PE20001422A1 - Antibioticos cetolidos - Google Patents
Antibioticos cetolidosInfo
- Publication number
- PE20001422A1 PE20001422A1 PE2000000013A PE0000132000A PE20001422A1 PE 20001422 A1 PE20001422 A1 PE 20001422A1 PE 2000000013 A PE2000000013 A PE 2000000013A PE 0000132000 A PE0000132000 A PE 0000132000A PE 20001422 A1 PE20001422 A1 PE 20001422A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cr4r5
- cyane
- alcoxy
- halogen
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title 1
- -1 TRIFLUOROMETOXY Chemical class 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 abstract 1
- 101000598778 Homo sapiens Protein OSCP1 Proteins 0.000 abstract 1
- 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 abstract 1
- 102100022673 Nuclear receptor subfamily 4 group A member 3 Human genes 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS CETOLIDOS DE FORMULA I, DONDE: X1 ES O, CR4R5, NR4; X2 ES =O, =NOR1; R1 ES H, ALQUILO C1-C1O OPCIONALMENTE REEMPLAZADO CON O, S, NR4, OPCIONALMENTE SUSTITUIDO CON 1-3 COO-ALQUILO C1-C10, ALCOXI C1-C10, NR4R5, S(O)n(ALQUILO C1-C10), ENTRE OTROS; n ES 0-2; R2 ES (CR4R5)n(HETEROCICLO DE 4 A 10 MIEMBROS), (CR4R5)n(ARILO C6-C10); n ES 0-6, SIENDO DE 1-3 R4 O R5 OPCIONALMENTE SUSTITUIDO CON HALOGENO; SIENDO HETEROCICLO Y ARILO OPCIONALMENTE SUSTITUIDOS CON 1-4 R3; R3 ES HALOGENO, CIANO, NITRO, TRIFLUOROMETOXI, TRIFLUOROMETILO, AZIDO, HIDROXI, ALCOXI C1-C6, ALQUILO C1-C10, ALQUENILO C2-C6, ALQUINILO C2-C6, C(O)R6, C(O)OR6, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6; R6 Y R7 SON H, ALQUILO C1-C6, (CR4R5)t(ARILO C6-C10), (CR4R5)t-(HETEROCICLO DE 4 A 10 MIEMBROS) ESTANDO EL GRUPO HETEROCICLO CON OXO Y LOS RESTOS ALQUILO ARILO Y HETEROCICLICO DE R6 Y R7 CON HALOGENO, CIANO, NITRO, NR4R5, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALQUILO C1-C6 ALQUENILO C2-C6, ALQUINILO C2-C6, HIDROXI, ALCOXI C1-C6; t ES 0-5; R8 ES H, CO-ALQUILO C1-C6, BENCILO, BENCILOXICARBONILO, (ALQUIL C1-C6)3SILILO; R9 ES ALQUILO C1-C6; R10 ES H, ALQUILO C1-C10; R11 ES Cl, Br, I, F, CIANO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS CETOLIDOS SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11734299P | 1999-01-27 | 1999-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001422A1 true PE20001422A1 (es) | 2000-12-18 |
Family
ID=22372371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000013A PE20001422A1 (es) | 1999-01-27 | 2000-01-06 | Antibioticos cetolidos |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6833444B2 (es) |
| EP (1) | EP1147121B1 (es) |
| JP (1) | JP3947360B2 (es) |
| KR (1) | KR20020002380A (es) |
| CN (1) | CN1342163A (es) |
| AP (1) | AP2001002222A0 (es) |
| AT (1) | ATE256694T1 (es) |
| AU (1) | AU1675400A (es) |
| BG (1) | BG105730A (es) |
| BR (1) | BR9916969A (es) |
| CA (1) | CA2359708C (es) |
| CO (1) | CO5150229A1 (es) |
| CZ (1) | CZ20012675A3 (es) |
| DE (1) | DE69913738T2 (es) |
| DK (1) | DK1147121T3 (es) |
| DZ (1) | DZ3000A1 (es) |
| EA (1) | EA200100623A1 (es) |
| EE (1) | EE200100394A (es) |
| ES (1) | ES2212655T3 (es) |
| HK (1) | HK1042707A1 (es) |
| HN (1) | HN2000000003A (es) |
| HR (1) | HRP20010559A2 (es) |
| HU (1) | HUP0105190A3 (es) |
| ID (1) | ID30233A (es) |
| IL (1) | IL144178A0 (es) |
| IS (1) | IS5984A (es) |
| MA (1) | MA26717A1 (es) |
| NO (1) | NO20013680L (es) |
| OA (1) | OA11753A (es) |
| PA (1) | PA8489501A1 (es) |
| PE (1) | PE20001422A1 (es) |
| PT (1) | PT1147121E (es) |
| SI (1) | SI1147121T1 (es) |
| SK (1) | SK10172001A3 (es) |
| TN (1) | TNSN00007A1 (es) |
| TR (1) | TR200102128T2 (es) |
| UY (1) | UY25990A1 (es) |
| WO (1) | WO2000044761A2 (es) |
| ZA (1) | ZA200105580B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| ATE256694T1 (de) | 1999-01-27 | 2004-01-15 | Pfizer Prod Inc | Ketolid-antibiotika |
| EP1171447A2 (en) | 1999-04-16 | 2002-01-16 | Ortho-McNeil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| NZ515027A (en) | 1999-04-16 | 2004-01-30 | Kosan Biosciences Inc | Erythromycin derivatives as antibiotics |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| CN1351608A (zh) | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13－甲基红霉素衍生物 |
| ES2222966T3 (es) | 2000-06-30 | 2005-02-16 | Pfizer Products Inc. | Macrolidos antibioticos. |
| US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| ATE345350T1 (de) * | 2000-12-21 | 2006-12-15 | Glaxo Group Ltd | Makrolidantibiotika |
| PE20030438A1 (es) * | 2001-09-05 | 2003-07-03 | Hokuriku Pharmaceutical | Medicamento que comprende un derivado de eritromicina como agente antituberculoso |
| EP3738591A3 (en) | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
| WO2006080954A1 (en) * | 2004-07-28 | 2006-08-03 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| EP2233493A1 (en) * | 2004-12-21 | 2010-09-29 | Pfizer Products Inc. | Macrolides |
| JP5126685B2 (ja) * | 2006-05-01 | 2013-01-23 | 大正製薬株式会社 | マクロライド誘導体 |
| WO2009055557A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| DK2358379T3 (en) | 2008-10-24 | 2016-03-07 | Cempra Pharmaceuticals Inc | BIOFORSVAR USING TRIAZOLHOLDIGE macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| EP2475253B1 (en) | 2009-09-10 | 2016-10-26 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
| JP5711352B2 (ja) | 2010-03-22 | 2015-04-30 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライドの結晶形、およびその使用 |
| WO2011146829A1 (en) | 2010-05-20 | 2011-11-24 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| US9815863B2 (en) | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| US10188674B2 (en) | 2012-03-27 | 2019-01-29 | Cempra Pharmaceuticals, Inc. | Parenteral formulations for administering macrolide antibiotics |
| EP2968801B1 (en) | 2013-03-14 | 2018-09-26 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| CN105188712A (zh) | 2013-03-15 | 2015-12-23 | 森普拉制药公司 | 用于制备大环内酯抗菌剂的收敛方法 |
| JP6332266B2 (ja) | 2013-03-28 | 2018-05-30 | 不二製油株式会社 | 緑豆蛋白ゲル状組成物及びチーズ様食品 |
| CN106518939B (zh) * | 2015-09-14 | 2019-12-31 | 江苏奥赛康药业有限公司 | 一种制备Solithromycin化合物的方法 |
| JP2019533669A (ja) * | 2016-10-04 | 2019-11-21 | バイオファーマティ ソシエテ アノニム | 抗菌活性を有するケトライド |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| IL114589A (en) | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2697524B1 (fr) | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5747466A (en) * | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2745290B1 (fr) | 1996-02-28 | 1998-04-03 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| GEP20012348B (en) | 1996-07-05 | 2001-01-25 | Pfizer | Erythromycins and Process for Their Preparation |
| FR2751656B1 (fr) | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| FR2757168B1 (fr) | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2760017B1 (fr) | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
| AU4472897A (en) | 1997-03-10 | 1998-09-29 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
| US20020025937A1 (en) | 2000-03-20 | 2002-02-28 | Yong-Jin Wu | 9-oxime erythromycin derivatives |
| ZA987689B (en) | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
| AU9649598A (en) | 1997-10-29 | 1999-05-17 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a, 11,12-carbamate derivatives |
| HN1998000159A (es) | 1997-10-29 | 1999-02-09 | Monsanto Co | Derivados de 9- amino - 3 ceto eritromicina |
| AU1390699A (en) | 1997-11-17 | 1999-06-07 | Imarx Pharmaceutical Corp. | A method of increasing nucleic acid synthesis with ultrasound |
| FR2771008B1 (fr) * | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| FR2777282B1 (fr) | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| ATE298761T1 (de) | 1998-09-22 | 2005-07-15 | Pfizer Prod Inc | Carbamat- und carbazatketolidantibiotika |
| US6100240A (en) * | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
| FR2785612A1 (fr) | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| AU5995299A (en) | 1998-11-03 | 2000-05-22 | Pfizer Products Inc. | Novel macrolide antibiotics |
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| DE69933897T2 (de) * | 1998-12-10 | 2007-03-15 | Pfizer Products Inc., Groton | Carbamat- und Carbazatketolid-Antibiotika |
| ATE256694T1 (de) | 1999-01-27 | 2004-01-15 | Pfizer Prod Inc | Ketolid-antibiotika |
| FR2789392B1 (fr) | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| EP1171447A2 (en) | 1999-04-16 | 2002-01-16 | Ortho-McNeil Pharmaceutical, Inc. | Ketolide antibacterials |
| NZ515027A (en) | 1999-04-16 | 2004-01-30 | Kosan Biosciences Inc | Erythromycin derivatives as antibiotics |
| US6355620B1 (en) | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
| CN1351608A (zh) | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13－甲基红霉素衍生物 |
| EP1114826A3 (en) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| EP1122261A3 (en) | 2000-01-31 | 2001-09-26 | Pfizer Products Inc. | 13 and 14-membered antibacterial macrolides |
| US20020061856A1 (en) | 2000-04-24 | 2002-05-23 | Yong-Jin Wu | Novel tricyclic erythromycin derivatives |
| ES2222966T3 (es) | 2000-06-30 | 2005-02-16 | Pfizer Products Inc. | Macrolidos antibioticos. |
-
1999
- 1999-12-28 AT AT99959627T patent/ATE256694T1/de not_active IP Right Cessation
- 1999-12-28 CZ CZ20012675A patent/CZ20012675A3/cs unknown
- 1999-12-28 ES ES99959627T patent/ES2212655T3/es not_active Expired - Lifetime
- 1999-12-28 DE DE69913738T patent/DE69913738T2/de not_active Expired - Lifetime
- 1999-12-28 DK DK99959627T patent/DK1147121T3/da active
- 1999-12-28 WO PCT/IB1999/002051 patent/WO2000044761A2/en not_active Ceased
- 1999-12-28 AU AU16754/00A patent/AU1675400A/en not_active Abandoned
- 1999-12-28 AP APAP/P/2001/002222A patent/AP2001002222A0/en unknown
- 1999-12-28 PT PT99959627T patent/PT1147121E/pt unknown
- 1999-12-28 TR TR2001/02128T patent/TR200102128T2/xx unknown
- 1999-12-28 SI SI9930486T patent/SI1147121T1/xx unknown
- 1999-12-28 JP JP2000596017A patent/JP3947360B2/ja not_active Expired - Fee Related
- 1999-12-28 SK SK1017-2001A patent/SK10172001A3/sk unknown
- 1999-12-28 CA CA002359708A patent/CA2359708C/en not_active Expired - Fee Related
- 1999-12-28 EP EP99959627A patent/EP1147121B1/en not_active Expired - Lifetime
- 1999-12-28 KR KR1020017009382A patent/KR20020002380A/ko not_active Ceased
- 1999-12-28 CN CN99815909A patent/CN1342163A/zh active Pending
- 1999-12-28 EA EA200100623A patent/EA200100623A1/ru unknown
- 1999-12-28 HK HK02104131.0A patent/HK1042707A1/zh unknown
- 1999-12-28 BR BR9916969-0A patent/BR9916969A/pt not_active Application Discontinuation
- 1999-12-28 IL IL14417899A patent/IL144178A0/xx unknown
- 1999-12-28 ID IDW00200101637A patent/ID30233A/id unknown
- 1999-12-28 EE EEP200100394A patent/EE200100394A/xx unknown
- 1999-12-28 HR HR20010559A patent/HRP20010559A2/hr not_active Application Discontinuation
- 1999-12-28 HU HU0105190A patent/HUP0105190A3/hu unknown
- 1999-12-28 OA OA1200100191A patent/OA11753A/en unknown
-
2000
- 2000-01-05 TN TNTNSN00007A patent/TNSN00007A1/fr unknown
- 2000-01-05 DZ DZ000002A patent/DZ3000A1/xx active
- 2000-01-06 PE PE2000000013A patent/PE20001422A1/es not_active Application Discontinuation
- 2000-01-06 HN HN2000000003A patent/HN2000000003A/es unknown
- 2000-01-06 MA MA25883A patent/MA26717A1/fr unknown
- 2000-01-06 PA PA20008489501A patent/PA8489501A1/es unknown
- 2000-01-21 CO CO00003460A patent/CO5150229A1/es unknown
- 2000-01-27 UY UY25990A patent/UY25990A1/es unknown
-
2001
- 2001-06-28 IS IS5984A patent/IS5984A/is unknown
- 2001-07-06 ZA ZA200105580A patent/ZA200105580B/en unknown
- 2001-07-25 BG BG105730A patent/BG105730A/xx unknown
- 2001-07-26 NO NO20013680A patent/NO20013680L/no not_active Application Discontinuation
-
2002
- 2002-04-05 US US10/116,969 patent/US6833444B2/en not_active Expired - Fee Related
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