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BRPI0909823A2 - conjugados antagonistas de peptídeo análogo de bombesina - Google Patents

conjugados antagonistas de peptídeo análogo de bombesina

Info

Publication number
BRPI0909823A2
BRPI0909823A2 BRPI0909823-2A BRPI0909823A BRPI0909823A2 BR PI0909823 A2 BRPI0909823 A2 BR PI0909823A2 BR PI0909823 A BRPI0909823 A BR PI0909823A BR PI0909823 A2 BRPI0909823 A2 BR PI0909823A2
Authority
BR
Brazil
Prior art keywords
peptide antagonist
analog peptide
bombesin analog
bombesin
antagonist conjugates
Prior art date
Application number
BRPI0909823-2A
Other languages
English (en)
Inventor
Maecke Helmut
Claude Reubi Jean
Mansi Rosalba
Original Assignee
Universitätsspital Basel
Universität Bern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39677415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0909823(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Universitätsspital Basel, Universität Bern filed Critical Universitätsspital Basel
Publication of BRPI0909823A2 publication Critical patent/BRPI0909823A2/pt
Publication of BRPI0909823B1 publication Critical patent/BRPI0909823B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

conjugados antagonistas de peptídeo análogo de bombesina". • a presente invenção refere-se a um medicamento terapêutico e diagnóstico, um conjugado antagonista de peptídeo análogo a bombesina é provido o qual tem a fórmula genérica (i): [a -(b)]-c, onde a é um quelante metal compreendendo pelo menos um metal radionuclídeo, b é um espaça-dor ligado a terminal n de c ou uma ligação covalente e c é um antagonista de peptídeo análogo a bombesina tendo uma sequência como reivindicada, onde ainda x é um inteiro de 1 a 3 e n é um inteiro de 1 a 6.
BRPI0909823-2A 2008-03-07 2009-02-27 Conjugados antagonistas de peptídeo análogo de bombesina, seu uso e seu processo de preparação, composição farmacêutica, processo para formação de imagem de receptores de bombesina e kit BRPI0909823B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08075180A EP2100900A1 (en) 2008-03-07 2008-03-07 Bombesin analog peptide antagonist conjugates
EP08075180.3 2008-03-07
PCT/EP2009/001403 WO2009109332A1 (en) 2008-03-07 2009-02-27 Bombesin analog peptide antagonist conjugates

Publications (2)

Publication Number Publication Date
BRPI0909823A2 true BRPI0909823A2 (pt) 2019-03-06
BRPI0909823B1 BRPI0909823B1 (pt) 2022-04-19

Family

ID=39677415

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909823-2A BRPI0909823B1 (pt) 2008-03-07 2009-02-27 Conjugados antagonistas de peptídeo análogo de bombesina, seu uso e seu processo de preparação, composição farmacêutica, processo para formação de imagem de receptores de bombesina e kit

Country Status (32)

Country Link
US (2) US9035023B2 (pt)
EP (2) EP2100900A1 (pt)
JP (1) JP5784911B2 (pt)
KR (2) KR101734553B1 (pt)
CN (1) CN101965358B (pt)
AR (1) AR070809A1 (pt)
AU (1) AU2009221204C1 (pt)
BR (1) BRPI0909823B1 (pt)
CA (1) CA2717427C (pt)
CL (1) CL2009000537A1 (pt)
CO (1) CO6290707A2 (pt)
CR (1) CR11671A (pt)
CY (1) CY1118687T1 (pt)
DK (1) DK2252628T3 (pt)
DO (1) DOP2010000269A (pt)
EC (1) ECSP10010467A (pt)
ES (1) ES2615805T3 (pt)
HU (1) HUE032980T2 (pt)
MX (1) MX2010009843A (pt)
NZ (1) NZ587795A (pt)
PA (1) PA8818501A1 (pt)
PE (1) PE20091753A1 (pt)
PL (1) PL2252628T3 (pt)
PT (1) PT2252628T (pt)
RU (1) RU2523531C2 (pt)
SI (1) SI2252628T1 (pt)
SV (1) SV2010003660A (pt)
TW (1) TWI515011B (pt)
UA (1) UA103314C2 (pt)
UY (1) UY31693A (pt)
WO (1) WO2009109332A1 (pt)
ZA (1) ZA201006385B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380596A1 (en) 2010-04-20 2011-10-26 Technische Universität München Cyclopentapeptide derivatives and uses thereof
EP2380597A1 (en) 2010-04-20 2011-10-26 Technische Universität München Cyclopeptide derivatives and uses thereof
SG190371A1 (en) * 2010-11-22 2013-06-28 Piramal Imaging Sa 177lutetium-labeled bombesin analogs for radiotherapy
WO2012156511A1 (en) * 2011-05-19 2012-11-22 Universitätsspital Basel Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents
US9839703B2 (en) 2012-09-25 2017-12-12 Advanced Accelerator Applications Usa, Inc. Radiolabeled GRPR-antagonists for diagnostic imaging and treatment of GRPR-positive cancer
EP2740726A1 (en) 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
EP2970154B1 (en) * 2013-03-13 2021-07-07 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications
US20150217006A1 (en) * 2014-02-06 2015-08-06 Immunomedics, Inc. Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer
EP3152226B1 (en) 2014-06-06 2019-05-29 Technische Universität München Modified cyclopentapeptides and uses thereof
EP2954933A1 (en) 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand
EP2954934A1 (en) 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand and use thereof
WO2015188934A1 (en) 2014-06-10 2015-12-17 3B Pharmaceuticals Gmbh Conjugate comprising a neurotensin receptor ligand and use thereof
WO2015192211A1 (en) 2014-06-16 2015-12-23 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
CN104610431B (zh) * 2014-11-26 2017-12-15 南京市第一医院 一种多肽及其应用
WO2017106798A2 (en) 2015-12-16 2017-06-22 Nepetx, Llc Compositions and methods for treating gluten intolerance and disorders arising therefrom
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
WO2018126183A2 (en) * 2016-12-29 2018-07-05 The General Hospital Corporation Her3 peptides for imaging and radiotherapy
KR102296752B1 (ko) 2017-01-12 2021-09-02 라디오메딕스 인크. 방사성동위원소에 킬레이팅된 옥트레오티드 유도체를 이용한 소마토스타틴 수용체를 과발현하는 암 세포의 치료
MA49398A (fr) * 2017-05-05 2020-04-22 Eric Steven Burak Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
RU2681318C1 (ru) * 2017-11-24 2019-03-06 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+
US20210402016A1 (en) * 2018-11-13 2021-12-30 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
BR112022000144A2 (pt) 2019-07-08 2022-02-22 3B Pharmaceuticals Gmbh Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
AU2020405585A1 (en) * 2019-12-19 2022-08-11 Technische Universität München Modified GRPR antagonist peptides for imaging and therapy of cancer
WO2021250240A1 (en) 2020-06-12 2021-12-16 Orano Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof
EP3973999A1 (en) 2020-09-28 2022-03-30 Orano Med Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof
WO2022123462A1 (en) 2020-12-09 2022-06-16 3B Pharmaceuticals Gmbh Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CH719832B1 (de) 2021-04-20 2025-09-15 Terrapower Isotopes Llc Generatoren auf der basis von titandioxid für die erzeugung von ac-225
IL313536A (en) 2021-12-17 2024-08-01 3B Pharmaceuticals Gmbh Ligands of carbonic anhydrase IX
WO2023178449A1 (en) 2022-03-25 2023-09-28 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
JP2025530229A (ja) 2022-09-07 2025-09-11 ３ベー ファーマシューティカルズ ゲーエムベーハー 前立腺特異的膜抗原（ｐｓｍａ）リガンドおよびその使用
CN117919452A (zh) * 2023-03-09 2024-04-26 中国科学院宁波材料技术与工程研究所 一种亚细胞器主动靶向成像探针及其制备方法
WO2024212808A1 (zh) * 2023-04-10 2024-10-17 湖南中晟全肽生物科技股份有限公司 蛙皮素类多肽化合物及其用途
EP4455159A1 (en) 2023-04-25 2024-10-30 3B Pharmaceuticals GmbH Gastric inhibitory peptide receptor ligands with bio-distribution modifier
WO2025054727A1 (en) * 2023-09-13 2025-03-20 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
CN120019818A (zh) * 2023-11-20 2025-05-20 湖南中晟全肽生物科技股份有限公司 一种多肽偶联药物及其制备方法和用途
WO2025109003A1 (en) 2023-11-21 2025-05-30 3B Pharmaceuticals Gmbh P-cadherin ligands
WO2025119203A1 (zh) * 2023-12-05 2025-06-12 烟台蓝纳成生物技术有限公司 一种异二聚体放射性核素偶联药物、制备及其应用
WO2025217074A1 (en) * 2024-04-08 2025-10-16 Radionetics Oncology, Inc. Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5021556A (en) 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
US5075099A (en) 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5364613A (en) 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
AU638043B2 (en) * 1989-07-20 1993-06-17 Novartis Ag Labeled polypeptide derivatives
US5367080A (en) 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
US5965107A (en) 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
WO1998047524A1 (en) 1997-04-22 1998-10-29 Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
CA2346154A1 (en) 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
US5886142A (en) 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
HUP0101598A3 (en) 1997-12-24 2002-08-28 Vertex Pharmaceuticals Inc Cam Prodrugs of aspartyl protease inhibitors and medicaments containing them
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
CA2432066A1 (en) * 2000-12-20 2002-06-27 Robert Denham Pinnock Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20080008649A1 (en) 2003-01-13 2008-01-10 Bracco Imaging S.P.A. Gastrin Releasing Peptide Compounds
CN100418585C (zh) * 2003-07-24 2008-09-17 伯拉考成像股份公司 稳定的放射性药物组合物及制备方法
WO2007109475A2 (en) 2006-03-16 2007-09-27 Bracco Imaging S.P.A. Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines
SG190371A1 (en) * 2010-11-22 2013-06-28 Piramal Imaging Sa 177lutetium-labeled bombesin analogs for radiotherapy

Also Published As

Publication number Publication date
CR11671A (es) 2010-11-01
PT2252628T (pt) 2017-02-10
HUE032980T2 (en) 2017-11-28
SV2010003660A (es) 2011-02-17
MX2010009843A (es) 2011-03-04
KR101734553B1 (ko) 2017-05-11
WO2009109332A1 (en) 2009-09-11
PL2252628T3 (pl) 2017-07-31
EP2252628A1 (en) 2010-11-24
KR20110014565A (ko) 2011-02-11
AU2009221204A1 (en) 2009-09-11
BRPI0909823B1 (pt) 2022-04-19
UA103314C2 (ru) 2013-10-10
KR20160128425A (ko) 2016-11-07
PE20091753A1 (es) 2009-12-13
SI2252628T1 (sl) 2017-05-31
RU2010140846A (ru) 2012-04-20
NZ587795A (en) 2012-07-27
EP2252628B1 (en) 2016-12-28
AR070809A1 (es) 2010-05-05
CA2717427A1 (en) 2009-09-11
CN101965358A (zh) 2011-02-02
US9035023B2 (en) 2015-05-19
AU2009221204C1 (en) 2016-12-08
CN101965358B (zh) 2019-09-03
CO6290707A2 (es) 2011-06-20
ES2615805T3 (es) 2017-06-08
ZA201006385B (en) 2016-10-26
JP5784911B2 (ja) 2015-09-24
TW200944239A (en) 2009-11-01
US20150265733A1 (en) 2015-09-24
CL2009000537A1 (es) 2010-07-19
UY31693A (es) 2010-01-05
US20110097266A1 (en) 2011-04-28
RU2523531C2 (ru) 2014-07-20
DOP2010000269A (es) 2010-10-31
PA8818501A1 (es) 2010-04-21
CY1118687T1 (el) 2017-07-12
ECSP10010467A (es) 2010-10-30
DK2252628T3 (en) 2017-02-06
JP2011515338A (ja) 2011-05-19
CA2717427C (en) 2016-02-23
EP2100900A1 (en) 2009-09-16
AU2009221204B2 (en) 2013-09-05
TWI515011B (zh) 2016-01-01

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