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MX2008005398A - Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer. - Google Patents

Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.

Info

Publication number
MX2008005398A
MX2008005398A MX2008005398A MX2008005398A MX2008005398A MX 2008005398 A MX2008005398 A MX 2008005398A MX 2008005398 A MX2008005398 A MX 2008005398A MX 2008005398 A MX2008005398 A MX 2008005398A MX 2008005398 A MX2008005398 A MX 2008005398A
Authority
MX
Mexico
Prior art keywords
cancer
treatment
aminopyrazole
tyrosine kinase
kinase inhibitors
Prior art date
Application number
MX2008005398A
Other languages
English (en)
Inventor
Mei Su
Bin Wang
Tao Wang
Huiping Guan
Stephanos Ioannidis
Xiaomei Feng
Ying Kan
Bo Peng
Hai-Jun Zhang
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2008005398A publication Critical patent/MX2008005398A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a novedosos compuestos que tienen la fórmula (I): (ver fórmula (I)) y a sus composiciones farmacéuticas, y a sus métodos de uso. Estos compuestos novedosos proporcionan un tratamiento para el cáncer.
MX2008005398A 2005-10-28 2006-10-26 Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer. MX2008005398A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73129905P 2005-10-28 2005-10-28
US80306106P 2006-05-24 2006-05-24
PCT/GB2006/003978 WO2007049041A1 (en) 2005-10-28 2006-10-26 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2008005398A true MX2008005398A (es) 2008-09-24

Family

ID=37575154

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008005398A MX2008005398A (es) 2005-10-28 2006-10-26 Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.

Country Status (22)

Country Link
US (3) US20080287475A1 (es)
EP (2) EP1945631B8 (es)
JP (1) JP2009513615A (es)
KR (1) KR20080063846A (es)
AR (1) AR056210A1 (es)
AU (1) AU2006307657B2 (es)
BR (1) BRPI0618011A2 (es)
CA (1) CA2626375A1 (es)
DK (1) DK1945631T3 (es)
EC (1) ECSP088450A (es)
ES (1) ES2391783T3 (es)
HR (1) HRP20120824T1 (es)
IL (1) IL190935A0 (es)
MX (1) MX2008005398A (es)
NO (1) NO20081893L (es)
NZ (1) NZ567584A (es)
PL (1) PL1945631T3 (es)
PT (1) PT1945631E (es)
RU (1) RU2463302C2 (es)
TW (1) TW200800963A (es)
UY (1) UY29886A1 (es)
WO (1) WO2007049041A1 (es)

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US20100160325A1 (en) 2010-06-24
WO2007049041A1 (en) 2007-05-03
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AR056210A1 (es) 2007-09-26
IL190935A0 (en) 2009-09-22
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