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TR200000945T2 - İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod - Google Patents

İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Info

Publication number
TR200000945T2
TR200000945T2 TR2000/00945T TR200000945T TR200000945T2 TR 200000945 T2 TR200000945 T2 TR 200000945T2 TR 2000/00945 T TR2000/00945 T TR 2000/00945T TR 200000945 T TR200000945 T TR 200000945T TR 200000945 T2 TR200000945 T2 TR 200000945T2
Authority
TR
Turkey
Prior art keywords
phenyl
substituted
preparation
group
cyanocyclohexanoic
Prior art date
Application number
TR2000/00945T
Other languages
English (en)
Inventor
Webb Kevin
Mendelson Wilford
Jianhoa Chen
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200000945T2 publication Critical patent/TR200000945T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bu bulus, bir formül (II): bilesigin bir grup I (a) ya da grup II (a) metal halidi ile, aprotik bir dipolar amid esasli solvent ve su vasitasi ile islenmesi ile, R' ya da R" 'nün en az birinin bir karboksil grubu oldugu asagidaki tipte bir bilesigin olusturulmasi ile ilgilidir.
TR2000/00945T 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod TR200000945T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
TR200000945T2 true TR200000945T2 (tr) 2000-10-23

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00945T TR200000945T2 (tr) 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Country Status (30)

Country Link
EP (1) EP1043930A4 (tr)
JP (1) JP2001519363A (tr)
KR (1) KR100560038B1 (tr)
CN (1) CN1192025C (tr)
AP (1) AP1335A (tr)
AR (1) AR015952A1 (tr)
AU (1) AU741832B2 (tr)
BG (1) BG104302A (tr)
BR (1) BR9814064A (tr)
CA (1) CA2305614A1 (tr)
DZ (1) DZ2619A1 (tr)
EA (1) EA003609B1 (tr)
HU (1) HUP0003905A3 (tr)
ID (1) ID25536A (tr)
IL (1) IL135434A (tr)
MA (1) MA24670A1 (tr)
MY (1) MY122105A (tr)
NO (1) NO20001777L (tr)
NZ (1) NZ503759A (tr)
OA (1) OA11347A (tr)
PE (1) PE121599A1 (tr)
PL (1) PL191974B1 (tr)
SA (1) SA99191000A (tr)
SK (1) SK4902000A3 (tr)
TR (1) TR200000945T2 (tr)
TW (1) TW440557B (tr)
UA (1) UA67753C2 (tr)
UY (2) UY25201A1 (tr)
WO (1) WO1999018793A1 (tr)
ZA (1) ZA989228B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1237851A4 (en) * 1999-12-15 2004-06-23 Smithkline Beecham SALES OF I CIS / I-4-CYANO-4-3- (CYCLOPENTYLOXY) -4-METHOXYPHENYL] CYCLHEXAN-1-CARBONIC ACID
DZ3285A1 (fr) * 2000-01-26 2001-08-02 Smithkline Beecham Corp Monohydrate cis-lithium-4-cyano-4-(3-(cyclopentyloxy)-4methoxyphenyl) cyclohexanecarboxylate
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
CA2436551A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
NZ526531A (en) 2001-01-31 2005-02-25 Pfizer Prod Inc Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
EE200300360A (et) 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
SA99191000A (ar) 2005-12-03
JP2001519363A (ja) 2001-10-23
IL135434A (en) 2004-12-15
PE121599A1 (es) 2000-02-19
CA2305614A1 (en) 1999-04-22
DZ2619A1 (fr) 2003-03-08
NO20001777L (no) 2000-05-03
TW440557B (en) 2001-06-16
KR20010015709A (ko) 2001-02-26
AU9687498A (en) 1999-05-03
CN1275052A (zh) 2000-11-29
AP2000001782A0 (en) 2000-06-30
PL339759A1 (en) 2001-01-02
OA11347A (en) 2003-12-17
MY122105A (en) 2006-03-31
ZA989228B (en) 1999-04-12
UY25524A1 (es) 2000-02-23
KR100560038B1 (ko) 2006-03-13
BR9814064A (pt) 2000-09-26
AR015952A1 (es) 2001-05-30
MA24670A1 (fr) 1999-07-01
HUP0003905A2 (en) 2001-03-28
CN1192025C (zh) 2005-03-09
EA200000406A1 (ru) 2000-10-30
IL135434A0 (en) 2001-05-20
SK4902000A3 (en) 2000-11-07
EP1043930A4 (en) 2004-09-15
EA003609B1 (ru) 2003-06-26
NZ503759A (en) 2002-03-01
AU741832B2 (en) 2001-12-13
AP1335A (en) 2004-11-29
HUP0003905A3 (en) 2002-01-28
UA67753C2 (uk) 2004-07-15
NO20001777D0 (no) 2000-04-06
UY25201A1 (es) 2001-08-27
EP1043930A1 (en) 2000-10-18
WO1999018793A1 (en) 1999-04-22
PL191974B1 (pl) 2006-07-31
BG104302A (en) 2001-08-31
ID25536A (id) 2000-10-12

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