TN2009000070A1 - Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors - Google Patents

Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors

Info

Publication number: TN2009000070A1
Authority: TN; Tunisia
Prior art keywords: treatment; disease; compounds; oxazolopyridines; benzoxazoles
Prior art date: 2006-09-15

Application number

TN2009000070A

Other languages

English (en)

Inventor

Marc Gerspacher

Pascal Furet

Eric Vangrevelinghe

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-15

Filing date

2009-02-27

Publication date

2010-08-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37717673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000070(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-02-27 Application filed by Novartis Ag filed Critical Novartis Ag

2010-08-19 Publication of TN2009000070A1 publication Critical patent/TN2009000070A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

TN2009000070A 2006-09-15 2009-02-27 Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors TN2009000070A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06120733A EP1900729A1 (fr)	2006-09-15	2006-09-15	Benzoxazoles et oxazolopyridines et leur utilisation comme inhibiteurs de Janus kinases
PCT/EP2007/007983 WO2008031594A1 (fr)	2006-09-15	2007-09-13	Benzoxazoles et oxazolopyridines utiles en tant qu'inhibiteurs des janus kinases

Publications (1)

Publication Number	Publication Date
TN2009000070A1 true TN2009000070A1 (en)	2010-08-19

Family

ID=37717673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2009000070A TN2009000070A1 (en)	2006-09-15	2009-02-27	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors

Country Status (30)

Country	Link
US (1)	US8629168B2 (fr)
EP (2)	EP1900729A1 (fr)
JP (1)	JP5325105B2 (fr)
KR (1)	KR20090064389A (fr)
CN (1)	CN101516860B (fr)
AR (1)	AR062786A1 (fr)
AT (1)	ATE532774T1 (fr)
AU (1)	AU2007296916B2 (fr)
BR (1)	BRPI0716841A2 (fr)
CA (1)	CA2660987A1 (fr)
CL (1)	CL2007002669A1 (fr)
CO (1)	CO6150142A2 (fr)
CR (1)	CR10639A (fr)
EA (1)	EA200900388A1 (fr)
ES (1)	ES2377148T3 (fr)
GT (1)	GT200900056A (fr)
IL (1)	IL196860A0 (fr)
MA (1)	MA30723B1 (fr)
MX (1)	MX2009002812A (fr)
NO (1)	NO20091469L (fr)
PA (1)	PA8748101A1 (fr)
PE (1)	PE20080842A1 (fr)
PL (1)	PL2066647T3 (fr)
PT (1)	PT2066647E (fr)
SM (1)	SMP200900023B (fr)
TN (1)	TN2009000070A1 (fr)
TW (1)	TW200819444A (fr)
UY (1)	UY30587A1 (fr)
WO (1)	WO2008031594A1 (fr)
ZA (1)	ZA200900477B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2467670B (en)	2007-10-04	2012-08-01	Intellikine Inc	Chemical entities and therapeutic uses thereof
US8993580B2 (en)	2008-03-14	2015-03-31	Intellikine Llc	Benzothiazole kinase inhibitors and methods of use
AU2009268611B2 (en)	2008-07-08	2015-04-09	Intellikine, Llc	Kinase inhibitors and methods of use
JP5449346B2 (ja) *	2008-07-15	2014-03-19	サノフイ	Ｅｄｇ−１受容体アゴニストとしてのオキサゾロピリミジン類
EP2323978A1 (fr) *	2008-08-12	2011-05-25	Takeda Pharmaceutical Company Limited	Composé amide
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
KR101361027B1 (ko)	2008-11-28	2014-02-11	코와 가부시키가이샤	피리딘-3-카르복시아미드 유도체
EP2518054A1 (fr)	2009-12-24	2012-10-31	Takeda Pharmaceutical Company Limited	Composé amide
AR079980A1 (es) *	2010-01-13	2012-03-07	Sanofi Aventis	Derivados de oxazolopirimidina sustituida en 2,5,7
CA2828483A1 (fr)	2011-02-23	2012-11-01	Intellikine, Llc	Combinaison d'inhibiteurs des kinases et utilisations associees
US8907093B2 (en) *	2011-07-07	2014-12-09	Sanofi	Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring
US8580816B2 (en) *	2011-07-07	2013-11-12	Sanofi	Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring
CN103102359B (zh) *	2011-11-15	2016-11-09	江苏先声药业有限公司	嘧啶类化合物及其应用
MX2014006479A (es)	2011-11-30	2015-01-22	Univ Emory	Inhibidores antivirales de la janus cinasa utiles en el tratamiento o prevencion de infecciones retrovirales y otras infecciones virales.
WO2014075318A1 (fr) *	2012-11-19	2014-05-22	江苏先声药业有限公司	Composés de pyrimidine et utilisation associée
JP6360881B2 (ja)	2013-03-22	2018-07-18	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ
CN103664759A (zh) *	2013-12-06	2014-03-26	常熟市联创化学有限公司	一种3-羟基-2-硝基吡啶的制备方法
DK3102195T3 (da)	2014-02-03	2021-12-20	Quadriga Biosciences Inc	Beta-substituerede beta-aminosyrer og analoger som kemoterapeutiske midler
BR112016017993A2 (pt)	2014-02-03	2017-08-08	Quadriga Biosciences Inc	Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
WO2016047678A1 (fr) *	2014-09-25	2016-03-31	武田薬品工業株式会社	Composé hétérocyclique
EP3331851A1 (fr)	2015-08-03	2018-06-13	Quadriga Biosciences, Inc.	Acides bêta-aminés substitués en bêta et analogues à utiliser en tant qu'agents de chimiothérapie et leurs utilisations
WO2021062163A1 (fr)	2019-09-27	2021-04-01	Disc Medicine, Inc.	Procédés de traitement de la myélofibrose et d'affections associées
CA3177830A1 (fr)	2020-05-13	2021-11-18	Maria BECONI	Anticorps anti-hemojuveline (hjv) pour le traitement de la myelofibrose
WO2022251597A1 (fr)	2021-05-28	2022-12-01	Verge Analytics, Inc.	Méthodes de traitement de troubles neurologiques avec des modulateurs de la protéine ribosomale s6 kinase alpha-1 (rsk1) et de la protéine ribosomale s6 kinase alpha-3 (rsk2)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1382339E (pt) *	1999-12-10	2008-02-06	Pfizer Prod Inc	Composições que contêm derivados de pirrolo[2,3-d]- pirimidina
SE0301373D0 (sv) *	2003-05-09	2003-05-09	Astrazeneca Ab	Novel compounds
DE10344223A1 (de) *	2003-09-24	2005-04-21	Merck Patent Gmbh	1,3-Benzoxazolylderivate als Kinase-Inhibitoren
GB0402140D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
EP1674467A1 (fr) *	2004-12-22	2006-06-28	4Sc Ag	Derives benzazoles 2,5- et 2,6-disubstitues utiles comme des inhibiteurs de la proteine kinase
CN101253171B (zh)	2005-09-02	2011-06-15	霍夫曼-拉罗奇有限公司	苯并噁唑、噁唑并吡啶、苯并噻唑和噻唑并吡啶衍生物
RU2009105826A (ru) *	2006-07-21	2010-08-27	Новартис АГ (CH)	2,4-ди(ариламино)питимидин-5-карбоксамидные соединения в качестве ингибиторов jak-киназ

2006
- 2006-09-15 EP EP06120733A patent/EP1900729A1/fr not_active Ceased
2007
- 2007-09-12 UY UY30587A patent/UY30587A1/es not_active Application Discontinuation
- 2007-09-13 WO PCT/EP2007/007983 patent/WO2008031594A1/fr not_active Ceased
- 2007-09-13 AU AU2007296916A patent/AU2007296916B2/en not_active Ceased
- 2007-09-13 PL PL07802300T patent/PL2066647T3/pl unknown
- 2007-09-13 PE PE2007001237A patent/PE20080842A1/es not_active Application Discontinuation
- 2007-09-13 EP EP07802300A patent/EP2066647B1/fr active Active
- 2007-09-13 MX MX2009002812A patent/MX2009002812A/es active IP Right Grant
- 2007-09-13 BR BRPI0716841-1A2A patent/BRPI0716841A2/pt not_active IP Right Cessation
- 2007-09-13 ES ES07802300T patent/ES2377148T3/es active Active
- 2007-09-13 KR KR1020097005248A patent/KR20090064389A/ko not_active Withdrawn
- 2007-09-13 CN CN2007800339907A patent/CN101516860B/zh not_active Expired - Fee Related
- 2007-09-13 AR ARP070104060A patent/AR062786A1/es unknown
- 2007-09-13 US US12/440,298 patent/US8629168B2/en not_active Expired - Fee Related
- 2007-09-13 AT AT07802300T patent/ATE532774T1/de active
- 2007-09-13 PT PT07802300T patent/PT2066647E/pt unknown
- 2007-09-13 EA EA200900388A patent/EA200900388A1/ru unknown
- 2007-09-13 CA CA002660987A patent/CA2660987A1/fr not_active Abandoned
- 2007-09-13 JP JP2009527741A patent/JP5325105B2/ja not_active Expired - Fee Related
- 2007-09-14 TW TW096134606A patent/TW200819444A/zh unknown
- 2007-09-14 CL CL200702669A patent/CL2007002669A1/es unknown
- 2007-09-14 PA PA20078748101A patent/PA8748101A1/es unknown
2009
- 2009-01-21 ZA ZA200900477A patent/ZA200900477B/xx unknown
- 2009-02-02 IL IL196860A patent/IL196860A0/en unknown
- 2009-02-26 CR CR10639A patent/CR10639A/es not_active Application Discontinuation
- 2009-02-27 TN TN2009000070A patent/TN2009000070A1/fr unknown
- 2009-03-10 CO CO09024347A patent/CO6150142A2/es unknown
- 2009-03-11 GT GT200900056A patent/GT200900056A/es unknown
- 2009-03-30 MA MA31738A patent/MA30723B1/fr unknown
- 2009-04-09 SM SM200900023T patent/SMP200900023B/it unknown
- 2009-04-15 NO NO20091469A patent/NO20091469L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AR062786A1 (es)	2008-12-03
NO20091469L (no)	2009-04-15
IL196860A0 (en)	2009-11-18
JP5325105B2 (ja)	2013-10-23
SMP200900023B (it)	2009-07-14
ATE532774T1 (de)	2011-11-15
CR10639A (es)	2009-07-03
JP2010503629A (ja)	2010-02-04
UY30587A1 (es)	2008-05-02
EP2066647B1 (fr)	2011-11-09
AU2007296916B2 (en)	2011-10-06
CL2007002669A1 (es)	2008-05-09
TW200819444A (en)	2008-05-01
CN101516860A (zh)	2009-08-26
PT2066647E (pt)	2012-01-17
MX2009002812A (es)	2009-03-31
PA8748101A1 (es)	2009-08-26
US20100009978A1 (en)	2010-01-14
EA200900388A1 (ru)	2009-08-28
WO2008031594A1 (fr)	2008-03-20
EP2066647A1 (fr)	2009-06-10
GT200900056A (es)	2011-11-08
CN101516860B (zh)	2012-06-27
AU2007296916A1 (en)	2008-03-20
BRPI0716841A2 (pt)	2013-10-01
ZA200900477B (en)	2010-01-27
PL2066647T3 (pl)	2012-04-30
CO6150142A2 (es)	2010-04-20
US8629168B2 (en)	2014-01-14
PE20080842A1 (es)	2008-08-11
EP1900729A1 (fr)	2008-03-19
KR20090064389A (ko)	2009-06-18
SMAP200900023A (it)	2009-05-11
ES2377148T3 (es)	2012-03-22
CA2660987A1 (fr)	2008-03-20
MA30723B1 (fr)	2009-09-01

Publication	Publication Date	Title
TN2009000070A1 (en)	2010-08-19	Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors
EA200970611A1 (ru)	2009-12-30	Замещенные пиразолохиназолиновые производные, способ их получения и их применение в качестве ингибиторов киназы
EA200501849A1 (ru)	2006-06-30	Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
TW200615266A (en)	2006-05-16	Organic compounds
EP1973407A4 (fr)	2010-09-15	Composes spiro et procedes d utilisation
SI2324008T1 (sl)	2012-08-31	3,4-diarilpirazoli kot protein-kinazni inhibitorji
NO20060113L (no)	2006-04-05	Pyrrolo(3,4-c)pyrazolderivater aktive som kinase inhibitorer
MX2008012422A (es)	2008-10-09	Derivados de furano y tiofeno, pirrol substituido con pirimidinil y piridil como inhibidores de cinasa.
IL181987A0 (en)	2007-07-04	Diaminotriazole derivatives and pharmaceutical compositions containing the same
MXPA06000302A (es)	2006-04-18	Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.
NO20072259L (no)	2007-06-06	Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer
NO20063758L (no)	2006-10-23	Pyrazolo[1,5-A]pyrimidin-7-yl-amin derivater for anvendelse i behandling av proteinkinase avhengige sykdommer
EA201000552A1 (ru)	2010-12-30	Производные пирроло[2,3-d]пиримидина в качестве ингибиторов протеинкиназы в
PL1896470T3 (pl)	2011-03-31	Pochodne pirolopirydynowe jako inhibitory kinazy białkowej
MXPA05013712A (es)	2006-03-08	Derivados de acido propionico, utiles en el tratamiento de trastornos de lipidos.
MX2010006748A (es)	2010-08-18	Pirazolo[1,5-a]pirimidinas utiles como inhibidores de jak2.
TW200634012A (en)	2006-10-01	3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents
AU2009282962A8 (en)	2011-11-10	Compounds as kinase inhibitors
BRPI0413438A (pt)	2006-10-17	derivados de pirimidilpirrol ativos como inibidores de cinase
MX2007004248A (es)	2007-06-12	Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa.
UA102219C2 (ru)	2013-06-25	Замещенные пиразолохиназолиновые производные, способ их получения и их применения как ингибиторов киназы
TW200745136A (en)	2007-12-16	4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
TW200502236A (en)	2005-01-16	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
DE602006019830D1 (de)	2011-03-10	Tetrahydro- und dihydrochinazolinone
GB0229022D0 (en)	2003-01-15	Organic Compounds