[go: up one dir, main page]

IL135434A0 - Method for preparing substituted 4-phenyl-4- cyanocyclohexanoic acids - Google Patents

Method for preparing substituted 4-phenyl-4- cyanocyclohexanoic acids

Info

Publication number
IL135434A0
IL135434A0 IL13543498A IL13543498A IL135434A0 IL 135434 A0 IL135434 A0 IL 135434A0 IL 13543498 A IL13543498 A IL 13543498A IL 13543498 A IL13543498 A IL 13543498A IL 135434 A0 IL135434 A0 IL 135434A0
Authority
IL
Israel
Prior art keywords
phenyl
preparing substituted
cyanocyclohexanoic
acids
cyanocyclohexanoic acids
Prior art date
Application number
IL13543498A
Other versions
IL135434A (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IL135434A0 publication Critical patent/IL135434A0/en
Publication of IL135434A publication Critical patent/IL135434A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL13543498A 1997-10-10 1998-10-07 Methods and intermediates for preparing substituted 4-phenyl-4-cyanocylohexane carboxylic acids IL135434A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
IL135434A0 true IL135434A0 (en) 2001-05-20
IL135434A IL135434A (en) 2004-12-15

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13543498A IL135434A (en) 1997-10-10 1998-10-07 Methods and intermediates for preparing substituted 4-phenyl-4-cyanocylohexane carboxylic acids

Country Status (30)

Country Link
EP (1) EP1043930A4 (en)
JP (1) JP2001519363A (en)
KR (1) KR100560038B1 (en)
CN (1) CN1192025C (en)
AP (1) AP1335A (en)
AR (1) AR015952A1 (en)
AU (1) AU741832B2 (en)
BG (1) BG104302A (en)
BR (1) BR9814064A (en)
CA (1) CA2305614A1 (en)
DZ (1) DZ2619A1 (en)
EA (1) EA003609B1 (en)
HU (1) HUP0003905A3 (en)
ID (1) ID25536A (en)
IL (1) IL135434A (en)
MA (1) MA24670A1 (en)
MY (1) MY122105A (en)
NO (1) NO20001777L (en)
NZ (1) NZ503759A (en)
OA (1) OA11347A (en)
PE (1) PE121599A1 (en)
PL (1) PL191974B1 (en)
SA (1) SA99191000A (en)
SK (1) SK4902000A3 (en)
TR (1) TR200000945T2 (en)
TW (1) TW440557B (en)
UA (1) UA67753C2 (en)
UY (2) UY25201A1 (en)
WO (1) WO1999018793A1 (en)
ZA (1) ZA989228B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1237851A4 (en) * 1999-12-15 2004-06-23 Smithkline Beecham SALTS OF i Cis /i -4-CYANO-4- 3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1-CARBOXYLIC ACID
DZ3285A1 (en) * 2000-01-26 2001-08-02 Smithkline Beecham Corp MONOHYDRATE CIS-LITHIUM-4-CYANO-4- (3- (CYCLOPENTYLOXY) -4METHOXYPHENYL) CYCLOHEXANECARBOXYLATE
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
CA2436551A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
NZ526531A (en) 2001-01-31 2005-02-25 Pfizer Prod Inc Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
EE200300360A (en) 2001-01-31 2003-12-15 Pfizer Products Inc. Biaryl derivatives of nicotinamide used as inhibitors of PDE4 isozymes
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (en) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 Preparation method of oxirane derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (en) * 1997-02-12 2000-11-08 Smithkline Beecham Corp METHOD FOR PREPARING SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS AND INTERMEDIATE COMPOUNDS
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
SA99191000A (en) 2005-12-03
JP2001519363A (en) 2001-10-23
IL135434A (en) 2004-12-15
PE121599A1 (en) 2000-02-19
CA2305614A1 (en) 1999-04-22
DZ2619A1 (en) 2003-03-08
NO20001777L (en) 2000-05-03
TW440557B (en) 2001-06-16
KR20010015709A (en) 2001-02-26
AU9687498A (en) 1999-05-03
CN1275052A (en) 2000-11-29
AP2000001782A0 (en) 2000-06-30
PL339759A1 (en) 2001-01-02
OA11347A (en) 2003-12-17
MY122105A (en) 2006-03-31
ZA989228B (en) 1999-04-12
UY25524A1 (en) 2000-02-23
KR100560038B1 (en) 2006-03-13
BR9814064A (en) 2000-09-26
AR015952A1 (en) 2001-05-30
MA24670A1 (en) 1999-07-01
HUP0003905A2 (en) 2001-03-28
CN1192025C (en) 2005-03-09
EA200000406A1 (en) 2000-10-30
SK4902000A3 (en) 2000-11-07
EP1043930A4 (en) 2004-09-15
EA003609B1 (en) 2003-06-26
NZ503759A (en) 2002-03-01
AU741832B2 (en) 2001-12-13
AP1335A (en) 2004-11-29
HUP0003905A3 (en) 2002-01-28
TR200000945T2 (en) 2000-10-23
UA67753C2 (en) 2004-07-15
NO20001777D0 (en) 2000-04-06
UY25201A1 (en) 2001-08-27
EP1043930A1 (en) 2000-10-18
WO1999018793A1 (en) 1999-04-22
PL191974B1 (en) 2006-07-31
BG104302A (en) 2001-08-31
ID25536A (en) 2000-10-12

Similar Documents

Publication Publication Date Title
HUP0004251A3 (en) Method for preparing bromomethyl-biphenyl derivatives
IL131000A0 (en) Method for preparing oxy-diphthalic anhydrides
IL129761A0 (en) Method for preparing cyclopropylamines
GB9713283D0 (en) Method for preparing aminoalkoxysiloxanes
EP1019359A4 (en) Process for preparing aminoarylacetylenes
HUP0003905A3 (en) Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
EG23935A (en) Process for preparing eprosartin
EG22077A (en) Process for preparing 4-substituted-ih-indole-3 glyoxamides
HUP0001801A3 (en) Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL132729A0 (en) Method for preparing formylphosphonic acid
IL134507A0 (en) Method for preparing oxazaphosphorin-2-amines
ZA9810859B (en) Process for preparing dialkylphosphinic acids.
HUP0001596A3 (en) Method for producing 5-aminomethyl-2-chloropyridines
HUP0003768A3 (en) Method for producing thiochloroformates
HUP0004658A3 (en) Method for preparing 1-phenylpyrazolin-3-carboxylic acid derivatives
IL136698A0 (en) Method for producing chlorobenzoxazolene
IL132968A0 (en) Method for producing 2-cyclododecyl-1-propanol
EG21405A (en) Method for preparing phosphorique acid
IL125646A (en) Process for preparing N-pyruvyl-L-proline
IL150957A0 (en) Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
SI1023279T1 (en) Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
HK1033538A (en) Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
ZA983777B (en) Method for preparing formylphosphonic acid
SI1032557T1 (en) Method for preparing bromomethyl-biphenyl derivatives
IL129506A0 (en) Method for preparing trimethylbenzoquinone

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees