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BR9912423A - Compostos e/ou derivados farmaceuticamente aceitáveis, composições farmacêuticas, métodos de tratamento das disordens neurológicas em pacientes e processos de preparação dos compostos ou derivados farmaceuticamente aceitáveis - Google Patents

Compostos e/ou derivados farmaceuticamente aceitáveis, composições farmacêuticas, métodos de tratamento das disordens neurológicas em pacientes e processos de preparação dos compostos ou derivados farmaceuticamente aceitáveis

Info

Publication number
BR9912423A
BR9912423A BR9912423-8A BR9912423A BR9912423A BR 9912423 A BR9912423 A BR 9912423A BR 9912423 A BR9912423 A BR 9912423A BR 9912423 A BR9912423 A BR 9912423A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
derivatives
compounds
acceptable compounds
methods
Prior art date
Application number
BR9912423-8A
Other languages
English (en)
Inventor
Susumo Katoh
Hiroshi Kawakami
Hiroki Tada
Maria Angelica Linton
Vicent Kalish
John Howard Tatlock
J Ernest Villafranca
Original Assignee
Agouron Pharmaceticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceticals Inc filed Critical Agouron Pharmaceticals Inc
Publication of BR9912423A publication Critical patent/BR9912423A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"COMPOSTOS E/OU DERIVADOS FARMACEUTICAMENTE ACEITáVEIS, COMPOSIçõES FARMACêUTICAS, MéTODOS DE TRATAMENTO DAS DISORDENS NEUROLóGICAS EM PACIENTES E PROCESSOS DE PREPARAçãO DOS COMPOSTOS OU DERIVADOS FARMACEUTICAMENTE ACEITáVEIS" Trata-se de compostos que inibem a atividade da enzima peptidil-prolil isomerase (rotamase) da proteína de ligação FK-506 (FKBP) e de composições que compreendem esses compostos. Os compostos inibidores de FKBP possuem um núcleo de azaamida bicíclica [3.3.1], [4.3.1] ou policíclica. As composições farmacêuticas que contêm esses compostos ajudam a estimular o crescimento de neuritos nas células nervosas e aumentam a regeneração dos nervos. Os métodos de tratamento de células nervosas com essas composições são úteis para promover o reparo de danos neuronais causados por doenças e traumas físicos.
BR9912423-8A 1998-07-17 1999-07-15 Compostos e/ou derivados farmaceuticamente aceitáveis, composições farmacêuticas, métodos de tratamento das disordens neurológicas em pacientes e processos de preparação dos compostos ou derivados farmaceuticamente aceitáveis BR9912423A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9329998P 1998-07-17 1998-07-17
US13288499P 1999-05-06 1999-05-06
PCT/US1999/015965 WO2000004020A1 (en) 1998-07-17 1999-07-15 Compounds, compositions, and methods for stimulating neuronal growth and elongation

Publications (1)

Publication Number Publication Date
BR9912423A true BR9912423A (pt) 2001-06-05

Family

ID=26787372

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912423-8A BR9912423A (pt) 1998-07-17 1999-07-15 Compostos e/ou derivados farmaceuticamente aceitáveis, composições farmacêuticas, métodos de tratamento das disordens neurológicas em pacientes e processos de preparação dos compostos ou derivados farmaceuticamente aceitáveis

Country Status (35)

Country Link
US (1) US6630472B1 (pt)
EP (1) EP1098897B1 (pt)
JP (1) JP2002520413A (pt)
KR (1) KR20010071920A (pt)
CN (1) CN1318067A (pt)
AP (1) AP2001002052A0 (pt)
AT (1) ATE268772T1 (pt)
AU (1) AU756912B2 (pt)
BG (1) BG105268A (pt)
BR (1) BR9912423A (pt)
CA (1) CA2337377A1 (pt)
DE (1) DE69917907T2 (pt)
DK (1) DK1098897T3 (pt)
EA (1) EA200100149A1 (pt)
EE (1) EE200100032A (pt)
ES (1) ES2226409T3 (pt)
GE (1) GEP20043368B (pt)
HR (1) HRP20010118A2 (pt)
HU (1) HUP0200637A3 (pt)
ID (1) ID27428A (pt)
IL (1) IL140676A0 (pt)
IS (1) IS5805A (pt)
LT (1) LT4850B (pt)
LV (1) LV12665B (pt)
NO (1) NO20010191L (pt)
NZ (1) NZ509211A (pt)
OA (1) OA11581A (pt)
PL (1) PL345598A1 (pt)
PT (1) PT1098897E (pt)
SI (1) SI20638A (pt)
SK (1) SK462001A3 (pt)
TR (1) TR200100122T2 (pt)
WO (1) WO2000004020A1 (pt)
YU (1) YU2901A (pt)
ZA (1) ZA200100320B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818643B1 (en) * 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
MXPA03010255A (es) * 2001-05-10 2005-03-07 Agouron Pharma Ligandos heterobiciclicos de proteinas de union a fk-506.
WO2015110271A1 (en) * 2014-01-24 2015-07-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders
EP2899192A1 (en) * 2014-01-24 2015-07-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5196352A (en) 1989-01-19 1993-03-23 Merck & Co., Inc. New FK-506 cytosolic binding protein
US5109112A (en) 1989-01-19 1992-04-28 Merck & Co., Inc. FK-506 cytosolic binding protein
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
CA2068062A1 (en) 1991-05-07 1992-11-08 Stephen A. Parent Yeast mutants
US5362629A (en) 1991-08-05 1994-11-08 President And Fellows Of Harvard College Detection of immunosuppressants
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
DE4219973A1 (de) 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5318895A (en) 1992-10-05 1994-06-07 Merck & Co., Inc. Aspergillus niger mutants
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
US5612350A (en) 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
DE4341402A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5457182A (en) 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
US5622866A (en) 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
US5696135A (en) 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US6037370A (en) 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5786378A (en) 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5780484A (en) 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US5840736A (en) 1996-11-13 1998-11-24 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
PA8442401A1 (es) 1996-12-09 2000-05-24 Guilford Pharm Inc Inhibidores polipropilos de ciclofilina
US5874449A (en) 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
US5935989A (en) 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
US5721256A (en) 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
ZA98825B (en) 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones

Also Published As

Publication number Publication date
SI20638A (sl) 2002-02-28
OA11581A (en) 2004-07-23
DE69917907D1 (de) 2004-07-15
HUP0200637A3 (en) 2003-05-28
EP1098897A1 (en) 2001-05-16
ES2226409T3 (es) 2005-03-16
DK1098897T3 (da) 2004-10-18
LV12665B (lv) 2001-11-20
NZ509211A (en) 2002-10-25
WO2000004020A1 (en) 2000-01-27
HRP20010118A2 (en) 2002-02-28
KR20010071920A (ko) 2001-07-31
LT4850B (lt) 2001-10-25
CN1318067A (zh) 2001-10-17
BG105268A (en) 2001-11-30
AP2001002052A0 (en) 2001-03-31
GEP20043368B (en) 2004-04-13
ID27428A (id) 2001-04-05
PT1098897E (pt) 2004-10-29
LT2001012A (en) 2001-07-25
ATE268772T1 (de) 2004-06-15
EA200100149A1 (ru) 2001-08-27
DE69917907T2 (de) 2005-06-30
EP1098897B1 (en) 2004-06-09
US6630472B1 (en) 2003-10-07
JP2002520413A (ja) 2002-07-09
AU756912B2 (en) 2003-01-23
ZA200100320B (en) 2002-07-11
PL345598A1 (en) 2001-12-17
LV12665A (en) 2001-05-20
AU4996399A (en) 2000-02-07
EE200100032A (et) 2002-06-17
IL140676A0 (en) 2002-02-10
IS5805A (is) 2001-01-12
TR200100122T2 (tr) 2001-08-21
CA2337377A1 (en) 2000-01-27
NO20010191D0 (no) 2001-01-12
SK462001A3 (en) 2002-02-05
YU2901A (sh) 2004-05-12
NO20010191L (no) 2001-03-16
HUP0200637A2 (en) 2002-08-28

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

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