PT3030662T - Métodos para estabilizar a produção de compostos derivados de acetil-coenzina a - Google Patents
Métodos para estabilizar a produção de compostos derivados de acetil-coenzina aInfo
- Publication number
- PT3030662T PT3030662T PT137482550T PT13748255T PT3030662T PT 3030662 T PT3030662 T PT 3030662T PT 137482550 T PT137482550 T PT 137482550T PT 13748255 T PT13748255 T PT 13748255T PT 3030662 T PT3030662 T PT 3030662T
- Authority
- PT
- Portugal
- Prior art keywords
- coenzyme
- acetyl
- methods
- derived compounds
- stabilizing production
- Prior art date
Links
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title 2
- 229940100228 acetyl coenzyme a Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2013/054028 WO2015020649A1 (en) | 2013-08-07 | 2013-08-07 | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
| EP13748255.0A EP3030662B1 (en) | 2013-08-07 | 2013-08-07 | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3030662T true PT3030662T (pt) | 2020-03-25 |
Family
ID=48980380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137482550T PT3030662T (pt) | 2013-08-07 | 2013-08-07 | Métodos para estabilizar a produção de compostos derivados de acetil-coenzina a |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10563229B2 (pt) |
| EP (2) | EP3030662B1 (pt) |
| AU (1) | AU2013397496B2 (pt) |
| BR (1) | BR112016002526B1 (pt) |
| CA (1) | CA2918891C (pt) |
| PT (1) | PT3030662T (pt) |
| WO (1) | WO2015020649A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015057154A2 (en) | 2013-10-18 | 2015-04-23 | Biopetrolia Ab | ENGINEERING OF ACETYL-CoA METABOLISM IN YEAST |
| US10808015B2 (en) | 2015-06-25 | 2020-10-20 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
| WO2017177147A1 (en) * | 2016-04-07 | 2017-10-12 | Avalos Jose L | System and method of optogenetically controlling metabolic pathways for the production of chemicals |
| WO2018031955A2 (en) | 2016-08-12 | 2018-02-15 | Amyris, Inc. | Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| CN110366595A (zh) | 2017-01-25 | 2019-10-22 | 阿迈瑞斯生物制品葡萄牙个人有限公司 | 倍半萜和类胡萝卜素的共同生成 |
| SG11202001058TA (en) | 2017-08-11 | 2020-03-30 | Amyris Inc | Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides |
| EP3720944A1 (en) | 2017-12-07 | 2020-10-14 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| KR20200111172A (ko) | 2017-12-21 | 2020-09-28 | 지머젠 인코포레이티드 | 네페탈락톨 산화 환원 효소, 네페탈락톨 합성 효소, 및 네페탈락톤을 생산할 수 있는 미생물 |
| CA3106250A1 (en) | 2018-07-12 | 2020-01-16 | Amyris, Inc. | Methods for controlling fermentation feed rates |
| AU2019360932A1 (en) | 2018-10-15 | 2021-05-06 | Amyris, Inc. | Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides |
| US10519475B1 (en) | 2018-11-21 | 2019-12-31 | Amyris, Inc. | Biosynthesis of compounds in yeast |
| BR112021014143A2 (pt) | 2019-01-24 | 2021-10-19 | Amyris, Inc. | Transportadores abc para produção de alta eficiência de rebaudiosídeos |
| BR112021018112A2 (pt) | 2019-03-15 | 2021-12-14 | Amyris Inc | Produção microbiana de compostos |
| CN111826357B (zh) * | 2019-04-15 | 2021-11-19 | 中国科学院分子植物科学卓越创新中心 | 三分三非典型iii型聚酮合酶及其应用 |
| US12480101B2 (en) | 2019-08-01 | 2025-11-25 | Amyris, Inc. | Modified host cells for high efficiency production of vanillin |
| JP2023542096A (ja) | 2020-09-15 | 2023-10-05 | アミリス， インコーポレイテッド | バニリンの高収率生成のための培養組成物及びその使用方法 |
| WO2022198088A1 (en) | 2021-03-19 | 2022-09-22 | Amyris, Inc. | Modified host cells for high efficiency production of vanillin |
| US20250340826A1 (en) | 2022-05-26 | 2025-11-06 | Amyris, Inc. | Improved oligosaccharide production in yeast |
| EP4540271A1 (en) | 2022-06-16 | 2025-04-23 | Amyris, Inc. | High ph methods and compositions for culturing genetically modified host cells |
| KR20250130385A (ko) | 2023-01-03 | 2025-09-01 | 아미리스 인코퍼레이티드 | 세스퀴테르페노이드를 생산할 수 있는 숙주 세포 및 이의 사용 방법 |
| EP4649142A1 (en) | 2023-01-10 | 2025-11-19 | Amyris, Inc. | Production of canthaxanthin |
| WO2024254488A1 (en) | 2023-06-09 | 2024-12-12 | Amyris, Inc. | Improved overlays for cannabinoid production |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR8F (fr) | 1960-07-11 | 1962-02-16 | Laboratoire A Castaigne | Applications thérapeutiques de l'arginase corps 45-25c. |
| US4703009A (en) | 1983-03-08 | 1987-10-27 | Merck & Co., Inc. | RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes |
| EP0118367B1 (en) | 1983-03-08 | 1989-04-26 | Merck & Co. Inc. | Recombinant dna cloning vector pve1, deletion and hybrid mutants, and recombinant derivatives thereof, products and processes |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5672497A (en) | 1986-03-21 | 1997-09-30 | Eli Lilly And Company | Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms |
| CA1340599C (en) | 1986-03-21 | 1999-06-22 | Karen Leigh Cox | Antibiotic-producing microorganisms |
| US5098837A (en) | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5149638A (en) | 1988-09-29 | 1992-09-22 | Eli Lilly And Company | Tylosin biosynthetic genes tylA, tylB and tylI |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| WO1993013663A1 (en) | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| US6060234A (en) | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| EP0726940A4 (en) | 1993-11-02 | 2001-05-23 | Merck & Co Inc | Dna encoding triol polyketide synthase |
| US5716849A (en) | 1994-06-08 | 1998-02-10 | Novartis Finance Corporation | Genes for the biosynthesis of soraphen |
| US5824545A (en) | 1995-11-01 | 1998-10-20 | Millennium Pharaceuticals, Inc. | Identification of eukaryotic growth-related genes and promoter isolation vector and method of use |
| CA2197524A1 (en) | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| CA2197160C (en) | 1996-02-22 | 2007-05-01 | Stanley Gene Burgett | Platenolide synthase gene |
| EP0929681B1 (en) | 1996-08-20 | 2006-09-13 | Novartis AG | Rifamycin biosynthesis gene cluster |
| WO1999005283A2 (fr) | 1997-07-25 | 1999-02-04 | Hoechst Marion Roussel | Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation |
| US6090601A (en) | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
| US6143526A (en) | 1998-03-09 | 2000-11-07 | Baltz; Richard H. | Biosynthetic genes for spinosyn insecticide production |
| NZ509006A (en) | 1998-05-28 | 2003-09-26 | Kosan Biosciences Inc | Recombinant narbonolide polyketide synthase |
| NZ508326A (en) | 1998-06-18 | 2003-10-31 | Novartis Ag | A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B |
| US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
| ATE346938T1 (de) | 1998-10-02 | 2006-12-15 | Kosan Biosciences Inc | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen |
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| FI20050870L (fi) * | 2005-09-01 | 2007-03-02 | Panimolaboratorio Bryggerilabo | Parannettu fermentointimenetelmä hiivageenejä korjaamalla |
| EP1981992A4 (en) | 2006-01-03 | 2010-01-06 | Massachusetts Inst Technology | PROMOTER CONSTRUCTION AND GENETIC CONTROL |
| EP2217711B2 (en) * | 2007-09-20 | 2025-04-23 | Amyris, Inc. | Production of isoprenoids |
| US20120196339A1 (en) * | 2011-01-31 | 2012-08-02 | Los Alamos National Security Llc | Production of industrially relevant compounds in prokaryotic organisms |
| US10808015B2 (en) * | 2015-06-25 | 2020-10-20 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
-
2013
- 2013-08-07 PT PT137482550T patent/PT3030662T/pt unknown
- 2013-08-07 WO PCT/US2013/054028 patent/WO2015020649A1/en not_active Ceased
- 2013-08-07 AU AU2013397496A patent/AU2013397496B2/en active Active
- 2013-08-07 US US14/910,240 patent/US10563229B2/en active Active
- 2013-08-07 EP EP13748255.0A patent/EP3030662B1/en active Active
- 2013-08-07 EP EP20151280.3A patent/EP3663392A1/en not_active Withdrawn
- 2013-08-07 CA CA2918891A patent/CA2918891C/en active Active
- 2013-08-07 BR BR112016002526-1A patent/BR112016002526B1/pt active IP Right Grant
-
2020
- 2020-01-02 US US16/733,191 patent/US11230716B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016002526B1 (pt) | 2021-11-23 |
| CA2918891C (en) | 2023-03-14 |
| US10563229B2 (en) | 2020-02-18 |
| CN105934517A (zh) | 2016-09-07 |
| US20200270643A1 (en) | 2020-08-27 |
| EP3030662A1 (en) | 2016-06-15 |
| EP3663392A1 (en) | 2020-06-10 |
| EP3030662B1 (en) | 2020-01-15 |
| CA2918891A1 (en) | 2015-02-12 |
| AU2013397496A1 (en) | 2016-02-18 |
| AU2013397496B2 (en) | 2020-03-12 |
| WO2015020649A1 (en) | 2015-02-12 |
| US20160177341A1 (en) | 2016-06-23 |
| BR112016002526A2 (pt) | 2018-03-27 |
| US11230716B2 (en) | 2022-01-25 |
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