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TN2010000248A1 - Derives d'indolinone et procede pour leur fabrication - Google Patents

Derives d'indolinone et procede pour leur fabrication

Info

Publication number
TN2010000248A1
TN2010000248A1 TN2010000248A TN2010000248A TN2010000248A1 TN 2010000248 A1 TN2010000248 A1 TN 2010000248A1 TN 2010000248 A TN2010000248 A TN 2010000248A TN 2010000248 A TN2010000248 A TN 2010000248A TN 2010000248 A1 TN2010000248 A1 TN 2010000248A1
Authority
TN
Tunisia
Prior art keywords
manufacture
indolinone derivatives
group
hydrogen atom
taken together
Prior art date
Application number
TN2010000248A
Other languages
English (en)
Inventor
Joern Merten
Svenja Renner
Carsten Reichel
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40718253&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000248(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TN2010000248A1 publication Critical patent/TN2010000248A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epidemiology (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des dérivés d'indolinone spécifiques, en particulier les composés de formule, dans laquelle R1 représente un atome d'hydrogène ou un groupe, et R2 et R3 représentent chacun un atome d'hydrogène ou R2 et R3 pris ensemble représentent un groupe, à condition que lorsque R1 représente un atome d'hydrogène, R2 et R3 pris ensemble représentent un groupe, et un procédé pour leur fabrication
TN2010000248A 2007-12-03 2010-06-01 Derives d'indolinone et procede pour leur fabrication TN2010000248A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07122123 2007-12-03
PCT/EP2008/066581 WO2009071524A2 (fr) 2007-12-03 2008-12-02 Dérivés indolinone et procédé pour les fabriquer

Publications (1)

Publication Number Publication Date
TN2010000248A1 true TN2010000248A1 (fr) 2011-11-11

Family

ID=40718253

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2010000248A TN2010000248A1 (fr) 2007-12-03 2010-06-01 Derives d'indolinone et procede pour leur fabrication

Country Status (35)

Country Link
US (1) US8067617B2 (fr)
EP (1) EP2229360B1 (fr)
JP (2) JP5933924B2 (fr)
KR (2) KR101712810B1 (fr)
CN (1) CN101883755B (fr)
AR (1) AR069531A1 (fr)
AU (1) AU2008333287B2 (fr)
BR (1) BRPI0819991B1 (fr)
CA (1) CA2705490C (fr)
CL (1) CL2008003599A1 (fr)
CO (1) CO6210751A2 (fr)
CY (1) CY1123333T1 (fr)
DK (1) DK2229360T3 (fr)
EA (1) EA016196B1 (fr)
EC (1) ECSP10010195A (fr)
ES (1) ES2818993T3 (fr)
HR (1) HRP20201480T1 (fr)
HU (1) HUE051550T2 (fr)
IL (1) IL205348A (fr)
LT (1) LT2229360T (fr)
MA (1) MA31989B1 (fr)
MX (1) MX2010005557A (fr)
MY (1) MY148574A (fr)
NZ (1) NZ585798A (fr)
PE (1) PE20091445A1 (fr)
PL (1) PL2229360T3 (fr)
PT (1) PT2229360T (fr)
RS (1) RS60818B1 (fr)
SI (1) SI2229360T1 (fr)
TN (1) TN2010000248A1 (fr)
TW (1) TWI432415B (fr)
UA (1) UA97872C2 (fr)
UY (1) UY31506A1 (fr)
WO (1) WO2009071524A2 (fr)
ZA (1) ZA201002723B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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UY31506A1 (es) * 2007-12-03 2009-08-03 Derivados de indolinona y procedimiento para su preparacion
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2012068441A2 (fr) 2010-11-19 2012-05-24 Ratiopharm Gmbh Sels d'intedanib et leurs formes à l'état solide
CN103787949A (zh) * 2012-10-31 2014-05-14 韩冰 一类保护移植器官的化合物及其用途
US20140350022A1 (en) 2013-05-10 2014-11-27 Boehringer Ingelheim International Gmbh Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
CA3172586C (fr) 2013-07-31 2025-10-14 Avalyn Pharma Inc. Composes d'imatinib en aerosol et utilisations connexes
US20140342772A1 (en) * 2013-09-12 2014-11-20 Bandwidth.Com, Inc. Predictive Caching of IP Data
CN104262232B (zh) * 2014-09-09 2016-05-04 苏州明锐医药科技有限公司 尼泰达尼的制备方法
CN105712923A (zh) * 2014-12-03 2016-06-29 江苏先声药业有限公司 一种尼达尼布杂质及其制备方法与应用
WO2016178064A1 (fr) 2015-05-06 2016-11-10 Suven Life Sciences Limited Polymorphe d'éthanesulfonate de nintedanib, procédés et intermédiaires associés
CN105001143A (zh) * 2015-07-24 2015-10-28 南京正大天晴制药有限公司 一种制备高纯度乙磺酸尼达尼布的方法
WO2017077551A2 (fr) 2015-11-03 2017-05-11 Mylan Laboratories Limited Esylate nintedanib amorphe et sa dispersion solide
CN109415314A (zh) * 2016-05-19 2019-03-01 上海诚妙医药科技有限公司 尼达尼布的新晶型及其制备方法及其用途
CN106543069A (zh) * 2016-09-20 2017-03-29 北京万全德众医药生物技术有限公司 6‑甲氧基羰基‑2‑氧代二氢吲哚的制备
CN108610308A (zh) * 2016-12-09 2018-10-02 上海奥博生物医药技术有限公司 一锅法制备尼达尼布中间体的方法
CN106841495B (zh) * 2017-04-21 2018-05-11 常州佳德医药科技有限公司 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法
WO2019048974A1 (fr) * 2017-09-06 2019-03-14 Glenmark Pharmaceuticals Limited Procédé de préparation de nintédanib
EP3710427B1 (fr) 2017-11-17 2023-03-08 Fermion Oy Synthèse d'un dérivé de 2-indolinone appelé intermédiaire pour la préparation de nintédanib
CN110746378B (zh) * 2018-12-03 2021-11-05 江苏豪森药业集团有限公司 一种胺基中间体的制备方法
CN111377845A (zh) * 2018-12-27 2020-07-07 江苏先声药业有限公司 3-(二甲氨基(苯基)亚甲基)-2-氧化吲哚-6-羧酸甲酯及其制备方法与应用
CN111662223B (zh) * 2019-03-08 2023-07-14 四川科伦药物研究院有限公司 二氢吲哚酮衍生物及其中间体的制备方法
AU2021321561A1 (en) * 2020-08-07 2023-03-09 Bdr Lifesciences Private Limited An improved highly efficient process for the prepration of nintedanib and pharmaceutically acceptable salt thereof
CN116947732A (zh) * 2023-07-28 2023-10-27 江苏阿尔法药业股份有限公司 一种尼达尼布中间体的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4876863A (fr) * 1972-01-22 1973-10-16
US6469181B1 (en) * 1995-01-30 2002-10-22 Catalytica, Inc. Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
PT1115704E (pt) 1998-09-25 2003-11-28 Boehringer Ingelheim Pharma Novas indolinonas substituidas com accao inibidora sobre varias quinases e complexos ciclina/cdk
US7291641B2 (en) * 1999-10-11 2007-11-06 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4623604B2 (ja) * 2006-11-06 2011-02-02 株式会社セラバリューズ 新規なオキシインドール誘導体
AU2008333286B2 (en) * 2007-12-03 2014-08-14 Boehringer Ingelheim International Gmbh Process for the manufacture of an indolinone derivative
UY31506A1 (es) * 2007-12-03 2009-08-03 Derivados de indolinona y procedimiento para su preparacion

Also Published As

Publication number Publication date
AU2008333287A1 (en) 2009-06-11
KR101676261B1 (ko) 2016-11-15
PL2229360T3 (pl) 2020-12-14
IL205348A0 (en) 2010-12-30
EA016196B1 (ru) 2012-03-30
CN101883755A (zh) 2010-11-10
MY148574A (en) 2013-04-30
MA31989B1 (fr) 2011-01-03
BRPI0819991B1 (pt) 2022-02-15
WO2009071524A3 (fr) 2009-10-01
BRPI0819991A2 (pt) 2015-05-12
MX2010005557A (es) 2010-06-01
KR20100097129A (ko) 2010-09-02
EP2229360A2 (fr) 2010-09-22
LT2229360T (lt) 2020-10-12
TWI432415B (zh) 2014-04-01
JP6044025B2 (ja) 2016-12-14
KR101712810B1 (ko) 2017-03-07
US20100311985A1 (en) 2010-12-09
AR069531A1 (es) 2010-01-27
US8067617B2 (en) 2011-11-29
SI2229360T1 (sl) 2020-11-30
HK1145682A1 (en) 2011-04-29
TW200930702A (en) 2009-07-16
UA97872C2 (ru) 2012-03-26
WO2009071524A2 (fr) 2009-06-11
HRP20201480T1 (hr) 2020-12-11
JP2011505346A (ja) 2011-02-24
CA2705490C (fr) 2016-02-02
EA201000883A1 (ru) 2010-12-30
CO6210751A2 (es) 2010-10-20
UY31506A1 (es) 2009-08-03
PE20091445A1 (es) 2009-10-19
EP2229360B1 (fr) 2020-07-01
KR20150116909A (ko) 2015-10-16
ES2818993T3 (es) 2021-04-14
PT2229360T (pt) 2020-09-15
CL2008003599A1 (es) 2010-08-20
JP2015071602A (ja) 2015-04-16
HUE051550T2 (hu) 2021-03-01
IL205348A (en) 2014-06-30
ECSP10010195A (es) 2010-07-30
RS60818B1 (sr) 2020-10-30
JP5933924B2 (ja) 2016-06-15
DK2229360T3 (da) 2020-09-28
CN101883755B (zh) 2013-06-26
NZ585798A (en) 2011-06-30
AU2008333287B2 (en) 2013-12-19
CY1123333T1 (el) 2021-12-31
ZA201002723B (en) 2010-12-29
CA2705490A1 (fr) 2009-06-11

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