SV2008003106A - Composicion farmaceutica estable que contiene docetaxel y un metodo para fabricarla - Google Patents
Composicion farmaceutica estable que contiene docetaxel y un metodo para fabricarlaInfo
- Publication number
- SV2008003106A SV2008003106A SV2008003106A SV2008003106A SV2008003106A SV 2008003106 A SV2008003106 A SV 2008003106A SV 2008003106 A SV2008003106 A SV 2008003106A SV 2008003106 A SV2008003106 A SV 2008003106A SV 2008003106 A SV2008003106 A SV 2008003106A
- Authority
- SV
- El Salvador
- Prior art keywords
- pharmaceutical composition
- docetaxel
- stable pharmaceutical
- manufacturing
- composition containing
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 4
- 229960003668 docetaxel Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- -1 HYDROXYPROPYLMETHYL Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN FARMACÉUTICA ESTABLE PARA INYECCIÓN, QUE CONTIENE DOCETAXEL Y A UN MÉTODO PARA PREPARARLA. MAS EN PARTICULAR, LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN FARMACÉUTICA PARA INYECCIÓN QUE CONTIENE DOCETAXEL QUE TIENE MEJOR ESTABILIDAD DURANTE EL ALMACENAMIENTO, QUE LAS MEDICACIONES CONVENCIONALES; QUE SE PREPARA DISOLVIENDO EL DOCETAXEL, UN COMPUESTO INSOLUBLE EN AGUA, EN AGUA DESTILADA, DESPUÉS DE MEZCLARLO CON CICLODEXTRINA (CD) Y UN POLÍMERO SOLUBLE EN AGUA, TAL COMO HIDROXIPROPILMETILCELULOSA (HPMC), POLIETILENGLICOL (PEG) O POLIVINILPIRROLIDONA (PVP), Y LIOFILIZANDO LA MEZCLA, Y A UN MÉTODO PARA PREPARARLA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20060045715 | 2006-05-22 | ||
| KR1020070049340A KR100917809B1 (ko) | 2006-05-22 | 2007-05-21 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2008003106A true SV2008003106A (es) | 2010-04-30 |
Family
ID=39090946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2008003106A SV2008003106A (es) | 2006-05-22 | 2008-11-24 | Composicion farmaceutica estable que contiene docetaxel y un metodo para fabricarla |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8791152B2 (es) |
| EP (1) | EP2019664B1 (es) |
| JP (1) | JP5369332B2 (es) |
| KR (2) | KR100917809B1 (es) |
| CN (1) | CN101484137B (es) |
| AU (1) | AU2007252371B2 (es) |
| BR (1) | BRPI0711893A2 (es) |
| CA (1) | CA2653124C (es) |
| CR (1) | CR10485A (es) |
| EA (1) | EA014071B1 (es) |
| EC (1) | ECSP088951A (es) |
| ES (1) | ES2560641T3 (es) |
| GE (1) | GEP20115200B (es) |
| GT (1) | GT200800257A (es) |
| IL (1) | IL195459A (es) |
| MA (1) | MA30501B1 (es) |
| MX (1) | MX2008014948A (es) |
| MY (1) | MY149627A (es) |
| NO (1) | NO20084932L (es) |
| NZ (1) | NZ573202A (es) |
| SV (1) | SV2008003106A (es) |
| TN (1) | TNSN08475A1 (es) |
| WO (1) | WO2007136219A1 (es) |
| ZA (1) | ZA200809998B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383554B (zh) | 2002-09-06 | 2018-06-08 | 天蓝制药公司 | 用于传递治疗剂的以环糊精为基础的聚合物 |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| CN102014918A (zh) * | 2007-04-20 | 2011-04-13 | 太阳医药工业有限公司 | 由微量沉淀产生的药学组合物 |
| KR101502533B1 (ko) * | 2007-11-22 | 2015-03-13 | 에스케이케미칼주식회사 | 우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법 |
| UA100543C2 (ru) * | 2007-12-24 | 2013-01-10 | Сан Фарма Адвансед Ресерч Компани Лимитед | Нанодисперсия, включающая наночастицы, которые содержат производное таксана |
| KR101053780B1 (ko) * | 2008-02-29 | 2011-08-02 | 동아제약주식회사 | 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물 |
| MX2011013726A (es) | 2009-06-19 | 2012-02-29 | Sun Pharma Advanced Res Co Ltd | Nanodispersión de un medicamento y proceso para su preparación. |
| CA2774015A1 (en) * | 2009-09-15 | 2011-03-24 | Cerulean Pharma Inc. | A cdp-camptothecin conjugate, particle or composition and uses thereof |
| MX2012005987A (es) | 2009-11-23 | 2012-06-25 | Cerulean Pharma Inc | Polimeros a base de ciclodextrina para administracion terapeutica. |
| AU2011248449B2 (en) | 2010-05-03 | 2016-09-15 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| WO2012161520A2 (ko) * | 2011-05-23 | 2012-11-29 | 에스케이케미칼 주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
| KR20120130740A (ko) * | 2011-05-23 | 2012-12-03 | 에스케이케미칼주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| EP2777691A1 (en) * | 2013-03-14 | 2014-09-17 | Pharmachemie B.V. | Taxoid - Purification of Liquid Excipients |
| KR20140147336A (ko) * | 2013-06-19 | 2014-12-30 | 에스케이케미칼주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
| CA2951912A1 (en) * | 2014-06-12 | 2015-12-17 | University Of Notre Dame Du Lac | Composition and method for the treatment of neurological diseases and cerebral injury |
| US10398785B2 (en) | 2015-03-16 | 2019-09-03 | Meridian Lab | Pharmaceutical compositions containing taxane-cyclodextrin complexes, method of making and methods of use |
| US11844782B2 (en) | 2015-10-20 | 2023-12-19 | Spepharm Ag | Aqueous composition comprising dantrolene |
| WO2018047074A1 (en) * | 2016-09-07 | 2018-03-15 | Cadila Healthcare Limited | Sterile injectable compositions comprising drug micelles |
| CN108066774B (zh) * | 2018-01-11 | 2023-04-18 | 比卡生物科技（广州）有限公司 | 一种注射用卡巴他赛组合物及其制备方法 |
| CN113456586B (zh) * | 2018-07-25 | 2022-06-10 | 比卡生物科技（广州）有限公司 | 一种注射用多西他赛组合物及其制备方法 |
| CN111603387A (zh) * | 2020-06-03 | 2020-09-01 | 芜湖市第二人民医院 | 一种多西他赛注射液存储装置及其配制方法 |
| CN116355289B (zh) * | 2023-03-31 | 2026-02-03 | 北京工商大学 | 一种纳米纤维膜及其原料、制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472945A (en) * | 1991-08-13 | 1995-12-05 | Temple University- Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| HUT73844A (en) * | 1994-11-11 | 1996-09-30 | Chinoin Gyogyszer Es Vegyeszet | New taxol complexes and pharmaceutical compositions containing them |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| HUP9701945A3 (en) | 1997-11-10 | 2000-04-28 | Hexal Ag | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
| US6133473A (en) * | 1998-06-25 | 2000-10-17 | Rohm And Haas Company | Synthesis of carbamate compounds |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| KR100310839B1 (ko) | 1999-03-23 | 2001-10-12 | 정기련 | 안정성이 개선된 파크리탁셀 가용화 주사제 조성물 |
| BR0010794A (pt) * | 1999-05-24 | 2002-06-04 | Sonus Pharma Inc | Emulsão-veìculo para drogas com fraca solubilidade |
| WO2000072827A2 (en) | 1999-05-27 | 2000-12-07 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US20030157161A1 (en) * | 2001-05-01 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents |
| KR100776557B1 (ko) * | 2001-07-13 | 2007-11-16 | 나노캬리아 가부시키가이샤 | 약물 내포 고분자 미셀의 동결 건조용 조성물 또는 미셀의제조방법 |
| KR20030041577A (ko) * | 2001-11-20 | 2003-05-27 | 디디에스텍주식회사 | 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물 |
| JP2003342168A (ja) * | 2002-05-24 | 2003-12-03 | Nano Career Kk | 注射用薬物含有ポリマーミセル製剤の製造方法 |
| JP2006500387A (ja) * | 2002-08-15 | 2006-01-05 | 雲清 劉 | 固形ナノ医薬およびその調製方法 |
| CN1502332A (zh) * | 2002-11-25 | 2004-06-09 | 刘云清 | 抗癌药紫杉醇自乳化固体纳米粒——注射用紫杉醇的制备方法 |
| US20040127551A1 (en) * | 2002-12-27 | 2004-07-01 | Kai Zhang | Taxane-based compositions and methods of use |
| JP2005075783A (ja) | 2003-09-01 | 2005-03-24 | Otsuka Pharmaceut Factory Inc | 難溶性化合物の可溶化または分散化用組成物 |
| US20080128314A1 (en) * | 2005-03-14 | 2008-06-05 | Koichi Takeda | Pharmaceutical Composition Containing Hardly Water Soluble Medicament |
-
2007
- 2007-05-21 KR KR1020070049340A patent/KR100917809B1/ko active Active
- 2007-05-22 MX MX2008014948A patent/MX2008014948A/es active IP Right Grant
- 2007-05-22 CA CA2653124A patent/CA2653124C/en not_active Expired - Fee Related
- 2007-05-22 MY MYPI20084753A patent/MY149627A/en unknown
- 2007-05-22 ES ES07746627.4T patent/ES2560641T3/es active Active
- 2007-05-22 US US12/301,700 patent/US8791152B2/en not_active Expired - Fee Related
- 2007-05-22 JP JP2009511943A patent/JP5369332B2/ja not_active Expired - Fee Related
- 2007-05-22 CN CN200780024837.8A patent/CN101484137B/zh not_active Expired - Fee Related
- 2007-05-22 AU AU2007252371A patent/AU2007252371B2/en not_active Ceased
- 2007-05-22 EA EA200870559A patent/EA014071B1/ru not_active IP Right Cessation
- 2007-05-22 WO PCT/KR2007/002479 patent/WO2007136219A1/en not_active Ceased
- 2007-05-22 NZ NZ573202A patent/NZ573202A/en not_active IP Right Cessation
- 2007-05-22 EP EP07746627.4A patent/EP2019664B1/en active Active
- 2007-05-22 BR BRPI0711893-7A patent/BRPI0711893A2/pt not_active IP Right Cessation
- 2007-05-22 GE GEAP200711018A patent/GEP20115200B/en unknown
-
2008
- 2008-11-21 GT GT200800257A patent/GT200800257A/es unknown
- 2008-11-21 TN TNP2008000475A patent/TNSN08475A1/en unknown
- 2008-11-23 IL IL195459A patent/IL195459A/en not_active IP Right Cessation
- 2008-11-24 SV SV2008003106A patent/SV2008003106A/es unknown
- 2008-11-25 ZA ZA200809998A patent/ZA200809998B/xx unknown
- 2008-11-25 NO NO20084932A patent/NO20084932L/no not_active Application Discontinuation
- 2008-12-05 MA MA31456A patent/MA30501B1/fr unknown
- 2008-12-09 CR CR10485A patent/CR10485A/es unknown
- 2008-12-11 EC EC2008008951A patent/ECSP088951A/es unknown
-
2009
- 2009-08-26 KR KR1020090079337A patent/KR100983376B1/ko active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SV2008003106A (es) | Composicion farmaceutica estable que contiene docetaxel y un metodo para fabricarla | |
| ES2536206T3 (es) | Parche medicinal | |
| ES2556585T3 (es) | Composiciones que comprenden sulfato de salbutamol | |
| ES2552651T3 (es) | Composición inyectable de polidesoxirribonucleótido para el tratamiento de enfermedades osteoarticulares | |
| AR088382A1 (es) | Formulaciones de etanercept estabilizadas con xilitol | |
| BRPI0615292A8 (pt) | composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada | |
| PE20140960A1 (es) | Formulaciones que comprenden un inhibidor de dpp4 | |
| NI201200013A (es) | Composición de insulina de acción prolongada | |
| AR048033A1 (es) | Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion | |
| EA201000747A1 (ru) | Система и способ трансдермальной доставки и способ получения системы трансдермальной доставки | |
| UY29410A1 (es) | Composiciones farmacéuticas en base a metilamidas del ácido 4-(4-/-3(-4-cloro-3-trifluorometifenil)ureido)fenoxi)piridin-2-carboxílico, procedimiento de preparación y aplicaciones. | |
| DOP2010000253A (es) | Sistema de administracion de drogas con efecto estabilizante | |
| CR9339A (es) | Formas farmaceuticas con propiedades farmacocineticas mejoradas | |
| CL2011001132A1 (es) | Metodo para reducir al minimo la inflamacion en el sitio de inyeccion durante la administracion subcutanea de una macromolecula que comprende agregar a una formulacion que contiene la macromolecula de 2% a 30% de ciclodextrina; formulacion que comprende un anticuerpo; y metodo para reducir al minimola precipitacion del anticuerpo. | |
| UY32761A (es) | Preparaciones termoestables y preparaciones insulinicas estables a las vibraciones | |
| AR056465A1 (es) | Composiciones que contienen derivados de taxano | |
| EA201170512A1 (ru) | Композиция для перорального введения | |
| BRPI0707334A8 (pt) | formulação de cápsula de gelatina mole e método para estabilização de um composto 15-ceto-prostaglandina | |
| UA114123C2 (xx) | Водна композиція диклофенаку | |
| BR112013004455A2 (pt) | composições para fornecimento gástrico de agentes ativos | |
| BR112012015437A2 (pt) | composição tópica substancialmente anidra de armazenamento estável | |
| WO2011056702A3 (en) | Fast dissolving/disintegrating coating compositions | |
| BR112015018200A2 (pt) | composição mastigável para administração oral e processo para preparar a mesma | |
| CL2012001159A1 (es) | Composicion que comprende un inhibidor de alfa-1-proteinasa (api), y como minimo, un aminoacido; kit que comprende dicha composicion que se utiliza como una composicion farmaceutica adecuada para administracion intravenosa. | |
| EA200701228A1 (ru) | Стабильные композиции фенофибрата с эфирами жирных кислот |