SMT201600281B - Trattamento di disturbi correlati a bdnf usando laquinimod - Google Patents
Trattamento di disturbi correlati a bdnf usando laquinimodInfo
- Publication number
- SMT201600281B SMT201600281B SM201600281T SM201600281T SMT201600281B SM T201600281 B SMT201600281 B SM T201600281B SM 201600281 T SM201600281 T SM 201600281T SM 201600281 T SM201600281 T SM 201600281T SM T201600281 B SMT201600281 B SM T201600281B
- Authority
- SM
- San Marino
- Prior art keywords
- laquinimod
- bdnf
- treatment
- related disorders
- disorders
- Prior art date
Links
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 title 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 title 1
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 title 1
- 229960004577 laquinimod Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27392009P | 2009-08-10 | 2009-08-10 | |
| PCT/US2010/002194 WO2011019375A1 (en) | 2009-08-10 | 2010-08-09 | Treatment of bdnf-related disorders using laquinimod |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600281B true SMT201600281B (it) | 2016-11-10 |
Family
ID=43535297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600281T SMT201600281B (it) | 2009-08-10 | 2016-08-18 | Trattamento di disturbi correlati a bdnf usando laquinimod |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9585878B2 (it) |
| EP (2) | EP2467372B1 (it) |
| JP (1) | JP5859438B2 (it) |
| AU (2) | AU2010282948C1 (it) |
| CA (1) | CA2771203C (it) |
| CY (1) | CY1117916T1 (it) |
| DK (1) | DK2467372T3 (it) |
| ES (2) | ES2586843T3 (it) |
| HK (1) | HK1225970A1 (it) |
| HR (1) | HRP20160997T1 (it) |
| HU (1) | HUE029983T2 (it) |
| IL (1) | IL217901B (it) |
| ME (1) | ME02495B (it) |
| PL (2) | PL3064206T3 (it) |
| PT (1) | PT2467372T (it) |
| RS (1) | RS55071B1 (it) |
| SI (1) | SI2467372T1 (it) |
| SM (1) | SMT201600281B (it) |
| WO (1) | WO2011019375A1 (it) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1937642E (pt) * | 2005-10-19 | 2014-11-25 | Teva Pharma | Cristais de sódio de laquinimod, e processos para o fabrico dos mesmos |
| KR20140091778A (ko) | 2006-06-12 | 2014-07-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
| PL2234485T3 (pl) | 2007-12-20 | 2014-06-30 | Teva Pharma | Stabilne preparaty lakwinimodu |
| KR20110048571A (ko) * | 2008-09-03 | 2011-05-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 면역 기능을 지닌 2―옥소―1,2―다이하이드로―퀴놀린 조절제 |
| KR20160148050A (ko) * | 2009-07-30 | 2016-12-23 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 크론병의 치료 |
| US9585878B2 (en) * | 2009-08-10 | 2017-03-07 | Teva Pharmaceutical Industries, Ltd. | Treatment of BDNF-related disorders using laquinimod |
| PH12012501740A1 (en) * | 2010-03-03 | 2012-11-12 | Teva Pharma | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
| KR20160129093A (ko) * | 2010-03-03 | 2016-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| PH12012501741A1 (en) * | 2010-03-03 | 2012-11-12 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
| WO2012006538A1 (en) | 2010-07-09 | 2012-01-12 | Teva Pharmaceutical Industries Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| CN103781354A (zh) * | 2011-07-28 | 2014-05-07 | 泰华制药工业有限公司 | 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症 |
| WO2013055907A1 (en) | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| CN104093310A (zh) | 2012-02-03 | 2014-10-08 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
| US9284276B2 (en) | 2012-02-16 | 2016-03-15 | Teva Pharmaceutical Industries, Ltd. | N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) * | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
| TW201410243A (zh) * | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型1(cb1)媒介之疾病之拉喹莫德(laquinimod) |
| AU2013323131A1 (en) * | 2012-09-27 | 2015-05-07 | Teva Pharmaceutical Industries Ltd. | Laquinimod and pridopidine for treating neurodegenerative disorders |
| JP2015533163A (ja) * | 2012-10-12 | 2015-11-19 | テバ ファーマシューティカル インダストリーズ リミティド | 多発性硬化症における視床損傷を低減するためのラキニモド |
| US8975279B2 (en) | 2012-11-07 | 2015-03-10 | Teva Pharmaceutical Industries, Ltd. | Amine salts of laquinimod |
| WO2014153145A2 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| CA2900977A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
| CA2930113A1 (en) * | 2013-11-15 | 2015-05-21 | Teva Pharmaceutical Industries Ltd. | Treatment of glaucoma using laquinimod |
| US20150174118A1 (en) * | 2013-12-20 | 2015-06-25 | Teva Pharmaceutical Industries, Ltd. | Use of laquinimod to delay huntington's disease progression |
| HK1231413A1 (zh) | 2014-04-29 | 2017-12-22 | Teva Pharmaceutical Industries Ltd. | 用於治疗具有高残疾状况的复发-缓解型多发性硬化症(rrms)的患者的拉喹莫德 |
| EP3193870A4 (en) * | 2014-09-16 | 2018-04-25 | Teva Pharmaceutical Industries Ltd. | Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod |
| KR20210045423A (ko) * | 2018-08-16 | 2021-04-26 | 바이오하벤 테라퓨틱스 리미티드 | 질환 치료를 위한 릴루졸 경구 붕해 정제의 용도 |
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| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| US8343996B2 (en) * | 2008-11-13 | 2013-01-01 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| SI2442651T1 (sl) | 2009-06-19 | 2015-10-30 | Teva Pharmaceutical Industries Ltd. | Zdravljenje multiple skleroze z lakvinimodom |
| US9585878B2 (en) * | 2009-08-10 | 2017-03-07 | Teva Pharmaceutical Industries, Ltd. | Treatment of BDNF-related disorders using laquinimod |
| PH12012501740A1 (en) | 2010-03-03 | 2012-11-12 | Teva Pharma | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
| PH12012501741A1 (en) | 2010-03-03 | 2012-11-12 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
| KR20160129093A (ko) | 2010-03-03 | 2016-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| EP2590653A4 (en) | 2010-07-09 | 2014-01-01 | Teva Pharma | 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROCHINOLINE-3-CARBOXAMIDE, SALT THEREOF AND APPLICATIONS THEREOF |
| WO2012006538A1 (en) | 2010-07-09 | 2012-01-12 | Teva Pharmaceutical Industries Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| SG10201509831XA (en) | 2010-12-07 | 2015-12-30 | Teva Pharma | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients |
| WO2013055907A1 (en) * | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
-
2010
- 2010-08-09 US US12/806,275 patent/US9585878B2/en active Active
- 2010-08-09 HU HUE10808442A patent/HUE029983T2/en unknown
- 2010-08-09 WO PCT/US2010/002194 patent/WO2011019375A1/en not_active Ceased
- 2010-08-09 EP EP10808442.7A patent/EP2467372B1/en active Active
- 2010-08-09 ME MEP-2016-162A patent/ME02495B/me unknown
- 2010-08-09 PL PL16160522T patent/PL3064206T3/pl unknown
- 2010-08-09 AU AU2010282948A patent/AU2010282948C1/en active Active
- 2010-08-09 PL PL10808442T patent/PL2467372T3/pl unknown
- 2010-08-09 DK DK10808442.7T patent/DK2467372T3/en active
- 2010-08-09 EP EP16160522.5A patent/EP3064206B1/en active Active
- 2010-08-09 RS RS20160664A patent/RS55071B1/sr unknown
- 2010-08-09 SI SI201031245A patent/SI2467372T1/sl unknown
- 2010-08-09 ES ES10808442.7T patent/ES2586843T3/es active Active
- 2010-08-09 ES ES16160522T patent/ES2731052T3/es active Active
- 2010-08-09 PT PT108084427T patent/PT2467372T/pt unknown
- 2010-08-09 JP JP2012524692A patent/JP5859438B2/ja not_active Expired - Fee Related
- 2010-08-09 HR HRP20160997TT patent/HRP20160997T1/hr unknown
- 2010-08-09 CA CA2771203A patent/CA2771203C/en active Active
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2012
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2016
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- 2016-08-16 CY CY20161100805T patent/CY1117916T1/el unknown
- 2016-08-18 SM SM201600281T patent/SMT201600281B/it unknown
- 2016-12-16 HK HK16114333.9A patent/HK1225970A1/en unknown
- 2016-12-21 AU AU2016277618A patent/AU2016277618A1/en not_active Abandoned
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2011019375A1 (en) | 2011-02-17 |
| AU2010282948C1 (en) | 2017-03-02 |
| EP2467372A4 (en) | 2013-01-09 |
| RS55071B1 (sr) | 2016-12-30 |
| IL217901B (en) | 2018-12-31 |
| EP3064206B1 (en) | 2019-03-20 |
| EP3064206A1 (en) | 2016-09-07 |
| AU2010282948A1 (en) | 2012-04-05 |
| ME02495B (me) | 2017-02-20 |
| PL2467372T3 (pl) | 2017-04-28 |
| JP5859438B2 (ja) | 2016-02-10 |
| HRP20160997T1 (hr) | 2016-10-07 |
| IL217901A0 (en) | 2012-03-29 |
| PT2467372T (pt) | 2016-08-23 |
| SI2467372T1 (sl) | 2016-09-30 |
| US20110034508A1 (en) | 2011-02-10 |
| ES2731052T3 (es) | 2019-11-13 |
| CA2771203C (en) | 2019-04-09 |
| DK2467372T3 (en) | 2016-08-22 |
| EP2467372B1 (en) | 2016-05-18 |
| CA2771203A1 (en) | 2011-02-17 |
| AU2010282948B2 (en) | 2016-09-29 |
| US9585878B2 (en) | 2017-03-07 |
| CY1117916T1 (el) | 2017-05-17 |
| HUE029983T2 (en) | 2017-04-28 |
| JP2013501784A (ja) | 2013-01-17 |
| US20160243103A1 (en) | 2016-08-25 |
| HK1225970A1 (en) | 2017-09-22 |
| PL3064206T3 (pl) | 2020-02-28 |
| EP2467372A1 (en) | 2012-06-27 |
| ES2586843T3 (es) | 2016-10-19 |
| AU2016277618A1 (en) | 2017-01-19 |
| US20170239234A1 (en) | 2017-08-24 |
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