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SV2001000298A - Carboxamidas de pirimidina utiles como inhibidores de isozimas pde4 ref. pc10698arms/bb - Google Patents

Carboxamidas de pirimidina utiles como inhibidores de isozimas pde4 ref. pc10698arms/bb

Info

Publication number
SV2001000298A
SV2001000298A SV2001000298A SV2001000298A SV2001000298A SV 2001000298 A SV2001000298 A SV 2001000298A SV 2001000298 A SV2001000298 A SV 2001000298A SV 2001000298 A SV2001000298 A SV 2001000298A SV 2001000298 A SV2001000298 A SV 2001000298A
Authority
SV
El Salvador
Prior art keywords
bicycle
rest
alkyl
chronic
pde4
Prior art date
Application number
SV2001000298A
Other languages
English (en)
Inventor
Robert James Chambers
Thomas Victor Magee
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SV2001000298A publication Critical patent/SV2001000298A/es

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Dermatology (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA SIGUIENTE: VER FORMULA, EN LA QUE J ES 0 ó 1; K ES 0 ó 1; M ES 0 ó 1; N ES 0 ó 1; W ES -O-; -S(=O)T-, EN EL QUE T ES O, 1 ó 2; o -N(R3)-; EN EL QUE R3 ES -H; - ALQUILO (C1-C3); -OR12; FENILO; O BENCILO; RC Y RD TIENEN EL MISMO SIGNIFICADO QUE RA Y RB SALVO PORQUE AL MENOS UNO DE RC Y RD DEBE SER -H, ZA ES (A) UN GRUPO HETEROCICLICO (C3-C9) SATURADO O INSATURADO, FUSIONADO O ABIERTO, CICLICO O BICICLICO, SELECCIONADO ENTRE FURANILO, TIENILO, PIRROLILO, PIRROLIDINILO, OXAZOLILO, ISOXAZOLILO, TIAZOLILO, ISOTIAZOLILO, MORFOLINILO, PIRAZOLILO, OXADIAZOLILO, TIADIAZOLILO, IMIDAZOLILO, PIRAZINILO, PIRIMIDINILO, PIRIDAZINILO, PIPERIDINILO, PIPERAZINILO, TRIAZOLILO, TETRAZOLILO,2,3-BENZOFURANILO, 2,3-DIHIDROBENZOFURANILO, 1,3-DIHIDROISOBENZOFURANILO, BENZO [B]TIENILO, INDOLILO, INDOLINILO, ISOINDOLINILO, 2H-1-BENZOPIRANILO, 4H-1-BENZOPIRANILO, 1H-2-BENZOPIRANILO, CROMANILO, ISOCROMANILO, QUINOLEILO, ISOQUINOLEILO, 1,2,3,4-TETRAHIDROQUINOLEILO, 1,2,3,4-TETRAHIDROISOQUINOLEILO, QUINUCLIDINILO, AZABICICLO [3.3.0] OCTANILO, 1,3-BENZODIOXOLILO, 3H-2,1-BENZOXATIOLILO, BENZOXAZOLILO, 1-2-BENZOISOXAZOLILO, 2,1-BENZOISOXAZOLILO, 1,2-BENZODITIOLILO, 1,3-BENZODITIOLILO, BENZOTIAZOLILO, 1,2-BENZOISOTIAZOLILO, BENZOIMIDAZOLILO, INDAZOLILO, 1, 4- BENZODIOXANILO, 4H-3,1- BENZOXAZINILO, 2H-1,4-BENZOXAZINILO, 1,4-BENZOTIAZINILO, 1,2-BENZOTIAZINILO, QUINAZOLINILO, QUINOXALINILO, QUINOXALINILO, FTALAZINILO, CINNOLINILO, 1,2,3-BENZOTIADIAZOLILO, 2H-1,2,4-BENZOTIADIAZILINILO, 2H-1,2,4-BENZOXADIAZINILO, BENZOXATRIAZINILO, 1,2,3-BENZOTRIAZINILO, 1,2,4-BENZOTRIAZINILO Y BENZOTETRAZINILO; O ZA ES (B) UN RESTO CICLOALQUILO (C3-C7) MONOCICLICO; UN RESTO CICLOALQUENILO (C5-C7) MONOCICLICO QUE ES UN MIEMBRO SELECCIONADO DEL GRUPO QUE CONSISTE EN CICLOPENTENILO, CICLOHEXENILO Y CICLOHEPTENILO; O UN RESTO CICLOALQUILO (C7-C10) O CICLOALQUENILO (C7-C10) BICICLICO QUE ES UN MIEMBRO SELECCIONADO DEL GRUPO QUE CONSISTE EN NORBORNANILO, NORBORNENILO, BICICLO [2.2.2] OCTANILO, BICICLO- [3.2.1] OCTANILO, BICICLO [3.3.0] OCTANILO, BICICLO (2.2.2) OCT- 5 - ENILO, BICICLO (2.2.2) OCT - 7 - ENILO, BICICLO (3.3.1) NONANILO, CICLODECANILO Y ADAMANTANILO; EN EL QUE DICHOS RESTOS CICLOALQUILO MONOCICLICOS Y BICICLICOS ESTAN SUSTITUIDOS CON 0-3 R16; o ZA ES (C) FENILO O PIRIDILO SUSTITUIDO CON DE 0 A 3 SUSTITUYENTES R4; EN EL QUE R4 ES -F, -CL, -CN, -OR12, -S(=0)P R12, -C(=0) OR12, -OC(=0) R12, -NO2, -C(=0) NR12 R13, -NR12 R13, -NR14 C(=0) R12, -NR14c(=0) OR12, -NR14 S(=0)P R12, -S(=0)P NR12 R13, -ALQUILO (C1 - C4), FENILO, BENCILO, O UN RESTO HETEROCICLO; Y E ES -H, -F, -CL, -CN, -OR12, ALQUILO (C1 - C4), HIDROXIALQUILO (1 - C4), -CF3, -NO2, -NR12 R13, -NR12 S(=0)2 R13, O -S(=0)2 NR12 R13.SE DESCRIBE TAMBIEN UN METODO PARA TRATAR A UN SUJETO QUE PADECE UNA ENFERMEDAD, TRASTORNO O ESTADO MEDIADO POR LA ISOZIMA PDE4, MEDIANTE EL QUE SE REGULA LA ACTIVACION Y LA DESGRANULACION DE EOSINOFILOS, QUE COMPRENDE ADMINISTRAR UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN COMPUESTO COMO EL ANTERIORMENTE DESCRITO. SE DESCRIBE ADEMAS LA UTILIDAD DE UNA COMPOSICION FARMACEUTICA PARA TRATAR ENFERMEDADES Y ESTADOS INFLAMATORIOS, RESPIRATORIOS Y ALERGICOS, ESPECIALMENTE EL ASMA; LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA (COPD), INCLUYENDO LA BRONQUITIS CRONICA, EL ENFISEMA Y LA BRONQUIECTASIA; LA RINITIS CRONICA; Y LA SINUSITIS CRONICA.
SV2001000298A 2000-01-31 2001-01-31 Carboxamidas de pirimidina utiles como inhibidores de isozimas pde4 ref. pc10698arms/bb SV2001000298A (es)

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Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
DE60019167T2 (de) * 1999-12-24 2006-05-11 Glaxo Group Ltd., Greenford Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticason
DE10110772A1 (de) * 2001-03-07 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren
US7776315B2 (en) 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
YU39503A (sh) 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Derivati pirimidina
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
DE60203652T2 (de) * 2001-01-31 2005-09-08 Pfizer Products Inc., Groton Nikotinsäureamid-Derivate und ihre Mimetika als Inhibitoren von PDE4-Isozyme
NZ526453A (en) * 2001-01-31 2005-01-28 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
OA12542A (en) * 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
CZ20031902A3 (cs) 2001-01-31 2004-07-14 Pfizer Products Inc. Etherové deriváty užitečné jako inhibitory isozymů PDE4
MXPA03010679A (es) * 2001-05-23 2004-03-02 Tanabe Seiyaku Co Una composicion para acelerar la cicatrizacion de fractura osea.
CN1537018A (zh) * 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
DE10142176A1 (de) * 2001-08-29 2003-03-27 Eucro Europe Contract Res Gmbh Verwendung einer Kombination aus ß-adrenergen Agonisten und NDMA-Antagonisten
DE10163991A1 (de) * 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
WO2003071870A1 (en) * 2002-02-26 2003-09-04 Schlesinger Stephen L Use of leukotriene receptor antagonist for treatment of scarring
MXPA04011528A (es) * 2002-05-28 2005-02-14 Altana Pharma Ag Preparacion farmaceutica que se puede aplicar por via topica.
DE10224888A1 (de) * 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040001895A1 (en) * 2002-06-17 2004-01-01 Pfizer Inc. Combination treatment for depression and anxiety
CA2496699C (en) * 2002-08-29 2012-07-17 Cipla Ltd. Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids
US9415102B2 (en) 2002-09-06 2016-08-16 Alexion Pharmaceuticals, Inc. High concentration formulations of anti-C5 antibodies
US20050271660A1 (en) 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
AU2003270330B2 (en) * 2002-09-06 2009-07-30 Alexion Pharmaceuticals, Inc. Method of treatment of asthma using antibodies to complement component C5
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
US7507531B2 (en) 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
JP4565193B2 (ja) 2003-04-23 2010-10-20 バレリタス， インコーポレイテッド 長い持続時間の医薬投与のための液圧作動式ポンプ
US7439241B2 (en) * 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US7132435B2 (en) 2003-07-25 2006-11-07 Pfizer Inc. Compounds
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317498D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Compounds
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317484D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317516D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
US20050020587A1 (en) * 2003-07-25 2005-01-27 Pfizer Inc Nicotinamide derivatives useful as PDE4 inhibitors
US20050059643A1 (en) * 2003-08-05 2005-03-17 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising a steroid and a betamimetic
EP1660661A2 (en) * 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
WO2005048985A2 (en) * 2003-11-14 2005-06-02 Baxter International Inc. Alpha 1-antitrypsin compositions and treatment methods using such compositions
US20090042951A1 (en) * 2004-02-20 2009-02-12 Robert Danziger Blood Pressure Reduction in Salt-Sensitive Hypertension
CA2559062A1 (en) * 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
AU2005237490A1 (en) * 2004-04-23 2005-11-10 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
RU2279878C2 (ru) * 2004-08-17 2006-07-20 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Способ защиты головного мозга в реконструктивной хирургии сонных артерий
EP3056492B1 (en) 2004-10-08 2021-09-22 AbbVie Inc. Meglumine salt and crystalline forms thereof of a drug (delafloxacin)
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
WO2006097547A1 (es) * 2005-03-17 2006-09-21 Proyecto De Biomedicina Cima S.L. Empleo de 5'-metiltioadenosina (mta) en la prevención y/o tratamiento de enfermedades autoinmunes y/o rechazo de transplantes
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
SG173319A1 (en) 2006-03-30 2011-08-29 Valeritas Inc Multi-cartridge fluid delivery device
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008088727A2 (en) * 2007-01-12 2008-07-24 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
US8080549B2 (en) * 2007-01-12 2011-12-20 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
GB0706398D0 (en) * 2007-04-02 2007-05-09 Univ Hospital Of North Staford Improvements in and relating to copd determination
JP2010523695A (ja) * 2007-04-11 2010-07-15 アルコン リサーチ， リミテッド アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用
US7989465B2 (en) * 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
TWI475996B (zh) * 2007-10-19 2015-03-11 Celgene Avilomics Res Inc 雜芳基化合物及其用途
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
AU2009244897B2 (en) 2008-04-16 2014-11-13 Alexion Pharmaceuticals, Inc. 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
KR20110051214A (ko) * 2008-07-30 2011-05-17 닛토덴코 가부시키가이샤 약물 담체
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
ES2631603T3 (es) * 2011-03-31 2017-09-01 Maruho Co., Ltd. Pomada con excelente estabilidad de formulación
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
CN102850321A (zh) * 2011-06-28 2013-01-02 中国科学院上海药物研究所 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途
US8877760B2 (en) 2011-11-23 2014-11-04 Portola Pharmaceuticals, Inc. Substituted pyrazine-2-carboxamide kinase inhibitors
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
KR102006547B1 (ko) * 2017-11-16 2019-08-01 서울대학교산학협력단 벤즈아미드 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 염증질환의 치료 또는 예방용 약학적 조성물
JP7334983B2 (ja) * 2018-01-11 2023-08-29 エンフィスィーマ ソリューションズ ベスローテン フェンノートシャップ 肺気腫及びその他の形態のｃｏｐｄの治療のための組成物及び方法
KR102200032B1 (ko) * 2019-03-13 2021-01-08 전남대학교산학협력단 호흡기 질환의 예방 또는 치료용 조성물
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861891A (en) * 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
TR200001847T2 (tr) 1997-04-04 2002-06-21 Pfizer Products Inc. Nikotinamid Türevleri
YU39503A (sh) * 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Derivati pirimidina

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