[go: up one dir, main page]

AR015952A1 - Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos - Google Patents

Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos

Info

Publication number
AR015952A1
AR015952A1 ARP980105002A ARP980105002A AR015952A1 AR 015952 A1 AR015952 A1 AR 015952A1 AR P980105002 A ARP980105002 A AR P980105002A AR P980105002 A ARP980105002 A AR P980105002A AR 015952 A1 AR015952 A1 AR 015952A1
Authority
AR
Argentina
Prior art keywords
cyanociclohexanoicos
phenyl
substituted
preparing
preparing acids
Prior art date
Application number
ARP980105002A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR015952A1 publication Critical patent/AR015952A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invencion se refiere a un método para preparar un compuesto de formula (I), en el que al menos uno de R o R es un grupo carboxilo, por tratamientode un compuesto de formula (II), con un haluro de un metal del Grupo I(a) o del Grupo II(a), con undisolvente aprotico dipolar, básicamente amídico, y agua.
ARP980105002A 1997-10-10 1998-10-07 Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos AR015952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
AR015952A1 true AR015952A1 (es) 2001-05-30

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105002A AR015952A1 (es) 1997-10-10 1998-10-07 Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos

Country Status (30)

Country Link
EP (1) EP1043930A4 (es)
JP (1) JP2001519363A (es)
KR (1) KR100560038B1 (es)
CN (1) CN1192025C (es)
AP (1) AP1335A (es)
AR (1) AR015952A1 (es)
AU (1) AU741832B2 (es)
BG (1) BG104302A (es)
BR (1) BR9814064A (es)
CA (1) CA2305614A1 (es)
DZ (1) DZ2619A1 (es)
EA (1) EA003609B1 (es)
HU (1) HUP0003905A3 (es)
ID (1) ID25536A (es)
IL (1) IL135434A (es)
MA (1) MA24670A1 (es)
MY (1) MY122105A (es)
NO (1) NO20001777L (es)
NZ (1) NZ503759A (es)
OA (1) OA11347A (es)
PE (1) PE121599A1 (es)
PL (1) PL191974B1 (es)
SA (1) SA99191000A (es)
SK (1) SK4902000A3 (es)
TR (1) TR200000945T2 (es)
TW (1) TW440557B (es)
UA (1) UA67753C2 (es)
UY (2) UY25201A1 (es)
WO (1) WO1999018793A1 (es)
ZA (1) ZA989228B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1237851A4 (en) * 1999-12-15 2004-06-23 Smithkline Beecham SALES OF I CIS / I-4-CYANO-4-3- (CYCLOPENTYLOXY) -4-METHOXYPHENYL] CYCLHEXAN-1-CARBONIC ACID
DZ3285A1 (fr) * 2000-01-26 2001-08-02 Smithkline Beecham Corp Monohydrate cis-lithium-4-cyano-4-(3-(cyclopentyloxy)-4methoxyphenyl) cyclohexanecarboxylate
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
CA2436551A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
NZ526531A (en) 2001-01-31 2005-02-25 Pfizer Prod Inc Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
EE200300360A (et) 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
SA99191000A (ar) 2005-12-03
JP2001519363A (ja) 2001-10-23
IL135434A (en) 2004-12-15
PE121599A1 (es) 2000-02-19
CA2305614A1 (en) 1999-04-22
DZ2619A1 (fr) 2003-03-08
NO20001777L (no) 2000-05-03
TW440557B (en) 2001-06-16
KR20010015709A (ko) 2001-02-26
AU9687498A (en) 1999-05-03
CN1275052A (zh) 2000-11-29
AP2000001782A0 (en) 2000-06-30
PL339759A1 (en) 2001-01-02
OA11347A (en) 2003-12-17
MY122105A (en) 2006-03-31
ZA989228B (en) 1999-04-12
UY25524A1 (es) 2000-02-23
KR100560038B1 (ko) 2006-03-13
BR9814064A (pt) 2000-09-26
MA24670A1 (fr) 1999-07-01
HUP0003905A2 (en) 2001-03-28
CN1192025C (zh) 2005-03-09
EA200000406A1 (ru) 2000-10-30
IL135434A0 (en) 2001-05-20
SK4902000A3 (en) 2000-11-07
EP1043930A4 (en) 2004-09-15
EA003609B1 (ru) 2003-06-26
NZ503759A (en) 2002-03-01
AU741832B2 (en) 2001-12-13
AP1335A (en) 2004-11-29
HUP0003905A3 (en) 2002-01-28
TR200000945T2 (tr) 2000-10-23
UA67753C2 (uk) 2004-07-15
NO20001777D0 (no) 2000-04-06
UY25201A1 (es) 2001-08-27
EP1043930A1 (en) 2000-10-18
WO1999018793A1 (en) 1999-04-22
PL191974B1 (pl) 2006-07-31
BG104302A (en) 2001-08-31
ID25536A (id) 2000-10-12

Similar Documents

Publication Publication Date Title
BR0010555A (pt) Inibidores de neuraminidases
EA200200481A1 (ru) Способ получения производных 4-трифторметилсульфинилпиразола
ES2195202T3 (es) Procedimiento para el tratamiento de superficies metalicas.
CO5150224A1 (es) Compuestos de triazol y su utilizacion
ES2184060T3 (es) Acidos 8-cian-1-ciclopropil-7-(2,8-diazabiciclo(4,3,0)-noman -8-il)-6-fluor-1,4-dihidro-4-oxo-3-quinolincarboxilicos, en caso dado substituidos, y sus derivados.
AR007144A1 (es) Composicion lubricante concentrada, lubricante que resulta de su dilucion y metodo
AR015952A1 (es) Metodo para preparar acidos 4-fenil-4-cianociclohexanoicos sustituidos
PA8521801A1 (es) Derivados de ciclopentil-glutaramida como inhibidores de endopeptidasa neutra
EA199900141A1 (ru) Цветообразующая композиция, содержащая реагент, включающий пирогаллольные структурные фрагменты, соль железа (ii) и органическую кислоту
EA200000804A1 (ru) Мета-азациклические соединения аминобензойной кислоты и их производные, являющиеся ингибиторами интегрина
ES2178205T3 (es) Compuestos amida indazol como agentes serotoninergicos.
UY23481A1 (es) Uso de compuestos de hidroxialquilfosfina en operaciones de precurtido de cueros
DK1077218T3 (da) Peptidomimetiske forbindelser omfattende RGD-sekvenser, som er nyttige som integrininhibitorer
ES2148858T3 (es) (aminoalquil- y acilaminoalquil-oxi)benciloxiquinolinas, procedimiento para su preparacion y su empleo como antagonistas de receptores de bradiquinina.
ATE211719T1 (de) Korrosionsinhibitoren enthaltender injektionszement
EA200100930A1 (ru) Способ лечения хозл
BR9909870A (pt) Pirrolidinas como inibidores de neuraminidases
DK0878606T3 (da) Formindskelse af metalkorrosivitet af organiske syrer
ES2173675T3 (es) Procedimiento de preparacion de carboxamido-4-azaesteroides.
ECSP982688A (es) Metodo para preparar acidos 4-fenil-4 cianociclohexanoicos sustituidos
EA199900735A1 (ru) Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот
DK1015415T3 (da) Nye stereoselektive fremgangsmåder til fremstilling af gabapentin-analoger
NZ507458A (en) Cyano-indole serotonin-reuptake inhibitor compound
BR9405302A (pt) Processo para a preparação de um composto e o referido composto
ES2110700T3 (es) Procedimiento para la preparacion de compuestos de cloruro de acido.

Legal Events

Date Code Title Description
FB Suspension of granting procedure