[go: up one dir, main page]

SV2013004582A - Los compuestos para el tratamiento y la prevención de la adhesión, las composiciones farmacéuticas relacionados con el compuesto y los métodos para la prevención y el tratamiento de adherencias - Google Patents

Los compuestos para el tratamiento y la prevención de la adhesión, las composiciones farmacéuticas relacionados con el compuesto y los métodos para la prevención y el tratamiento de adherencias

Info

Publication number
SV2013004582A
SV2013004582A SV2013004582A SV2013004582A SV2013004582A SV 2013004582 A SV2013004582 A SV 2013004582A SV 2013004582 A SV2013004582 A SV 2013004582A SV 2013004582 A SV2013004582 A SV 2013004582A SV 2013004582 A SV2013004582 A SV 2013004582A
Authority
SV
El Salvador
Prior art keywords
treatment
prevention
compounds
adherences
pharmaceutical compositions
Prior art date
Application number
SV2013004582A
Other languages
English (en)
Inventor
Mikhail Gennadievich Shurygin
Irina Aleksandrovna Shurygina
Original Assignee
Pharmasyntez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2011119848/15A external-priority patent/RU2011119848A/ru
Application filed by Pharmasyntez filed Critical Pharmasyntez
Publication of SV2013004582A publication Critical patent/SV2013004582A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/0206Polyalkylene(poly)amines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08L79/06Polyhydrazides; Polytriazoles; Polyamino-triazoles; Polyoxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCIÓN SE REFIERE AL CAMPO DE LA FARMACIA, MEDICINA CLÍNICA Y EXPERIMENTAL Y LA MEDICINA VETERINARIA, Y EN PARTICULAR, A NUEVOS COMPUESTOS INHIBITORIOS DE UNA P38 MAP QUINASA CON UNA ESTRUCTURA DEL TIPO (I) - (VII) QUE PUEDEN SER UTILIZADOS PARA EL TRATAMIENTO O LA PROFILAXIS DE ADHERENCIA. LA INVENCIÓN DA A CONOCER COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN UNA CANTIDAD EFICAZ DE LA SUSTANCIA SB203580 O UNO DE LOS COMPUESTOS DEL TIPO (I) (VII) O UNA COMBINACIÓN DE LOS MISMOS Y UN VEHÍCULO FARMACÉUTICAMENTE ACEPTABLE, UN DILUYENTE O UN EXCIPIENTE. TAMBIÉN SE DESCRIBE EL USO DE LA SUSTANCIA SB203580 COMO UN AGENTE QUE TIENE ACTIVIDAD ANTI-ADHERENCIA. TAMBIÉN SE DESCRIBE: UN MÉTODO PARA LA PROFILAXIS Y/O TRATAMIENTO DE UNA ENFERMEDAD O UNA CONDICIÓN EN LA CUAL EXISTE LA POSIBILIDAD DE LA FORMACIÓN Y/O EL CRECIMIENTO DE LAS ADHERENCIAS QUE HACE QUE SEA POSIBLE PRESCINDIR DE LA ADMINISTRACIÓN ADICIONAL DE UNA PREPARACIÓN EN EL PERÍODO POSTOPERATORIO
SV2013004582A 2011-05-17 2013-11-15 Los compuestos para el tratamiento y la prevención de la adhesión, las composiciones farmacéuticas relacionados con el compuesto y los métodos para la prevención y el tratamiento de adherencias SV2013004582A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011119848/15A RU2011119848A (ru) 2011-05-17 2011-05-17 Способ профилактики спайкообразования
RU2011153043 2011-12-26

Publications (1)

Publication Number Publication Date
SV2013004582A true SV2013004582A (es) 2018-11-12

Family

ID=47176372

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2013004582A SV2013004582A (es) 2011-05-17 2013-11-15 Los compuestos para el tratamiento y la prevención de la adhesión, las composiciones farmacéuticas relacionados con el compuesto y los métodos para la prevención y el tratamiento de adherencias

Country Status (31)

Country Link
US (2) US10172952B2 (es)
EP (2) EP2716684B1 (es)
JP (2) JP5936683B2 (es)
KR (2) KR20170034950A (es)
CN (1) CN103534293B (es)
AP (1) AP3694A (es)
AU (3) AU2012257347A1 (es)
BR (1) BR112013029616B1 (es)
CA (1) CA2836268C (es)
CL (1) CL2013003305A1 (es)
CO (1) CO6801779A2 (es)
CR (1) CR20130600A (es)
CY (1) CY1122190T1 (es)
DK (1) DK2716684T3 (es)
DO (1) DOP2013000266A (es)
EA (1) EA025493B1 (es)
GE (1) GEP201706614B (es)
IL (1) IL229423B (es)
LT (1) LT2716684T (es)
MA (1) MA35189B1 (es)
MX (2) MX369019B (es)
NI (1) NI201300124A (es)
PE (1) PE20141161A1 (es)
PH (1) PH12013502381B1 (es)
PL (1) PL2716684T3 (es)
RS (1) RS59382B1 (es)
RU (1) RU2582975C2 (es)
SI (1) SI2716684T1 (es)
SV (1) SV2013004582A (es)
WO (1) WO2012156938A1 (es)
ZA (1) ZA201308542B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA025493B1 (ru) * 2011-05-17 2016-12-30 Акционерное Общество "Фармасинтез" Соединения, фармацевтические композиции и способ профилактики и лечения спаечного процесса
RU2745965C1 (ru) * 2020-11-23 2021-04-05 Галина Анатольевна Пучкина Способ профилактики послеоперационного спаечного процесса органов малого таза
RU2749435C1 (ru) * 2020-11-27 2021-06-10 Федеральное государственное бюджетное научное учреждение "Иркутский научный центр хирургии и травматологии" Способ лечения энтеральной недостаточности при воспалительных и травматических повреждениях брюшины

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA945363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
US20020028798A1 (en) * 1995-12-12 2002-03-07 Omeros Medical Systems Irrigation solution and method for inhibition of pain and inflammation
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997005878A1 (en) * 1995-08-10 1997-02-20 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5894971A (en) 1998-02-02 1999-04-20 Huang; Te Chien Tool holder for attaching tools to user's hand
US6521223B1 (en) 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
CA2419633C (en) * 2000-08-17 2011-05-10 Pfizer Inc. Substituted imidazoles as tafia inhibitors
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
WO2004060405A2 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
US7728013B2 (en) * 2005-05-10 2010-06-01 Intermune, Inc. Method of modulating stress-activated protein kinase system
CN101443044A (zh) * 2005-09-22 2009-05-27 哈达斯特医学研究服务与开发有限公司 治疗活性化合物的葡聚糖和阿拉伯半乳聚糖结合物
CN101535308A (zh) * 2006-11-09 2009-09-16 霍夫曼-拉罗奇有限公司 作为激酶抑制剂的取代的6-苯基-吡啶并[2,3-d]嘧啶-7-酮衍生物及其使用方法
JP5530635B2 (ja) * 2007-02-14 2014-06-25 独立行政法人科学技術振興機構 腸管癒着抑制剤
WO2009028965A1 (en) * 2007-08-28 2009-03-05 Theodore Athanasiadis Surgical hydrogel
RU2363476C1 (ru) 2007-12-20 2009-08-10 Марина Сергеевна Гомон Способ профилактики образования послеоперационных спаек
WO2009103821A2 (de) * 2008-02-23 2009-08-27 Virologik Gmbh Mittel zur behandlung von virusinfektionen
US8205286B1 (en) 2008-10-21 2012-06-26 Milagros Diaz Pillow for female breasts
EA025493B1 (ru) * 2011-05-17 2016-12-30 Акционерное Общество "Фармасинтез" Соединения, фармацевтические композиции и способ профилактики и лечения спаечного процесса
US20140259423A1 (en) 2013-03-13 2014-09-18 Evan Joseph FALCK Helmet Pillow

Also Published As

Publication number Publication date
RU2013155582A (ru) 2015-06-27
HK1189012A1 (en) 2014-05-23
IL229423B (en) 2018-04-30
KR20170034950A (ko) 2017-03-29
NZ618882A (en) 2016-03-31
IL229423A0 (en) 2014-01-30
EP2716684A4 (en) 2015-07-15
ZA201308542B (en) 2014-07-30
EP2716684A1 (en) 2014-04-09
EP3569636A1 (en) 2019-11-20
EP2716684B1 (en) 2019-06-26
WO2012156938A1 (ru) 2012-11-22
KR20140074259A (ko) 2014-06-17
AU2012257347A1 (en) 2014-01-09
SI2716684T1 (sl) 2019-11-29
JP2014515057A (ja) 2014-06-26
PL2716684T3 (pl) 2020-01-31
CO6801779A2 (es) 2013-11-29
MX382507B (es) 2025-03-13
PE20141161A1 (es) 2014-10-01
US10172952B2 (en) 2019-01-08
NI201300124A (es) 2014-02-25
GEP201706614B (en) 2017-02-10
AU2015213303A1 (en) 2015-09-03
CR20130600A (es) 2014-04-29
AU2017221883B2 (en) 2019-06-20
CY1122190T1 (el) 2020-11-25
MX369019B (es) 2019-10-24
RU2582975C2 (ru) 2016-04-27
LT2716684T (lt) 2019-09-25
MX2019011386A (es) 2019-10-30
CA2836268A1 (en) 2012-11-22
PH12013502381A1 (en) 2014-02-10
DOP2013000266A (es) 2014-06-01
BR112013029616A2 (pt) 2020-08-25
PH12013502381B1 (en) 2021-03-26
EA201301275A1 (ru) 2014-03-31
US20190125886A1 (en) 2019-05-02
AU2017221883A1 (en) 2017-09-28
AP3694A (en) 2016-04-30
RS59382B1 (sr) 2019-11-29
MX2013013409A (es) 2014-07-11
CN103534293A (zh) 2014-01-22
DK2716684T3 (da) 2019-09-30
CL2013003305A1 (es) 2014-07-18
US20140079663A1 (en) 2014-03-20
EA025493B1 (ru) 2016-12-30
CN103534293B (zh) 2015-10-21
JP5936683B2 (ja) 2016-06-22
JP2016175931A (ja) 2016-10-06
BR112013029616B1 (pt) 2022-09-20
AP2013007258A0 (en) 2013-11-30
CA2836268C (en) 2018-07-03
MA35189B1 (fr) 2014-06-02
US10493164B2 (en) 2019-12-03

Similar Documents

Publication Publication Date Title
MX339205B (es) Formulaciones de adamts13 liquidas y liofilizadas, estabilizadas.
MX2020004467A (es) Metodos para el tratamiento o la prevencion del asma mediante la administracion de antagonista de il-4r.
MX2015012559A (es) Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson.
ECSP19025350A (es) Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi)
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
CL2013003227A1 (es) “compuestos derivados de indazol sustituidos, moduladores de la actividad de proteínas quinasas; proceso de obtención de ellos; método in vitro para inhibir proteínas quinasas; composición y combinación farmacéutica que los comprende; y su uso en el tratamiento del cáncer" pct
MX2009006786A (es) Composiciones y metodos para el tratamiento de infecciones y tumores.
UY33183A (es) Compuestos inhibidores de virus flaviviridae, composición farmaceutica que los contiene y su uso en la manufactura de un medicamento
AR090456A1 (es) Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos
CU24350B1 (es) DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET
GT201200126A (es) Derivados de la cromenona con actividad anti-tumoral
HN2011001195A (es) Compuestos que expanden las celulas madre hematopoieticas
DOP2012000314A (es) Compuestos, composiciones de tiocetato y metodos de uso
AR096892A1 (es) Una combinación farmacéutica para el tratamiento del melanoma
WO2015148415A3 (en) Use of the fl118 core chemical structure platform to generate fl118 derivatives for treatment of human disease
AR099569A1 (es) Derivados de insulina y los usos médicos de estos
BR112017006113A8 (pt) usos de auristatina, composições farmacêuticas, formas de dosagem para o tratamento de câncer e kits.
CL2016000008A1 (es) Tratamiento de lesiones inflamatorias de rosacea con ivermectina.
MX360554B (es) Composiciones que comprenden y metodos que utilizan inhibidores de co-transportadores de glucosa-sodio 1 y 2.
DOP2016000253A (es) Nuevos compuestos
BR112017008993A2 (pt) métodos e composições especificamente para o tratamento de transtorno de déficit de atenção
DOP2016000254A (es) Formulaciones farmeceuticas de inhibidor de la quinasa pan-raf, procedimientos para su preparacion, y metodos de uso.
SV2017005466A (es) Pirazolpiridinaminas como inhibidores de mknk1 y mknk2
MX383254B (es) Combinacion que comprende un glucocorticoide y edo-s101.
PE20181332A1 (es) Metodos de sedacion y formulacion parenteral para uso durante el tratamiento de cuidados criticos