[go: up one dir, main page]

MA20150231A1 - Procédé de fabrication d'undécapeptides cycliques - Google Patents

Procédé de fabrication d'undécapeptides cycliques

Info

Publication number
MA20150231A1
MA20150231A1 MA37498A MA37498A MA20150231A1 MA 20150231 A1 MA20150231 A1 MA 20150231A1 MA 37498 A MA37498 A MA 37498A MA 37498 A MA37498 A MA 37498A MA 20150231 A1 MA20150231 A1 MA 20150231A1
Authority
MA
Morocco
Prior art keywords
cyclic undecapeptides
producing cyclic
cyclosporin
undecapeptides
alisporivir
Prior art date
Application number
MA37498A
Other languages
English (en)
Inventor
Fabrice Gallou
Bernard Riss
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA20150231(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA20150231A1 publication Critical patent/MA20150231A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés et des intermédiaires utiles pour la fabrication d'undécapeptides cycliques, tels que l'alisporivir, un dérivé non-immunosuppresseur de la cyclosporine a. La cyclosporine est acylée sur la chaîne latérale butényl-méthyl-thréonine puis soumise à une réaction d'ouverture de cycle (le cycle s'ouvre entre les résidus sarcosine et
MA37498A 2012-05-09 2013-05-08 Procédé de fabrication d'undécapeptides cycliques MA20150231A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261644616P 2012-05-09 2012-05-09
PCT/EP2013/059672 WO2013167703A1 (fr) 2012-05-09 2013-05-08 Procédé de fabrication d'undécapeptides cycliques

Publications (1)

Publication Number Publication Date
MA20150231A1 true MA20150231A1 (fr) 2015-07-31

Family

ID=48444372

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37498A MA20150231A1 (fr) 2012-05-09 2013-05-08 Procédé de fabrication d'undécapeptides cycliques

Country Status (24)

Country Link
US (2) US20150087808A1 (fr)
EP (1) EP2847211A1 (fr)
JP (3) JP2015517481A (fr)
KR (1) KR20150006435A (fr)
CN (2) CN108715606A (fr)
AR (1) AR090964A1 (fr)
AU (2) AU2013257989A1 (fr)
BR (1) BR112014027648A2 (fr)
CA (1) CA2868940A1 (fr)
CL (1) CL2014003014A1 (fr)
CO (1) CO7141428A2 (fr)
EA (1) EA024903B1 (fr)
EC (1) ECSP14030537A (fr)
HK (1) HK1202555A1 (fr)
IL (1) IL235428A0 (fr)
IN (1) IN2014DN08483A (fr)
MA (1) MA20150231A1 (fr)
MX (1) MX2014013613A (fr)
PE (1) PE20142433A1 (fr)
PH (1) PH12014502499A1 (fr)
SG (1) SG11201406303XA (fr)
TN (1) TN2014000411A1 (fr)
TW (1) TW201350508A (fr)
WO (1) WO2013167703A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105693820A (zh) * 2014-11-27 2016-06-22 武汉药明康德新药开发有限公司 一种降解环孢菌素a的方法
EP3623378B1 (fr) 2017-05-12 2025-07-02 Chugai Seiyaku Kabushiki Kaisha Procédé de production d'un composé organique cyclique

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
BR9911724A (pt) * 1998-07-01 2001-03-20 Debiopharm Sa Ciclosporina que tem um perfil de atividade melhorado
ATE330968T1 (de) * 1999-02-05 2006-07-15 Debiopharm Sa Cyclosporin-derivate und verfahren zu deren herstellung
RU2290196C2 (ru) * 2001-04-20 2006-12-27 Дебиофарм С.А. Модифицированный циклоспорин, который можно использовать в качестве пролекарства, и его применение
SI1436321T1 (sl) * 2001-10-19 2006-12-31 Isotechnika Inc Sinteza analogov ciklosporina
TW200505946A (en) 2003-04-08 2005-02-16 Hoffmann La Roche Process for preparation of cyclosporin a analog
ES2357587T3 (es) * 2004-10-01 2011-04-27 Debiopharm S.A. Uso de (d-meala)3-(etval)4-ciclosporina para el tratamiento de infección por hepatitis c.
CA2592343A1 (fr) * 2004-12-17 2006-06-22 Isotechnika Inc. Metabolites d'analogues de la cyclosporine
JP5801534B2 (ja) 2007-01-04 2015-10-28 デビオファーム インターナショナル ソシエテ アノニム ウールリッヒ型先天筋ジストロフィーの処置のための、非免疫抑制性シクロスポリン
AU2008304313B2 (en) 2007-09-26 2013-01-10 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) * 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
WO2009098533A1 (fr) 2008-02-08 2009-08-13 Debiopharm Sa Cyclosporine non immunosuppressive pour le traitement de la dystrophie musculaire
CN102202679B (zh) 2008-11-06 2014-05-07 帝柏奥研究制药有限公司 环十一缩酚酸肽化合物及其作为药物的用途
CA2748389A1 (fr) * 2008-12-31 2010-07-08 Scynexis, Inc. Derives de cyclosporine a
KR101476626B1 (ko) * 2009-01-30 2014-12-26 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US9573978B2 (en) * 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection

Also Published As

Publication number Publication date
SG11201406303XA (en) 2014-11-27
JP2018035154A (ja) 2018-03-08
CA2868940A1 (fr) 2013-11-14
EA024903B1 (ru) 2016-10-31
PE20142433A1 (es) 2015-02-02
PH12014502499A1 (en) 2014-12-22
HK1202555A1 (en) 2015-10-02
US9840534B2 (en) 2017-12-12
AU2016222370A1 (en) 2016-09-15
CO7141428A2 (es) 2014-12-12
KR20150006435A (ko) 2015-01-16
AU2016222370B2 (en) 2017-10-05
AR090964A1 (es) 2014-12-17
WO2013167703A1 (fr) 2013-11-14
TN2014000411A1 (en) 2015-12-21
US20160304554A1 (en) 2016-10-20
EA201492036A1 (ru) 2015-02-27
US20150087808A1 (en) 2015-03-26
IL235428A0 (en) 2014-12-31
CN104284902A (zh) 2015-01-14
IN2014DN08483A (fr) 2015-05-08
JP2015517481A (ja) 2015-06-22
WO2013167703A9 (fr) 2014-11-20
CL2014003014A1 (es) 2015-03-06
AU2013257989A1 (en) 2014-10-23
CN108715606A (zh) 2018-10-30
ECSP14030537A (es) 2015-09-30
EP2847211A1 (fr) 2015-03-18
JP2020033349A (ja) 2020-03-05
BR112014027648A2 (pt) 2017-06-27
MX2014013613A (es) 2015-02-12
TW201350508A (zh) 2013-12-16

Similar Documents

Publication Publication Date Title
EP3409282A4 (fr) Préparation solide, procédé de production de la préparation solide, et procédé pour générer de l'hydrogène
MA34641B1 (fr) Anticorps anti-il-23
MA31904B1 (fr) Anticorps bispecifiques bivalents
DE502008003182D1 (de) Oduktionscharge von ringförmigen schalenkatalysatoren k entnommenen teilmenge in ein reaktionsrohr eines rohrbündelreaktors
BR112014010001A2 (pt) "processo de fabricação de produtos de organosilício com qualidade aprimorada usando catalisadores heterogêneos de metal precioso"
MA33537B1 (fr) Anticorps anti-cdcp1 humanisés
MX340573B (es) Proceso para la fabricacion de compuestos farmaceuticamente activos.
NO20072288L (no) Sulfonamid pert-substituerte bicykler for okklusly arteriesykdom
EA201390156A1 (ru) ПРОИЗВОДСТВО ИНТЕР-АЛЬФА-ИНГИБИТОРНЫХ БЕЛКОВ (IaIp) ИЗ ПЛАЗМЫ
MA31834B1 (fr) 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, leur procédé de production et leur utilisation comme anti-inflammatoires
MX360855B (es) Procedimiento para la preparación de una composición que comprende complejos metálicos en una matriz orgánica aceitosa.
MY162533A (en) Process for the manufacture of a 1,2-epoxide and a device for carrying out said process
MA20150231A1 (fr) Procédé de fabrication d'undécapeptides cycliques
EA200700906A1 (ru) Низкотемпературный промышленный процесс
FR2938777B1 (fr) Catalyseur en coquille, procede de preparation et utilisation de ce catalyseur.
EP2654758A4 (fr) Composition comprenant au moins deux composés qui induit l'indolamine 2,3-dioxygénase (ido), pour le traitement d'un trouble auto-immun d'un sujet souffrant ou d'un rejet immunitaire d'organes
EP2559655A4 (fr) Procédé pour synthétiser des matériaux de nanoélectrode par utilisation d'un procédé de combustion ultrarapide, et matériaux de nanoélectrode synthétisés par le procédé
PE20091969A1 (es) ANTICUERPOS ANTI-PirB
FR3056584B1 (fr) Procede de fabrication du 1-chloro-2,2-difluoroethane
MA39387A1 (fr) Colorants réactifs fluorescents, procédé de production et utilisation de ceux-ci
CL2012003371A1 (es) Compuestos intermediarios de la síntesis de agomelatina; y el procedimiento de obtención de agomelatina a partir de dichos compuestos intermediarios
IN2012DN00862A (fr)
EP2554247A4 (fr) Membrane exempte de défauts utilisée pour séparer l'hydrogène, procédé de production de cette membrane et procédé de séparation de l'hydrogène
MA34648B1 (fr) Photosensibilisateurs et leur utilisation pour la production d'hydrogène à partir d'eau
CA2594869C (fr) Procede de preparation de 10,11-dihydro-10-hydroxy-5h-dibenzo/b,f/azepine-5-carboxamide