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TNSN97070A1 - Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant - Google Patents

Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant

Info

Publication number
TNSN97070A1
TNSN97070A1 TNTNSN97070A TNSN97070A TNSN97070A1 TN SN97070 A1 TNSN97070 A1 TN SN97070A1 TN TNSN97070 A TNTNSN97070 A TN TNSN97070A TN SN97070 A TNSN97070 A TN SN97070A TN SN97070 A1 TNSN97070 A1 TN SN97070A1
Authority
TN
Tunisia
Prior art keywords
preparation
compositions containing
imidazole derivatives
substituted imidazole
compounds
Prior art date
Application number
TNTNSN97070A
Other languages
English (en)
Inventor
Marfat Anthony
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN97070A1 publication Critical patent/TNSN97070A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE R, R1, et R2 REPRESENTENT DIVERS SUSBTITUANTS. ELLE CONCERNE EN OUTRE DES PROCEDES ET INTERMEDIAIRES POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITION POUR L'INHIBITION DE LA PHOSPHODIESTERASE (PDE) DE TYPE IV OU DE LA PRODUCTION DU FACTEUR DE NECROSE TUMORALE (TNF) CHEZ UN MAMMIFERE.
TNTNSN97070A 1996-05-03 1997-04-30 Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant TNSN97070A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1686196P 1996-05-03 1996-05-03

Publications (1)

Publication Number Publication Date
TNSN97070A1 true TNSN97070A1 (fr) 2005-03-15

Family

ID=21779401

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97070A TNSN97070A1 (fr) 1996-05-03 1997-04-30 Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant

Country Status (41)

Country Link
US (2) US6211222B1 (fr)
EP (1) EP0912521B1 (fr)
JP (1) JP3148254B2 (fr)
KR (1) KR100339935B1 (fr)
CN (2) CN1112359C (fr)
AP (4) AP1147A (fr)
AR (1) AR006906A1 (fr)
AT (1) ATE292626T1 (fr)
AU (1) AU725576B2 (fr)
BG (1) BG64211B1 (fr)
BR (1) BR9709051A (fr)
CA (2) CA2252982C (fr)
CO (1) CO4650038A1 (fr)
CZ (1) CZ292825B6 (fr)
DE (1) DE69732966T2 (fr)
DZ (1) DZ2217A1 (fr)
EA (1) EA002272B1 (fr)
ES (1) ES2238079T3 (fr)
GT (1) GT199700043A (fr)
HN (1) HN1997000046A (fr)
HR (1) HRP970227B1 (fr)
HU (1) HUP9902459A3 (fr)
ID (1) ID16856A (fr)
IL (2) IL126547A (fr)
IS (1) IS4871A (fr)
MA (1) MA24158A1 (fr)
MY (1) MY132499A (fr)
NO (1) NO312959B1 (fr)
NZ (1) NZ332240A (fr)
OA (1) OA10904A (fr)
PE (1) PE64598A1 (fr)
PL (1) PL329836A1 (fr)
SK (1) SK148298A3 (fr)
TN (1) TNSN97070A1 (fr)
TR (1) TR199802202T2 (fr)
TW (1) TW449585B (fr)
UA (1) UA65536C2 (fr)
UY (1) UY24532A1 (fr)
WO (1) WO1997042174A1 (fr)
YU (1) YU16397A (fr)
ZA (1) ZA973804B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用
EP0983249B1 (fr) * 1997-05-08 2002-03-13 Pfizer Products Inc. Procedes et produits intermediaires pour la preparation de derives d'indazole substitues
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
CZ20001621A3 (cs) * 1997-11-04 2001-08-15 Pfizer Products Inc. Bioisoterické nahrazení katecholu indazolem v terapeuticky aktivních sloučeninách
AU754184B2 (en) * 1997-11-04 2002-11-07 Pfizer Products Inc. Therapeutically active compounds based on indazole bioisostere replacement of catechol in PDE4 inhibitors
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
JP2000198734A (ja) * 1998-12-30 2000-07-18 Pfizer Inc 胃運動性減弱および関連疾患の治療のための運動性増強薬
US6303782B1 (en) * 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
EP1244649B1 (fr) * 1999-12-23 2005-03-02 Icos Corporation Inhibiteurs de phosphodiesterase specifique d'amp cyclique
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
AU2002217111B2 (en) 2001-12-14 2007-05-31 Merck Serono Sa Methods of inducing ovulation using a non-polypeptide cAMP level modulator
US20040034084A1 (en) * 2002-05-24 2004-02-19 Celgene Corporation Methods for using JNK inhibitors for treating or preventing disease-related wasting
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US20050019366A1 (en) * 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
DE10318610A1 (de) 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス,インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス,インコーポレイティド Pde阻害による神経新生の調節
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス,インコーポレイティド 神経発生のgaba受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US8277809B2 (en) * 2006-04-21 2012-10-02 Centocor, Inc. CXCL13 antagonists and their use for the treatment of inflammatory diseases
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
AU2018360766B2 (en) 2017-11-06 2024-09-19 Rapt Therapeutics, Inc. Anticancer agents

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JPS5654437A (en) * 1979-10-09 1981-05-14 Konishiroku Photo Ind Co Ltd Direct positive image forming method
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JP2525286B2 (ja) * 1990-11-26 1996-08-14 日本原子力研究所 超耐熱性炭化ケイ素繊維の製造方法
TW223004B (fr) * 1991-11-25 1994-05-01 Sumitomo Chemical Co
US5444038A (en) * 1992-03-09 1995-08-22 Zeneca Limited Arylindazoles and their use as herbicides
WO1993018008A1 (fr) * 1992-03-09 1993-09-16 Zeneca Limited Nouveaux arylindazoles et leur utilisation comme herbicides
CZ283425B6 (cs) * 1992-04-02 1998-04-15 Smithkline Beecham Corporation Fenylové deriváty a farmaceutické prostředky s jejich obsahem
US5554620A (en) * 1993-09-14 1996-09-10 Sterling Winthrop Inc. Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof
US5440038A (en) * 1993-12-07 1995-08-08 Miles Inc. Process for the purification of substituted 4-amino-1,2,4-triazine-5-ones
NZ292991A (en) * 1994-10-20 1999-02-25 Pfizer Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them
DE69516298T2 (de) * 1994-10-21 2000-12-28 Elisha Technologies Co. L.L.C., Moberly Korrosionsverhinderndes puffer-system für metallprodukte
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
EP0983249B1 (fr) * 1997-05-08 2002-03-13 Pfizer Products Inc. Procedes et produits intermediaires pour la preparation de derives d'indazole substitues

Also Published As

Publication number Publication date
IS4871A (is) 1998-10-16
JPH11508284A (ja) 1999-07-21
AR006906A1 (es) 1999-09-29
AP9700975A0 (en) 1997-07-31
NO985095L (no) 1998-12-29
BG64211B1 (bg) 2004-05-31
CN1422849A (zh) 2003-06-11
NO312959B1 (no) 2002-07-22
EA199800882A1 (ru) 1999-06-24
AP1147A (en) 2003-02-25
IL126547A (en) 2003-03-12
HRP970227A2 (en) 2000-12-31
US6127398A (en) 2000-10-03
ID16856A (id) 1997-11-13
KR20000010751A (ko) 2000-02-25
ES2238079T3 (es) 2005-08-16
CZ292825B6 (cs) 2003-12-17
EP0912521B1 (fr) 2005-04-06
ATE292626T1 (de) 2005-04-15
IL126547A0 (en) 1999-08-17
GT199700043A (es) 1998-10-02
UA65536C2 (en) 2004-04-15
EP0912521A1 (fr) 1999-05-06
HRP970227B1 (en) 2002-06-30
HUP9902459A2 (hu) 1999-11-29
DE69732966D1 (de) 2005-05-12
CA2252982C (fr) 2002-10-08
DZ2217A1 (fr) 2002-12-03
CN1217714A (zh) 1999-05-26
CA2389918A1 (fr) 1997-11-13
AU725576B2 (en) 2000-10-12
TW449585B (en) 2001-08-11
HN1997000046A (es) 1997-06-26
CN1112359C (zh) 2003-06-25
CO4650038A1 (es) 1998-09-03
NO985095D0 (no) 1998-11-02
PE64598A1 (es) 1998-10-26
OA10904A (en) 2001-10-11
BG102946A (en) 1999-11-30
AP2001002304A0 (en) 2001-12-31
PL329836A1 (en) 1999-04-12
HK1019443A1 (en) 2000-02-11
MY132499A (en) 2007-10-31
US6211222B1 (en) 2001-04-03
TR199802202T2 (xx) 1999-02-22
KR100339935B1 (ko) 2002-07-18
AP2001002294A0 (en) 2001-12-31
IL152083A0 (en) 2003-05-29
EA002272B1 (ru) 2002-02-28
CA2252982A1 (fr) 1997-11-13
SK148298A3 (en) 2000-02-14
AU1937397A (en) 1997-11-26
BR9709051A (pt) 1999-08-03
UY24532A1 (es) 2000-09-29
ZA973804B (en) 1998-11-02
AP1146A (en) 2003-02-25
YU16397A (sh) 1999-12-27
MA24158A1 (fr) 1997-12-31
DE69732966T2 (de) 2005-09-08
HUP9902459A3 (en) 2001-10-29
CZ349298A3 (cs) 1999-09-15
NZ332240A (en) 2000-07-28
AP0102304A0 (en) 1997-11-03
WO1997042174A1 (fr) 1997-11-13
JP3148254B2 (ja) 2001-03-19

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