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PE20141161A1 - Los compuestos para el tratamiento y la prevencion de la adhesion, las composiciones farmaceuticas relacionados con el compuesto y los metodos para la prevencion y el tratamiento de adherencias - Google Patents

Los compuestos para el tratamiento y la prevencion de la adhesion, las composiciones farmaceuticas relacionados con el compuesto y los metodos para la prevencion y el tratamiento de adherencias

Info

Publication number
PE20141161A1
PE20141161A1 PE2013002510A PE2013002510A PE20141161A1 PE 20141161 A1 PE20141161 A1 PE 20141161A1 PE 2013002510 A PE2013002510 A PE 2013002510A PE 2013002510 A PE2013002510 A PE 2013002510A PE 20141161 A1 PE20141161 A1 PE 20141161A1
Authority
PE
Peru
Prior art keywords
treatment
prevention
compounds
compound
adhesions
Prior art date
Application number
PE2013002510A
Other languages
English (en)
Inventor
Mikhail Gennadievich Shurygin
Irina Aleksandrovna Shurygina
Original Assignee
Pharmasyntez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2011119848/15A external-priority patent/RU2011119848A/ru
Application filed by Pharmasyntez filed Critical Pharmasyntez
Publication of PE20141161A1 publication Critical patent/PE20141161A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08L79/06—Polyhydrazides; Polytriazoles; Polyamino-triazoles; Polyoxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS INHIBIDORES DE LA p38 MAP QUINASA TALES COMO 4-(4-FLUOROFENIL)-2-(4-METILSULFONILFENIL)-5-(4-PIRIDIL)-1H-IMIDAZOL, EL COMPUESTO DE FORMULA (I), ENTRE OTROS, DONDE R1 ES UNA UNIDAD ESTRUCTURAL DE POLIMEROS SOLUBLES EN AGUA DE CARACTER BASICO DE ORIGEN NATURAL O SINTETICO TAL COMO QUITOSANO, POLIVINILTETRAZOL, POLIVINILPIRIDINAS, ENTRE OTROS; x E y SON NUMEROS ENTEROS DIFERENTES DE 0. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTIADHERENCIA SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES ACOMPANADAS DE EXUDADO, SANGRADO O DANO EN LA MEMBRANA SEROSA
PE2013002510A 2011-05-17 2012-05-17 Los compuestos para el tratamiento y la prevencion de la adhesion, las composiciones farmaceuticas relacionados con el compuesto y los metodos para la prevencion y el tratamiento de adherencias PE20141161A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011119848/15A RU2011119848A (ru) 2011-05-17 2011-05-17 Способ профилактики спайкообразования
RU2011153043 2011-12-26

Publications (1)

Publication Number Publication Date
PE20141161A1 true PE20141161A1 (es) 2014-10-01

Family

ID=47176372

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002510A PE20141161A1 (es) 2011-05-17 2012-05-17 Los compuestos para el tratamiento y la prevencion de la adhesion, las composiciones farmaceuticas relacionados con el compuesto y los metodos para la prevencion y el tratamiento de adherencias

Country Status (31)

Country Link
US (2) US10172952B2 (es)
EP (2) EP2716684B1 (es)
JP (2) JP5936683B2 (es)
KR (2) KR20170034950A (es)
CN (1) CN103534293B (es)
AP (1) AP3694A (es)
AU (3) AU2012257347A1 (es)
BR (1) BR112013029616B1 (es)
CA (1) CA2836268C (es)
CL (1) CL2013003305A1 (es)
CO (1) CO6801779A2 (es)
CR (1) CR20130600A (es)
CY (1) CY1122190T1 (es)
DK (1) DK2716684T3 (es)
DO (1) DOP2013000266A (es)
EA (1) EA025493B1 (es)
GE (1) GEP201706614B (es)
IL (1) IL229423B (es)
LT (1) LT2716684T (es)
MA (1) MA35189B1 (es)
MX (2) MX369019B (es)
NI (1) NI201300124A (es)
PE (1) PE20141161A1 (es)
PH (1) PH12013502381B1 (es)
PL (1) PL2716684T3 (es)
RS (1) RS59382B1 (es)
RU (1) RU2582975C2 (es)
SI (1) SI2716684T1 (es)
SV (1) SV2013004582A (es)
WO (1) WO2012156938A1 (es)
ZA (1) ZA201308542B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA025493B1 (ru) * 2011-05-17 2016-12-30 Акционерное Общество "Фармасинтез" Соединения, фармацевтические композиции и способ профилактики и лечения спаечного процесса
RU2745965C1 (ru) * 2020-11-23 2021-04-05 Галина Анатольевна Пучкина Способ профилактики послеоперационного спаечного процесса органов малого таза
RU2749435C1 (ru) * 2020-11-27 2021-06-10 Федеральное государственное бюджетное научное учреждение "Иркутский научный центр хирургии и травматологии" Способ лечения энтеральной недостаточности при воспалительных и травматических повреждениях брюшины

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ZA945363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
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US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997005878A1 (en) * 1995-08-10 1997-02-20 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5894971A (en) 1998-02-02 1999-04-20 Huang; Te Chien Tool holder for attaching tools to user's hand
US6521223B1 (en) 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
CA2419633C (en) * 2000-08-17 2011-05-10 Pfizer Inc. Substituted imidazoles as tafia inhibitors
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
WO2004060405A2 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
US7728013B2 (en) * 2005-05-10 2010-06-01 Intermune, Inc. Method of modulating stress-activated protein kinase system
CN101443044A (zh) * 2005-09-22 2009-05-27 哈达斯特医学研究服务与开发有限公司 治疗活性化合物的葡聚糖和阿拉伯半乳聚糖结合物
CN101535308A (zh) * 2006-11-09 2009-09-16 霍夫曼-拉罗奇有限公司 作为激酶抑制剂的取代的6-苯基-吡啶并[2，3-d]嘧啶-7-酮衍生物及其使用方法
JP5530635B2 (ja) * 2007-02-14 2014-06-25 独立行政法人科学技術振興機構 腸管癒着抑制剤
WO2009028965A1 (en) * 2007-08-28 2009-03-05 Theodore Athanasiadis Surgical hydrogel
RU2363476C1 (ru) 2007-12-20 2009-08-10 Марина Сергеевна Гомон Способ профилактики образования послеоперационных спаек
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US8205286B1 (en) 2008-10-21 2012-06-26 Milagros Diaz Pillow for female breasts
EA025493B1 (ru) * 2011-05-17 2016-12-30 Акционерное Общество "Фармасинтез" Соединения, фармацевтические композиции и способ профилактики и лечения спаечного процесса
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Also Published As

Publication number Publication date
RU2013155582A (ru) 2015-06-27
HK1189012A1 (en) 2014-05-23
IL229423B (en) 2018-04-30
KR20170034950A (ko) 2017-03-29
NZ618882A (en) 2016-03-31
IL229423A0 (en) 2014-01-30
EP2716684A4 (en) 2015-07-15
ZA201308542B (en) 2014-07-30
EP2716684A1 (en) 2014-04-09
EP3569636A1 (en) 2019-11-20
EP2716684B1 (en) 2019-06-26
WO2012156938A1 (ru) 2012-11-22
KR20140074259A (ko) 2014-06-17
AU2012257347A1 (en) 2014-01-09
SI2716684T1 (sl) 2019-11-29
JP2014515057A (ja) 2014-06-26
PL2716684T3 (pl) 2020-01-31
CO6801779A2 (es) 2013-11-29
MX382507B (es) 2025-03-13
US10172952B2 (en) 2019-01-08
NI201300124A (es) 2014-02-25
GEP201706614B (en) 2017-02-10
AU2015213303A1 (en) 2015-09-03
CR20130600A (es) 2014-04-29
AU2017221883B2 (en) 2019-06-20
CY1122190T1 (el) 2020-11-25
MX369019B (es) 2019-10-24
RU2582975C2 (ru) 2016-04-27
LT2716684T (lt) 2019-09-25
MX2019011386A (es) 2019-10-30
SV2013004582A (es) 2018-11-12
CA2836268A1 (en) 2012-11-22
PH12013502381A1 (en) 2014-02-10
DOP2013000266A (es) 2014-06-01
BR112013029616A2 (pt) 2020-08-25
PH12013502381B1 (en) 2021-03-26
EA201301275A1 (ru) 2014-03-31
US20190125886A1 (en) 2019-05-02
AU2017221883A1 (en) 2017-09-28
AP3694A (en) 2016-04-30
RS59382B1 (sr) 2019-11-29
MX2013013409A (es) 2014-07-11
CN103534293A (zh) 2014-01-22
DK2716684T3 (da) 2019-09-30
CL2013003305A1 (es) 2014-07-18
US20140079663A1 (en) 2014-03-20
EA025493B1 (ru) 2016-12-30
CN103534293B (zh) 2015-10-21
JP5936683B2 (ja) 2016-06-22
JP2016175931A (ja) 2016-10-06
BR112013029616B1 (pt) 2022-09-20
AP2013007258A0 (en) 2013-11-30
CA2836268C (en) 2018-07-03
MA35189B1 (fr) 2014-06-02
US10493164B2 (en) 2019-12-03

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