SV2009003193A - Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- SV2009003193A SV2009003193A SV2009003193A SV2009003193A SV2009003193A SV 2009003193 A SV2009003193 A SV 2009003193A SV 2009003193 A SV2009003193 A SV 2009003193A SV 2009003193 A SV2009003193 A SV 2009003193A SV 2009003193 A SV2009003193 A SV 2009003193A
- Authority
- SV
- El Salvador
- Prior art keywords
- group
- derivatives
- cyclealkyl
- renting
- piridinas
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCIÓN SE REFIERE A LOS DERIVADOS DE FORMULA GENERAL (I) EN LA QUE: R1 REPRESENTA: UN GRUPO FENILO O UN GRUPO NAFTILO, PUDIENDO ESTAR ESTOS DOS GRUPOS OPCIONALMENTE SUSTITUIDOS; R2, R3 REPRESENTAN, INDEPENDIENTEMENTE EL UNO DEL OTRO, UN ÁTOMO DE HIDROGENO, UN GRUPO ALQUILO(C1-C6), CICLOALQUILO(C3-C7), CICLOALQUIL(C3-C7)ALQUILENO(C1-C3), OPCIONALMENTE SUSTITUIDO; UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO; R4 REPRESENTA: UN ÁTOMO DE HIDROGENO, UN GRUPO ALQUILO(C1-C6), CICLOALQUILO(C3-C7) 0 CICLOALQUIL(C3-C7)ALQUILENO(C1-C3), OPCIONALMENTE SUSTITUIDO; UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO CON UNO O VARIOS SUSTITUYENTES EN ESTADO DE BASE 0 DE SAL DE ADICIÓN A UN ACIDO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608350A FR2906250B1 (fr) | 2006-09-22 | 2006-09-22 | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2009003193A true SV2009003193A (es) | 2010-02-01 |
Family
ID=37841968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2009003193A SV2009003193A (es) | 2006-09-22 | 2009-03-19 | Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeutica |
Country Status (43)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
| FR2928921B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique |
| FR2933609B1 (fr) | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| FR2950345B1 (fr) * | 2009-09-18 | 2011-09-23 | Sanofi Aventis | Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique |
| FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
| FR2953520B1 (fr) * | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
| EP2925756B1 (en) * | 2012-11-29 | 2017-02-01 | F. Hoffmann-La Roche AG | Imidazopyridine derivatives |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| EP3070085B1 (en) * | 2013-02-04 | 2019-01-09 | Janssen Pharmaceutica NV | Flap modulators |
| DK3027615T3 (da) * | 2013-08-02 | 2021-10-25 | Pasteur Institut Korea | Antiinfektionsforbindelser |
| KR20170137165A (ko) | 2015-04-10 | 2017-12-12 | 베이진 엘티디 | 인돌아민 및/또는 트립토판 2,3-디옥시게나아제로서 신규한 5 또는 8-치환된 이미다조[1,5-a]피리딘 |
| US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SG11201804152RA (en) | 2015-11-19 | 2018-06-28 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| EP3828171A1 (en) | 2015-12-22 | 2021-06-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| TW201808902A (zh) | 2016-05-26 | 2018-03-16 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| AU2017281285C1 (en) | 2016-06-20 | 2022-05-12 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3484866B1 (en) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3515914A4 (en) * | 2016-09-24 | 2020-04-15 | BeiGene, Ltd. | INNOVATIVE 5- OR 8-SUBSTITUTED IMIDAZO [1,5-A] PYRIDINE AS SELECTIVE INHIBITORS OF INDOLEAMINE AND / OR TRYPTOPHANE-2,3-DIOXYGENASES |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| PE20200005A1 (es) | 2016-12-22 | 2020-01-06 | Incyte Corp | Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de internalizacion pd-l1 |
| IL295660A (en) | 2016-12-22 | 2022-10-01 | Incyte Corp | Benzooxazole derivatives as immunomodulators |
| EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2019101188A1 (en) | 2017-11-25 | 2019-05-31 | Beigene, Ltd. | Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases |
| KR20250067967A (ko) | 2018-03-30 | 2025-05-15 | 인사이트 코포레이션 | 면역조절제로서 복소환형 화합물 |
| HUE061503T2 (hu) | 2018-05-11 | 2023-07-28 | Incyte Corp | Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| TWI879811B (zh) | 2019-09-30 | 2025-04-11 | 美商英塞特公司 | 作為免疫調節劑之吡啶并[3,2-d]嘧啶化合物 |
| PH12022551136A1 (en) | 2019-11-11 | 2023-10-09 | Incyte Corp | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| TWI759962B (zh) * | 2019-11-13 | 2022-04-01 | 香港商新旭生技股份有限公司 | 用於降解tau蛋白聚集體的化合物及其用途 |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| CN116670114A (zh) | 2020-11-06 | 2023-08-29 | 因赛特公司 | 用于制备pd-1/pd-l1抑制剂以及其盐和结晶形式的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4041624B2 (ja) * | 1999-07-21 | 2008-01-30 | 三井化学株式会社 | 有機電界発光素子 |
| AU2001249672A1 (en) * | 2000-03-31 | 2001-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists |
| GB0119911D0 (en) * | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
| WO2004026867A2 (en) * | 2002-09-19 | 2004-04-01 | Schering Corporation | Imidazopyridines as cyclin dependent kinase inhibitors |
| GB0303503D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| JP2007527908A (ja) * | 2004-03-08 | 2007-10-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗原虫薬としての新規ジカチオン性イミダゾ［１，２−ａ］ピリジン、及び５，６，７，８−テトラヒドロ−イミダゾ［１，２−ａ］ピリジン |
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2006
- 2006-09-22 FR FR0608350A patent/FR2906250B1/fr active Active
-
2007
- 2007-09-13 TW TW096134253A patent/TWI381837B/zh not_active IP Right Cessation
- 2007-09-19 PL PL07848251T patent/PL2069342T3/pl unknown
- 2007-09-19 NZ NZ575337A patent/NZ575337A/en not_active IP Right Cessation
- 2007-09-19 RS RSP-2010/0356A patent/RS51412B/sr unknown
- 2007-09-19 MY MYPI20091157A patent/MY145603A/en unknown
- 2007-09-19 AR ARP070104136A patent/AR062897A1/es not_active Application Discontinuation
- 2007-09-19 CA CA2662848A patent/CA2662848C/fr not_active Expired - Fee Related
- 2007-09-19 AT AT07848251T patent/ATE467633T1/de active
- 2007-09-19 AU AU2007298856A patent/AU2007298856B2/en not_active Ceased
- 2007-09-19 UA UAA200903928A patent/UA95976C2/ru unknown
- 2007-09-19 ZA ZA200901551A patent/ZA200901551B/xx unknown
- 2007-09-19 BR BRPI0718517-0A patent/BRPI0718517A2/pt active Search and Examination
- 2007-09-19 HR HR20100408T patent/HRP20100408T1/hr unknown
- 2007-09-19 WO PCT/FR2007/001517 patent/WO2008034974A1/fr not_active Ceased
- 2007-09-19 DE DE602007006525T patent/DE602007006525D1/de active Active
- 2007-09-19 DK DK07848251.0T patent/DK2069342T3/da active
- 2007-09-19 KR KR1020097005741A patent/KR101470039B1/ko not_active Expired - Fee Related
- 2007-09-19 MX MX2009002802A patent/MX2009002802A/es active IP Right Grant
- 2007-09-19 CN CN2007800352403A patent/CN101516881B/zh not_active Expired - Fee Related
- 2007-09-19 ME MEP-2009-107A patent/ME00615B/me unknown
- 2007-09-19 SI SI200730316T patent/SI2069342T1/sl unknown
- 2007-09-19 EP EP07848251A patent/EP2069342B1/fr active Active
- 2007-09-19 ES ES07848251T patent/ES2345016T3/es active Active
- 2007-09-19 EA EA200970311A patent/EA017442B1/ru not_active IP Right Cessation
- 2007-09-19 JP JP2009528752A patent/JP5336378B2/ja not_active Expired - Fee Related
- 2007-09-19 PT PT07848251T patent/PT2069342E/pt unknown
- 2007-09-20 PE PE2007001266A patent/PE20080671A1/es not_active Application Discontinuation
- 2007-09-20 JO JO2007401A patent/JO2643B1/en active
- 2007-09-21 CL CL200702733A patent/CL2007002733A1/es unknown
- 2007-09-21 UY UY30603A patent/UY30603A1/es not_active Application Discontinuation
-
2009
- 2009-02-26 CR CR10643A patent/CR10643A/es unknown
- 2009-03-02 IL IL197352A patent/IL197352A/en not_active IP Right Cessation
- 2009-03-05 GT GT200900049A patent/GT200900049A/es unknown
- 2009-03-10 TN TN2009000081A patent/TN2009000081A1/fr unknown
- 2009-03-18 HN HN2009000502A patent/HN2009000502A/es unknown
- 2009-03-19 SV SV2009003193A patent/SV2009003193A/es active IP Right Grant
- 2009-03-19 NI NI200900037A patent/NI200900037A/es unknown
- 2009-03-19 US US12/407,449 patent/US7915284B2/en not_active Expired - Fee Related
- 2009-03-19 CO CO09028759A patent/CO6160308A2/es unknown
- 2009-04-16 MA MA31788A patent/MA30792B1/fr unknown
- 2009-04-20 NO NO20091562A patent/NO20091562L/no not_active Application Discontinuation
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2010
- 2010-07-20 CY CY20101100678T patent/CY1110232T1/el unknown
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