-07
ES2191371T3 (es) 2003-09-01
EA002623B1 (ru) 2002-06-27
US20030069434A1 (en) 2003-04-10
PE20000129A1 (es) 2000-03-11
EE200000380A (et) 2001-12-17
DE59807213D1 (de) 2003-03-20
US6780855B2 (en) 2004-08-24
HUP0100568A2 (hu) 2001-08-28
AU2276399A (en) 1999-07-19
KR20010024806A (ko) 2001-03-26
WO1999033855A1 (de) 1999-07-08
SK9442000A3 (en) 2001-04-09
IL136938A0 (en) 2001-06-14
HUP0100568A3 (en) 2002-01-28
EP1042355A1 (de) 2000-10-11
CA2316444A1 (en) 1999-07-08
NZ505348A (en) 2002-10-25
BR9814416A (pt) 2000-10-10
ATE232543T1 (de) 2003-02-15
IS5526A (is) 2000-06-09
CN1286693A (zh) 2001-03-07
EA200000711A1 (ru) 2001-02-26
DK1042355T3 (da) 2003-04-22
JP2001527088A (ja) 2001-12-25

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