[go: up one dir, main page]

TN2009000024A1 - Prodrug of cinnamide compound - Google Patents

Prodrug of cinnamide compound

Info

Publication number
TN2009000024A1
TN2009000024A1 TN2009000024A TN2009000024A TN2009000024A1 TN 2009000024 A1 TN2009000024 A1 TN 2009000024A1 TN 2009000024 A TN2009000024 A TN 2009000024A TN 2009000024 A TN2009000024 A TN 2009000024A TN 2009000024 A1 TN2009000024 A1 TN 2009000024A1
Authority
TN
Tunisia
Prior art keywords
prodrug
cinnamide compound
formula
group
cinnamide
Prior art date
Application number
TN2009000024A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Noritaka Kitazawa
Nobuaki Sato
Toshihiko Kaneko
Koichi Ito
Mamoru Takaishi
Ikuo Kushida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of TN2009000024A1 publication Critical patent/TN2009000024A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Seasonings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cultivation Of Plants (AREA)
  • Plural Heterocyclic Compounds (AREA)
TN2009000024A 2006-07-28 2009-01-23 Prodrug of cinnamide compound TN2009000024A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82076106P 2006-07-28 2006-07-28
JP2006206007 2006-07-28
US86925906P 2006-12-08 2006-12-08
JP2006331274 2006-12-08
PCT/JP2007/064637 WO2008013213A1 (fr) 2006-07-28 2007-07-26 Promédicament d'un composé cinnamide

Publications (1)

Publication Number Publication Date
TN2009000024A1 true TN2009000024A1 (en) 2010-08-19

Family

ID=38981524

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000024A TN2009000024A1 (en) 2006-07-28 2009-01-23 Prodrug of cinnamide compound

Country Status (25)

Country Link
US (1) US7737141B2 (fr)
EP (1) EP2048143A4 (fr)
JP (1) JPWO2008013213A1 (fr)
KR (1) KR20090033910A (fr)
AR (1) AR062095A1 (fr)
AU (1) AU2007277729A1 (fr)
CA (1) CA2658037A1 (fr)
CO (1) CO6150153A2 (fr)
CR (1) CR10499A (fr)
EA (1) EA200970172A1 (fr)
EC (1) ECSP099091A (fr)
GE (1) GEP20115176B (fr)
HN (1) HN2009000157A (fr)
IL (1) IL196351A0 (fr)
MA (1) MA30636B1 (fr)
MX (1) MX2008015504A (fr)
MY (1) MY144971A (fr)
NO (1) NO20090541L (fr)
NZ (1) NZ574102A (fr)
PE (1) PE20080281A1 (fr)
SA (1) SA07280403B1 (fr)
SV (1) SV2009003157A (fr)
TN (1) TN2009000024A1 (fr)
TW (1) TW200821319A (fr)
WO (1) WO2008013213A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY149038A (en) * 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
ES2338904T3 (es) * 2004-10-26 2010-05-13 EISAI R&D MANAGEMENT CO., LTD. Forma amorfa de compuestos de cinamida.
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
JPWO2007058305A1 (ja) * 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体の製造方法
TWI370130B (en) * 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
JP5221144B2 (ja) * 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
PE20081791A1 (es) * 2007-02-28 2009-02-07 Eisai Randd Man Co Ltd Dos derivados ciclicos de oxomorfolina
CA2687262A1 (fr) * 2007-05-16 2008-11-20 Naoyuki Shimomura Procede de production monotope pour un derive de cinnamide
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
AR068121A1 (es) 2007-08-31 2009-11-04 Eisai R&D Man Co Ltd Compuestos multiciclicos para tratar enfermedades neurodegenerativas
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
KR101204213B1 (ko) 2007-12-21 2012-11-26 에프. 호프만-라 로슈 아게 오렉신 수용체 길항제로서의 헤테로아릴 유도체
ES2375919T3 (es) 2008-01-11 2012-03-07 F. Hoffmann-La Roche Ag Moduladores de beta-amiloide.
CA2712095A1 (fr) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Composes cristallins de cinnamide ou sels de ceux-ci
CN101952275B (zh) 2008-02-22 2014-06-18 弗·哈夫曼-拉罗切有限公司 β-淀粉样蛋白的调节剂
MX2011003246A (es) 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
BRPI0921348A2 (pt) 2008-11-10 2019-09-24 Hoffmann La Roche moduladores heterocíclicos da gama secretase
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US9018253B2 (en) 2010-07-02 2015-04-28 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
EP2590936B1 (fr) * 2010-07-02 2018-12-12 Bio-Pharm Solutions Co., Ltd. Composé de phénylcarbamate et relaxant musculaire le contenant
CN103282346B (zh) 2011-01-13 2014-11-19 比皮艾思药物研发有限公司 用于制备苯基氨基甲酸酯衍生物的方法
US8901066B2 (en) 2011-06-15 2014-12-02 Basf Se Branched polyesters with sulfonate groups
MX341198B (es) 2011-06-15 2016-08-11 Basf Se Poliesteres ramificados con grupos sulfonato.
MX353024B (es) * 2011-12-27 2017-12-18 Bio Pharm Solutions Co Ltd Compuestos de fenil carbamato para uso en la prevencion o tratamiento de epilepsia.
ES2998534T3 (en) 2013-03-12 2025-02-20 Bio Pharm Solutions Co Ltd Phenyl carbamate compounds for use in preventing or treating pediatric epilesy
CN105209430B (zh) * 2013-03-12 2019-09-13 比皮艾思药物研发有限公司 苯基氨基甲酸酯化合物及包含其的神经保护组合物
JP7208137B2 (ja) * 2016-12-09 2023-01-18 デナリ セラピューティクス インコーポレイテッド 化合物、組成物および方法
CN110143935B (zh) * 2019-06-03 2022-09-30 华侨大学 一种2,5-二取代呋喃衍生物的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2061432T3 (es) * 1985-10-09 1994-12-16 Shell Int Research Nuevas amidas de acido acrilico.
DE3541716A1 (de) 1985-11-26 1987-05-27 Celamerck Gmbh & Co Kg Neue acrylsaeureamide
JPH03206042A (ja) 1990-01-06 1991-09-09 Takeda Chem Ind Ltd 降圧剤
CA2050591A1 (fr) * 1990-02-08 1991-08-09 Hitoshi Oinuma Derives de benzenesulfonamide
JPH05194517A (ja) 1992-01-16 1993-08-03 Tanabe Seiyaku Co Ltd 6−メルカプトプリン誘導体及びその製法
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
EP0784612A1 (fr) 1994-10-04 1997-07-23 Fujisawa Pharmaceutical Co., Ltd. Derives d'uree et leur utilisation comme inhibiteurs de l'acat
JPH08283219A (ja) 1995-04-07 1996-10-29 Eisai Co Ltd アラルキルアミノアルキルアミド誘導体
HUP9901478A3 (en) * 1996-05-10 1999-11-29 Icos Corp Bothell Carboline derivatives, their use, production thereof and medicaments containing the same
WO1998003166A1 (fr) 1996-07-22 1998-01-29 Monsanto Company Inhibiteurs de metalloproteases a base de sulfonamide de thiol
JP2001508767A (ja) 1996-12-02 2001-07-03 藤沢薬品工業株式会社 5―ht拮抗作用を有するインドール―ウレア誘導体
JP3108997B2 (ja) 1997-03-31 2000-11-13 武田薬品工業株式会社 アゾール化合物、その製造法および用途
KR20010005792A (ko) 1997-03-31 2001-01-15 다케다 야쿠힌 고교 가부시키가이샤 아졸 화합물, 이의 제조 방법 및 용도
CA2317008C (fr) 1997-12-31 2009-01-20 The University Of Kansas Remedes contenant des precurseurs hydrosolubles d'amines tertiaires et leurs procedes d'obtention
GB9816984D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
US6235728B1 (en) * 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
WO2000050391A1 (fr) 1999-02-26 2000-08-31 Merck & Co., Inc. Nouveaux composes de sulfonamide et utilisations correspondantes
US7053087B1 (en) * 1999-03-04 2006-05-30 Cardiome Pharma Corp. Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
WO2001068585A1 (fr) 2000-03-14 2001-09-20 Fujisawa Pharmaceutical Co., Ltd. Nouveaux composes amides
US20010051642A1 (en) * 2000-04-17 2001-12-13 Kyunghye Ahn Method for treating Alzheimer's disease
CA2405170A1 (fr) 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Methode de traitement se basant sur l'utilisation de derives de phenyle et de biaryle comme inhibiteurs de prostaglandine e
SK8402003A3 (en) * 2000-12-04 2004-04-06 Hoffmann La Roche Phenylethenyl or phenylethinyl derivatives as glutamate receptor or antagonists
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
PL373484A1 (en) 2001-12-10 2005-09-05 Amgen Inc. Vanilloid receptor ligands and their use in treatments
SI1465861T1 (sl) 2001-12-20 2009-12-31 Bristol Myers Squibb Co Alfa-(n-sulfonamido)acetamidni derivati kot beta-amiloid inhibitorji
JP2003206280A (ja) 2001-12-28 2003-07-22 Takeda Chem Ind Ltd ビアリール化合物およびその用途
DE10211101A1 (de) 2002-03-14 2003-09-25 Basf Ag Katalysatoren und Verfahren zur Herstellung von Aminen
GB0207436D0 (en) 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
WO2003099284A1 (fr) * 2002-05-22 2003-12-04 Amgen Inc. Amino-pyridine, derives de pyridine et de pyridazine utilises comme ligands de recepteur vanilloide permettant de traiter une douleur
DK1511710T3 (en) 2002-05-31 2014-02-24 Proteotech Inc RELATIONSHIPS, PREPARATIONS AND METHODS FOR TREATING AMYLOID DISEASES AND SYNUCLEINOPATHES, SUCH AS ALZHEIMER'S DISEASE, TYPE 2-DIABETES AND PARKINSON'S DISEASE
CN1304371C (zh) 2002-07-12 2007-03-14 塞诺菲-安万特德国有限公司 杂环取代的苯甲酰脲、其药物和制备药物的用途
US6900354B2 (en) * 2002-07-15 2005-05-31 Hoffman-La Roche Inc. 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives
CA2514363A1 (fr) * 2003-02-12 2004-08-26 Transtech Pharma, Inc. Utilisation de derives d'azoles substitues en tant qu'agents therapeutiques
CA2525547C (fr) * 2003-05-14 2012-07-03 Torreypines Therapeutics, Inc. Composes et leurs utilisations pour la modulation de l'amyloide-beta
AU2004268621C1 (en) * 2003-08-29 2011-08-18 Exelixis, Inc. c-Kit modulators and methods of use
GEP20084571B (en) 2003-12-22 2008-12-25 Pfizer Triazole derivatives as vasopressin antagonists
NZ548208A (en) * 2004-02-12 2010-09-30 Transtech Pharma Inc Substituted azole derivatives, compositions, and methods of use
MY149038A (en) * 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
ES2338904T3 (es) 2004-10-26 2010-05-13 EISAI R&D MANAGEMENT CO., LTD. Forma amorfa de compuestos de cinamida.
US20060241038A1 (en) 2005-04-20 2006-10-26 Eisai Co., Ltd. Therapeutic agent for Abeta related disorders
WO2007034282A2 (fr) 2005-09-19 2007-03-29 Pfizer Products Inc. Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a
JPWO2007058305A1 (ja) * 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体の製造方法
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
JP5221144B2 (ja) 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP1992618B1 (fr) 2006-03-09 2012-01-18 Eisai R&D Management Co., Ltd. Dérivé polycyclique de cinnamide
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
EP2117311A4 (fr) 2007-02-08 2011-05-11 Merck Sharp & Dohme Agents thérapeutiques
RU2009144998A (ru) 2007-05-07 2011-06-20 Шеринг Корпорейшн (US) Модуляторы гамма-секретазы
RU2009140182A (ru) * 2007-05-11 2011-06-20 Ф. Хоффманн-Ля Рош Аг (Ch) Гетариланилины в качестве модуляторов для бета-амилоида
EP2166854A4 (fr) 2007-06-13 2012-05-16 Merck Sharp & Dohme Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés
MX2010001506A (es) 2007-08-06 2010-03-10 Schering Corp Moduladores de gamma secretasa.

Also Published As

Publication number Publication date
SA07280403B1 (ar) 2010-12-01
GEP20115176B (en) 2011-03-10
EP2048143A1 (fr) 2009-04-15
NZ574102A (en) 2010-10-29
CR10499A (es) 2009-03-20
EA200970172A1 (ru) 2009-08-28
HN2009000157A (es) 2011-01-24
EP2048143A4 (fr) 2010-11-03
US20090048213A1 (en) 2009-02-19
US7737141B2 (en) 2010-06-15
NO20090541L (no) 2009-02-03
CA2658037A1 (fr) 2008-01-31
MX2008015504A (es) 2008-12-18
MA30636B1 (fr) 2009-08-03
WO2008013213A1 (fr) 2008-01-31
SV2009003157A (es) 2010-01-12
JPWO2008013213A1 (ja) 2009-12-17
TW200821319A (en) 2008-05-16
PE20080281A1 (es) 2008-05-05
IL196351A0 (en) 2009-09-22
ECSP099091A (es) 2009-02-27
AR062095A1 (es) 2008-10-15
KR20090033910A (ko) 2009-04-06
MY144971A (en) 2011-11-30
AU2007277729A1 (en) 2008-01-31
CO6150153A2 (es) 2010-04-20

Similar Documents

Publication Publication Date Title
TN2009000024A1 (en) Prodrug of cinnamide compound
NZ592497A (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
IN2014CN00613A (fr)
WO2008108378A3 (fr) Dérivé bicyclique d'oxomorpholine
MX2011009354A (es) Compuesto de piridazinona y su uso.
AU2008303600A8 (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
TW200732306A (en) Pyrimidine derivatives
TNSN08407A1 (en) Organic compounds
MX2010001773A (es) Metodo para preparar derivados de 5-haloalquil-4,5-dihidroisoxasol .
WO2008114817A1 (fr) Nouveau composé d'adénine
MY148703A (en) Polycyclic cinnamide derivatives
MY172034A (en) Intermediate for producing bicyclic ?-amino acid derivative
UA105185C2 (uk) Піроли
WO2007081571A3 (fr) Inhibiteurs de cetp
WO2007133352A3 (fr) Inhibiteurs de kinase macrocycliques
WO2009069736A1 (fr) Composé azoté
WO2008105058A1 (fr) Sulfamides
TW200745034A (en) New compounds
SG170049A1 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
MX2010001344A (es) Compuesto de acido fenilacetico.
WO2006113509A3 (fr) Analogues de quinobenzoxazines et procedes d'utilisation de ceux-ci
MY159183A (en) 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
MY149400A (en) Bridged six-membered ring compounds
ATE500212T1 (de) Bisphenol monoester
MX2010010471A (es) Derivado de tetrahidroisoquinolina novedoso.