ME01819B - Upotreba 7-hloro-n,n,5-trimetil-4-okso-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1- acetamida kao biomarkera nivoa perifernih benzodiazepinskih receptora - Google Patents

Upotreba 7-hloro-n,n,5-trimetil-4-okso-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1- acetamida kao biomarkera nivoa perifernih benzodiazepinskih receptora

Info

Publication number: ME01819B
Authority: ME; Montenegro
Prior art keywords: pyridazino; biomarker; acetamide; indole; dihydro
Prior art date: 2008-10-28

Application number

MEP-2014-31A

Other languages

English (en)

Inventor

Jesus Benavides

Hervé Boutin

Marie-Noëlle Castel

Annelaure Damont

Frédéric Dolle

Philippe Hantraye

Frank Marguet

Thomas Rooney

Luc Rivron

Bertrand Tavitian

Cyrille Thominiaux

Original Assignee

Sanofi Sa

Commissariat Energie Atomique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-28

Filing date

2009-10-27

Publication date

2014-09-20

2009-10-27 Application filed by Sanofi Sa, Commissariat Energie Atomique filed Critical Sanofi Sa

2014-09-20 Publication of ME01819B publication Critical patent/ME01819B/me

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

MEP-2014-31A 2008-10-28 2009-10-27 Upotreba 7-hloro-n,n,5-trimetil-4-okso-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1- acetamida kao biomarkera nivoa perifernih benzodiazepinskih receptora ME01819B (me)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08291013A EP2181717A1 (en)	2008-10-28	2008-10-28	Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
EP09760593.5A EP2349352B1 (en)	2008-10-28	2009-10-27	Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
PCT/IB2009/007562 WO2010049819A1 (en)	2008-10-28	2009-10-27	Use of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Publications (1)

Publication Number	Publication Date
ME01819B true ME01819B (me)	2014-09-20

Family

ID=40262247

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MEP-2014-31A ME01819B (me)	2008-10-28	2009-10-27	Upotreba 7-hloro-n,n,5-trimetil-4-okso-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1- acetamida kao biomarkera nivoa perifernih benzodiazepinskih receptora
MEP-2011-72A ME01128B (me)	2008-10-28	2009-10-27	Upotreba 7-hlor-n,n,5-trimetil-4-okso-3-fenil- 3,5-dihidro-4h-piridazino [4,5-b]indol-1-acetamida kao biomarkera za nivoe perifernih benzodiazepinskih receptora

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
MEP-2011-72A ME01128B (me)	2008-10-28	2009-10-27	Upotreba 7-hlor-n,n,5-trimetil-4-okso-3-fenil- 3,5-dihidro-4h-piridazino [4,5-b]indol-1-acetamida kao biomarkera za nivoe perifernih benzodiazepinskih receptora

Country Status (31)

Country	Link
US (2)	US20120039816A1 (me)
EP (2)	EP2181717A1 (me)
JP (1)	JP5743894B2 (me)
KR (2)	KR20160070846A (me)
CN (1)	CN102223899B (me)
AR (1)	AR073983A1 (me)
AU (1)	AU2009309339C1 (me)
BR (1)	BRPI0920412A2 (me)
CA (1)	CA2741620C (me)
CL (2)	CL2011000954A1 (me)
CO (1)	CO6382141A2 (me)
CY (1)	CY1115211T1 (me)
DK (1)	DK2349352T3 (me)
EA (1)	EA020612B1 (me)
ES (1)	ES2452665T3 (me)
HR (1)	HRP20140250T1 (me)
IL (1)	IL212473A (me)
MA (1)	MA32803B1 (me)
ME (2)	ME01819B (me)
MX (1)	MX2011004420A (me)
MY (1)	MY152968A (me)
NZ (1)	NZ592479A (me)
PL (1)	PL2349352T3 (me)
PT (1)	PT2349352E (me)
RS (1)	RS53273B (me)
SI (1)	SI2349352T1 (me)
SM (1)	SMT201400070B (me)
TW (1)	TWI450728B (me)
UY (1)	UY32206A (me)
WO (1)	WO2010049819A1 (me)
ZA (1)	ZA201103082B (me)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201016038D0 (en) *	2010-09-24	2010-11-10	Ge Healthcare Ltd	In vivo imaging method
GB201016411D0 (en)	2010-09-30	2010-11-10	Ge Healthcare Ltd	In vivo imaging method for cancer
US12068061B2 (en) *	2021-01-15	2024-08-20	Minnetronix Neuro, Inc.	Systems and methods for managing, monitoring, and treating patient conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2766823B1 (fr)	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
JP4362457B2 (ja) *	2005-04-26	2009-11-11	独立行政法人科学技術振興機構	神経因性疼痛治療剤
KR20090063220A (ko) *	2006-08-24	2009-06-17	오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션	말초 벤조디아제핀 수용체를 표적화하기 위한 플루오르화된리간드
CA2680762A1 (en) *	2007-03-12	2008-09-25	National Institute Of Radiological Sciences	Pet visualization of amyloid-associated neuroinflammation in the brain
EP1997515A1 (en) *	2007-05-30	2008-12-03	Bayer Schering Pharma Aktiengesellschaft	Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation

2008
- 2008-10-28 EP EP08291013A patent/EP2181717A1/en not_active Withdrawn
2009
- 2009-10-27 RS RS20140138A patent/RS53273B/sr unknown
- 2009-10-27 WO PCT/IB2009/007562 patent/WO2010049819A1/en not_active Ceased
- 2009-10-27 DK DK09760593.5T patent/DK2349352T3/da active
- 2009-10-27 KR KR1020167015060A patent/KR20160070846A/ko not_active Ceased
- 2009-10-27 MY MYPI20111854 patent/MY152968A/en unknown
- 2009-10-27 US US13/126,648 patent/US20120039816A1/en not_active Abandoned
- 2009-10-27 ME MEP-2014-31A patent/ME01819B/me unknown
- 2009-10-27 CA CA2741620A patent/CA2741620C/en not_active Expired - Fee Related
- 2009-10-27 CN CN200980143233.4A patent/CN102223899B/zh not_active Expired - Fee Related
- 2009-10-27 PT PT97605935T patent/PT2349352E/pt unknown
- 2009-10-27 MX MX2011004420A patent/MX2011004420A/es active IP Right Grant
- 2009-10-27 PL PL09760593T patent/PL2349352T3/pl unknown
- 2009-10-27 AR ARP090104122A patent/AR073983A1/es unknown
- 2009-10-27 KR KR1020117009627A patent/KR20110098711A/ko not_active Ceased
- 2009-10-27 BR BRPI0920412A patent/BRPI0920412A2/pt not_active Application Discontinuation
- 2009-10-27 AU AU2009309339A patent/AU2009309339C1/en not_active Ceased
- 2009-10-27 ES ES09760593.5T patent/ES2452665T3/es active Active
- 2009-10-27 NZ NZ592479A patent/NZ592479A/xx not_active IP Right Cessation
- 2009-10-27 EA EA201170613A patent/EA020612B1/ru not_active IP Right Cessation
- 2009-10-27 JP JP2011533855A patent/JP5743894B2/ja not_active Expired - Fee Related
- 2009-10-27 EP EP09760593.5A patent/EP2349352B1/en active Active
- 2009-10-27 SI SI200930891T patent/SI2349352T1/sl unknown
- 2009-10-27 ME MEP-2011-72A patent/ME01128B/me unknown
- 2009-10-27 HR HRP20140250AT patent/HRP20140250T1/hr unknown
- 2009-10-28 TW TW098136524A patent/TWI450728B/zh not_active IP Right Cessation
- 2009-10-28 UY UY0001032206A patent/UY32206A/es not_active Application Discontinuation
2011
- 2011-04-26 IL IL212473A patent/IL212473A/en not_active IP Right Cessation
- 2011-04-26 ZA ZA2011/03082A patent/ZA201103082B/en unknown
- 2011-04-27 CO CO11051319A patent/CO6382141A2/es active IP Right Grant
- 2011-04-28 CL CL2011000954A patent/CL2011000954A1/es unknown
- 2011-05-19 MA MA33858A patent/MA32803B1/fr unknown
2013
- 2013-04-15 CL CL2013001041A patent/CL2013001041A1/es unknown
2014
- 2014-03-24 CY CY20141100222T patent/CY1115211T1/el unknown
- 2014-06-12 SM SM201400070T patent/SMT201400070B/xx unknown
2016
- 2016-11-10 US US15/347,965 patent/US20170160287A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ZA201103082B (en)	2013-01-30
UY32206A (es)	2010-05-31
PT2349352E (pt)	2014-04-03
CA2741620C (en)	2016-08-16
DK2349352T3 (da)	2014-03-31
AU2009309339C1 (en)	2016-01-14
CO6382141A2 (es)	2012-02-15
MX2011004420A (es)	2011-11-18
BRPI0920412A2 (pt)	2015-12-22
AU2009309339A1 (en)	2010-05-06
CY1115211T1 (el)	2017-01-04
TWI450728B (zh)	2014-09-01
MA32803B1 (fr)	2011-11-01
CN102223899B (zh)	2014-08-27
EP2349352A1 (en)	2011-08-03
IL212473A0 (en)	2011-06-30
HK1161686A1 (en)	2012-08-03
ES2452665T3 (es)	2014-04-02
IL212473A (en)	2015-01-29
CL2011000954A1 (es)	2012-01-20
JP2012507031A (ja)	2012-03-22
TW201029671A (en)	2010-08-16
AR073983A1 (es)	2010-12-15
RS53273B (sr)	2014-08-29
NZ592479A (en)	2013-03-28
WO2010049819A1 (en)	2010-05-06
WO2010049819A8 (en)	2011-05-26
EP2181717A1 (en)	2010-05-05
EA020612B1 (ru)	2014-12-30
US20120039816A1 (en)	2012-02-16
KR20110098711A (ko)	2011-09-01
SMT201400070B (it)	2014-07-07
EA201170613A1 (ru)	2011-12-30
US20170160287A1 (en)	2017-06-08
JP5743894B2 (ja)	2015-07-01
PL2349352T3 (pl)	2014-05-30
CN102223899A (zh)	2011-10-19
SI2349352T1 (sl)	2014-07-31
MY152968A (en)	2014-12-15
KR20160070846A (ko)	2016-06-20
CA2741620A1 (en)	2010-05-06
ME01128B (me)	2013-03-20
EP2349352B1 (en)	2013-12-25
AU2009309339B2 (en)	2015-08-27
CL2013001041A1 (es)	2014-01-24
HRP20140250T1 (hr)	2014-06-20

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IL206666A0 (en)	2010-12-30	N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
ZA201105257B (en)	2012-03-28	3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyrimidine derivatives
EP2074012A4 (en)	2010-09-08	BATTERY SEAT
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GB0807665D0 (en)	2008-06-04	Smartseats (toilet seats)
AU2007901250A0 (en)	2007-03-22	Shaped exercise cushion
GB0810471D0 (en)	2008-07-09	Dual isobase/belt fix car seat base