IN2014DN08483A - - Google Patents

Info

Publication number: IN2014DN08483A
Authority: IN; India
Prior art keywords: leu; subjected; val; linear; methyl
Prior art date: 2012-05-09

Application number

Other languages

English (en)

Inventor

Fabrice Gallou

Bernard Riss

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-05-09

Filing date

2013-05-08

Publication date

2015-05-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN08483(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-05-08 Application filed by Novartis Ag filed Critical Novartis Ag

2015-05-08 Publication of IN2014DN08483A publication Critical patent/IN2014DN08483A/en

Links

239000000543 intermediate Substances 0.000 abstract 3
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 2
OLROWHGDTNFZBH-XEMWPYQTSA-N Alisporivir Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(CC)C(=O)[C@@H](C)N(C)C1=O OLROWHGDTNFZBH-XEMWPYQTSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
108010077895 Sarcosine Proteins 0.000 abstract 1
108010058359 alisporivir Proteins 0.000 abstract 1
229950004789 alisporivir Drugs 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
XJODGRWDFZVTKW-ZCFIWIBFSA-N n-methylleucine Chemical group CN[C@@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-ZCFIWIBFSA-N 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
238000007142 ring opening reaction Methods 0.000 abstract 1
229940043230 sarcosine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IN8483DEN2014 2012-05-09 2013-05-08 IN2014DN08483A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261644616P	2012-05-09	2012-05-09
PCT/EP2013/059672 WO2013167703A1 (fr)	2012-05-09	2013-05-08	Procédé de fabrication d'undécapeptides cycliques

Publications (1)

Publication Number	Publication Date
IN2014DN08483A true IN2014DN08483A (fr)	2015-05-08

Family

ID=48444372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN8483DEN2014 IN2014DN08483A (fr)	2012-05-09	2013-05-08

Country Status (24)

Country	Link
US (2)	US20150087808A1 (fr)
EP (1)	EP2847211A1 (fr)
JP (3)	JP2015517481A (fr)
KR (1)	KR20150006435A (fr)
CN (2)	CN108715606A (fr)
AR (1)	AR090964A1 (fr)
AU (2)	AU2013257989A1 (fr)
BR (1)	BR112014027648A2 (fr)
CA (1)	CA2868940A1 (fr)
CL (1)	CL2014003014A1 (fr)
CO (1)	CO7141428A2 (fr)
EA (1)	EA024903B1 (fr)
EC (1)	ECSP14030537A (fr)
HK (1)	HK1202555A1 (fr)
IL (1)	IL235428A0 (fr)
IN (1)	IN2014DN08483A (fr)
MA (1)	MA20150231A1 (fr)
MX (1)	MX2014013613A (fr)
PE (1)	PE20142433A1 (fr)
PH (1)	PH12014502499A1 (fr)
SG (1)	SG11201406303XA (fr)
TN (1)	TN2014000411A1 (fr)
TW (1)	TW201350508A (fr)
WO (1)	WO2013167703A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105693820A (zh) *	2014-11-27	2016-06-22	武汉药明康德新药开发有限公司	一种降解环孢菌素a的方法
EP3623378B1 (fr)	2017-05-12	2025-07-02	Chugai Seiyaku Kabushiki Kaisha	Procédé de production d'un composé organique cyclique

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT401177B (de) *	1993-10-22	1996-07-25	Biochemie Gmbh	Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
BR9911724A (pt) *	1998-07-01	2001-03-20	Debiopharm Sa	Ciclosporina que tem um perfil de atividade melhorado
ATE330968T1 (de) *	1999-02-05	2006-07-15	Debiopharm Sa	Cyclosporin-derivate und verfahren zu deren herstellung
RU2290196C2 (ru) *	2001-04-20	2006-12-27	Дебиофарм С.А.	Модифицированный циклоспорин, который можно использовать в качестве пролекарства, и его применение
SI1436321T1 (sl) *	2001-10-19	2006-12-31	Isotechnika Inc	Sinteza analogov ciklosporina
TW200505946A (en)	2003-04-08	2005-02-16	Hoffmann La Roche	Process for preparation of cyclosporin a analog
ES2357587T3 (es) *	2004-10-01	2011-04-27	Debiopharm S.A.	Uso de (d-meala)3-(etval)4-ciclosporina para el tratamiento de infección por hepatitis c.
CA2592343A1 (fr) *	2004-12-17	2006-06-22	Isotechnika Inc.	Metabolites d'analogues de la cyclosporine
JP5801534B2 (ja)	2007-01-04	2015-10-28	デビオファームインターナショナルソシエテアノニム	ウールリッヒ型先天筋ジストロフィーの処置のための、非免疫抑制性シクロスポリン
AU2008304313B2 (en)	2007-09-26	2013-01-10	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) *	2007-12-14	2011-03-22	Siemens Healthcare Diagnostics Inc.	Methods for detection of hydrophobic drugs
WO2009098533A1 (fr)	2008-02-08	2009-08-13	Debiopharm Sa	Cyclosporine non immunosuppressive pour le traitement de la dystrophie musculaire
CN102202679B (zh)	2008-11-06	2014-05-07	帝柏奥研究制药有限公司	环十一缩酚酸肽化合物及其作为药物的用途
CA2748389A1 (fr) *	2008-12-31	2010-07-08	Scynexis, Inc.	Derives de cyclosporine a
KR101476626B1 (ko) *	2009-01-30	2014-12-26	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US9573978B2 (en) *	2010-08-12	2017-02-21	S&T Global, Inc.	Cyclosporin derivatives for the treatment and prevention of a viral infection

2013
- 2013-05-07 AR ARP130101557A patent/AR090964A1/es unknown
- 2013-05-08 AU AU2013257989A patent/AU2013257989A1/en not_active Abandoned
- 2013-05-08 SG SG11201406303XA patent/SG11201406303XA/en unknown
- 2013-05-08 IN IN8483DEN2014 patent/IN2014DN08483A/en unknown
- 2013-05-08 EA EA201492036A patent/EA024903B1/ru not_active IP Right Cessation
- 2013-05-08 TW TW102116414A patent/TW201350508A/zh unknown
- 2013-05-08 BR BR112014027648A patent/BR112014027648A2/pt not_active IP Right Cessation
- 2013-05-08 JP JP2015510823A patent/JP2015517481A/ja not_active Withdrawn
- 2013-05-08 MX MX2014013613A patent/MX2014013613A/es unknown
- 2013-05-08 CN CN201810575515.2A patent/CN108715606A/zh active Pending
- 2013-05-08 US US14/399,261 patent/US20150087808A1/en not_active Abandoned
- 2013-05-08 WO PCT/EP2013/059672 patent/WO2013167703A1/fr not_active Ceased
- 2013-05-08 MA MA37498A patent/MA20150231A1/fr unknown
- 2013-05-08 PE PE2014001983A patent/PE20142433A1/es not_active Application Discontinuation
- 2013-05-08 EP EP13722740.1A patent/EP2847211A1/fr not_active Withdrawn
- 2013-05-08 CN CN201380023760.8A patent/CN104284902A/zh active Pending
- 2013-05-08 KR KR1020147031112A patent/KR20150006435A/ko not_active Withdrawn
- 2013-05-08 CA CA2868940A patent/CA2868940A1/fr not_active Abandoned
- 2013-05-08 HK HK15102858.0A patent/HK1202555A1/xx unknown
2014
- 2014-09-30 TN TNP2014000411A patent/TN2014000411A1/fr unknown
- 2014-10-30 IL IL235428A patent/IL235428A0/en unknown
- 2014-11-07 CL CL2014003014A patent/CL2014003014A1/es unknown
- 2014-11-10 PH PH12014502499A patent/PH12014502499A1/en unknown
- 2014-11-10 CO CO14248207A patent/CO7141428A2/es unknown
- 2014-12-08 EC ECIEPI201430537A patent/ECSP14030537A/es unknown
2016
- 2016-06-30 US US15/198,152 patent/US9840534B2/en not_active Expired - Fee Related
- 2016-08-31 AU AU2016222370A patent/AU2016222370B2/en not_active Ceased
2017
- 2017-08-29 JP JP2017164867A patent/JP2018035154A/ja not_active Withdrawn
2019
- 2019-09-30 JP JP2019179311A patent/JP2020033349A/ja active Pending

Also Published As

Publication number	Publication date
SG11201406303XA (en)	2014-11-27
MA20150231A1 (fr)	2015-07-31
JP2018035154A (ja)	2018-03-08
CA2868940A1 (fr)	2013-11-14
EA024903B1 (ru)	2016-10-31
PE20142433A1 (es)	2015-02-02
PH12014502499A1 (en)	2014-12-22
HK1202555A1 (en)	2015-10-02
US9840534B2 (en)	2017-12-12
AU2016222370A1 (en)	2016-09-15
CO7141428A2 (es)	2014-12-12
KR20150006435A (ko)	2015-01-16
AU2016222370B2 (en)	2017-10-05
AR090964A1 (es)	2014-12-17
WO2013167703A1 (fr)	2013-11-14
TN2014000411A1 (en)	2015-12-21
US20160304554A1 (en)	2016-10-20
EA201492036A1 (ru)	2015-02-27
US20150087808A1 (en)	2015-03-26
IL235428A0 (en)	2014-12-31
CN104284902A (zh)	2015-01-14
JP2015517481A (ja)	2015-06-22
WO2013167703A9 (fr)	2014-11-20
CL2014003014A1 (es)	2015-03-06
AU2013257989A1 (en)	2014-10-23
CN108715606A (zh)	2018-10-30
ECSP14030537A (es)	2015-09-30
EP2847211A1 (fr)	2015-03-18
JP2020033349A (ja)	2020-03-05
BR112014027648A2 (pt)	2017-06-27
MX2014013613A (es)	2015-02-12
TW201350508A (zh)	2013-12-16

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IN2014DN08483A (fr)	2015-05-08
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Carroux et al.	2013	Unprecedented 17‐residue peptaibiotics produced by marine‐derived Trichoderma atroviride
MX2022002433A (es)	2022-05-19	Análogos de compstatina y sus usos médicos.
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McKinnie et al.	2012	The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S
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MX2021006809A (es)	2021-08-24	Rutas lineales en fase de solucion para hexapeptidos de wnt.
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