CL2007002669A1 - Compuestos derivados de benzoxazol-2,7-disustituido y oxazol[5,4-c]-piridina; proceso de fabricacion; composicion farmaceutica; y uso en el tratamiento de una enfermedad mediada por las cinasas jack2 y/o jack3 tal como cancer. - Google Patents

Compuestos derivados de benzoxazol-2,7-disustituido y oxazol[5,4-c]-piridina; proceso de fabricacion; composicion farmaceutica; y uso en el tratamiento de una enfermedad mediada por las cinasas jack2 y/o jack3 tal como cancer.

Info

Publication number: CL2007002669A1
Authority: CL; Chile
Prior art keywords: jack3; jack2; disustituted; piridina; benzoxazol
Prior art date: 2006-09-15

Application number

CL200702669A

Other languages

English (en)

Inventor

Marc Furet Pascal Y Gerspacher

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-15

Filing date

2007-09-14

Publication date

2008-05-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37717673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007002669(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-09-14 Application filed by Novartis Ag filed Critical Novartis Ag

2008-05-09 Publication of CL2007002669A1 publication Critical patent/CL2007002669A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

CL200702669A 2006-09-15 2007-09-14 Compuestos derivados de benzoxazol-2,7-disustituido y oxazol[5,4-c]-piridina; proceso de fabricacion; composicion farmaceutica; y uso en el tratamiento de una enfermedad mediada por las cinasas jack2 y/o jack3 tal como cancer. CL2007002669A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06120733A EP1900729A1 (en)	2006-09-15	2006-09-15	Benzoxazoles and oxazolopyridines being useful as Janus kinases inhibitors

Publications (1)

Publication Number	Publication Date
CL2007002669A1 true CL2007002669A1 (es)	2008-05-09

Family

ID=37717673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200702669A CL2007002669A1 (es)	2006-09-15	2007-09-14	Compuestos derivados de benzoxazol-2,7-disustituido y oxazol[5,4-c]-piridina; proceso de fabricacion; composicion farmaceutica; y uso en el tratamiento de una enfermedad mediada por las cinasas jack2 y/o jack3 tal como cancer.

Country Status (30)

Country	Link
US (1)	US8629168B2 (es)
EP (2)	EP1900729A1 (es)
JP (1)	JP5325105B2 (es)
KR (1)	KR20090064389A (es)
CN (1)	CN101516860B (es)
AR (1)	AR062786A1 (es)
AT (1)	ATE532774T1 (es)
AU (1)	AU2007296916B2 (es)
BR (1)	BRPI0716841A2 (es)
CA (1)	CA2660987A1 (es)
CL (1)	CL2007002669A1 (es)
CO (1)	CO6150142A2 (es)
CR (1)	CR10639A (es)
EA (1)	EA200900388A1 (es)
ES (1)	ES2377148T3 (es)
GT (1)	GT200900056A (es)
IL (1)	IL196860A0 (es)
MA (1)	MA30723B1 (es)
MX (1)	MX2009002812A (es)
NO (1)	NO20091469L (es)
PA (1)	PA8748101A1 (es)
PE (1)	PE20080842A1 (es)
PL (1)	PL2066647T3 (es)
PT (1)	PT2066647E (es)
SM (1)	SMP200900023B (es)
TN (1)	TN2009000070A1 (es)
TW (1)	TW200819444A (es)
UY (1)	UY30587A1 (es)
WO (1)	WO2008031594A1 (es)
ZA (1)	ZA200900477B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2467670B (en)	2007-10-04	2012-08-01	Intellikine Inc	Chemical entities and therapeutic uses thereof
US8993580B2 (en)	2008-03-14	2015-03-31	Intellikine Llc	Benzothiazole kinase inhibitors and methods of use
AU2009268611B2 (en)	2008-07-08	2015-04-09	Intellikine, Llc	Kinase inhibitors and methods of use
JP5449346B2 (ja) *	2008-07-15	2014-03-19	サノフイ	Ｅｄｇ−１受容体アゴニストとしてのオキサゾロピリミジン類
EP2323978A1 (en) *	2008-08-12	2011-05-25	Takeda Pharmaceutical Company Limited	Amide compound
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
KR101361027B1 (ko)	2008-11-28	2014-02-11	코와 가부시키가이샤	피리딘-3-카르복시아미드 유도체
EP2518054A1 (en)	2009-12-24	2012-10-31	Takeda Pharmaceutical Company Limited	Amide compound
AR079980A1 (es) *	2010-01-13	2012-03-07	Sanofi Aventis	Derivados de oxazolopirimidina sustituida en 2,5,7
CA2828483A1 (en)	2011-02-23	2012-11-01	Intellikine, Llc	Combination of kinase inhibitors and uses thereof
US8907093B2 (en) *	2011-07-07	2014-12-09	Sanofi	Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring
US8580816B2 (en) *	2011-07-07	2013-11-12	Sanofi	Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring
CN103102359B (zh) *	2011-11-15	2016-11-09	江苏先声药业有限公司	嘧啶类化合物及其应用
MX2014006479A (es)	2011-11-30	2015-01-22	Univ Emory	Inhibidores antivirales de la janus cinasa utiles en el tratamiento o prevencion de infecciones retrovirales y otras infecciones virales.
WO2014075318A1 (zh) *	2012-11-19	2014-05-22	江苏先声药业有限公司	嘧啶类化合物及其应用
JP6360881B2 (ja)	2013-03-22	2018-07-18	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ
CN103664759A (zh) *	2013-12-06	2014-03-26	常熟市联创化学有限公司	一种3-羟基-2-硝基吡啶的制备方法
DK3102195T3 (da)	2014-02-03	2021-12-20	Quadriga Biosciences Inc	Beta-substituerede beta-aminosyrer og analoger som kemoterapeutiske midler
BR112016017993A2 (pt)	2014-02-03	2017-08-08	Quadriga Biosciences Inc	Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
WO2016047678A1 (ja) *	2014-09-25	2016-03-31	武田薬品工業株式会社	複素環化合物
EP3331851A1 (en)	2015-08-03	2018-06-13	Quadriga Biosciences, Inc.	Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
WO2021062163A1 (en)	2019-09-27	2021-04-01	Disc Medicine, Inc.	Methods for treating myelofibrosis and related conditions
CA3177830A1 (en)	2020-05-13	2021-11-18	Maria BECONI	Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
WO2022251597A1 (en)	2021-05-28	2022-12-01	Verge Analytics, Inc.	Methods of treating neurological disorders with modulators of ribosomal protein s6 kinase alpha-1 (rsk1) and ribosomal protein s6 kinase alpha-3 (rsk2)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1382339E (pt) *	1999-12-10	2008-02-06	Pfizer Prod Inc	Composições que contêm derivados de pirrolo[2,3-d]- pirimidina
SE0301373D0 (sv) *	2003-05-09	2003-05-09	Astrazeneca Ab	Novel compounds
DE10344223A1 (de) *	2003-09-24	2005-04-21	Merck Patent Gmbh	1,3-Benzoxazolylderivate als Kinase-Inhibitoren
GB0402140D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
EP1674467A1 (en) *	2004-12-22	2006-06-28	4Sc Ag	2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
CN101253171B (zh)	2005-09-02	2011-06-15	霍夫曼-拉罗奇有限公司	苯并噁唑、噁唑并吡啶、苯并噻唑和噻唑并吡啶衍生物
RU2009105826A (ru) *	2006-07-21	2010-08-27	Новартис АГ (CH)	2,4-ди(ариламино)питимидин-5-карбоксамидные соединения в качестве ингибиторов jak-киназ

2006
- 2006-09-15 EP EP06120733A patent/EP1900729A1/en not_active Ceased
2007
- 2007-09-12 UY UY30587A patent/UY30587A1/es not_active Application Discontinuation
- 2007-09-13 WO PCT/EP2007/007983 patent/WO2008031594A1/en not_active Ceased
- 2007-09-13 AU AU2007296916A patent/AU2007296916B2/en not_active Ceased
- 2007-09-13 PL PL07802300T patent/PL2066647T3/pl unknown
- 2007-09-13 PE PE2007001237A patent/PE20080842A1/es not_active Application Discontinuation
- 2007-09-13 EP EP07802300A patent/EP2066647B1/en active Active
- 2007-09-13 MX MX2009002812A patent/MX2009002812A/es active IP Right Grant
- 2007-09-13 BR BRPI0716841-1A2A patent/BRPI0716841A2/pt not_active IP Right Cessation
- 2007-09-13 ES ES07802300T patent/ES2377148T3/es active Active
- 2007-09-13 KR KR1020097005248A patent/KR20090064389A/ko not_active Withdrawn
- 2007-09-13 CN CN2007800339907A patent/CN101516860B/zh not_active Expired - Fee Related
- 2007-09-13 AR ARP070104060A patent/AR062786A1/es unknown
- 2007-09-13 US US12/440,298 patent/US8629168B2/en not_active Expired - Fee Related
- 2007-09-13 AT AT07802300T patent/ATE532774T1/de active
- 2007-09-13 PT PT07802300T patent/PT2066647E/pt unknown
- 2007-09-13 EA EA200900388A patent/EA200900388A1/ru unknown
- 2007-09-13 CA CA002660987A patent/CA2660987A1/en not_active Abandoned
- 2007-09-13 JP JP2009527741A patent/JP5325105B2/ja not_active Expired - Fee Related
- 2007-09-14 TW TW096134606A patent/TW200819444A/zh unknown
- 2007-09-14 CL CL200702669A patent/CL2007002669A1/es unknown
- 2007-09-14 PA PA20078748101A patent/PA8748101A1/es unknown
2009
- 2009-01-21 ZA ZA200900477A patent/ZA200900477B/xx unknown
- 2009-02-02 IL IL196860A patent/IL196860A0/en unknown
- 2009-02-26 CR CR10639A patent/CR10639A/es not_active Application Discontinuation
- 2009-02-27 TN TN2009000070A patent/TN2009000070A1/fr unknown
- 2009-03-10 CO CO09024347A patent/CO6150142A2/es unknown
- 2009-03-11 GT GT200900056A patent/GT200900056A/es unknown
- 2009-03-30 MA MA31738A patent/MA30723B1/fr unknown
- 2009-04-09 SM SM200900023T patent/SMP200900023B/it unknown
- 2009-04-15 NO NO20091469A patent/NO20091469L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AR062786A1 (es)	2008-12-03
NO20091469L (no)	2009-04-15
IL196860A0 (en)	2009-11-18
JP5325105B2 (ja)	2013-10-23
SMP200900023B (it)	2009-07-14
ATE532774T1 (de)	2011-11-15
CR10639A (es)	2009-07-03
JP2010503629A (ja)	2010-02-04
UY30587A1 (es)	2008-05-02
EP2066647B1 (en)	2011-11-09
AU2007296916B2 (en)	2011-10-06
TW200819444A (en)	2008-05-01
CN101516860A (zh)	2009-08-26
PT2066647E (pt)	2012-01-17
MX2009002812A (es)	2009-03-31
PA8748101A1 (es)	2009-08-26
US20100009978A1 (en)	2010-01-14
EA200900388A1 (ru)	2009-08-28
WO2008031594A1 (en)	2008-03-20
EP2066647A1 (en)	2009-06-10
TN2009000070A1 (en)	2010-08-19
GT200900056A (es)	2011-11-08
CN101516860B (zh)	2012-06-27
AU2007296916A1 (en)	2008-03-20
BRPI0716841A2 (pt)	2013-10-01
ZA200900477B (en)	2010-01-27
PL2066647T3 (pl)	2012-04-30
CO6150142A2 (es)	2010-04-20
US8629168B2 (en)	2014-01-14
PE20080842A1 (es)	2008-08-11
EP1900729A1 (en)	2008-03-19
KR20090064389A (ko)	2009-06-18
SMAP200900023A (it)	2009-05-11
ES2377148T3 (es)	2012-03-22
CA2660987A1 (en)	2008-03-20
MA30723B1 (fr)	2009-09-01

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