MX2023008146A - Proceso para preparar un resto enlazador de conjugados. - Google Patents
Proceso para preparar un resto enlazador de conjugados.Info
- Publication number
- MX2023008146A MX2023008146A MX2023008146A MX2023008146A MX2023008146A MX 2023008146 A MX2023008146 A MX 2023008146A MX 2023008146 A MX2023008146 A MX 2023008146A MX 2023008146 A MX2023008146 A MX 2023008146A MX 2023008146 A MX2023008146 A MX 2023008146A
- Authority
- MX
- Mexico
- Prior art keywords
- preparing
- linking moiety
- processes
- targeting moieties
- conjugate linking
- Prior art date
Links
- 125000005647 linker group Chemical group 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- KXLYWPHYXPEYSD-KBPBESRZSA-N (1S,2S)-2-benzylsulfanylcycloheptan-1-ol Chemical compound O[C@@H](CCCCC1)[C@H]1SCC1=CC=CC=C1 KXLYWPHYXPEYSD-KBPBESRZSA-N 0.000 abstract 1
- BSQRYKFTXPXVIK-WHFBIAKZSA-N (1S,2S)-2-sulfanylcyclopentan-1-ol Chemical compound O[C@@H](CCC1)[C@H]1S BSQRYKFTXPXVIK-WHFBIAKZSA-N 0.000 abstract 1
- KFEUHCXDITWBNA-STQMWFEESA-N (1s,2s)-2-benzylsulfanylcyclohexan-1-ol Chemical compound O[C@H]1CCCC[C@@H]1SCC1=CC=CC=C1 KFEUHCXDITWBNA-STQMWFEESA-N 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 101710098554 Lipase B Proteins 0.000 abstract 1
- 241001661345 Moesziomyces antarcticus Species 0.000 abstract 1
- KPJQEIHXBJFQDP-WDSKDSINSA-N O[C@H]1CCCC[C@@H]1S Chemical compound O[C@H]1CCCC[C@@H]1S KPJQEIHXBJFQDP-WDSKDSINSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/087—Acrylic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
La presente invención se refiere a procesos para preparar enlazadores que son útiles en la conjugación de moléculas terapéuticas (por ejemplo, agentes citotóxicos) con restos de direccionamiento (por ejemplo, proteínas, péptidos, anticuerpos, nanopartículas, ácidos nucleicos). Durante los procesos, se usaron lipasas como la lipasa B de Candida antarctica para la resolución enantioselectiva de (S,S)-2-benciltiociclohexanol o (S,S)-2-benciltiocicloheptanol en presencia de un agente acilante, que se reducen para desprotegerlos y producir (S,S)-2-mercaptociclohexanol o (S,S)-2-mercaptociclopentanol, que pueden usarse para unir moléculas terapéuticas con restos de direccionamiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135088P | 2021-01-08 | 2021-01-08 | |
| PCT/US2022/011629 WO2022150596A1 (en) | 2021-01-08 | 2022-01-07 | Process for preparing a conjugate linking moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023008146A true MX2023008146A (es) | 2023-07-24 |
Family
ID=80446978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023008146A MX2023008146A (es) | 2021-01-08 | 2022-01-07 | Proceso para preparar un resto enlazador de conjugados. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240093250A1 (es) |
| EP (1) | EP4274905A1 (es) |
| JP (1) | JP2024503380A (es) |
| KR (1) | KR20230141786A (es) |
| CN (1) | CN116940691A (es) |
| AU (1) | AU2022206297A1 (es) |
| CA (1) | CA3207488A1 (es) |
| CL (1) | CL2023001983A1 (es) |
| CO (1) | CO2023010359A2 (es) |
| CR (1) | CR20230378A (es) |
| IL (1) | IL304234A (es) |
| MX (1) | MX2023008146A (es) |
| PE (1) | PE20240119A1 (es) |
| WO (1) | WO2022150596A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022000450A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 3 Inc | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos. |
| PH12022550039A1 (en) | 2019-07-10 | 2023-06-26 | Cybrexa 3 Inc | Peptide conjugates of cytotoxins as therapeutics |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199800127T1 (xx) | 1995-08-02 | 1998-04-21 | Newcastle University Ventures Limited | Benzimidazol bile�ikleri. |
| DE59911249D1 (de) | 1998-11-03 | 2005-01-13 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| SK287338B6 (sk) | 1999-01-11 | 2010-07-07 | Agouron Pharmaceuticals, Inc. | Tricyklická zlúčenina, jej použitie a farmaceutická kompozícia s jej obsahom |
| DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| JP4336011B2 (ja) * | 1999-12-20 | 2009-09-30 | 甲南化工株式会社 | リパーゼを利用した光学活性アズレントリフルオロエタノール誘導体の両鏡像体の製造方法 |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| EP1501822B1 (en) | 2002-04-30 | 2010-12-15 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| EP1846014B1 (en) | 2005-01-18 | 2012-10-24 | The Board of Governors for Higher Education State of Rhode Island and Providence Plantations | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide |
| EP1957477B1 (en) | 2005-09-29 | 2011-12-07 | Abbott Laboratories | 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors |
| UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| EP2805945B1 (en) | 2007-01-10 | 2019-04-03 | MSD Italia S.r.l. | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| CA3032185C (en) | 2010-07-13 | 2021-08-03 | Council on Postsecondary Education, State of Rhode Island and Providence Plantations | Environmentally sensitive composition comprising a ph triggered peptide and uses thereof |
| EP2643281A4 (en) * | 2010-11-26 | 2014-06-04 | Basf Se | PREPARATION OF ISOMERICALLY PURE SUBSTITUTED CYCLOHEXANOLS |
| ES2684506T3 (es) * | 2011-07-15 | 2018-10-03 | Natureworks Llc | Separación de R,R y S,S-lactidas |
| MX2020007060A (es) | 2018-01-05 | 2020-11-11 | Cybrexa 1 Inc | Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas. |
| PH12022550039A1 (en) | 2019-07-10 | 2023-06-26 | Cybrexa 3 Inc | Peptide conjugates of cytotoxins as therapeutics |
| MX2022000450A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 3 Inc | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos. |
-
2022
- 2022-01-07 MX MX2023008146A patent/MX2023008146A/es unknown
- 2022-01-07 US US18/271,121 patent/US20240093250A1/en active Pending
- 2022-01-07 KR KR1020237026474A patent/KR20230141786A/ko active Pending
- 2022-01-07 EP EP22705192.7A patent/EP4274905A1/en active Pending
- 2022-01-07 AU AU2022206297A patent/AU2022206297A1/en active Pending
- 2022-01-07 JP JP2023541615A patent/JP2024503380A/ja active Pending
- 2022-01-07 WO PCT/US2022/011629 patent/WO2022150596A1/en not_active Ceased
- 2022-01-07 PE PE2023002021A patent/PE20240119A1/es unknown
- 2022-01-07 CN CN202280015657.8A patent/CN116940691A/zh active Pending
- 2022-01-07 CR CR20230378A patent/CR20230378A/es unknown
- 2022-01-07 CA CA3207488A patent/CA3207488A1/en active Pending
-
2023
- 2023-07-04 IL IL304234A patent/IL304234A/en unknown
- 2023-07-05 CL CL2023001983A patent/CL2023001983A1/es unknown
- 2023-08-04 CO CONC2023/0010359A patent/CO2023010359A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230141786A (ko) | 2023-10-10 |
| JP2024503380A (ja) | 2024-01-25 |
| US20240093250A1 (en) | 2024-03-21 |
| CA3207488A1 (en) | 2022-07-14 |
| CR20230378A (es) | 2023-10-27 |
| AU2022206297A1 (en) | 2023-08-03 |
| EP4274905A1 (en) | 2023-11-15 |
| AU2022206297A9 (en) | 2024-09-19 |
| CL2023001983A1 (es) | 2023-12-15 |
| WO2022150596A1 (en) | 2022-07-14 |
| IL304234A (en) | 2023-09-01 |
| CN116940691A (zh) | 2023-10-24 |
| PE20240119A1 (es) | 2024-01-22 |
| CO2023010359A2 (es) | 2023-10-30 |
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