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SV2010003660A - Conjugados antagonistas peptidicos analogos a la bombesina - Google Patents

Conjugados antagonistas peptidicos analogos a la bombesina

Info

Publication number
SV2010003660A
SV2010003660A SV2010003660A SV2010003660A SV2010003660A SV 2010003660 A SV2010003660 A SV 2010003660A SV 2010003660 A SV2010003660 A SV 2010003660A SV 2010003660 A SV2010003660 A SV 2010003660A SV 2010003660 A SV2010003660 A SV 2010003660A
Authority
SV
El Salvador
Prior art keywords
bomb
analogs
peptidic antagonist
antagonist conjugates
peptidic
Prior art date
Application number
SV2010003660A
Other languages
English (en)
Inventor
Helmut Maecke
Jean Claude Reubi
Rosalba Mansi
Original Assignee
Universitaetsspital Basel
Univ Bern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39677415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2010003660(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Universitaetsspital Basel, Univ Bern filed Critical Universitaetsspital Basel
Publication of SV2010003660A publication Critical patent/SV2010003660A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN MEDICAMENTO DE DIAGNÓSTICO Y TERAPÉUTICO QUE COMPRENDE UN CONJUGADO ANTAGONISTA PEPTÍDICO ANÁLOGO A LA BOMBESINA QUE TIENE LA FORMULA GENERAL (I), DONDE A ES UN QUELANTE DE METALES QUE COMPRENDE AL MENOS UN RADIONUCLEIDO METÁLICO, B ES UN SEPARADOR UNIDO AL EXTREMO N DE C, O UN ENLACE COVALENTE, Y C ES UN ANTAGONISTA PEPTÍDICO ANÁLOGO A LA BOMBESINA QUE TIENE UNA SECUENCIA COMO LA REIVINDICADA, DONDE ADEMÁS, X ES UN NUMERO ENTERO ENTRE 1 Y 3, Y N ES UN NÚMERO ENTERO ENTRE 1 Y 6(I) [A-(B)N]X-C (FIG. 1)
SV2010003660A 2008-03-07 2010-09-07 Conjugados antagonistas peptidicos analogos a la bombesina SV2010003660A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08075180A EP2100900A1 (en) 2008-03-07 2008-03-07 Bombesin analog peptide antagonist conjugates

Publications (1)

Publication Number Publication Date
SV2010003660A true SV2010003660A (es) 2011-02-17

Family

ID=39677415

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2010003660A SV2010003660A (es) 2008-03-07 2010-09-07 Conjugados antagonistas peptidicos analogos a la bombesina

Country Status (32)

Country Link
US (2) US9035023B2 (es)
EP (2) EP2100900A1 (es)
JP (1) JP5784911B2 (es)
KR (2) KR101734553B1 (es)
CN (1) CN101965358B (es)
AR (1) AR070809A1 (es)
AU (1) AU2009221204C1 (es)
BR (1) BRPI0909823B1 (es)
CA (1) CA2717427C (es)
CL (1) CL2009000537A1 (es)
CO (1) CO6290707A2 (es)
CR (1) CR11671A (es)
CY (1) CY1118687T1 (es)
DK (1) DK2252628T3 (es)
DO (1) DOP2010000269A (es)
EC (1) ECSP10010467A (es)
ES (1) ES2615805T3 (es)
HU (1) HUE032980T2 (es)
MX (1) MX2010009843A (es)
NZ (1) NZ587795A (es)
PA (1) PA8818501A1 (es)
PE (1) PE20091753A1 (es)
PL (1) PL2252628T3 (es)
PT (1) PT2252628T (es)
RU (1) RU2523531C2 (es)
SI (1) SI2252628T1 (es)
SV (1) SV2010003660A (es)
TW (1) TWI515011B (es)
UA (1) UA103314C2 (es)
UY (1) UY31693A (es)
WO (1) WO2009109332A1 (es)
ZA (1) ZA201006385B (es)

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AU2020405585A1 (en) * 2019-12-19 2022-08-11 Technische Universität München Modified GRPR antagonist peptides for imaging and therapy of cancer
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EP3973999A1 (en) * 2020-09-28 2022-03-30 Orano Med Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof
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CN117919452A (zh) * 2023-03-09 2024-04-26 中国科学院宁波材料技术与工程研究所 一种亚细胞器主动靶向成像探针及其制备方法
WO2024212808A1 (zh) * 2023-04-10 2024-10-17 湖南中晟全肽生物科技股份有限公司 蛙皮素类多肽化合物及其用途
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Also Published As

Publication number Publication date
BRPI0909823A2 (pt) 2019-03-06
CR11671A (es) 2010-11-01
PL2252628T3 (pl) 2017-07-31
HUE032980T2 (en) 2017-11-28
DK2252628T3 (en) 2017-02-06
AU2009221204B2 (en) 2013-09-05
PE20091753A1 (es) 2009-12-13
CY1118687T1 (el) 2017-07-12
PA8818501A1 (es) 2010-04-21
EP2252628A1 (en) 2010-11-24
MX2010009843A (es) 2011-03-04
JP2011515338A (ja) 2011-05-19
EP2252628B1 (en) 2016-12-28
DOP2010000269A (es) 2010-10-31
US9035023B2 (en) 2015-05-19
SI2252628T1 (sl) 2017-05-31
KR101734553B1 (ko) 2017-05-11
PT2252628T (pt) 2017-02-10
TWI515011B (zh) 2016-01-01
CA2717427C (en) 2016-02-23
ES2615805T3 (es) 2017-06-08
EP2100900A1 (en) 2009-09-16
WO2009109332A1 (en) 2009-09-11
CA2717427A1 (en) 2009-09-11
AU2009221204A1 (en) 2009-09-11
US20110097266A1 (en) 2011-04-28
JP5784911B2 (ja) 2015-09-24
ZA201006385B (en) 2016-10-26
CL2009000537A1 (es) 2010-07-19
AR070809A1 (es) 2010-05-05
TW200944239A (en) 2009-11-01
US20150265733A1 (en) 2015-09-24
AU2009221204C1 (en) 2016-12-08
KR20160128425A (ko) 2016-11-07
UA103314C2 (ru) 2013-10-10
NZ587795A (en) 2012-07-27
CO6290707A2 (es) 2011-06-20
RU2010140846A (ru) 2012-04-20
CN101965358B (zh) 2019-09-03
RU2523531C2 (ru) 2014-07-20
UY31693A (es) 2010-01-05
CN101965358A (zh) 2011-02-02
BRPI0909823B1 (pt) 2022-04-19
ECSP10010467A (es) 2010-10-30
KR20110014565A (ko) 2011-02-11

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