SV2018005722A - Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- SV2018005722A SV2018005722A SV2018005722A SV2018005722A SV2018005722A SV 2018005722 A SV2018005722 A SV 2018005722A SV 2018005722 A SV2018005722 A SV 2018005722A SV 2018005722 A SV2018005722 A SV 2018005722A SV 2018005722 A SV2018005722 A SV 2018005722A
- Authority
- SV
- El Salvador
- Prior art keywords
- ammonium
- preparation
- pharmaceutical compositions
- compositions containing
- new derivatives
- Prior art date
Links
- 150000003863 ammonium salts Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
COMPUESTOS DE FÓRMULA (I): (VER FORMULA) EN LA QUE R1, R2, R3, R4, R5, R6 E Y SON COMO SE HAN DEFINIDO EN LA DESCRIPCIÓN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1650411A FR3046792B1 (fr) | 2016-01-19 | 2016-01-19 | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2018005722A true SV2018005722A (es) | 2018-10-10 |
Family
ID=55752504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2018005722A SV2018005722A (es) | 2016-01-19 | 2018-07-10 | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (43)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UY37560A (es) | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
| KR102576567B1 (ko) * | 2017-01-06 | 2023-09-07 | 르 라보레또레 쎄르비에르 | Mcl-1 억제제와 탁산 화합물의 조합물, 이의 용도 및 약학적 조성물 |
| BR112019026959A2 (pt) | 2017-06-22 | 2020-07-07 | Les Laboratoires Servier | combinação de um inibidor de mcl-1 e um tratamento com padrão de atendimento para cânceres hematológicos, seus usos e composições farmacêuticas |
| TW201920204A (zh) * | 2017-08-15 | 2019-06-01 | 美商艾伯維有限公司 | 大環ｍｃｌ-１抑制劑以及使用方法 |
| US10676485B2 (en) | 2017-08-15 | 2020-06-09 | Abbvie Inc. | Macrocyclic MCL-1 inhibitors and methods of use |
| MX2020001719A (es) * | 2017-08-15 | 2020-11-06 | Abbvie Inc | Inhibidores macrocíclicos de mcl-1 y metodos de uso. |
| CN108424417B (zh) * | 2017-12-21 | 2019-09-20 | 河南真实生物科技有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
| AR116635A1 (es) | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| TWI849001B (zh) | 2018-11-14 | 2024-07-21 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物 |
| PL3891156T3 (pl) * | 2018-12-06 | 2024-05-13 | Les Laboratoires Servier | Nowe krystaliczne formy inhibitora MCL-1, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne |
| WO2020236817A2 (en) | 2019-05-20 | 2020-11-26 | Novartis Ag | Mcl-1 inhibitor antibody-drug conjugates and methods of use |
| AR119156A1 (es) | 2019-06-17 | 2021-11-24 | Servier Lab | Combinación de un inhibidor de mcl-1 y un tratamiento estándar de atención médica para cáncer de mama, usos y composiciones farmacéuticas de la misma |
| CN114746428B (zh) * | 2019-10-03 | 2025-05-16 | 加利福尼亚技术学院 | Mcl1抑制剂及其应用 |
| KR20230138444A (ko) * | 2020-11-24 | 2023-10-05 | 노파르티스 아게 | Mcl-1 억제제 항체-약물 접합체 및 사용 방법 |
| WO2022216946A1 (en) * | 2021-04-07 | 2022-10-13 | California Institute Of Technology | Mcl1 inhibitors and uses thereof |
| CA3222269A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
| KR20240019330A (ko) | 2021-06-11 | 2024-02-14 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 저해제와 항체 약물 접합체의 조합 |
| JP2025517435A (ja) | 2022-05-20 | 2025-06-05 | ノバルティス アーゲー | 抗新生物薬化合物の抗体－薬物コンジュゲートおよびその使用の方法 |
| TW202540186A (zh) | 2023-11-22 | 2025-10-16 | 瑞士商諾華公司 | 抗ｃｄ７抗體藥物結合物及其使用方法 |
| TW202540185A (zh) | 2023-11-22 | 2025-10-16 | 法商施維雅藥廠 | 抗cd74抗體藥物結合物及其使用方法 |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
| JP2001511182A (ja) * | 1997-02-09 | 2001-08-07 | ファーモス コーポレイション | ステロイドホルモンの永久に荷電された誘導体の増進された抗血管形成誘導活性 |
| AU2005260077A1 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
| MX2010004260A (es) * | 2007-10-16 | 2010-04-30 | Wyeth Llc | Compuestos de tienopirimidina y pirazolopirimidina y su uso como inhibidores de mtor cinasa y pi3 cinasa. |
| JP5502072B2 (ja) * | 2008-04-30 | 2014-05-28 | ナショナル ヘルス リサーチ インスティテューツ | オーロラキナーゼ阻害剤としての縮合二環式ピリミジン化合物 |
| TWI385174B (zh) * | 2008-11-10 | 2013-02-11 | Nat Health Research Institutes | 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 |
| CN102464667B (zh) * | 2010-11-03 | 2014-06-04 | 中国科学院上海药物研究所 | 一类五元杂环并嘧啶类化合物及其制备方法和用途 |
| JP2016504988A (ja) * | 2012-11-14 | 2016-02-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | イミダゾピリジン誘導体 |
| RS57461B1 (sr) * | 2013-05-02 | 2018-09-28 | Hoffmann La Roche | Derivati purina kao agonisti cb2 receptora |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2016
- 2016-01-19 FR FR1650411A patent/FR3046792B1/fr not_active Expired - Fee Related
- 2016-12-19 HU HUE16816667A patent/HUE048449T2/hu unknown
- 2016-12-19 KR KR1020187023819A patent/KR102805983B1/ko active Active
- 2016-12-19 CA CA3011761A patent/CA3011761C/en active Active
- 2016-12-19 ES ES16816667T patent/ES2760545T3/es active Active
- 2016-12-19 ME MEP-2019-336A patent/ME03555B/me unknown
- 2016-12-19 WO PCT/EP2016/081688 patent/WO2017125224A1/en not_active Ceased
- 2016-12-19 CR CR20180363A patent/CR20180363A/es unknown
- 2016-12-19 CN CN201680080679.7A patent/CN108602841B/zh active Active
- 2016-12-19 EA EA201891622A patent/EA036932B1/ru unknown
- 2016-12-19 JP JP2018555822A patent/JP6871275B2/ja active Active
- 2016-12-19 MA MA43639A patent/MA43639B1/fr unknown
- 2016-12-19 RS RS20191499A patent/RS59622B1/sr unknown
- 2016-12-19 LT LT16816667T patent/LT3405471T/lt unknown
- 2016-12-19 DK DK16816667.6T patent/DK3405471T3/da active
- 2016-12-19 EP EP16816667.6A patent/EP3405471B1/en active Active
- 2016-12-19 SI SI201630558T patent/SI3405471T1/sl unknown
- 2016-12-19 CU CU2018000073A patent/CU20180073A7/es unknown
- 2016-12-19 BR BR112018014536-0A patent/BR112018014536B1/pt active IP Right Grant
- 2016-12-19 RU RU2018129308A patent/RU2743098C2/ru active
- 2016-12-19 GE GEAP201614858A patent/GEP20207126B/en unknown
- 2016-12-19 MX MX2018008808A patent/MX376028B/es active IP Right Grant
- 2016-12-19 PE PE2018001293A patent/PE20190336A1/es unknown
- 2016-12-19 US US16/069,891 patent/US10457689B2/en active Active
- 2016-12-19 MY MYPI2018702472A patent/MY196352A/en unknown
- 2016-12-19 MD MDE20181134T patent/MD3405471T2/ro unknown
- 2016-12-19 PT PT168166676T patent/PT3405471T/pt unknown
- 2016-12-19 AU AU2016387870A patent/AU2016387870B2/en active Active
- 2016-12-19 HR HRP20192073TT patent/HRP20192073T1/hr unknown
- 2016-12-19 TN TNP/2018/000239A patent/TN2018000239A1/en unknown
- 2016-12-19 GE GEAP202014858A patent/GEAP202014858A/en unknown
- 2016-12-19 UA UAA201808693A patent/UA123508C2/uk unknown
- 2016-12-19 SG SG11201805913QA patent/SG11201805913QA/en unknown
- 2016-12-19 PL PL16816667T patent/PL3405471T3/pl unknown
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2018
- 2018-07-10 SV SV2018005722A patent/SV2018005722A/es unknown
- 2018-07-11 IL IL260550A patent/IL260550B/en active IP Right Grant
- 2018-07-12 PH PH12018501506A patent/PH12018501506A1/en unknown
- 2018-07-13 CL CL2018001908A patent/CL2018001908A1/es unknown
- 2018-07-16 CO CONC2018/0007443A patent/CO2018007443A2/es unknown
- 2018-07-17 EC ECSENADI201853634A patent/ECSP18053634A/es unknown
- 2018-07-17 NI NI201800076A patent/NI201800076A/es unknown
- 2018-07-17 ZA ZA2018/04770A patent/ZA201804770B/en unknown
- 2018-07-19 SA SA518392049A patent/SA518392049B1/ar unknown
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2020
- 2020-01-27 CY CY20201100072T patent/CY1122560T1/el unknown
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