TN2014000411A1 - Process for the manufacture of cyclic undecapeptides - Google Patents

Process for the manufacture of cyclic undecapeptides

Info

Publication number: TN2014000411A1
Authority: TN; Tunisia
Prior art keywords: leu; manufacture; ala; methyl; subjected
Prior art date: 2012-05-09

Application number

TNP2014000411A

Other languages

English (en)

Inventor

Fabrice Gallou

Bernard Riss

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-05-09

Filing date

2014-09-30

Publication date

2015-12-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000411(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-09-30 Application filed by Novartis Ag filed Critical Novartis Ag

2015-12-21 Publication of TN2014000411A1 publication Critical patent/TN2014000411A1/fr

Links

125000004122 cyclic group Chemical group 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 abstract 3
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 2
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical group CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 abstract 1
OLROWHGDTNFZBH-XEMWPYQTSA-N Alisporivir Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(CC)C(=O)[C@@H](C)N(C)C1=O OLROWHGDTNFZBH-XEMWPYQTSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
108010077895 Sarcosine Proteins 0.000 abstract 1
108010058359 alisporivir Proteins 0.000 abstract 1
229950004789 alisporivir Drugs 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
238000007142 ring opening reaction Methods 0.000 abstract 1
229940043230 sarcosine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

TNP2014000411A 2012-05-09 2014-09-30 Process for the manufacture of cyclic undecapeptides TN2014000411A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261644616P	2012-05-09	2012-05-09
PCT/EP2013/059672 WO2013167703A1 (fr)	2012-05-09	2013-05-08	Procédé de fabrication d'undécapeptides cycliques

Publications (1)

Publication Number	Publication Date
TN2014000411A1 true TN2014000411A1 (en)	2015-12-21

Family

ID=48444372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2014000411A TN2014000411A1 (en)	2012-05-09	2014-09-30	Process for the manufacture of cyclic undecapeptides

Country Status (24)

Country	Link
US (2)	US20150087808A1 (fr)
EP (1)	EP2847211A1 (fr)
JP (3)	JP2015517481A (fr)
KR (1)	KR20150006435A (fr)
CN (2)	CN104284902A (fr)
AR (1)	AR090964A1 (fr)
AU (2)	AU2013257989A1 (fr)
BR (1)	BR112014027648A2 (fr)
CA (1)	CA2868940A1 (fr)
CL (1)	CL2014003014A1 (fr)
CO (1)	CO7141428A2 (fr)
EA (1)	EA024903B1 (fr)
EC (1)	ECSP14030537A (fr)
HK (1)	HK1202555A1 (fr)
IL (1)	IL235428A0 (fr)
IN (1)	IN2014DN08483A (fr)
MA (1)	MA20150231A1 (fr)
MX (1)	MX2014013613A (fr)
PE (1)	PE20142433A1 (fr)
PH (1)	PH12014502499A1 (fr)
SG (1)	SG11201406303XA (fr)
TN (1)	TN2014000411A1 (fr)
TW (1)	TW201350508A (fr)
WO (1)	WO2013167703A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105693820A (zh) *	2014-11-27	2016-06-22	武汉药明康德新药开发有限公司	一种降解环孢菌素a的方法
JP7634933B2 (ja)	2017-05-12	2025-02-25	中外製薬株式会社	環状有機化合物の製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT401177B (de) *	1993-10-22	1996-07-25	Biochemie Gmbh	Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
DE69928938T2 (de) *	1998-07-01	2006-08-17	Debiopharm S.A.	Neues cyclosporin mit verbesserter wirkung
ATE330968T1 (de) *	1999-02-05	2006-07-15	Debiopharm Sa	Cyclosporin-derivate und verfahren zu deren herstellung
DE60208180T2 (de) *	2001-04-20	2006-08-17	Debiopharm S.A.	Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
DE60231570D1 (de) *	2001-10-19	2009-04-23	Isotechnika Inc	Synthese von Cyclosporinanalogen
TW200505946A (en)	2003-04-08	2005-02-16	Hoffmann La Roche	Process for preparation of cyclosporin a analog
BRPI0515494A (pt) *	2004-10-01	2008-07-29	Debiopharm Sa	uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina
KR20070100284A (ko) *	2004-12-17	2007-10-10	이소테크니카 인코포레이티드	시클로스포린 유사체의 대사산물
EP2124992A2 (fr)	2007-01-04	2009-12-02	Debiopharm S.A.	Cyclosporine non immunosuppressive pour le traitement de la dystrophie musculaire congénitale d'ullrich
AU2008304313B2 (en)	2007-09-26	2013-01-10	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) *	2007-12-14	2011-03-22	Siemens Healthcare Diagnostics Inc.	Methods for detection of hydrophobic drugs
WO2009098533A1 (fr)	2008-02-08	2009-08-13	Debiopharm Sa	Cyclosporine non immunosuppressive pour le traitement de la dystrophie musculaire
UA102414C2 (ru)	2008-11-06	2013-07-10	Дебио Решерш Фармасьютик С.А.	Циклоундекадепсипептидные соединения для лечения инфекций, вызванных вирусом гепатита с
AU2009334790B2 (en) *	2008-12-31	2016-09-08	Scynexis, Inc.	Derivatives of cyclosporin A
KR101476626B1 (ko) *	2009-01-30	2014-12-26	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
WO2012021796A2 (fr) *	2010-08-12	2012-02-16	S&T Global, Inc.	Nouveaux dérivés de cyclosporine destinés à la prévention ou au traitement d'une infection virale

2013
- 2013-05-07 AR ARP130101557A patent/AR090964A1/es unknown
- 2013-05-08 JP JP2015510823A patent/JP2015517481A/ja not_active Withdrawn
- 2013-05-08 TW TW102116414A patent/TW201350508A/zh unknown
- 2013-05-08 HK HK15102858.0A patent/HK1202555A1/xx unknown
- 2013-05-08 PE PE2014001983A patent/PE20142433A1/es not_active Application Discontinuation
- 2013-05-08 EP EP13722740.1A patent/EP2847211A1/fr not_active Withdrawn
- 2013-05-08 CN CN201380023760.8A patent/CN104284902A/zh active Pending
- 2013-05-08 MA MA37498A patent/MA20150231A1/fr unknown
- 2013-05-08 US US14/399,261 patent/US20150087808A1/en not_active Abandoned
- 2013-05-08 CA CA2868940A patent/CA2868940A1/fr not_active Abandoned
- 2013-05-08 BR BR112014027648A patent/BR112014027648A2/pt not_active IP Right Cessation
- 2013-05-08 AU AU2013257989A patent/AU2013257989A1/en not_active Abandoned
- 2013-05-08 KR KR1020147031112A patent/KR20150006435A/ko not_active Withdrawn
- 2013-05-08 EA EA201492036A patent/EA024903B1/ru not_active IP Right Cessation
- 2013-05-08 MX MX2014013613A patent/MX2014013613A/es unknown
- 2013-05-08 CN CN201810575515.2A patent/CN108715606A/zh active Pending
- 2013-05-08 WO PCT/EP2013/059672 patent/WO2013167703A1/fr not_active Ceased
- 2013-05-08 SG SG11201406303XA patent/SG11201406303XA/en unknown
- 2013-05-08 IN IN8483DEN2014 patent/IN2014DN08483A/en unknown
2014
- 2014-09-30 TN TNP2014000411A patent/TN2014000411A1/fr unknown
- 2014-10-30 IL IL235428A patent/IL235428A0/en unknown
- 2014-11-07 CL CL2014003014A patent/CL2014003014A1/es unknown
- 2014-11-10 CO CO14248207A patent/CO7141428A2/es unknown
- 2014-11-10 PH PH12014502499A patent/PH12014502499A1/en unknown
- 2014-12-08 EC ECIEPI201430537A patent/ECSP14030537A/es unknown
2016
- 2016-06-30 US US15/198,152 patent/US9840534B2/en not_active Expired - Fee Related
- 2016-08-31 AU AU2016222370A patent/AU2016222370B2/en not_active Ceased
2017
- 2017-08-29 JP JP2017164867A patent/JP2018035154A/ja not_active Withdrawn
2019
- 2019-09-30 JP JP2019179311A patent/JP2020033349A/ja active Pending

Also Published As

Publication number	Publication date
CN108715606A (zh)	2018-10-30
CN104284902A (zh)	2015-01-14
BR112014027648A2 (pt)	2017-06-27
IN2014DN08483A (fr)	2015-05-08
CO7141428A2 (es)	2014-12-12
HK1202555A1 (en)	2015-10-02
US9840534B2 (en)	2017-12-12
PH12014502499A1 (en)	2014-12-22
KR20150006435A (ko)	2015-01-16
IL235428A0 (en)	2014-12-31
MX2014013613A (es)	2015-02-12
SG11201406303XA (en)	2014-11-27
TW201350508A (zh)	2013-12-16
US20160304554A1 (en)	2016-10-20
PE20142433A1 (es)	2015-02-02
WO2013167703A9 (fr)	2014-11-20
EA201492036A1 (ru)	2015-02-27
AU2016222370A1 (en)	2016-09-15
JP2015517481A (ja)	2015-06-22
AU2016222370B2 (en)	2017-10-05
AU2013257989A1 (en)	2014-10-23
JP2018035154A (ja)	2018-03-08
MA20150231A1 (fr)	2015-07-31
WO2013167703A1 (fr)	2013-11-14
AR090964A1 (es)	2014-12-17
US20150087808A1 (en)	2015-03-26
ECSP14030537A (es)	2015-09-30
EA024903B1 (ru)	2016-10-31
CA2868940A1 (fr)	2013-11-14
EP2847211A1 (fr)	2015-03-18
CL2014003014A1 (es)	2015-03-06
JP2020033349A (ja)	2020-03-05

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PE20121033A1 (es)	2012-08-02	Produccion recombinante de peptidos
PH12014502499A1 (en)	2014-12-22	Process for the manufacture of cyclic undecapeptides
IN2014MN01822A (fr)	2015-07-03
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WO2011117583A3 (fr)	2012-01-12	Procédé
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