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BR9911349A - Genes para a biossìntese de epotilonas - Google Patents

Genes para a biossìntese de epotilonas

Info

Publication number
BR9911349A
BR9911349A BR9911349-0A BR9911349A BR9911349A BR 9911349 A BR9911349 A BR 9911349A BR 9911349 A BR9911349 A BR 9911349A BR 9911349 A BR9911349 A BR 9911349A
Authority
BR
Brazil
Prior art keywords
genes
epothilone
biosynthesis
epothilone biosynthesis
biosysynthesis
Prior art date
Application number
BR9911349-0A
Other languages
English (en)
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Joern Goerlach
Devon Cyr
Original Assignee
Novartis Ag Novartis S A Novar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Novartis S A Novar filed Critical Novartis Ag Novartis S A Novar
Publication of BR9911349A publication Critical patent/BR9911349A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Patente de Invenção: <B>"GENES PARA A BIOSSìNTESE DE EPOTILONAS"<D>. Moléculas de ácido nucléico são isoladas de Sorangium Cellulosum que codifica polipeptídios necessários para a biossíntese de epotilona. São revelados processos para a produção de epotilona em hospedeiros recombinantes transformados com os genes da invenção. Desta maneira, epotilona pode ser produzida em quantidades grandes o bastante para permitir sua purificação e uso nas formulações farmacêuticas, tais como aquelas para tratamento do câncer.
BR9911349-0A 1998-06-18 1999-06-16 Genes para a biossìntese de epotilonas BR9911349A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (1)

Publication Number Publication Date
BR9911349A true BR9911349A (pt) 2001-03-13

Family

ID=27378840

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911349-0A BR9911349A (pt) 1998-06-18 1999-06-16 Genes para a biossìntese de epotilonas

Country Status (16)

Country Link
EP (1) EP1088078A2 (pt)
JP (3) JP2002518004A (pt)
KR (1) KR100511233B1 (pt)
CN (1) CN100374565C (pt)
AU (1) AU753567B2 (pt)
BR (1) BR9911349A (pt)
CA (1) CA2329774A1 (pt)
HU (1) HUP0102186A3 (pt)
ID (1) ID29128A (pt)
IL (3) IL139735A0 (pt)
NO (2) NO20006195L (pt)
NZ (1) NZ508326A (pt)
PL (1) PL200157B1 (pt)
SK (1) SK19242000A3 (pt)
TR (1) TR200003759T2 (pt)
WO (1) WO1999066028A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DE69734362T2 (de) 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
WO2000031247A2 (en) * 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US20030113715A1 (en) * 2000-01-21 2003-06-19 Daniel Santi Method for cloning polyketide synthase genes
KR20070092334A (ko) * 2000-04-28 2007-09-12 코산 바이오사이언시즈, 인코포레이티드 폴리케타이드의 제조방법
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
IL155306A0 (en) 2000-10-13 2003-11-23 Univ Mississippi Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
AU2003218110A1 (en) 2002-03-12 2003-09-29 Bristol-Myers Squibb Company C3-cyano epothilone derivatives
CN101310022B (zh) * 2005-01-31 2013-01-16 默沙东公司 大规模生产质粒dna的上游和下游纯化方法
EP2668284B1 (en) 2011-01-28 2014-10-15 Amyris, Inc. Gel-encapsulated microcolony screening
JP2014519028A (ja) 2011-05-13 2014-08-07 アミリス， インコーポレイテッド 水不混和性化合物（ｗｉｃ）の微生物産生を検出するための方法および組成物
US10927382B2 (en) 2012-08-07 2021-02-23 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
CA2903053C (en) 2013-03-15 2023-01-17 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
BR112016002526B1 (pt) 2013-08-07 2021-11-23 Total Marketing Services Método para produção de um composto heterólogo não catabólico, e, composição de fermentação
WO2016210350A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196698C (zh) * 1996-11-18 2005-04-13 生物技术研究有限公司(Gbf) Epothilone D、E和F,其制备方法,以及作为细胞抑制剂和植物保护剂的应用

Also Published As

Publication number Publication date
NO20091055L (no) 2001-02-16
PL200157B1 (pl) 2008-12-31
CN100374565C (zh) 2008-03-12
PL345579A1 (en) 2001-12-17
WO1999066028A3 (en) 2000-06-29
IL139735A0 (en) 2002-02-10
TR200003759T2 (tr) 2001-06-21
EP1088078A2 (en) 2001-04-04
NO20006195D0 (no) 2000-12-06
AU4611699A (en) 2000-01-05
ID29128A (id) 2001-08-02
SK19242000A3 (sk) 2001-07-10
NZ508326A (en) 2003-10-31
AU753567B2 (en) 2002-10-24
HUP0102186A3 (en) 2005-10-28
CA2329774A1 (en) 1999-12-23
WO1999066028A2 (en) 1999-12-23
HUP0102186A2 (hu) 2001-10-28
JP2002518004A (ja) 2002-06-25
IL139735A (en) 2009-06-15
JP2006061166A (ja) 2006-03-09
IL190391A0 (en) 2008-11-03
JP2008092958A (ja) 2008-04-24
NO20006195L (no) 2001-02-16
KR20010052962A (ko) 2001-06-25
KR100511233B1 (ko) 2005-08-31
CN1305530A (zh) 2001-07-25

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10, 24, 25 E 37 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]