SK17112002A3 - Deriváty pyridin-2-ylaminoalkylkarbonylglycyl-beta-alanínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom - Google Patents

Deriváty pyridin-2-ylaminoalkylkarbonylglycyl-beta-alanínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom Download PDF

Info

Publication number: SK17112002A3
Authority: SK; Slovakia
Prior art keywords: formula; compound; pyridin; butanoylamino; ylamino
Prior art date: 2000-06-13

Application number

SK1711-2002A

Other languages

English (en)

Slovak (sk)

Inventor

G�Nter H�Lzemann

Simon Goodman

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-13

Filing date

2001-06-12

Publication date

2003-04-01

2001-06-12 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-04-01 Publication of SK17112002A3 publication Critical patent/SK17112002A3/sk

Links

150000001875 compounds Chemical class 0.000 claims abstract description 108
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PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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238000010647 peptide synthesis reaction Methods 0.000 description 1
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UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
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230000035790 physiological processes and functions Effects 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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239000011591 potassium Substances 0.000 description 1
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239000003755 preservative agent Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
OTRCLINFKXQIBG-UHFFFAOYSA-N propylsulfonyl propane-1-sulfonate Chemical compound CCCS(=O)(=O)OS(=O)(=O)CCC OTRCLINFKXQIBG-UHFFFAOYSA-N 0.000 description 1
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QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
DVFXLNFDWATPMW-IWOKLKJTSA-N tert-butyldiphenylsilyl Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)C(C)(C)C)[C@@H](OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](CC(O2)N2C3=NC=NC(N)=C3N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)O)C1 DVFXLNFDWATPMW-IWOKLKJTSA-N 0.000 description 1
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125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000012360 testing method Methods 0.000 description 1
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URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

SK1711-2002A 2000-06-13 2001-06-12 Deriváty pyridin-2-ylaminoalkylkarbonylglycyl-beta-alanínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom SK17112002A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10028402A DE10028402A1 (de)	2000-06-13	2000-06-13	Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate
PCT/EP2001/006661 WO2001096365A1 (fr)	2000-06-13	2001-06-12	Pyridin-2-yl-aminoalkylcarbonylglycyl-$g(b)-alanine et ses derives

Publications (1)

Publication Number	Publication Date
SK17112002A3 true SK17112002A3 (sk)	2003-04-01

Family

ID=7645128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1711-2002A SK17112002A3 (sk)	2000-06-13	2001-06-12	Deriváty pyridin-2-ylaminoalkylkarbonylglycyl-beta-alanínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom

Country Status (18)

Country	Link
US (1)	US20030171304A1 (fr)
EP (1)	EP1290010A1 (fr)
JP (1)	JP2004503562A (fr)
KR (1)	KR20030022145A (fr)
CN (1)	CN1436196A (fr)
AR (1)	AR028714A1 (fr)
AU (1)	AU6606301A (fr)
BR (1)	BR0111555A (fr)
CA (1)	CA2414000A1 (fr)
CZ (1)	CZ20023952A3 (fr)
DE (1)	DE10028402A1 (fr)
HU (1)	HUP0303716A2 (fr)
MX (1)	MXPA02012411A (fr)
NO (1)	NO20025968L (fr)
PL (1)	PL358671A1 (fr)
SK (1)	SK17112002A3 (fr)
WO (1)	WO2001096365A1 (fr)
ZA (1)	ZA200209410B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6455734B1 (en)	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
CA2375827C (fr)	1999-06-01	2017-01-10	Biogen, Inc.	Anticorps monoclonal bloqueur contre vla-1 et utilisation dudit anticorps pour le traitement de troubles inflammatoires
HUP0402250A3 (en)	2001-04-13	2007-06-28	Biogen Idec Inc	Antibodies to vla-1
US6908935B2 (en)	2002-05-23	2005-06-21	Amgen Inc.	Calcium receptor modulating agents
US7176322B2 (en)	2002-05-23	2007-02-13	Amgen Inc.	Calcium receptor modulating agents
WO2005090329A1 (fr)	2004-03-24	2005-09-29	Jerini Ag	Nouveaux composes pour l'inhibition de l'angiogenese et leurs utilisation
US20090196912A1 (en) *	2004-07-30	2009-08-06	Gpc Botech Ag	Pyridinylamines
JP5496658B2 (ja)	2006-05-25	2014-05-21	バイオジェン・アイデック・エムエイ・インコーポレイテッド	脳卒中を処置する方法
ES2400633T3 (es) *	2008-11-24	2013-04-11	Basf Se	Composición curable que comprende una base termolatente
CA2864539C (fr)	2012-02-16	2022-06-07	Santarus, Inc.	Formulations d'anticorps
SG11202002967SA (en)	2017-11-01	2020-05-28	Arrowhead Pharmaceuticals Inc	Integrin ligands and uses thereof
BR112023020626A2 (pt)	2021-04-08	2023-12-19	Arrowhead Pharmaceuticals Inc	Agentes de rnai para inibir a expressão do receptor para produtos finais de glicação avançada, composições dos mesmos e métodos de uso
WO2025152967A1 (fr) *	2024-01-15	2025-07-24	武汉人福创新药物研发中心有限公司	COMPOSÉS CIBLANT αVβ6 ET LEUR UTILISATION
CN120309684A (zh) *	2024-01-15	2025-07-15	武汉人福创新药物研发中心有限公司	靶向化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000502704A (ja) *	1995-12-29	2000-03-07	スミスクライン・ビーチャム・コーポレイション	ビトロネクチン受容体拮抗物質

2000
- 2000-06-13 DE DE10028402A patent/DE10028402A1/de not_active Withdrawn
2001
- 2001-06-12 MX MXPA02012411A patent/MXPA02012411A/es unknown
- 2001-06-12 CN CN01811104A patent/CN1436196A/zh active Pending
- 2001-06-12 KR KR1020027016894A patent/KR20030022145A/ko not_active Withdrawn
- 2001-06-12 EP EP01943499A patent/EP1290010A1/fr not_active Withdrawn
- 2001-06-12 PL PL01358671A patent/PL358671A1/xx unknown
- 2001-06-12 CA CA002414000A patent/CA2414000A1/fr not_active Abandoned
- 2001-06-12 WO PCT/EP2001/006661 patent/WO2001096365A1/fr not_active Ceased
- 2001-06-12 HU HU0303716A patent/HUP0303716A2/hu unknown
- 2001-06-12 CZ CZ20023952A patent/CZ20023952A3/cs unknown
- 2001-06-12 SK SK1711-2002A patent/SK17112002A3/sk unknown
- 2001-06-12 BR BR0111555-3A patent/BR0111555A/pt not_active Application Discontinuation
- 2001-06-12 AU AU66063/01A patent/AU6606301A/en not_active Abandoned
- 2001-06-12 US US10/297,989 patent/US20030171304A1/en not_active Abandoned
- 2001-06-12 JP JP2002510506A patent/JP2004503562A/ja active Pending
- 2001-06-13 AR ARP010102804A patent/AR028714A1/es unknown
2002
- 2002-11-19 ZA ZA200209410A patent/ZA200209410B/en unknown
- 2002-12-12 NO NO20025968A patent/NO20025968L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0111555A (pt)	2003-07-08
US20030171304A1 (en)	2003-09-11
AR028714A1 (es)	2003-05-21
PL358671A1 (en)	2004-08-09
ZA200209410B (en)	2004-02-19
HUP0303716A2 (hu)	2004-03-01
CZ20023952A3 (cs)	2003-03-12
DE10028402A1 (de)	2001-12-20
MXPA02012411A (es)	2003-04-25
AU6606301A (en)	2001-12-24
NO20025968D0 (no)	2002-12-12
CN1436196A (zh)	2003-08-13
EP1290010A1 (fr)	2003-03-12
KR20030022145A (ko)	2003-03-15
WO2001096365A1 (fr)	2001-12-20
JP2004503562A (ja)	2004-02-05
NO20025968L (no)	2002-12-12
CA2414000A1 (fr)	2002-12-03

Publication	Publication Date	Title
AU2002254900B2 (en)	2008-04-10	Inhibitors of integrin AlphavBeta6
JP2000516575A (ja)	2000-12-12	インテグリンインヒビターとしてのフェニルアラニン誘導体
SK412001A3 (en)	2001-08-06	Diacylhydrazine derivatives as integrin inhibitors
SK17112002A3 (sk)	2003-04-01	Deriváty pyridin-2-ylaminoalkylkarbonylglycyl-beta-alanínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom
EP0822931A1 (fr)	1998-02-11	Piperazinones utiles comme inhibiteurs d'agregation plaquettaire
US6576637B1 (en)	2003-06-10	β-alanine derivatives
EP1472224B1 (fr)	2012-07-11	3-alkanoylamino-acide propionique dérivés utilisés comme inhibiteurs de l'intégrine avss6
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