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TN2014000537A1 - 4-(amino-substitue) – 7h-pyrrolo [2, 3-d] pyrimidines nouvelles servant d'inhibiteurs de lrrk2 - Google Patents

4-(amino-substitue) – 7h-pyrrolo [2, 3-d] pyrimidines nouvelles servant d'inhibiteurs de lrrk2

Info

Publication number
TN2014000537A1
TN2014000537A1 TN2014000537A TN2014000537A TN2014000537A1 TN 2014000537 A1 TN2014000537 A1 TN 2014000537A1 TN 2014000537 A TN2014000537 A TN 2014000537A TN 2014000537 A TN2014000537 A TN 2014000537A TN 2014000537 A1 TN2014000537 A1 TN 2014000537A1
Authority
TN
Tunisia
Prior art keywords
lrrk2
pyrrolo
pyrimidines
inhibitors
amino
Prior art date
Application number
TN2014000537A
Other languages
English (en)
Inventor
Patrick Robert Verhoest
Paul Galatsis
Matthew Merrill Hayward
Jaclyn Henderson
Bethany Lyn Kormos
Ravi G Kurumbail
Antonia Friederike Stepan
Travis T Wager
Lei Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000537(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of TN2014000537A1 publication Critical patent/TN2014000537A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention propose des dérivés de 7H-pyrrolo[2,3-c]pyrimidine – 4, 5 – disubstitués de formule I, et leurs sels pharmaceutiquement acceptables, dans laquelle R1, R2, R3, R4 et R5 répondent aux définitions figurant dans le présent mémoire. La présente invention concerne également des compositions pharmaceutiques comprenant les composés de formule I et l'utilisation des composés dans le traitement de maladies associées à LRRK2, telles que des maladies neurodégénératives comprenant la maladie de parkinson ou la maladie d'alzheimer, le cancer, la maladie de crohn ou la lèpre.
TN2014000537A 2012-06-29 2014-12-26 4-(amino-substitue) – 7h-pyrrolo [2, 3-d] pyrimidines nouvelles servant d'inhibiteurs de lrrk2 TN2014000537A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US201361820828P 2013-05-08 2013-05-08
PCT/IB2013/055039 WO2014001973A1 (fr) 2012-06-29 2013-06-19 Nouvelles 7h-pyrrolo[2,3-d]pyrimidines substituées par un groupe amino en position 4, utilisées comme inhibiteurs de lrrk2

Publications (1)

Publication Number Publication Date
TN2014000537A1 true TN2014000537A1 (fr) 2016-03-30

Family

ID=49029142

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2014000537A TN2014000537A1 (fr) 2012-06-29 2014-12-26 4-(amino-substitue) – 7h-pyrrolo [2, 3-d] pyrimidines nouvelles servant d'inhibiteurs de lrrk2

Country Status (31)

Country Link
US (2) US9156845B2 (fr)
EP (2) EP2867236B1 (fr)
JP (3) JP6189948B2 (fr)
KR (1) KR20150027267A (fr)
CN (2) CN105732639A (fr)
AP (1) AP3902A (fr)
AR (1) AR091628A1 (fr)
AU (1) AU2013282869B2 (fr)
BR (1) BR112014032913A2 (fr)
CA (1) CA2878054C (fr)
CL (1) CL2014003566A1 (fr)
CO (1) CO7160063A2 (fr)
CR (1) CR20140566A (fr)
DO (1) DOP2014000303A (fr)
EA (1) EA025186B1 (fr)
ES (1) ES2637245T3 (fr)
GE (1) GEP201706620B (fr)
GT (1) GT201400301A (fr)
IL (1) IL236294A (fr)
MD (1) MD20140130A2 (fr)
MX (1) MX2014015769A (fr)
NI (1) NI201400151A (fr)
NZ (1) NZ702571A (fr)
PE (1) PE20150153A1 (fr)
PH (1) PH12014502886B1 (fr)
SG (1) SG11201408044QA (fr)
TN (1) TN2014000537A1 (fr)
TW (1) TWI482774B (fr)
UY (1) UY34883A (fr)
WO (1) WO2014001973A1 (fr)
ZA (1) ZA201409136B (fr)

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