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TN2009000178A1 - Substituted pyrazole and triazole compounds as ksp inhibitors - Google Patents

Substituted pyrazole and triazole compounds as ksp inhibitors

Info

Publication number
TN2009000178A1
TN2009000178A1 TNP2009000178A TN2009000178A TN2009000178A1 TN 2009000178 A1 TN2009000178 A1 TN 2009000178A1 TN P2009000178 A TNP2009000178 A TN P2009000178A TN 2009000178 A TN2009000178 A TN 2009000178A TN 2009000178 A1 TN2009000178 A1 TN 2009000178A1
Authority
TN
Tunisia
Prior art keywords
triazole compounds
substituted pyrazole
ksp inhibitors
pharmaceutically acceptable
ksp
Prior art date
Application number
TNP2009000178A
Other languages
English (en)
Inventor
Yi Xia
Kris G Mendenhall
Paul A Barsanti
Annette O Walter
David Duhl
Paul A Renhowe
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2009000178A1 publication Critical patent/TN2009000178A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TNP2009000178A 2006-11-13 2009-05-08 Substituted pyrazole and triazole compounds as ksp inhibitors TN2009000178A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85896406P 2006-11-13 2006-11-13
PCT/US2007/084154 WO2008063912A1 (fr) 2006-11-13 2007-11-08 Composés de pyrazole et de triazole substitués comme inhibiteurs de ksp

Publications (1)

Publication Number Publication Date
TN2009000178A1 true TN2009000178A1 (en) 2010-10-18

Family

ID=39144618

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000178A TN2009000178A1 (en) 2006-11-13 2009-05-08 Substituted pyrazole and triazole compounds as ksp inhibitors

Country Status (32)

Country Link
US (2) US7902240B2 (fr)
EP (1) EP2091926B1 (fr)
JP (1) JP5264755B2 (fr)
KR (1) KR20090081020A (fr)
CN (1) CN101558049B (fr)
AR (1) AR063805A1 (fr)
AU (1) AU2007323998B2 (fr)
BR (1) BRPI0719002A2 (fr)
CA (1) CA2668661A1 (fr)
CL (1) CL2007003272A1 (fr)
CO (1) CO6382171A2 (fr)
CR (1) CR10787A (fr)
DO (1) DOP2009000106A (fr)
EA (1) EA017748B1 (fr)
EC (1) ECSP099326A (fr)
ES (1) ES2557478T3 (fr)
GE (1) GEP20125389B (fr)
GT (1) GT200900122A (fr)
HN (1) HN2009000968A (fr)
IL (1) IL198471A0 (fr)
MA (1) MA30959B1 (fr)
MX (1) MX2009005071A (fr)
NI (1) NI200900084A (fr)
NO (1) NO20092226L (fr)
NZ (1) NZ576640A (fr)
PE (1) PE20081169A1 (fr)
SM (1) SMP200900045B (fr)
TN (1) TN2009000178A1 (fr)
TW (1) TW200831480A (fr)
UA (1) UA97256C2 (fr)
WO (1) WO2008063912A1 (fr)
ZA (1) ZA200902940B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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MX2009005071A (es) * 2006-11-13 2009-05-25 Novartis Ag Compuestos de pirazol y triazol sustituidos como inhibidores de ksp.
JP2010515687A (ja) * 2007-01-05 2010-05-13 ノバルティス アーゲー キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体
WO2011128388A2 (fr) * 2010-04-15 2011-10-20 Novartis Ag Composés d'oxazole et de thiazole comme inhibiteurs de ksp
KR20130100056A (ko) * 2010-04-15 2013-09-09 노파르티스 아게 Ｋｓｐ 억제제로서의 트리아졸 화합물
BR112015012843B8 (pt) * 2012-12-05 2023-04-25 Merck Sharp & Dohme Método para sintetizar o composto
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
JP2016516035A (ja) * 2013-03-15 2016-06-02 ノバルティス アーゲー 細胞増殖阻害剤およびそれらのコンジュゲート
BR112016012658B1 (pt) 2013-12-04 2022-06-21 Merck Sharp & Dohme Corp Métodos para sintetizar inibidores da transcriptase reversa e composto
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
US20190161499A1 (en) * 2015-12-11 2019-05-30 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
CN115210229A (zh) 2020-01-03 2022-10-18 博格有限责任公司 多环酰胺作为治疗癌症的ube2k调节剂

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US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5185450A (en) * 1991-02-19 1993-02-09 University Of South Florida Tetrazolium compounds for cell viability assays
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Also Published As

Publication number Publication date
EP2091926B1 (fr) 2015-10-21
JP2010509365A (ja) 2010-03-25
NI200900084A (es) 2010-01-29
ZA200902940B (en) 2010-05-26
CN101558049A (zh) 2009-10-14
BRPI0719002A2 (pt) 2013-12-17
PE20081169A1 (es) 2008-09-24
AU2007323998B2 (en) 2011-09-22
GEP20125389B (en) 2012-01-25
KR20090081020A (ko) 2009-07-27
AR063805A1 (es) 2009-02-18
US7902240B2 (en) 2011-03-08
AU2007323998A1 (en) 2008-05-29
ECSP099326A (es) 2009-06-30
SMAP200900045A (it) 2009-07-14
US20080200462A1 (en) 2008-08-21
DOP2009000106A (es) 2009-05-31
CA2668661A1 (fr) 2008-05-29
CO6382171A2 (es) 2012-02-15
JP5264755B2 (ja) 2013-08-14
NO20092226L (no) 2009-08-12
HN2009000968A (es) 2011-10-25
CL2007003272A1 (es) 2008-03-24
NZ576640A (en) 2011-10-28
WO2008063912A1 (fr) 2008-05-29
EA200900631A1 (ru) 2009-12-30
TW200831480A (en) 2008-08-01
EA017748B1 (ru) 2013-02-28
CR10787A (es) 2009-07-02
IL198471A0 (en) 2010-02-17
GT200900122A (es) 2011-09-14
US8129358B2 (en) 2012-03-06
MA30959B1 (fr) 2009-12-01
UA97256C2 (ru) 2012-01-25
SMP200900045B (it) 2010-03-01
CN101558049B (zh) 2012-08-15
EP2091926A1 (fr) 2009-08-26
US20100034813A1 (en) 2010-02-11
ES2557478T3 (es) 2016-01-26
MX2009005071A (es) 2009-05-25

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