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NI201400151A - 7H - PIRROLO [ 2, 3 - d ] PIRIMIDINAS 4 - ( AMINO - SUBSTITUIDAS ) NOVEDOSAS COMO INHIBIDORES DE LRRK2. - Google Patents

7H - PIRROLO [ 2, 3 - d ] PIRIMIDINAS 4 - ( AMINO - SUBSTITUIDAS ) NOVEDOSAS COMO INHIBIDORES DE LRRK2.

Info

Publication number
NI201400151A
NI201400151A NI201400151A NI201400151A NI201400151A NI 201400151 A NI201400151 A NI 201400151A NI 201400151 A NI201400151 A NI 201400151A NI 201400151 A NI201400151 A NI 201400151A NI 201400151 A NI201400151 A NI 201400151A
Authority
NI
Nicaragua
Prior art keywords
pirrolo
pyrimidines
novelty
amino
substituted
Prior art date
Application number
NI201400151A
Other languages
English (en)
Inventor
Galatsis Paul
Merril Hayward Matthew
Henderson Jaclyn
Lyn Kormos Bethany
G Kurumbail Ravi
Friederike Stepan Antonia
Robert Verhoest Patrick
T Wager Travis
Zhang Lei
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201400151(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NI201400151A publication Critical patent/NI201400151A/es
Application filed by Pfizer filed Critical Pfizer

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona derivados novedosos de 7H - pirrolo [ 2, 3 - d ] pirimidina 4, 5 - disubstituida de la fórmula I, y las sales farmacéuticamente aceptables de los mismos en donde R1, R2, R3, R4 y R5 son como se definieron en la especificación. La invención también está dirigida a composiciones farmacéuticas que comprenden los compuestos de la fórmula I y al uso de los compuestos en el tratamiento de enfermedades asociadas con LRRK2, tales como enfermedades neurodegenerativas que incluyen enfermedad de Parkinson o enfermedad de Alzheimer, cáncer, enfermedad de Crohn o lepra.
NI201400151A 2012-06-29 2015-12-19 7H - PIRROLO [ 2, 3 - d ] PIRIMIDINAS 4 - ( AMINO - SUBSTITUIDAS ) NOVEDOSAS COMO INHIBIDORES DE LRRK2. NI201400151A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US201361820828P 2013-05-08 2013-05-08

Publications (1)

Publication Number Publication Date
NI201400151A true NI201400151A (es) 2015-06-05

Family

ID=49029142

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201400151A NI201400151A (es) 2012-06-29 2015-12-19 7H - PIRROLO [ 2, 3 - d ] PIRIMIDINAS 4 - ( AMINO - SUBSTITUIDAS ) NOVEDOSAS COMO INHIBIDORES DE LRRK2.

Country Status (31)

Country Link
US (2) US9156845B2 (es)
EP (2) EP3255049A1 (es)
JP (3) JP6189948B2 (es)
KR (1) KR20150027267A (es)
CN (2) CN105732639A (es)
AP (1) AP3902A (es)
AR (1) AR091628A1 (es)
AU (1) AU2013282869B2 (es)
BR (1) BR112014032913A2 (es)
CA (1) CA2878054C (es)
CL (1) CL2014003566A1 (es)
CO (1) CO7160063A2 (es)
CR (1) CR20140566A (es)
DO (1) DOP2014000303A (es)
EA (1) EA025186B1 (es)
ES (1) ES2637245T3 (es)
GE (1) GEP201706620B (es)
GT (1) GT201400301A (es)
IL (1) IL236294A (es)
MD (1) MD20140130A2 (es)
MX (1) MX2014015769A (es)
NI (1) NI201400151A (es)
NZ (1) NZ702571A (es)
PE (1) PE20150153A1 (es)
PH (1) PH12014502886B1 (es)
SG (1) SG11201408044QA (es)
TN (1) TN2014000537A1 (es)
TW (1) TWI482774B (es)
UY (1) UY34883A (es)
WO (1) WO2014001973A1 (es)
ZA (1) ZA201409136B (es)

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