[go: up one dir, main page]

SV2003000162A - Los inhibidores triciclicos de poli (adp-ribosa) polimerasas - Google Patents

Los inhibidores triciclicos de poli (adp-ribosa) polimerasas

Info

Publication number
SV2003000162A
SV2003000162A SV2000000162A SV2000000162A SV2003000162A SV 2003000162 A SV2003000162 A SV 2003000162A SV 2000000162 A SV2000000162 A SV 2000000162A SV 2000000162 A SV2000000162 A SV 2000000162A SV 2003000162 A SV2003000162 A SV 2003000162A
Authority
SV
El Salvador
Prior art keywords
adp
inhibitors
ribosa
tricycle
polymerases
Prior art date
Application number
SV2000000162A
Other languages
English (en)
Inventor
Stephen Evan Webber
Stephen E Webber
Robert Arnold Kumpf
Joseph Timothy Marakovitz
Brian Walter Eastman
Original Assignee
Cancer Res Campaign Tech
Agouron Pharma
Cancer Res Technology Li Mited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Campaign Tech, Agouron Pharma, Cancer Res Technology Li Mited filed Critical Cancer Res Campaign Tech
Publication of SV2003000162A publication Critical patent/SV2003000162A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS COMPUESTOS DE LA FORMULA MOSTRADA ABAJO SON INHIBIDORES POLI(ADP-RIBOSILO)TRANSFERASE, VER FORMULAS, ESTOS COMPUESTOS SON UTILES COMO TERAPEUTICOS EN EL TRATAMIENTO DE CANCERES Y EN EL MEJORAMIENTO DE LOS EFECTOS DE EMBOLIAS CEREBRALES, TRAUMAS A LA CABEZA, Y ENFERMEDADES NEURODEGENERATIVAS.
SV2000000162A 1999-08-31 2000-08-31 Los inhibidores triciclicos de poli (adp-ribosa) polimerasas SV2003000162A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15214299P 1999-08-31 1999-08-31

Publications (1)

Publication Number Publication Date
SV2003000162A true SV2003000162A (es) 2003-07-29

Family

ID=22541675

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000162A SV2003000162A (es) 1999-08-31 2000-08-31 Los inhibidores triciclicos de poli (adp-ribosa) polimerasas

Country Status (48)

Country Link
US (1) US6548494B1 (es)
EP (1) EP1208104B1 (es)
JP (1) JP4272375B2 (es)
KR (1) KR20020038742A (es)
CN (1) CN1384835A (es)
AP (1) AP1553A (es)
AR (1) AR035162A1 (es)
AT (1) ATE287406T1 (es)
AU (1) AU781826B2 (es)
BG (1) BG106562A (es)
BR (1) BR0015051A (es)
CA (1) CA2382404C (es)
CO (1) CO5200769A1 (es)
CR (1) CR6577A (es)
CZ (1) CZ2002613A3 (es)
DE (1) DE60017575T2 (es)
DK (1) DK1208104T3 (es)
DO (1) DOP2000000069A (es)
DZ (1) DZ3216A1 (es)
EA (1) EA200200306A1 (es)
EC (1) ECSP003637A (es)
EE (1) EE200200100A (es)
ES (1) ES2234657T3 (es)
GE (1) GEP20043268B (es)
GT (1) GT200000145A (es)
HK (1) HK1045509B (es)
HR (1) HRP20020271A2 (es)
HU (1) HUP0202703A3 (es)
IL (1) IL147863A0 (es)
IS (1) IS6289A (es)
MA (1) MA25876A1 (es)
MX (1) MXPA02002138A (es)
MY (1) MY135910A (es)
NO (1) NO322475B1 (es)
NZ (1) NZ516793A (es)
OA (1) OA12016A (es)
PA (1) PA8501801A1 (es)
PE (1) PE20010538A1 (es)
PL (1) PL354242A1 (es)
PT (1) PT1208104E (es)
SI (1) SI1208104T1 (es)
SK (1) SK2592002A3 (es)
SV (1) SV2003000162A (es)
UA (1) UA73144C2 (es)
UY (1) UY26323A1 (es)
WO (1) WO2001016136A2 (es)
YU (1) YU15102A (es)
ZA (1) ZA200200830B (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
DE19946289A1 (de) * 1999-09-28 2001-03-29 Basf Ag Benzodiazepin-Derivate, deren Herstellung und Anwendung
WO2001023390A2 (de) * 1999-09-28 2001-04-05 Basf Aktiengesellschaft Azepinoindol-derivate, deren herstellung und anwendung
DE10021468A1 (de) * 2000-05-04 2001-11-08 Basf Ag Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
FR2816942B1 (fr) * 2000-11-23 2003-05-09 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
WO2003051879A1 (en) * 2001-12-14 2003-06-26 Altana Pharma Ag Known and novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors
US7026311B2 (en) 2002-01-10 2006-04-11 Abbott Gmbh & Co., Kg Dibenzodiazepine derivatives, their preparation and use
EP1501822B1 (en) 2002-04-30 2010-12-15 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2003103666A2 (en) * 2002-06-07 2003-12-18 Altana Pharma Ag Novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones
RS20050522A (sr) 2003-01-09 2007-12-31 Pfizer Inc., Triciklična jedinjenja inhibitori protein kinaze za pojačavanje efikasnosti anti-neoplastičnih agenasa i terapije zračenjem
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
NZ544989A (en) * 2003-07-25 2009-10-30 Cancer Rec Tech Ltd Tricyclic PARP inhibitors
GB0317466D0 (en) * 2003-07-25 2003-08-27 Univ Sheffield Use
WO2005035534A1 (ja) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
BRPI0417056A (pt) 2003-12-01 2007-02-06 Kudos Pharm Ltd inibidores de reparo de dano no dna para tratamento de cáncer
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
MX2007003311A (es) * 2004-09-22 2007-05-16 Pfizer Procedimiento para preparar inhibidores de poli (adp-ribosa) polimerasas.
EP1841771A4 (en) * 2005-01-19 2008-09-24 Mgi Gp Inc COMPOUNDS OF DIAZABENZO [DE] ANTHRACENE-3-ONE AND USE IN INHIBITION OF PARP
US7812013B2 (en) 2005-06-14 2010-10-12 Schering Corporation Macrocyclic heterocyclic aspartyl protease inhibitors
JPWO2006137510A1 (ja) * 2005-06-24 2009-01-22 小野薬品工業株式会社 脳血管障害時における出血低減剤
NZ587586A (en) * 2005-07-18 2012-04-27 Bipar Sciences Inc Treatment of cancer
US20070032469A1 (en) * 2005-08-05 2007-02-08 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
US20070292883A1 (en) * 2006-06-12 2007-12-20 Ossovskaya Valeria S Method of treating diseases with PARP inhibitors
US20080262062A1 (en) * 2006-11-20 2008-10-23 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
EP2061479A4 (en) * 2006-09-05 2010-08-04 Bipar Sciences Inc FETTIC ACID SYNTHESIS INHIBITED BY PARP HEMMER AND TREATMENT PROCEDURES THEREWITH
AU2007292387A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
CA2690091A1 (en) 2007-06-05 2008-12-11 Nsab, Filial Af Neurosearch Sweden Ab, Sverige New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
WO2008154129A1 (en) * 2007-06-08 2008-12-18 Bausch & Lomb Incorporated Pharmaceutical compositions and method for treating, reducing, ameliorating, alleviating, or preventing dry eye
RU2010108008A (ru) 2007-09-14 2011-10-20 Астразенека Аб (Se) Фталазиноновые производные
CA2705537A1 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20090123419A1 (en) * 2007-11-12 2009-05-14 Bipar Sciences Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20090149397A1 (en) * 2007-12-07 2009-06-11 Bipar Sciences Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
CA2713156A1 (en) * 2008-02-04 2009-08-13 Bipar Sciences, Inc. Methods of diagnosing and treating parp-mediated diseases
GB0804755D0 (en) * 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
RS55157B2 (sr) 2008-10-07 2023-10-31 Kudos Pharm Ltd Farmaceutska formulacija 514
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
EP2892344A1 (de) * 2012-09-05 2015-07-15 Bayer CropScience AG Verwendung substituierter benzodiazepinone und benzazepinone oder deren salze als wirkstoffe gegen abiotischen pflanzenstress
JP6407303B2 (ja) * 2014-01-05 2018-10-17 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ ポリ（ａｄｐ−リボース）ポリメラーゼ−１（ｐａｒｐ−１）のための放射標識トレーサー、その方法および使用
WO2017013237A1 (en) 2015-07-23 2017-01-26 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2018022851A1 (en) 2016-07-28 2018-02-01 Mitobridge, Inc. Methods of treating acute kidney injury
RU2019114863A (ru) 2016-11-02 2020-12-03 Иммуноджен, Инк. Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
EP3615026B1 (en) 2017-04-28 2021-03-03 Akribes Biomedical GmbH A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing
MX2020007060A (es) 2018-01-05 2020-11-11 Cybrexa 1 Inc Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas.
EP3765613A1 (en) 2018-03-13 2021-01-20 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
US11535633B2 (en) 2018-06-28 2022-12-27 Jiangsu Hengrui Medicine Co., Ltd. Fused tricyclic heterocycle compounds and therapeutic uses thereof
JP7584802B2 (ja) * 2018-08-24 2024-11-18 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド 高活性ｓｔｉｎｇタンパク質アゴニスト
CN113195473B (zh) * 2018-12-14 2022-11-22 江苏恒瑞医药股份有限公司 三环化合物作为sting激动剂及其制备方法和医药用途
CN116804019A (zh) * 2019-02-02 2023-09-26 正大天晴药业集团股份有限公司 用于parp抑制剂的吲哚并七元酰肟类似物
CN111909157B (zh) * 2019-05-07 2023-02-03 南京药石科技股份有限公司 Ezh2抑制剂及其用途
PH12022550039A1 (en) 2019-07-10 2023-06-26 Cybrexa 3 Inc Peptide conjugates of cytotoxins as therapeutics
MX2022000450A (es) 2019-07-10 2022-04-25 Cybrexa 3 Inc Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos.
GB201913030D0 (en) 2019-09-10 2019-10-23 Francis Crick Institute Ltd Treatment of hr deficient cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CA3176206A1 (en) 2020-04-28 2021-11-04 Debnath Bhuniya Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
MX2023008146A (es) 2021-01-08 2023-07-24 Cybrexa 2 Inc Proceso para preparar un resto enlazador de conjugados.
WO2022155172A1 (en) 2021-01-13 2022-07-21 Cybrexa 3, Inc. Peptide conjugates of therapeutics
US20240199582A1 (en) 2021-04-08 2024-06-20 Rhizen Pharmaceuticals Ag Inhibitors of poly(adp-ribose) polymerase
CA3250650A1 (en) * 2022-02-11 2023-08-17 The University Of North Carolina At Chapel Hill ARYLBENZOISOXAZOLE COMPOUNDS USED AS IP6K AND IPMK INHIBITORS AND THEIR METHODS OF USE
WO2024261243A1 (en) 2023-06-21 2024-12-26 Hemispherian As Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer
WO2025106920A1 (en) * 2023-11-15 2025-05-22 Yale University Parp pet imaging agents and methods of using the same

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052390A (es) 1964-03-24
US3642820A (en) * 1969-11-03 1972-02-15 Upjohn Co 4 5-dihydropyrrolo(3 2 1-jk)(1 4)bezodiazepines
US3734919A (en) * 1969-11-03 1973-05-22 Upjohn Co 4,5-di-hydropyrrolo(3,2,1-jk)(1,4)benzodiazepin-7(6h)-ones and 4,5-di-hydropyrrolo(1,2,3-ef)(1,5)benzodiazepin-6(7h)-ones
DE2056215A1 (de) 1970-11-16 1972-05-18 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Verfahren zur Herstellung von N-Mono-(beta-Cyanäthyl>anilinen
US3883590A (en) 1971-06-01 1975-05-13 Universal Oil Prod Co Preparation of n-alkylarylcarboxamides
US3978066A (en) 1973-11-06 1976-08-31 Ayerst, Mckenna And Harrison Ltd. Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives
US3900477A (en) 1973-11-06 1975-08-19 Ayerst Mckenna & Harrison 5-amino-and 5-hydrazinodihydropyrroloisoquinoline derivatives
US3950343A (en) 1973-11-06 1976-04-13 Ayerst, Mckenna And Harrison Ltd. Pyrroloisoquinoline derivatives
JPS57144286A (en) 1981-03-02 1982-09-06 Takeda Chem Ind Ltd Azepinoindole derivative and its preparation
US4910193A (en) 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
DE4125292A1 (de) 1991-07-31 1993-02-04 Kali Chemie Pharma Gmbh 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5342946A (en) 1992-12-02 1994-08-30 Guilford Pharmaceuticals Inc. Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors
AU674613B2 (en) 1993-09-28 1997-01-02 Otsuka Pharmaceutical Co., Ltd. Quinoxaline derivative as antidiabetic agent
US5587384A (en) 1994-02-04 1996-12-24 The Johns Hopkins University Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5561161A (en) 1994-03-25 1996-10-01 Oxigene, Inc. Methods of administering and pharmaceutical formulations containing n-substituted benzamides and/or acid addition salts thereof
US5589483A (en) 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
ES2105959B1 (es) 1995-01-17 1998-07-01 Zeneca Pharma Sa Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion.
US5756548A (en) 1995-04-03 1998-05-26 Centaur Pharmaceuticals, Inc. Acetamidobenzamide compounds for neurodegenerative disorders
US5659082A (en) 1995-04-03 1997-08-19 Centaur Pharmaceuticals, Inc. Nitro- and aminobenzamide compounds for neurodegenerative disorders
TR199800127T1 (xx) 1995-08-02 1998-04-21 Newcastle University Ventures Limited Benzimidazol bile�ikleri.
HUT76302A (en) 1995-11-30 1997-07-28 Chinoin Gyogyszer Es Vegyeszet Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them
GB9702701D0 (en) 1997-02-01 1997-04-02 Univ Newcastle Ventures Ltd Quinazolinone compounds
NZ501650A (en) 1997-05-13 2001-11-30 Octamer Inc Use of a pADPRT inhibitory compound that is not 3-aminobenzamide to treat inflammation and inflammatory diseases in mammals
US20020028813A1 (en) 1997-09-03 2002-03-07 Paul F. Jackson Thioalkyl compounds, methods, and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
WO1999011644A1 (en) 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
US20020022636A1 (en) 1997-09-03 2002-02-21 Jia-He Li Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
AU9298098A (en) 1997-09-03 1999-03-22 Guilford Pharmaceuticals Inc. Amino-substituted compounds, methods, and compositions for inhibiting parp activity
EP1077946A1 (en) 1998-05-15 2001-02-28 Guilford Pharmaceuticals Inc. Fused tricyclic compounds which inhibit parp activity
JP2002515488A (ja) 1998-05-15 2002-05-28 ギルフォード ファーマシューティカルズ インコーポレイテッド カルボキサミド化合物、組成物、及びｐａｒｐ活性の抑制方法

Also Published As

Publication number Publication date
CZ2002613A3 (cs) 2002-08-14
NO322475B1 (no) 2006-10-09
EE200200100A (et) 2003-06-16
WO2001016136A3 (en) 2001-06-21
MXPA02002138A (es) 2003-08-20
CA2382404C (en) 2009-03-24
HUP0202703A2 (hu) 2002-12-28
ECSP003637A (es) 2002-03-25
JP2003513015A (ja) 2003-04-08
IL147863A0 (en) 2002-08-14
BG106562A (bg) 2003-03-31
MA25876A1 (fr) 2003-10-01
US6548494B1 (en) 2003-04-15
WO2001016136A2 (en) 2001-03-08
YU15102A (sh) 2004-12-31
HRP20020271A2 (en) 2005-12-31
ES2234657T3 (es) 2005-07-01
DE60017575D1 (de) 2005-02-24
DK1208104T3 (da) 2005-05-02
SI1208104T1 (en) 2005-06-30
CN1384835A (zh) 2002-12-11
NO20020421D0 (no) 2002-01-28
UY26323A1 (es) 2001-04-30
IS6289A (is) 2002-02-27
AU7338900A (en) 2001-03-26
PA8501801A1 (es) 2002-08-26
NO20020421L (no) 2002-04-25
DZ3216A1 (fr) 2001-03-08
EP1208104B1 (en) 2005-01-19
JP4272375B2 (ja) 2009-06-03
PT1208104E (pt) 2005-04-29
CO5200769A1 (es) 2002-09-27
UA73144C2 (en) 2005-06-15
SK2592002A3 (en) 2002-10-08
HK1045509B (en) 2005-04-29
CA2382404A1 (en) 2001-03-08
KR20020038742A (ko) 2002-05-23
AU781826B2 (en) 2005-06-16
ATE287406T1 (de) 2005-02-15
BR0015051A (pt) 2002-06-25
EA200200306A1 (ru) 2002-08-29
HUP0202703A3 (en) 2004-12-28
MY135910A (en) 2008-07-31
GEP20043268B (en) 2004-06-25
HK1045509A1 (en) 2002-11-29
AR035162A1 (es) 2004-05-05
DE60017575T2 (de) 2005-06-09
ZA200200830B (en) 2003-03-26
PL354242A1 (en) 2003-12-29
OA12016A (en) 2006-04-19
NZ516793A (en) 2004-03-26
EP1208104A2 (en) 2002-05-29
WO2001016136B1 (en) 2001-11-15
GT200000145A (es) 2002-02-21
PE20010538A1 (es) 2001-05-22
AP1553A (en) 2006-01-18
CR6577A (es) 2003-12-05
DOP2000000069A (es) 2002-08-30

Similar Documents

Publication Publication Date Title
SV2003000162A (es) Los inhibidores triciclicos de poli (adp-ribosa) polimerasas
SV2002000195A (es) Compuestos farmaceuticamente activos ref. pcs10342 afae/bb
ECSP003699A (es) Inhibidores de fab i
ATE302775T1 (de) Carbolinderivate
DE60022226D1 (de) Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
BR0115436A (pt) Compostos de piperazinilpirazina atuando como antagonistas do receptor 5ht-2 de serotonina
HN2002000028A (es) Pirimidinas inhibidoras de metaloproteinasas
ES2188584T3 (es) Derivados heterociclicos de amina.
DK1277754T3 (da) Imidazopyridinderivater
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
ATE433981T1 (de) Heterocyclische verbindungen
AR027518A1 (es) Inhibidores de girasas y usos de los mismos
AR027293A1 (es) Derivados aminados de dihidro-1,3,5-triazina y sus aplicaciones en terapeutica
CY1108808T1 (el) Ενωσεις μοτιλιδης
DK1643984T3 (da) Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler
DK1390371T3 (da) Oxazolo- og furopyrimidiner samt deres anvendelse i lægemidler mod tumorer
ATE297931T1 (de) Tricyclische imidazopyridine
DK1313740T3 (da) Prodrugs af imidazopyridinderivater
MX9700959A (es) Derivados de becimidazol que tienen actividad dopaminergica.
ATE356131T1 (de) Tricyclische imidazopyridine
UY28535A1 (es) Derivados de bencimidazol, composiciones que los contienen, preparacion y usos de los mismos.
MXPA03003798A (es) Derivados triciclicos de indol con actividad antiangiogenica.
ATE246174T1 (de) Tosylprolin-derivate als thymidylat-synthase inhibitoren
EA200600092A1 (ru) Новые цитотоксические депсипептиды
DE60219788D1 (de) Tetrazyklische verbindungen als pde5-inhibitoren