[go: up one dir, main page]

SMT201400070B - Impiego della 7-cloro-n,n,5-trimetil-4-osso-3-fenil-3,5-diidro-4H-piridazino[4,5-B]indolo-1-acetamide come un biomarcatore di livelli del recettore periferico di benzo-diazepine - Google Patents

Impiego della 7-cloro-n,n,5-trimetil-4-osso-3-fenil-3,5-diidro-4H-piridazino[4,5-B]indolo-1-acetamide come un biomarcatore di livelli del recettore periferico di benzo-diazepine

Info

Publication number
SMT201400070B
SMT201400070B SM201400070T SM201400070T SMT201400070B SM T201400070 B SMT201400070 B SM T201400070B SM 201400070 T SM201400070 T SM 201400070T SM 201400070 T SM201400070 T SM 201400070T SM T201400070 B SMT201400070 B SM T201400070B
Authority
SM
San Marino
Prior art keywords
diazepine
biomarker
pyridazine
acetamide
indole
Prior art date
Application number
SM201400070T
Other languages
English (en)
Italian (it)
Inventor
Jesus Benavides
Herve Boutin
Marie-Noelle Castel
Annelaure Damont
Frederic Dolle
Philippe Hantraye
Frank Marguet
Thomas Rooney
Luc Rivron
Bertrand Tavitian
Cyrille Thominiaux
Original Assignee
Sanofi Sa
Commissariat Energie Atomique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Commissariat Energie Atomique filed Critical Sanofi Sa
Publication of SMT201400070B publication Critical patent/SMT201400070B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SM201400070T 2008-10-28 2014-06-12 Impiego della 7-cloro-n,n,5-trimetil-4-osso-3-fenil-3,5-diidro-4H-piridazino[4,5-B]indolo-1-acetamide come un biomarcatore di livelli del recettore periferico di benzo-diazepine SMT201400070B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08291013A EP2181717A1 (en) 2008-10-28 2008-10-28 Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
PCT/IB2009/007562 WO2010049819A1 (en) 2008-10-28 2009-10-27 Use of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Publications (1)

Publication Number Publication Date
SMT201400070B true SMT201400070B (it) 2014-07-07

Family

ID=40262247

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201400070T SMT201400070B (it) 2008-10-28 2014-06-12 Impiego della 7-cloro-n,n,5-trimetil-4-osso-3-fenil-3,5-diidro-4H-piridazino[4,5-B]indolo-1-acetamide come un biomarcatore di livelli del recettore periferico di benzo-diazepine

Country Status (31)

Country Link
US (2) US20120039816A1 (xx)
EP (2) EP2181717A1 (xx)
JP (1) JP5743894B2 (xx)
KR (2) KR20110098711A (xx)
CN (1) CN102223899B (xx)
AR (1) AR073983A1 (xx)
AU (1) AU2009309339C1 (xx)
BR (1) BRPI0920412A2 (xx)
CA (1) CA2741620C (xx)
CL (2) CL2011000954A1 (xx)
CO (1) CO6382141A2 (xx)
CY (1) CY1115211T1 (xx)
DK (1) DK2349352T3 (xx)
EA (1) EA020612B1 (xx)
ES (1) ES2452665T3 (xx)
HR (1) HRP20140250T1 (xx)
IL (1) IL212473A (xx)
MA (1) MA32803B1 (xx)
ME (2) ME01128B (xx)
MX (1) MX2011004420A (xx)
MY (1) MY152968A (xx)
NZ (1) NZ592479A (xx)
PL (1) PL2349352T3 (xx)
PT (1) PT2349352E (xx)
RS (1) RS53273B (xx)
SI (1) SI2349352T1 (xx)
SM (1) SMT201400070B (xx)
TW (1) TWI450728B (xx)
UY (1) UY32206A (xx)
WO (1) WO2010049819A1 (xx)
ZA (1) ZA201103082B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
EP4278367A1 (en) * 2021-01-15 2023-11-22 Minnetronix Neuro, Inc. Systems and methods for managing, monitoring, and treating patient conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
JP4362457B2 (ja) * 2005-04-26 2009-11-11 独立行政法人科学技術振興機構 神経因性疼痛治療剤
JP2010501491A (ja) * 2006-08-24 2010-01-21 オーストラリアン ヌークリア サイエンス アンド テクノロジー オーガニゼイション 末梢性ベンゾジアゼピン受容体をターゲッティングするためのフッ化リガンド
CA2680762A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
EP1997515A1 (en) * 2007-05-30 2008-12-03 Bayer Schering Pharma Aktiengesellschaft Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation

Also Published As

Publication number Publication date
KR20110098711A (ko) 2011-09-01
BRPI0920412A2 (pt) 2015-12-22
UY32206A (es) 2010-05-31
EP2349352B1 (en) 2013-12-25
ZA201103082B (en) 2013-01-30
SI2349352T1 (sl) 2014-07-31
JP5743894B2 (ja) 2015-07-01
ME01819B (me) 2014-09-20
WO2010049819A8 (en) 2011-05-26
JP2012507031A (ja) 2012-03-22
CL2011000954A1 (es) 2012-01-20
US20170160287A1 (en) 2017-06-08
CN102223899B (zh) 2014-08-27
NZ592479A (en) 2013-03-28
TWI450728B (zh) 2014-09-01
EP2181717A1 (en) 2010-05-05
WO2010049819A1 (en) 2010-05-06
AU2009309339C1 (en) 2016-01-14
CN102223899A (zh) 2011-10-19
IL212473A (en) 2015-01-29
CY1115211T1 (el) 2017-01-04
CL2013001041A1 (es) 2014-01-24
AU2009309339A1 (en) 2010-05-06
EA201170613A1 (ru) 2011-12-30
US20120039816A1 (en) 2012-02-16
AR073983A1 (es) 2010-12-15
PT2349352E (pt) 2014-04-03
PL2349352T3 (pl) 2014-05-30
DK2349352T3 (da) 2014-03-31
AU2009309339B2 (en) 2015-08-27
HK1161686A1 (en) 2012-08-03
ES2452665T3 (es) 2014-04-02
CO6382141A2 (es) 2012-02-15
MA32803B1 (fr) 2011-11-01
TW201029671A (en) 2010-08-16
CA2741620A1 (en) 2010-05-06
EP2349352A1 (en) 2011-08-03
MX2011004420A (es) 2011-11-18
MY152968A (en) 2014-12-15
EA020612B1 (ru) 2014-12-30
RS53273B (sr) 2014-08-29
ME01128B (me) 2013-03-20
IL212473A0 (en) 2011-06-30
CA2741620C (en) 2016-08-16
KR20160070846A (ko) 2016-06-20
HRP20140250T1 (hr) 2014-06-20

Similar Documents

Publication Publication Date Title
LTPA2017019I1 (lt) Žmogaus antikūnai, pasižymintys dideliu giminingumu PCSK9
BRPI1005796A2 (pt) rolo de exercício
CO6920295A2 (es) Derivados de [1,2,3]triazolo[4,5-d]pirimidina como agonistas del receptor de canabinoides 2
CR10849A (es) Derivados de benzamida como agonistas del receptor ep4
SI2324831T1 (sl) Terapija s pirfenidonom, izogibajoäśa se fluvoksaminu
BRPI1014843A2 (pt) dispositivo de medição de urina.
BRPI0917980A2 (pt) subcanalização com aumento de potência
BRPI0919948A2 (pt) Pirido[4,3-b]indois contendo porções rígidas
EP2483275A4 (en) HETEROCYCLIC FUSIONED POSITIVE ALLOSTERIC PYRAZOLO [4,3-C] PYRIDINE-3-ON-M1 RECEPTOR MODULATORS
BRPI0920899A2 (pt) macrociclos peptidomiméticos com propriedades melhoradas
BR112012000107A2 (pt) receptores de células t.
DOP2011000388A (es) Carboxamidas 5-fenilo-[1,2,4] triazolo [1,5-a] piridina-2-il como inhibidores jak
CO6930360A2 (es) Derivados de [1,2,3]triazolo[4,5-d]pirimidina como agonistas preferentes del receptor de canabinoides 2
DK2356123T3 (da) Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulener
BRPI0922832A2 (pt) nonapeptídeo com atividade antitumor
BRPI0923194A2 (pt) fabricacao de bateria
EP2490007A4 (en) CUVETTE
BRPI0909304A2 (pt) Salto de sapato regulável em altura e com mecanismo de amortecimento
MY160945A (en) Use of accommodative error measurements in providing ophthalmic lenses
EP2443124A4 (en) SUBSTITUTED 1,3,8-TRIAZASPIRO- [4.5-] DECANE-2,4-DIONE
SMT201400070B (it) Impiego della 7-cloro-n,n,5-trimetil-4-osso-3-fenil-3,5-diidro-4H-piridazino[4,5-B]indolo-1-acetamide come un biomarcatore di livelli del recettore periferico di benzo-diazepine
BRPI0822637A2 (pt) Uso de lanosta-8, 24-dien-3-óis
BRPI1016115A2 (pt) derivados de pirrolidina como antogonistas de receptador de nks.
DK2414365T3 (da) SUBSTITUEREDE [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINER OG ANVENDELSE HERAF SOM KALIUMKANALMODULATORER
ES1070595Y (es) Kit de inflado