SK19242000A3 - Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu - Google Patents

Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu Download PDF

Info

Publication number: SK19242000A3
Authority: SK; Slovakia
Prior art keywords: seq; nucleotides; amino acids; nucleic acid; amino
Prior art date: 1998-06-18

Application number

SK1924-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Thomas Schupp

James Madison Ligon

Istvan Molnar

Ross Zirkle

J�Rn G�Rlach

Devon Cyr

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-18

Filing date

1999-06-16

Publication date

2001-07-10

1999-06-16 Application filed by Novartis Ag filed Critical Novartis Ag

2001-07-10 Publication of SK19242000A3 publication Critical patent/SK19242000A3/sk

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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

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SK1924-2000A 1998-06-18 1999-06-16 Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu SK19242000A3 (sk)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9950498A	1998-06-18	1998-06-18
US10163198P	1998-09-24	1998-09-24
US11890699P	1999-02-05	1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en)	1998-06-18	1999-06-16	Genes for the biosynthesis of epothilones

Publications (1)

Publication Number	Publication Date
SK19242000A3 true SK19242000A3 (sk)	2001-07-10

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SK1924-2000A SK19242000A3 (sk)	1998-06-18	1999-06-16	Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu

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EP (1)	EP1088078A2 (pt)
JP (3)	JP2002518004A (pt)
KR (1)	KR100511233B1 (pt)
CN (1)	CN100374565C (pt)
AU (1)	AU753567B2 (pt)
BR (1)	BR9911349A (pt)
CA (1)	CA2329774A1 (pt)
HU (1)	HUP0102186A3 (pt)
ID (1)	ID29128A (pt)
IL (3)	IL139735A0 (pt)
NO (2)	NO20006195L (pt)
NZ (1)	NZ508326A (pt)
PL (1)	PL200157B1 (pt)
SK (1)	SK19242000A3 (pt)
TR (1)	TR200003759T2 (pt)
WO (1)	WO1999066028A2 (pt)

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NZ511722A (en)	1998-11-20	2004-05-28	Kosan Biosciences Inc	Recombinant methods and materials for producing epothilone and epothilone derivatives
WO2001053533A2 (en) *	2000-01-21	2001-07-26	Kosan Biosciences, Inc.	Method for cloning polyketide synthase genes
NZ546497A (en) *	2000-04-28	2008-04-30	Kosan Biosciences Inc	Production of polyketides
US6998256B2 (en)	2000-04-28	2006-02-14	Kosan Biosciences, Inc.	Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US7257562B2 (en)	2000-10-13	2007-08-14	Thallion Pharmaceuticals Inc.	High throughput method for discovery of gene clusters
IL155306A0 (en)	2000-10-13	2003-11-23	Univ Mississippi	Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
DK1483251T3 (da)	2002-03-12	2010-04-12	Bristol Myers Squibb Co	C3-cyano-epothilon-derivater
WO2006083721A2 (en) *	2005-01-31	2006-08-10	Merck & Co., Inc.	Purification process for piasmid dna
WO2012103516A1 (en)	2011-01-28	2012-08-02	Amyris, Inc.	Gel-encapsulated microcolony screening
US20140057314A1 (en)	2011-05-13	2014-02-27	Amyris, Inc.	Methods and compositions for detecting microbial production of water-immiscible compounds
WO2014025941A1 (en)	2012-08-07	2014-02-13	Jiang Hanxiao	Methods for stabilizing production of acetyl-coenzyme a derived compounds
EP2971027B1 (en)	2013-03-15	2019-01-30	Amyris, Inc.	Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
PT3030662T (pt)	2013-08-07	2020-03-25	Amyris Inc	Métodos para estabilizar a produção de compostos derivados de acetil-coenzina a
US10808015B2 (en)	2015-06-25	2020-10-20	Amyris, Inc.	Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) *	2015-12-24	2022-08-05	武汉合生科技有限公司	化合物的生物合成基因簇及其应用
CN111138444B (zh) *	2020-01-08	2022-05-03	山东大学	一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

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1998
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- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/en not_active Ceased
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/hu unknown
- 1999-06-16 BR BR9911349-0A patent/BR9911349A/pt not_active Application Discontinuation
- 1999-06-16 CN CNB998074217A patent/CN100374565C/zh not_active Expired - Fee Related
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- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/sk not_active Application Discontinuation
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Also Published As

Publication number	Publication date
NZ508326A (en)	2003-10-31
HUP0102186A2 (hu)	2001-10-28
WO1999066028A3 (en)	2000-06-29
IL190391A0 (en)	2008-11-03
NO20006195D0 (no)	2000-12-06
PL200157B1 (pl)	2008-12-31
AU4611699A (en)	2000-01-05
BR9911349A (pt)	2001-03-13
CN1305530A (zh)	2001-07-25
IL139735A0 (en)	2002-02-10
AU753567B2 (en)	2002-10-24
NO20006195L (no)	2001-02-16
PL345579A1 (en)	2001-12-17
KR100511233B1 (ko)	2005-08-31
TR200003759T2 (tr)	2001-06-21
HUP0102186A3 (en)	2005-10-28
JP2008092958A (ja)	2008-04-24
JP2002518004A (ja)	2002-06-25
IL139735A (en)	2009-06-15
JP2006061166A (ja)	2006-03-09
NO20091055L (no)	2001-02-16
ID29128A (id)	2001-08-02
KR20010052962A (ko)	2001-06-25
CN100374565C (zh)	2008-03-12
WO1999066028A2 (en)	1999-12-23
EP1088078A2 (en)	2001-04-04
CA2329774A1 (en)	1999-12-23

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US7172884B2 (en)	2007-02-06	Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
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CN101809030A (zh)	2010-08-18	硫肽前体蛋白质、编码该蛋白质的基因及其用途
CN100374566C (zh)	2008-03-12	用于epothilone生物合成的基因
JP2023012549A (ja)	2023-01-25	改変ストレプトマイセス・フンジシディカス分離株およびその使用
KR20050050146A (ko)	2005-05-27	글리코펩티드 항생제 ａ４０９２６의 생합성을 위한 유전자및 단백질
MXPA00012342A (en)	2001-11-21	Genes for the biosynthesis of epothilones
CZ20004693A3 (cs)	2001-03-14	Izolovaná nukleová kyselina kódující polypeptid účastnící se biosyntézy epothilonu, chimérický gen, vektor a hostitelské buňky obsahující tuto nukleovou kyselinu
RU2265054C2 (ru)	2005-11-27	Рекомбинантная клетка-хозяин (варианты) и клон вас
CA2381427A1 (en)	2001-02-22	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
RU2234532C2 (ru)	2004-08-20	Нуклеиновая кислота (варианты), ее использование для экспрессии эпотилонов, полипептид (варианты), клон бактерий е.coli
RU2773311C2 (ru)	2022-06-01	Модифицированные изоляты streptomyces fungicidicus и их применение
CN1041182A (zh)	1990-04-11	抗生素ge2270
HK1113387B (en)	2012-06-08	Microorganism producing epothilone
CZ279196B6 (cs)	1995-01-18	Protinádorové antibiotikum kedarcidin

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