SK462001A3 - Compounds, compositions, and methods for stimulating neuronal growth and elongation - Google Patents

Compounds, compositions, and methods for stimulating neuronal growth and elongation Download PDF

Info

Publication number: SK462001A3
Authority: SK; Slovakia
Prior art keywords: alkyl; group; compound; substituted; unsubstituted
Prior art date: 1998-07-17

Application number

SK46-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Susumu Katoh

Hiroshi Kawakami

Hiroki Tada

Maria Angelica Linton

Vincent Kalish

John Howard Tatlock

Jesus Ernesto Villafranca

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-17

Filing date

1999-07-15

Publication date

2002-02-05

1999-07-15 Application filed by Agouron Pharma filed Critical Agouron Pharma

2002-02-05 Publication of SK462001A3 publication Critical patent/SK462001A3/sk

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 261
238000000034 method Methods 0.000 title claims abstract description 30
239000000203 mixture Substances 0.000 title abstract description 50
230000004936 stimulating effect Effects 0.000 title description 9
230000007514 neuronal growth Effects 0.000 title description 4
101710103508 FK506-binding protein Proteins 0.000 claims abstract description 56
101710104425 FK506-binding protein 2 Proteins 0.000 claims abstract description 56
101710104423 FK506-binding protein 3 Proteins 0.000 claims abstract description 56
101710104333 FK506-binding protein 4 Proteins 0.000 claims abstract description 56
101710104342 FK506-binding protein 5 Proteins 0.000 claims abstract description 56
101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 claims abstract description 56
101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
101710114693 Outer membrane protein MIP Proteins 0.000 claims abstract description 56
101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 claims abstract description 56
101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 claims abstract description 56
101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 claims abstract description 56
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101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 claims abstract description 56
101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 claims abstract description 56
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101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
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101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 56
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
238000002360 preparation method Methods 0.000 claims description 21
229910052757 nitrogen Inorganic materials 0.000 claims description 20
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 19
229910052799 carbon Inorganic materials 0.000 claims description 18
239000003795 chemical substances by application Substances 0.000 claims description 18
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 14
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125000000168 pyrrolyl group Chemical group 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
238000011552 rat model Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
125000006413 ring segment Chemical group 0.000 description 1
229940121392 rotamase inhibitor Drugs 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
238000009097 single-agent therapy Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000000779 smoke Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
JXAZAUKOWVKTLO-UHFFFAOYSA-L sodium pyrosulfate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)OS([O-])(=O)=O JXAZAUKOWVKTLO-UHFFFAOYSA-L 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000012439 solid excipient Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000003419 tautomerization reaction Methods 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
229910021516 thallium(I) hydroxide Inorganic materials 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000005945 translocation Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
HYWCXWRMUZYRPH-UHFFFAOYSA-N trimethyl(prop-2-enyl)silane Chemical compound C[Si](C)(C)CC=C HYWCXWRMUZYRPH-UHFFFAOYSA-N 0.000 description 1
ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
230000002792 vascular Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

SK46-2001A 1998-07-17 1999-07-15 Compounds, compositions, and methods for stimulating neuronal growth and elongation SK462001A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9329998P	1998-07-17	1998-07-17
US13288499P	1999-05-06	1999-05-06
PCT/US1999/015965 WO2000004020A1 (en)	1998-07-17	1999-07-15	Compounds, compositions, and methods for stimulating neuronal growth and elongation

Publications (1)

Publication Number	Publication Date
SK462001A3 true SK462001A3 (en)	2002-02-05

Family

ID=26787372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK46-2001A SK462001A3 (en)	1998-07-17	1999-07-15	Compounds, compositions, and methods for stimulating neuronal growth and elongation

Country Status (35)

Country	Link
US (1)	US6630472B1 (et)
EP (1)	EP1098897B1 (et)
JP (1)	JP2002520413A (et)
KR (1)	KR20010071920A (et)
CN (1)	CN1318067A (et)
AP (1)	AP2001002052A0 (et)
AT (1)	ATE268772T1 (et)
AU (1)	AU756912B2 (et)
BG (1)	BG105268A (et)
BR (1)	BR9912423A (et)
CA (1)	CA2337377A1 (et)
DE (1)	DE69917907T2 (et)
DK (1)	DK1098897T3 (et)
EA (1)	EA200100149A1 (et)
EE (1)	EE200100032A (et)
ES (1)	ES2226409T3 (et)
GE (1)	GEP20043368B (et)
HR (1)	HRP20010118A2 (et)
HU (1)	HUP0200637A3 (et)
ID (1)	ID27428A (et)
IL (1)	IL140676A0 (et)
IS (1)	IS5805A (et)
LT (1)	LT4850B (et)
LV (1)	LV12665B (et)
NO (1)	NO20010191L (et)
NZ (1)	NZ509211A (et)
OA (1)	OA11581A (et)
PL (1)	PL345598A1 (et)
PT (1)	PT1098897E (et)
SI (1)	SI20638A (et)
SK (1)	SK462001A3 (et)
TR (1)	TR200100122T2 (et)
WO (1)	WO2000004020A1 (et)
YU (1)	YU2901A (et)
ZA (1)	ZA200100320B (et)

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MXPA03010255A (es) *	2001-05-10	2005-03-07	Agouron Pharma	Ligandos heterobiciclicos de proteinas de union a fk-506.
WO2015110271A1 (en) *	2014-01-24	2015-07-30	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders
EP2899192A1 (en) *	2014-01-24	2015-07-29	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders

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1999
- 1999-07-15 KR KR1020017000654A patent/KR20010071920A/ko not_active Ceased
- 1999-07-15 SI SI9920067A patent/SI20638A/sl not_active IP Right Cessation
- 1999-07-15 SK SK46-2001A patent/SK462001A3/sk unknown
- 1999-07-15 NZ NZ509211A patent/NZ509211A/xx unknown
- 1999-07-15 PL PL99345598A patent/PL345598A1/xx not_active Application Discontinuation
- 1999-07-15 JP JP2000560126A patent/JP2002520413A/ja not_active Withdrawn
- 1999-07-15 OA OA1200100015A patent/OA11581A/en unknown
- 1999-07-15 YU YU2901A patent/YU2901A/sh unknown
- 1999-07-15 HU HU0200637A patent/HUP0200637A3/hu unknown
- 1999-07-15 GE GE4273A patent/GEP20043368B/en unknown
- 1999-07-15 EP EP99934043A patent/EP1098897B1/en not_active Expired - Lifetime
- 1999-07-15 BR BR9912423-8A patent/BR9912423A/pt not_active Application Discontinuation
- 1999-07-15 TR TR2001/00122T patent/TR200100122T2/xx unknown
- 1999-07-15 AP APAP/P/2001/002052A patent/AP2001002052A0/en unknown
- 1999-07-15 CA CA002337377A patent/CA2337377A1/en not_active Abandoned
- 1999-07-15 WO PCT/US1999/015965 patent/WO2000004020A1/en not_active Ceased
- 1999-07-15 DK DK99934043T patent/DK1098897T3/da active
- 1999-07-15 EE EEP200100032A patent/EE200100032A/et unknown
- 1999-07-15 ES ES99934043T patent/ES2226409T3/es not_active Expired - Lifetime
- 1999-07-15 IL IL14067699A patent/IL140676A0/xx unknown
- 1999-07-15 AT AT99934043T patent/ATE268772T1/de not_active IP Right Cessation
- 1999-07-15 EA EA200100149A patent/EA200100149A1/ru unknown
- 1999-07-15 PT PT99934043T patent/PT1098897E/pt unknown
- 1999-07-15 HR HR20010118A patent/HRP20010118A2/hr not_active Application Discontinuation
- 1999-07-15 AU AU49963/99A patent/AU756912B2/en not_active Ceased
- 1999-07-15 ID IDW20010130A patent/ID27428A/id unknown
- 1999-07-15 CN CN99810848A patent/CN1318067A/zh active Pending
- 1999-07-15 DE DE69917907T patent/DE69917907T2/de not_active Expired - Fee Related
- 1999-07-16 US US09/356,240 patent/US6630472B1/en not_active Expired - Fee Related
2001
- 2001-01-11 ZA ZA200100320A patent/ZA200100320B/en unknown
- 2001-01-12 NO NO20010191A patent/NO20010191L/no not_active Application Discontinuation
- 2001-01-12 IS IS5805A patent/IS5805A/is unknown
- 2001-02-15 LT LT2001012A patent/LT4850B/lt not_active IP Right Cessation
- 2001-02-16 BG BG105268A patent/BG105268A/xx unknown
- 2001-03-13 LV LV010023A patent/LV12665B/lv unknown

Also Published As

Publication number	Publication date
SI20638A (sl)	2002-02-28
OA11581A (en)	2004-07-23
DE69917907D1 (de)	2004-07-15
HUP0200637A3 (en)	2003-05-28
EP1098897A1 (en)	2001-05-16
ES2226409T3 (es)	2005-03-16
DK1098897T3 (da)	2004-10-18
LV12665B (lv)	2001-11-20
NZ509211A (en)	2002-10-25
WO2000004020A1 (en)	2000-01-27
HRP20010118A2 (en)	2002-02-28
KR20010071920A (ko)	2001-07-31
LT4850B (lt)	2001-10-25
CN1318067A (zh)	2001-10-17
BG105268A (en)	2001-11-30
AP2001002052A0 (en)	2001-03-31
GEP20043368B (en)	2004-04-13
ID27428A (id)	2001-04-05
PT1098897E (pt)	2004-10-29
LT2001012A (en)	2001-07-25
ATE268772T1 (de)	2004-06-15
EA200100149A1 (ru)	2001-08-27
DE69917907T2 (de)	2005-06-30
EP1098897B1 (en)	2004-06-09
US6630472B1 (en)	2003-10-07
JP2002520413A (ja)	2002-07-09
AU756912B2 (en)	2003-01-23
ZA200100320B (en)	2002-07-11
PL345598A1 (en)	2001-12-17
LV12665A (en)	2001-05-20
AU4996399A (en)	2000-02-07
BR9912423A (pt)	2001-06-05
EE200100032A (et)	2002-06-17
IL140676A0 (en)	2002-02-10
IS5805A (is)	2001-01-12
TR200100122T2 (tr)	2001-08-21
CA2337377A1 (en)	2000-01-27
NO20010191D0 (no)	2001-01-12
YU2901A (sh)	2004-05-12
NO20010191L (no)	2001-03-16
HUP0200637A2 (en)	2002-08-28

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